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Hyaluronic acid

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By Targets:	Amyloid-β (2) Bacterial (3) Biochemical Assay Reagents (16) Endogenous Metabolite (3) Glycosidase (2) NF-κB (1) Transmembrane Glycoprotein (3)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (1)
Oligonucleotides:	Polymers (1)

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Targets Recommended: Amino acid Transporter Amino Acid Derivatives Amino Acid Decarboxylase Hydroxycarboxylic Acid Receptor (HCAR) Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0633A

Hyaluronic acid Maximum Cited Publications 13 Publications Verification Hyaluronan; Hyaluronate	Endogenous Metabolite Bacterial	Cancer
Hyaluronic acid (corn fermented) is a biopolymer composed of repeating units of disaccharides with various applications.

HY-B0633

Hyaluronic acid sodium Maximum Cited Publications 13 Publications Verification Sodium hyaluronate	Endogenous Metabolite Bacterial	Cancer
Hyaluronic acid sodium (Sodium hyaluronate) is a biopolymer composed of repeating units of disaccharides with various applications.

HY-B0633D

Hyaluronic acid sodium (MW 200-1560)	Endogenous Metabolite Bacterial	Cancer
Hyaluronic acid sodium (MW 200-1560) is a biopolymer composed of repeating disaccharide units with a molecular weight of 1000-2000. Hyaluronic acid sodium (MW 200-1560) has a wide range of applications .

HY-B0633C

Hyaluronic acid (Mw:1000-2000Da)	Biochemical Assay Reagents	Inflammation/Immunology
Hyaluronic acid (Mw:1000-2000Da) is a long-chain, unbranched polysaccharide with a molecular weight of 1000-2000 Dalton. Hyaluronic acid (Mw:1000-2000Da) regulates tissue homeostasis and stress resistance, exhibits a pro-inflammatory effect (while hyaluronic acid with high molecular weight exhibits an anti-inflammatory effect), and promotes angiogenesis and tissue remodeling. Hyaluronic acid (Mw:1000-2000Da) exhibits good biocompatible and biodegradable characteristics, that can be used in drug delivery systems and tissue engineering .

HY-158220

Hyaluronic acid Methacryloyl (MW 400 kDa) HAMA (MW 400 kDa)	Biochemical Assay Reagents	Others
Hyaluronic acid Methacryloyl (HAMA) is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

HY-158220A

Hyaluronic acid Methacryloyl (MW 150 kDa) HAMA (MW 150 kDa)	Biochemical Assay Reagents	Others
Hyaluronic acid Methacryloyl (HAMA) MW 150 kDa is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

HY-W540661

Hyaluronic acid tetrasaccharide, 98%	Biochemical Assay Reagents	Others
Hyaluronic acid tetrasaccharide, 98% is a naturally occurring polysaccharide found in the extracellular matrix of connective tissues. Hyaluronic acid tetrasaccharide can be used as a substrate for enzyme assays to characterize hyaluronidases and other hyaluronic acid-degrading enzymes.

HY-158220C

Hyaluronic acid methacryloyl (MW 50000) HAMA (MW 50000)	Biochemical Assay Reagents	Others
Hyaluronic acid methacryloyl (MW 50000) (HAMA (MW 50000)) is a Hyaluronic acid (HY-B0633A) derivative. Hyaluronic acid methacryloyl-based material system has been applied in many biomedical research fields .

HY-158220B

Hyaluronic acid methacryloyl (MW 10000) HAMA (MW 10000)	Biochemical Assay Reagents	Others
Hyaluronic acid methacryloyl (MW 10000) (HAMA (MW 10000)) is a Hyaluronic acid (HY-B0633A) derivative. Hyaluronic acid methacryloyl-based material system has been applied in many biomedical research fields .

HY-B0633E

Hyaluronic acid, low endotoxin Hyaluronan, low endotoxin; Hyaluronate, low endotoxin	Biochemical Assay Reagents	Others
Hyaluronic acid, low endotoxin (Hyaluronan, low endotoxin) is a biopolymer composed of repeating units of disaccharides with various applications .

HY-172442

Hyaluronidase	Biochemical Assay Reagents	Others
Hyaluronidase is an enzyme that can break down hyaluronic acid. Hyaluronidase can increase the absorption of drugs into tissues and reduce tissue damage in cases of drug extravasation .

HY-108903A

Hyaluronidase, Ovine testes 5+ Cited Publications	Glycosidase Biochemical Assay Reagents	Metabolic Disease
Hyaluronidase, Ovine testes is an enzyme responsible for catalyzing the degradation of hyaluronic acid. It is used to improve the absorption and dispersion of gastrointestinal fluids, drugs, and contrast agents. Hyaluronidase, Ovine testes can enhance the diffusion or delivery of local agent (LA) that can suppress or relieve pain or immunoglobulins (Igs) .

HY-164069

Aldehyde Sodium Hyaluronate	Biochemical Assay Reagents	Others
Aldehyde Sodium Hyaluronate is a hyaluronic acid derivative with good moisturizing properties and biocompatibility, and can be used in the research of pharmaceutical and cosmetic fields .

HY-149898

HA-CD44 interaction inhibitor 1	Transmembrane Glycoprotein	Cancer
Antitumor agent-109 (compound 6) is an inhibitor of hyaluronic acid (HY-B0633A) targeting to CD44, as well as an anti-tumor agent. Hyaluronic acid interacts with differentiation cluster 44 (CD44) and is involved in tumor growth and invasion. Antitumor agent-109 inhibits MDA-MB-231 cells with EC50 value of 0.59 μM .

HY-164066

Sodium Acetylated Hyaluronate	Biochemical Assay Reagents	Others
Sodium Acetylated Hyaluronate is an acetylated hyaluronic acid derivative with anti-wrinkle and deep skin penetration properties, which can be used in skin aging research and cosmetic development .

HY-164065

Sodium Hyaluronate Hydroxypropyltrimonium Chloride	Biochemical Assay Reagents	Others
Sodium Hyaluronate Hydroxypropyltrimonium Chloride is a modified form of hyaluronic acid that has been modified by adding positively charged hydroxypropyltrimonium chloride groups to improve its adsorption and retention on the skin. Sodium Hyaluronate Hydroxypropyltrimonium Chloride has good moisturizing and ionic properties and can be used in the research of pharmaceutical and cosmetic fields .

HY-107910

Hyaluronidase, Bovine testes 5+ Cited Publications Hyaluronate 4-glycanohydrolase, Bovine testes; Hyaluronoglucosaminidase, Bovine testes	NF-κB	Inflammation/Immunology Cancer
Hyaluronidase, Bovine testes (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is an endoglycosidase that depolymerizes Hyaluronic acid (HA) (HY-B0633A) by cleavage of glycosidic bonds. Hyaluronidase degrades HA and activates membrane receptors that trigger pathways converging in NF-κB activation. Hyaluronidase is employed in the research of granulomatous foreign body reactions, soft-tissue necrosis caused by vascular compromise and uncomplicated nodules, overcorrection, inflamed nodules or tissue ischemia associated with HA filler injection .

HY-N0187

4-Methylumbelliferone 4 Publications Verification Hymecromone; 4-MU	Others	Cardiovascular Disease Cancer
4-Methylumbelliferone is a hyaluronic acid biosynthesis inhibitor with antitumoral and antimetastatic effects.

HY-164067

Silylanization hyaluronate ester	Biochemical Assay Reagents	Others
Silylanization hyaluronate ester is a hyaluronate ester derivative with good moisturizing properties and biocompatibility, and can be used in cosmetic research .

HY-N6613

Polygalacturonic acid Galacturonic acid polymer	Others	Infection Inflammation/Immunology
Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity .

HY-N7700

Guluronic acid G2013	Amyloid-β	Inflammation/Immunology
Guluronic acid (G2013), one of the organic building blocks of hyaluronic acid, is a nonsteroidal anti-inflammatory agent has favorable anti-inflammatory effect .

HY-N0187R

4-Methylumbelliferone (Standard)	Others	Cardiovascular Disease Cancer
4-Methylumbelliferone (Standard) is the analytical standard of 4-Methylumbelliferone. This product is intended for research and analytical applications. 4-Methylumbelliferone is a hyaluronic acid biosynthesis inhibitor with antitumoral and antimetastatic effects.

HY-108903

Hyaluronidase (human recombinant) 5+ Cited Publications Hylenex; Vorhyaluronidase alfa; rHuPH 20	Biochemical Assay Reagents Glycosidase	Metabolic Disease
Hyaluronidase (human recombinant) (Hylenex; Vorhyaluronidase alfa; rHuPH 20) is an enzyme that catalyzes the degradation of hyaluronic acid. Hyaluronidase (human recombinant) is used to improve the absorption and dispersal of parenteral fluids, medications, and contrast media .

HY-149897

HA-CD44 interaction inhibitor 2	Transmembrane Glycoprotein	Cancer
HA-CD44 interaction inhibitor 2 (compound 5) is an Hyaluronic acid (HA)-CD44 interaction inhibitor that effectively disrupts the integrity of cancer spheroids. HA-CD44 interaction inhibitor 2 also exhibits antiproliferative activity against cancer cells .

HY-W097018

Iomeprol intermediate-1	Biochemical Assay Reagents	Others
Iomeprol intermediate-1 (compound 5) is an iodinated polysaccharide compound used in the synthesis of contrast agents. The amino group of Iomeprol intermediate-1 can be coupled to the carboxyl group of the D-glucuronide subunit of non-animal stable hyaluronic acid (NASHA), providing a water-soluble, radiopaque moiety .

HY-148495

Carnosine conjugated hyalyronate	Amyloid-β	Neurological Disease
Carnosine conjugated hyalyronate is a hyaluronic acid derivative functionalized with the dipeptide carnosine (Carnosine, Car) and has the ability to resist Aβ amyloid aggregation. Carnosine conjugated hyalyronate dissolves amyloid fibrils and reduces Aβ-induced toxicity in vitro. The effectiveness of Carnosine conjugated hyalyronate against amyloid aggregation is directly proportional to the Carnosine loading .

HY-W097018R

Iomeprol intermediate-1 (Standard)	Biochemical Assay Reagents	Others
Iomeprol intermediate-1 (Standard) is the analytical standard of Iomeprol intermediate-1. This product is intended for research and analytical applications. Iomeprol intermediate-1 (compound 5) is an iodinated polysaccharide compound used in the synthesis of contrast agents. The amino group of Iomeprol intermediate-1 can be coupled to the carboxyl group of the D-glucuronide subunit of non-animal stable hyaluronic acid (NASHA), providing a water-soluble, radiopaque moiety .

HY-170955

HA-CD44 interaction inhibitor 3	Transmembrane Glycoprotein	Cancer
HA-CD44 interaction inhibitor 3 (compound 5d) is a Hyaluronic acid (HY-B0633A) (HA)-CD44 interaction inhibitor with antiproliferative activities. HA-CD44 interaction inhibitor 3 inhibits MDA-MB-231 (CD44++) cells and MCF-7 cells (CD44--) with EC₅₀s of 4.24 μM and 14.74 μM, respectively. HA-CD44 interaction inhibitor 3 shows the potential for cancer research .

Cat. No.	Product Name	Type

HY-B0633A

Hyaluronic acid 10+ Cited Publications Hyaluronan; Hyaluronate	Drug Delivery
Hyaluronic acid (corn fermented) is a biopolymer composed of repeating units of disaccharides with various applications.

HY-158220

Hyaluronic acid Methacryloyl (MW 400 kDa) HAMA (MW 400 kDa)	3D Bioprinting
Hyaluronic acid Methacryloyl (HAMA) is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

Hyaluronic acid Methacryloyl (MW 400 kDa)

HAMA (MW 400 kDa)

3D Bioprinting

Hyaluronic acid Methacryloyl (HAMA) is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

HY-158220A

Hyaluronic acid Methacryloyl (MW 150 kDa) HAMA (MW 150 kDa)	3D Bioprinting
Hyaluronic acid Methacryloyl (HAMA) MW 150 kDa is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

Hyaluronic acid Methacryloyl (MW 150 kDa)

HAMA (MW 150 kDa)

3D Bioprinting

Hyaluronic acid Methacryloyl (HAMA) MW 150 kDa is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

HY-W540661

Hyaluronic acid tetrasaccharide, 98%	Carbohydrates
Hyaluronic acid tetrasaccharide, 98% is a naturally occurring polysaccharide found in the extracellular matrix of connective tissues. Hyaluronic acid tetrasaccharide can be used as a substrate for enzyme assays to characterize hyaluronidases and other hyaluronic acid-degrading enzymes.

HY-158220C

Hyaluronic acid methacryloyl (MW 50000) HAMA (MW 50000)	3D Bioprinting
Hyaluronic acid methacryloyl (MW 50000) (HAMA (MW 50000)) is a Hyaluronic acid (HY-B0633A) derivative. Hyaluronic acid methacryloyl-based material system has been applied in many biomedical research fields .

HY-158220B

Hyaluronic acid methacryloyl (MW 10000) HAMA (MW 10000)	3D Bioprinting
Hyaluronic acid methacryloyl (MW 10000) (HAMA (MW 10000)) is a Hyaluronic acid (HY-B0633A) derivative. Hyaluronic acid methacryloyl-based material system has been applied in many biomedical research fields .

HY-B0633E

Hyaluronic acid, low endotoxin Hyaluronan, low endotoxin; Hyaluronate, low endotoxin	3D Bioprinting
Hyaluronic acid, low endotoxin (Hyaluronan, low endotoxin) is a biopolymer composed of repeating units of disaccharides with various applications .

Cat. No.	Product Name	Target	Research Area

HY-P0123

SPACE peptide 3 Publications Verification	Peptides	Others
SPACE peptide is a skin penetrating peptide (SPPs). SPACE peptide can enhance topical delivery of a macromolecule, hyaluronic acid .

Hyaluronic acid Maximum Cited Publications 13 Publications Verification Hyaluronan; Hyaluronate	Structural Classification Zea mays L. Classification of Application Fields Source classification Moisture Plants Endogenous metabolite Human Gut Microbiota Metabolites Polysaccharides Microorganisms Gramineae Cosmetic Research Disease Research Fields Saccharides Cancer	Endogenous Metabolite Bacterial
Hyaluronic acid (corn fermented) is a biopolymer composed of repeating units of disaccharides with various applications.

Hyaluronic acid sodium Maximum Cited Publications 13 Publications Verification Sodium hyaluronate	Structural Classification Microorganisms Animals Classification of Application Fields Source classification Cosmetic Research Disease Research Fields Saccharides Cancer	Endogenous Metabolite Bacterial
Hyaluronic acid sodium (Sodium hyaluronate) is a biopolymer composed of repeating units of disaccharides with various applications.

4-Methylumbelliferone 4 Publications Verification Hymecromone; 4-MU	Cardiovascular Disease Structural Classification Classification of Application Fields Polygonaceae Reynoutria japonica Houtt. Source classification Coumarins Plants Monophenols Microorganisms Phenols Phenylpropanoids Disease Research Fields	Others
4-Methylumbelliferone is a hyaluronic acid biosynthesis inhibitor with antitumoral and antimetastatic effects.

Polygalacturonic acid Galacturonic acid polymer	Infection Structural Classification Natural Products Polysaccharides Classification of Application Fields Malus pumila Mill. Rosaceae Plants Inflammation/Immunology Disease Research Fields Saccharides	Others
Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity .

4-Methylumbelliferone (Standard)	Structural Classification Monophenols Microorganisms Polygonaceae Reynoutria japonica Houtt. Source classification Coumarins Phenols Phenylpropanoids Plants	Others
4-Methylumbelliferone (Standard) is the analytical standard of 4-Methylumbelliferone. This product is intended for research and analytical applications. 4-Methylumbelliferone is a hyaluronic acid biosynthesis inhibitor with antitumoral and antimetastatic effects.

Species:	Human (1) Mouse (2)
Tag:	His (2) Fc (1)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70161

	LYVE-1 Protein, Human (HEK293, His) rHuLymphatic vessel endothelial Hyaluronic acid receptor 1/LYVE-1, His; Lymphatic Vessel Endothelial Hyaluronic acid Receptor 1; LYVE-1; Cell Surface Retention Sequence-Binding Protein 1; CRSBP-1; Extracellular Link Domain-Containing Protein 1; Hyaluronic acid Receptor; LYVE1; CRSBP1; HAR; XLKD1	Human	HEK293
	The LYVE-1 protein is a ligand-specific transporter that regulates molecular transport between the trans-Golgi network (TGN) and the plasma membrane. It plays a key role in autocrine cell growth regulation, mediating the uptake and catabolism of growth regulators through cell surface retention sequences. LYVE-1 Protein, Human (HEK293, His) is the recombinant human-derived LYVE-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of LYVE-1 Protein, Human (HEK293, His) is 219 a.a., with molecular weight of 40-60 kDa.

HY-P74764

	LYVE-1 Protein, Mouse (HEK293, Fc) Lymphatic vessel endothelial Hyaluronic acid receptor 1; LYVE-1; CRSBP-1	Mouse	HEK293
	The LYVE-1 protein is a ligand-specific transporter that regulates molecular transport between the trans-Golgi network (TGN) and the plasma membrane. It plays a key role in autocrine cell growth regulation, mediating the uptake and catabolism of growth regulators through cell surface retention sequences. LYVE-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived LYVE-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LYVE-1 Protein, Mouse (HEK293, Fc) is 205 a.a., with molecular weight of ~63 kDa.

HY-P72222

	HAS2 Protein, Mouse (His) Has2; Hyaluronan synthase 2; EC 2.4.1.212; Hyaluronate synthase 2; Hyaluronic acid synthase 2; HA synthase 2	Mouse	E. coli
	The HAS2 protein adds GlcNAc or GlcUA monosaccharides to hyaluronic acid, playing a crucial role in its synthesis. HAS2 Protein, Mouse (His) is the recombinant mouse-derived HAS2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HAS2 Protein, Mouse (His) is 308 a.a., with molecular weight of ~39.9 kDa.

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HY-P83403

	LYVE1 Antibody (YA3148) CRSBP 1; CRSBP-1; CRSBP1; Hyaluronic acid receptor	WB, IHC-P, IP	Human, Mouse
	LYVE1 Antibody (YA3148) is a non-conjugated IgG antibody, targeting LYVE1, with a predicted molecular weight of 35 kDa (observed band size: 35 kDa). LYVE1 Antibody (YA3148) can be used for WB experiment in human, mouse, rat background.

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HY-B0633A

Hyaluronic acid 10+ Cited Publications Hyaluronan; Hyaluronate		Polymers
Hyaluronic acid (corn fermented) is a biopolymer composed of repeating units of disaccharides with various applications.

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Hyaluronic acid

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

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Recombinant Proteins

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Oligonucleotides

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