Search Result

Isoforms Recommended:	IL-4

Results for "

IL-4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (28) Itk (1) Adrenergic Receptor (5) Bacterial (1) Biochemical Assay Reagents (1) Cannabinoid Receptor (1) Cytochrome P450 (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (3) Histamine Receptor (1) IFNAR (2) IKK (1) Influenza Virus (1) JAK (4) Leukotriene Receptor (1) Monoamine Oxidase (1) NF-κB (1) Phosphodiesterase (PDE) (3) Prostaglandin Receptor (1) Small Interfering RNA (siRNA) (5) STAT (5) TGF-beta/Smad (2) TNF Receptor (7) Toll-like Receptor (TLR) (1) VEGFR (5)
By Research Areas:	Cancer (12) Cardiovascular Disease (7) Infection (6) Inflammation/Immunology (38) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (5) siRNAs (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Interleukin Related IRAK Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139092

IL-4-inhibitor-1	Interleukin Related	Infection Cancer
IL-4-inhibitor-1 (compound 52) is an *IL-4* inhibitor, with an EC₅₀ of 1.81 µM .

HY-P990093

Stapokibart CM310	Interleukin Related	Inflammation/Immunology
Stapokibart (CM310) is a humanised monoclonal antibody targeting IL-4Rα and efficiently blocks the interaction of cytokines IL-4 and IL-13 with their co-receptor subunit IL-4Rα. Stapokibart has the capacity to interact with IL-4Rα in humans, cynomolgus monkeys, and rats .

HY-RS06765

IL4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL4 Human Pre-designed siRNA Set A contains three designed siRNAs for IL4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL4 Human Pre-designed siRNA Set A IL4 Human Pre-designed siRNA Set A

HY-RS06766

Il4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il4 Mouse Pre-designed siRNA Set A Il4 Mouse Pre-designed siRNA Set A

HY-RS06767

Il4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il4 Rat Pre-designed siRNA Set A Il4 Rat Pre-designed siRNA Set A

HY-RS06769

IL4R Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL4R Human Pre-designed siRNA Set A contains three designed siRNAs for IL4R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL4R Human Pre-designed siRNA Set A IL4R Human Pre-designed siRNA Set A

HY-RS06768

IL4I1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL4I1 Human Pre-designed siRNA Set A contains three designed siRNAs for IL4I1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL4I1 Human Pre-designed siRNA Set A IL4I1 Human Pre-designed siRNA Set A

HY-P99883

Romilkimab SAR156597	Interleukin Related	Others
Romilkimab (SAR156597) is a chimeric humanized IG antibody that specifically targets IL-4 and IL13 .

HY-B0010C

(S,S)-Formoterol (+)-Formoterol	Interleukin Related	Inflammation/Immunology
(S,S)-Formoterol ((+)-Formoterol) is a (S,S)-enantiomer of Formoterol. (S,S)-Formoterol can promote asthma by enhancing IL-4 production in mast cells of the asthmatic airway .

HY-116609

C6 L-threo Ceramide	Interleukin Related	Inflammation/Immunology
C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides . C6 L-threo Ceramide significantly inhibits IL-4 production in T cells. Anti-allergic agents .

HY-N2426

Clerodendrin	Interleukin Related	Inflammation/Immunology
Clerodendrin is a nature product could be isolated from Lobelia chinensis. Clerodendrin is a potent dual **Interleukin-4 (IL-4) inhibitor and β-hexosaminidase (Hex)** inhibitor .

HY-162726

GCS-11	Interleukin Related	Cancer
GCS-11 is a powerful natural killer T (NKT) cell agonist. It boosts the production of IFN-γ and IL-4, with a particular selectivity for IFN-γ. GCS-11 exhibits anticancer activity. GCS-11 has the potential for research into cancer immunotherapies or vaccine development as a promising adjuvant .

HY-P990090

Rademikibart CBP-201	Interleukin Related	Inflammation/Immunology
Rademikibart (CBP-201) is a human monoclonal antibody targeting IL-4Rα with a KD of 20.7 pM when binding to human IL-4Rα epitopes. Rademikibart does not bind to IL-4Rα from other species. Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation and TARC production in PBMCs. Rademikibart has the potential for moderate-to-severe Th2 inflammatory diseases research .

HY-162248

JAK1/2-IN-1	JAK Interleukin Related	Inflammation/Immunology Cancer
JAK1/2-IN-1 is a potent JAK1 and JAK2 inhibitor with IC₅₀ values of 0.4 nM and 8.1 nM, respectively. JAK1/2-IN-1 also inhibits *IL-4* and IL-13 with IC₅₀s of 136.5 nM and 19.1 nM, respectively (WO2023244775A1; Example 33a) .

HY-P9926

Dupilumab 1 Publications Verification REGN-668; SAR-231893	Interleukin Related	Inflammation/Immunology Cancer
Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both *IL-4* and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis .

HY-N7652

Terminolic acid	Bacterial	Infection Inflammation/Immunology
Terminolic acid is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum. Terminolic acid can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. Terminolic acid also exhibits moderate antibacterial activity .

HY-15131

PNRI-299	Interleukin Related	Inflammation/Immunology
PNRI-299 is a selective AP-1 transcription inhibitor with an IC₅₀ of 20 uM. PNRI-299 is a selective APE/Ref-1 inhibitor. PNRI-299 has no effect on NF-κB transcription or thioredoxin (up to 200 uM). PNRI-299 significantly reduces airway eosinophil infiltration, mucus hypersecretion, edema, and IL-4 levels in a mouse asthma model .

HY-108013

Armillarisin A	Interleukin Related	Inflammation/Immunology
Armillarisin A has the potential for the ulcerative colitis (UC) study. Armillarisin A increases IL-4 and lower IL-1β .

HY-N3312

Matairesinol	Endogenous Metabolite	Infection
Matairesinol confers anti-allergic effects in an allergic dermatitis mouse model. DfE-induced changes in IL-4 and IFN-γ mRNA expression in the ears of NC/Nga mice were reversed by matairesinol application .

HY-165484

AVP-13358	Interleukin Related	Inflammation/Immunology
AVP-13358 is an orally active IgE inhibitor that effectively suppresses immunoglobulin E (IgE)-mediated immune responses, with IC₅₀ values of 8 and 3 nM for IgE inhibition in vivo and in vitro in BALB/c mice, respectively. AVP-13358 acts directly on T cells, inhibiting the production and release of *IL-4, IL-5, and IL-13. It also targets other markers critical for the development of allergic responses, including the B cell IgE* receptor (CD23) in human monocytes and the CD23 and *IL-4* receptors in mouse B cells. AVP-13358 can be used in research related to anti-allergic responses .

HY-N0600

Ginsenoside F3	Interleukin Related IFNAR	Inflammation/Immunology
Ginsenoside F3, a component of PPTGs (an minor saponin in the leaves of Panax ginseng), has immunoenhancing activity by regulating production and gene expression of type 1 cytokines (IL-2, IFN-gamma) and type 2 cytokines (IL-4 and IL-10) .

HY-163704

KRN7000 analog 1	IFNAR Interleukin Related	Inflammation/Immunology Cancer
KRN7000 analog 1 exhibits good Th1-biased immune response through induction of interferon-γ (IFN-γ) and reduction of interleukin-4 (IL-4). KRN7000 analog 1 is potential as an antitumor agent and vaccine adjuvant .

HY-N3312R

Matairesinol (Standard)	Endogenous Metabolite	Infection
Matairesinol (Standard) is the analytical standard of Matairesinol. This product is intended for research and analytical applications. Matairesinol confers anti-allergic effects in an allergic dermatitis mouse model. DfE-induced changes in IL-4 and IFN-γ mRNA expression in the ears of NC/Nga mice were reversed by matairesinol application .

HY-162727

GCS-12	Others	Inflammation/Immunology Cancer
GCS-12 is a Th1/2-balanced sulfonamide glycolipid with improved interaction with CD1d. GCS-12 is an agonist for natural killer T (NKT) cell, that induces the secretion of cytokine IFN-γ and IL-4, and exhibits immunomodulatory and anti-tumor activities in mice .

HY-155951

JAK3-IN-14	JAK	Cancer
JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC₅₀ values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC₅₀ values of 600 and 500 nM, respectively .

HY-17002

Suplatast (Tosilate) 1 Publications Verification IPD 1151T	Interleukin Related	Inflammation/Immunology
Suplatast Tosilate (IPD 1151T) is an orally active Th2 cytokine inhibitor which can inhibit both IL-4 and IL-5 production from Th2 cells and suppress IgE synthesis. Suplatast Tosilate is an anti-allergic agent. Suplatast Tosilate has antiasthmatic, anti-inflammatory and antifibrotic activity ^[4].

HY-B0446

Naphazoline hydrochloride Naphthazoline hydrochloride	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology Cancer
Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research .

HY-111326

Naphazoline Naphthazoline	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology
Naphazoline (Naphthazoline) is a potent α-adrenergic receptor agonist. Naphazoline reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline can be used for non-bacterial conjunctivitis research .

HY-111326A

Naphazoline nitrate Naphthazoline nitrate	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology Cancer
Naphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline nitrate can be used for non-bacterial conjunctivitis research .

HY-134771

YM-341619 1 Publications Verification AS1617612	STAT	Inflammation/Immunology
YM-341619 (AS1617612) is a potent and orally active STAT6 inhibitor with an IC₅₀ of 0.70 nM. YM-341619 inhibits Th2 differentiation in mouse spleen T cells induced by IL-4 (IC₅₀=0.28 nM) without affecting Th1 cell differentiation . YM-341619 is a promising compound for the the research of allergic diseases, such as allergic asthma .

HY-125019

iJak-381	JAK STAT	Inflammation/Immunology
iJak-381 is a JAK1/2 inhibitor with anti-inflammatory activity. iJak-381 blocks IL-13 signaling and also inhibits *IL-4* and IL-6 signaling pathways. iJak-381 also reduced p-STAT6 levels and inhibited the influx of inflammatory cells into the lungs of mice. iJak-381 inhibits airway hyperresponsiveness (AHR) .

HY-B0446R

Naphazoline hydrochloride (Standard)	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology
Naphazoline (hydrochloride) (Standard) is the analytical standard of Naphazoline (hydrochloride). This product is intended for research and analytical applications. Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research .

HY-B0539

Desloratadine Maximum Cited Publications 9 Publications Verification Sch34117	Histamine Receptor TNF Receptor Leukotriene Receptor	Inflammation/Immunology
Desloratadine (Sch34117) is an orally active and selective H1 receptor antagonist (K_i=0.9 nM) with anti-inflammatory and anti-allergic activities. Desloratadine inhibits the release of histamine and LTC4 from human basophils and targets the regulatory signals of *IL-4* and IL-13 production in basophils. Desloratadine significantly alleviates SAR symptoms in patients with concurrent asthma and can be used in the study of seasonal allergic rhinitis and chronic idiopathic urticaria ^[4] .

HY-111326AR

Naphazoline nitrate (Standard)	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology
Naphazoline (nitrate) (Standard) is the analytical standard of Naphazoline (nitrate). This product is intended for research and analytical applications. Naphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline nitrate can be used for non-bacterial conjunctivitis research .

HY-163670

TLR7 agonist 21	Toll-like Receptor (TLR)	Infection
TLR7 agonist 21 (Compound 27B) is a selective agonist for Toll-like receptor 7(TLR7), with an EC₅₀ of 17.53 nM (for human TLR7) and 41.7 nM (for mouse TLR7). TLR7 agonist 21 stimulates the secretion of pro-inflammatory cytokines, such as IL-6, TNF-α, IFN-α1, and IL-4. TLR7 agonist 21 acts as a vaccine adjuvant, increases levels of IgG and IgA, and protects the mouse from influenza virus infections .

HY-144683

PF-07038124	Phosphodiesterase (PDE)	Inflammation/Immunology
PF-07038124 is a *PDE4* inhibitor with an IC₅₀ of 0.5 nM for PDE4B2. PF-07038124 shows inhibitory activities against IL-13, IL4, and IFNγ (IC₅₀=125, 4.1, 1.06 nM, respectively). PF-07038124 can be used for research of atopic dermatitis and plaque psoriasis .

HY-144683A

PF-07038124 hydrochloride	Phosphodiesterase (PDE)	Inflammation/Immunology
PF-07038124 hydrochloride is a *PDE4* inhibitor with an IC₅₀ of 0.5 nM for PDE4B2. PF-07038124 hydrochloride shows inhibitory activities against IL-13, IL4, and IFNγ (IC₅₀=125, 4.1, 1.06 nM, respectively). PF-07038124 hydrochloride can be used for research of atopic dermatitis and plaque psoriasis .

HY-144684

PDE4-IN-8	Phosphodiesterase (PDE) Interleukin Related	Cancer
PDE4-IN-8 (Example 5) is a potent *PDE4* inhibitor with an IC₅₀ of 0.93 nM for PDE4B2.PDE4-IN-8 has little effect on IL13 (IC₅₀=4.04 nM), IL4 (IC₅₀=36.33 nM), IFNy (IC₅₀=2394 nM) .

HY-141582

Ceramide 3 N-Stearoyl phytosphingosine	Biochemical Assay Reagents	Others
C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation.

HY-124273

C2 L-threo Ceramide (d18:1/2:0) L-threo Cer(d18:1/2:0); L-threo Ceramide (d18:1/2:0); N-acetyl-L-threo-Sphingosine	Endogenous Metabolite	Cardiovascular Disease
C2 L-threo Ceramide (d18:1/2:0) (L-threo Cer(d18:1/2:0); L-threo Ceramide (d18:1/2:0)) is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide. C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0/G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.

HY-P99724

Manfidokimab AK120	Interleukin Related	Inflammation/Immunology
Manfidokimab (AK120) is an anti-interleukin 4 receptor alpha (IL-4Rα) IgG4 monoclonal antibody .

HY-162404

Smad2/3-IN-2	STAT TGF-beta/Smad Interleukin Related	Inflammation/Immunology
Smad2/3-IN-2 (Compound 3) is an inhibitor for TGF-β-dependent Smad2/3 and IL-4-dependent STAT6 signaling pathway, with IC₅₀s of 90 and 20 nM, respectively .

HY-162405

Smad2/3-IN-1	STAT TGF-beta/Smad Interleukin Related	Inflammation/Immunology
Smad2/3-IN-2 (Compound 27) is an inhibitor for TGF-β-dependent Smad2/3 and IL-4-dependent STAT6 signaling pathway, with IC₅₀s of 90 and 20 nM, respectively .

HY-P990708

Bizaxofusp MDNA55; NBI-3001; PRX-321	Interleukin Related	Inflammation/Immunology
Bizaxofusp is an anti-IL4R monoclonal antibody .

HY-13232

ITK antagonist	Itk	Inflammation/Immunology
ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC₅₀=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC₅₀ of 160 nM .

HY-134772

AS1810722	STAT Cytochrome P450	Inflammation/Immunology
AS1810722 is an orally active and potent STAT6 inhibitor with an IC₅₀ of 1.9 nM. AS1810722 shows a good profile of *CYP3A4* inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research .

HY-P99025

Lebrikizumab TNX-650	Interleukin Related	Neurological Disease Inflammation/Immunology
Lebrikizumab (TNX-650) is an IgG4 humanized anti-interleukin-13 (IL-13) mAb with anti-itch effects that specifically binds to IL-13 in a non-receptor binding domain and inhibits its function. Lebrikizumab inhibits the IL-13 driven Th2 inflammatory response and blocks the signaling of IL-4Rα/IL-13Rα1. Lebrikizumab can be used for the research of asthma, atopic dermatitis and neuroinflammatory diseases .

HY-19544

JAK3-IN-1	JAK	Cancer
JAK3-IN-1 is a potent, selective and orally active JAK3 inhibitor with an IC₅₀ of 4.8 nM. JAK3-IN-1 shows over 180-fold more selective for JAK3 than JAK1 (IC₅₀ of 896 nM) and JAK2 (IC₅₀ of 1050 nM) .

HY-152576

CB2R agonist 1	Cannabinoid Receptor	Inflammation/Immunology
CB2R agonist 1 is a selective ligand of cannabinoid receptor subtype 2 (CB2R) with an EC₅₀ value of 0.56 µM. CB2R agonist 1 has high affinity and excellent selectivity for human CB2R and CB1R respectively. CB2R agonist 1 regulates the production of pro-inflammatory cytokines and anti-inflammatory cytokines and play an immunomodulatory role .

HY-16768

Fevipiprant 1 Publications Verification QAW039; NVP-QAW039	Prostaglandin Receptor	Cardiovascular Disease
Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandin D2 (DP2) receptor antagonist with an K_d value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma .

Cat. No.	Product Name	Type

HY-141582

Ceramide 3

N-Stearoyl phytosphingosine

Drug Delivery

C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation.

Cat. No.	Product Name	Target	Research Area

HY-P990122

*Anti-Rat IL-4* Antibody (OX-81)**	Inhibitory Antibodies	Others
Anti-Rat IL-4 Antibody (OX-81) is a -derived type antibody inhibitor, targeting to rat IL-4.

HY-P990121

*Anti-Mouse IL-4* Antibody (11B11)** 1 Publications Verification	Inhibitory Antibodies	Others
Anti-Mouse IL-4 Antibody (11B11) is a rat-derived IgG1, κ type antibody inhibitor, targeting to mouse IL-4.

HY-P990093

Stapokibart CM310	Interleukin Related	Inflammation/Immunology
Stapokibart (CM310) is a humanised monoclonal antibody targeting IL-4Rα and efficiently blocks the interaction of cytokines IL-4 and IL-13 with their co-receptor subunit IL-4Rα. Stapokibart has the capacity to interact with IL-4Rα in humans, cynomolgus monkeys, and rats .

HY-P990090

Rademikibart CBP-201	Interleukin Related	Inflammation/Immunology
Rademikibart (CBP-201) is a human monoclonal antibody targeting IL-4Rα with a KD of 20.7 pM when binding to human IL-4Rα epitopes. Rademikibart does not bind to IL-4Rα from other species. Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation and TARC production in PBMCs. Rademikibart has the potential for moderate-to-severe Th2 inflammatory diseases research .

HY-P9926

Dupilumab 1 Publications Verification REGN-668; SAR-231893	Interleukin Related	Inflammation/Immunology Cancer
Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both *IL-4* and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis .

HY-P99724

Manfidokimab AK120	Interleukin Related	Inflammation/Immunology
Manfidokimab (AK120) is an anti-interleukin 4 receptor alpha (IL-4Rα) IgG4 monoclonal antibody .

HY-P99935

Elarekibep PRS-060; AZD1402	Inhibitory Antibodies	Inflammation/Immunology
Elarekibep (PRS-060) (AZD1402) is a high affinity, slowly dissociating, long-acting full antagonist of *IL-4Ra*. Elarekibep can be used for the research of T2 endotype asthma .

HY-P990800

*Anti-Mouse IL-4* Antibody (BVD6-24G2)**	Inhibitory Antibodies	Others
Anti-Mouse IL-4 Antibody (BVD6-24G2) is a kind of rat IgG1 kappa in vivo mouse antibody, targeting to *IL-4. The recommend isotype control of Anti-Mouse IL-4* Antibody (BVD6-24G2): Rat IgG1 kappa, Isotype Control (HY-P99979).

HY-P99883

Romilkimab SAR156597	Interleukin Related	Others
Romilkimab (SAR156597) is a chimeric humanized IG antibody that specifically targets IL-4 and IL13 .

HY-P990837

*Anti-IL-4* Antibody (MP4-25D2)**	Inhibitory Antibodies	Others
Anti-IL-4 Antibody (MP4-25D2) is a kind of rat IgG1, κ chimeric antibody, targeting to human *IL-4. The recommend isotype control of Anti-IL-4* Antibody (MP4-25D2): Rat IgG1 kappa, Isotype Control (HY-P99979).

HY-P990708

Bizaxofusp MDNA55; NBI-3001; PRX-321	Interleukin Related	Inflammation/Immunology
Bizaxofusp is an anti-IL4R monoclonal antibody .

HY-P99801

Pascolizumab SB-240683	Inhibitory Antibodies	Metabolic Disease
Pascolizumab (SB-240683) is a humanized anti-IL-4 monoclonal antibody. Pascolizumab has the potential for the research of asthma .

HY-P99025

Lebrikizumab TNX-650	Interleukin Related	Neurological Disease Inflammation/Immunology
Lebrikizumab (TNX-650) is an IgG4 humanized anti-interleukin-13 (IL-13) mAb with anti-itch effects that specifically binds to IL-13 in a non-receptor binding domain and inhibits its function. Lebrikizumab inhibits the IL-13 driven Th2 inflammatory response and blocks the signaling of IL-4Rα/IL-13Rα1. Lebrikizumab can be used for the research of asthma, atopic dermatitis and neuroinflammatory diseases .

HY-P9950

Omalizumab 1 Publications Verification Olizumab; rhuMab-E25	Inhibitory Antibodies	Inflammation/Immunology Cancer
Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a K_D of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a K_D of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research .

Recombinant Proteins Recommended:

IL-4

Species:	Human (19) Porcine (1) Rhesus Macaque (1) Mouse (9) Bovine (1) Rat (2) Cynomolgus (5) Canine (2) Pig (1)
Tag:	His (22) Tag Free (14) Strep (1) Avi (3) Fc (5)
Source:	HEK293 (21) CHO (3) P. pastoris (1) Sf9 insect cells (2) E. coli (14)

Cat. No.	Compare	Product Name	Species	Source

HY-P7219

	IL-4 Protein, Porcine (CHO) rPoIL-4; BSF-1; IL4	Porcine	CHO
	IL-4 Protein, Porcine (CHO) is the prime anti-infalmmatory cytokine involves in cell proliferation, various gene expression and avert apoptosis in IL-4 expressing cells.

HY-P70445

	IL-4 Protein, Human Maximum Cited Publications 13 Publications Verification Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4	Human	E. coli
	IL-4 Protein, Human is a potent lymphoid cell growth factor, which stimulates the growth and survivability of B-cells and T-cells.

HY-P70750

	IL-4 Protein, Human (HEK293) 2 Publications Verification Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4	Human	HEK293
	IL-4 Protein, Human (HEK293) is a potent lymphoid cell growth factor, which stimulates the growth and survivability of B-cells and T-cells. IL-4 Protein, Human (HEK293) is a recombinant human interleukin-4 (rhIL-4) expressed in HEK293 cells.

HY-P70764

	IL-4 Protein, Human (HEK293, His) Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4	Human	HEK293
	IL-4 Protein, Human (HEK293, His) is a potent lymphoid cell growth factor, which stimulates the growth and survivability of B-cells and T-cells. IL-4 Protein, Human (HEK293, His) is a recombinant human interleukin-4 (rhIL-4) expressed in HEK 293 cells with a His tag.

HY-P73214

	IL-4 Protein, Canine 1 Publications Verification Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1	Canine	E. coli
	The IL-4 protein actively participates in the B cell activation process, acting as a costimulator for DNA synthesis. It induces the expression of class II MHC molecules on resting B cells, enhances IgE and IgG1 secretion and cell surface expression, and modulates CD23 expression on lymphocytes and monocytes. IL-4 Protein, Canine is the recombinant canine-derived IL-4 protein, expressed by E. coli , with N-Met labeled tag. The total length of IL-4 Protein, Canine is 108 a.a., with molecular weight of 12-14 kDa.

HY-P71859

	IL-4 Protein, Rhesus macaque IL4Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1	Rhesus Macaque	E. coli
	IL-4 protein actively engages in B-cell activation, serving as a costimulator for DNA synthesis, inducing class II MHC molecule expression, and enhancing IgE and IgG1 secretion. It regulates CD23 expression on lymphocytes and monocytes, positively influences IL31RA expression in macrophages, and induces autophagy in dendritic cells through mTORC1 signaling interference and RUFY4 induction. IL-4 Protein, Rhesus macaque is the recombinant Rhesus Macaque-derived IL-4 protein, expressed by E. coli , with tag free.

HY-P70653

	IL-4 Protein, Mouse (HEK293, His) 5+ Cited Publications Interleukin-4; IL-4; IL4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor; Lymphocyte stimulatory factor 1	Mouse	HEK293
	IL-4 Protein, Mouse (HEK293, His) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression.IL-4 Protein, Mouse (HEK293, His) is a recombinant mouse interleukin-4 (rhIL-4) expressed in HEK 293 cells with a His tag.

HY-P73215

	IL-4 Protein, Mouse (Q136D, Y139D, sf9, His) Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1	Mouse	Sf9 insect cells
	Interleukin 4 (IL-4) Protein is a pleiotropic cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. IL-4 participates in STAT6 signaling and regulates the expression of MHC II, IgE, IgG1 amd CD23. IL-4 Protein, Mouse (Q136D, Y139D, sf9, His) is the recombinant mouse-derived IL-4 protein, expressed by Sf9 insect cells , with C-His labeled tag and Q136D, Y139D, , , mutation.

HY-P77510

	IL-4 Protein, Human (Biotinylated) Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1	Human	E. coli
	The IL-4 protein is primarily secreted by mast cells, T cells, eosinophils, and basophils and is critical for antibody production, hematopoiesis, and immune responses. It induces MHC class II expression on B cells, enhances IgE and IgG1 secretion, and modulates CD23 and IL31RA expression. IL-4 Protein, Human (Biotinylated) is the recombinant human-derived IL-4 protein, expressed by E. coli , with tag free.

HY-P71794

	IL-4 Protein, Cynomolgus (P.pastoris, His) IL4Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1	Cynomolgus	P. pastoris
	IL-4 protein has an important effect on B cell activation, acting as a costimulator for DNA synthesis and promoting the expression of class II MHC molecules on resting B cells. It enhances IgE and IgG1 secretion and cell surface expression while also regulating CD23 expression on lymphocytes and monocytes. IL-4 Protein, Cynomolgus (P.pastoris, His) is the recombinant cynomolgus-derived IL-4 protein, expressed by P. pastoris , with N-His labeled tag. The total length of IL-4 Protein, Cynomolgus (P.pastoris, His) is 129 a.a., with molecular weight of ~16.9 kDa.

HY-P7042

	IL-4 Protein, Human (CHO) 3 Publications Verification rHuIL-4; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra	Human	CHO
	IL-4 Protein, Human (CHO) is a CHO cell derived, potent lymphoid cell growth factor, which stimulates the growth and survivability of B-cells and T-cells.

HY-P7080

	IL-4 Protein, Mouse (CHO) 5+ Cited Publications rMuIL-4; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra	Mouse	CHO
	IL-4 Protein, Mouse (CHO) is a species-specific cytokine which promotes the proliferation, differentiation and cell-surface protein modulation of B lymphocytes.

HY-P70644

	IL-4 Protein, Mouse 3 Publications Verification Interleukin-4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; IGG1 induction factor; Lymphocyte stimulatory factor 1; IL-4; BSF-1	Mouse	E. coli
	IL-4 Protein, Mouse is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression.

HY-P700748

	IL-4 Protein, Cynomolgus (HEK293, His) IL4; IL-4; interleukin 4; MGC79402; pitrakinra; B cell growth factor 1; BCDF; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; BSF-1	Cynomolgus	HEK293
	IL-4 protein has an important effect on B cell activation, acting as a costimulator for DNA synthesis and promoting the expression of class II MHC molecules on resting B cells. It enhances IgE and IgG1 secretion and cell surface expression while also regulating CD23 expression on lymphocytes and monocytes. IL-4 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-4 Protein, Cynomolgus (HEK293, His) is 129 a.a., with molecular weight of 23-28 kDa.

HY-P78466

	IL-4 Protein, Human (HEK293, His-Avi) IL4; IL-4; interleukin 4; MGC79402; pitrakinra; B cell growth factor 1; BCDF; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; BSF-1	Human	HEK293
	The IL-4 protein is primarily secreted by mast cells, T cells, eosinophils, and basophils and is critical for antibody production, hematopoiesis, and immune responses. It induces MHC class II expression on B cells, enhances IgE and IgG1 secretion, and modulates CD23 and IL31RA expression. IL-4 Protein, Human (HEK293, His-Avi) is the recombinant human-derived IL-4 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78153

	IL-4 Protein, Human (Biotinylated, HEK293, His-Avi) IL4; IL-4; interleukin 4; MGC79402; pitrakinra; B cell growth factor 1; BCDF; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; BSF-1	Human	HEK293
	The IL-4 protein is primarily secreted by mast cells, T cells, eosinophils, and basophils and is critical for antibody production, hematopoiesis, and immune responses. It induces MHC class II expression on B cells, enhances IgE and IgG1 secretion, and modulates CD23 and IL31RA expression. IL-4 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-4 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P79117

	IL-4 Protein, Bovine Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Interleukin 4	Bovine	E. coli
	IL-4 Protein, a key participant in B-cell activation and various cell types, acts as a costimulator of DNA synthesis. It induces class II MHC molecules on B-cells, enhances IgE and IgG1 secretion and expression, and regulates CD23 on lymphocytes and monocytes. IL-4 positively regulates IL31RA in macrophages and stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and inducing RUFY4. IL-4 Protein, Bovine is the recombinant bovine-derived IL-4 protein, expressed by E. coli , with tag free.

HY-P700001

	IL-4R alpha protein, Canine (HEK293, His) Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124	Canine	HEK293
	IL-4R alpha protein, Canine (HEK293, His) is the recombinant canine-derived IL-4R alpha protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL-4R alpha protein, Canine (HEK293, His) is 229 a.a., with molecular weight of 35-55 kDa.

HY-P701093

	IL-4 Protein, Mouse (HEK293) rMuIL-4; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra	Mouse	HEK293
	IL-4 Protein, Mouse (HEK293) is a species-specific cytokine which promotes the proliferation, differentiation and cell-surface protein modulation of B lymphocytes.

HY-P70710

	IL-4R alpha/CD124 Protein, Human (HEK293, His) Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124; IL-4-binding protein; IL4-BP; IL4R; IL4RA	Human	HEK293
	IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Human consists of 825 amino acids (M1-S825) with a transmembrane domain (233-256 a.a) and a soluble form (1-227 a.a). Soluble IL-4R (sIL-4R) inhibits IL4-mediated cell proliferation and IL-5 up-regulation by T-cells. IL-4R alpha/CD124, Human (M26-H232) is produced in HEK293 cells with a C-Terminal His-tag.

HY-P70712

	IL-4R alpha/CD124 Protein, Human (HEK293, Fc) Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124; IL-4-binding protein; IL4-BP; IL4R; IL4RA	Human	HEK293
	IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Human consists of 825 amino acids (M1-S825) with a transmembrane domain (233-256 a.a) and a soluble form (1-227 a.a). Soluble IL-4R (sIL-4R) inhibits IL4-mediated cell proliferation and IL-5 up-regulation by T-cells. IL-4R alpha/CD124, Human (M26-Q231) is produced in HEK293 cells with a C-Terminal hFc-tag.

HY-P70325

	IL-4R alpha/CD124 Protein, Human (HEK293, mFc) rHuInterleukin-4 receptor subunit alpha/IL-4 RA, mFc; Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124; IL-4-binding protein; IL4-BP; IL4R; IL4RA	Human	HEK293
	IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Human consists of 825 amino acids (M1-S825) with a transmembrane domain (233-256 a.a) and a soluble form (1-227 a.a). Soluble IL-4R (sIL-4R) inhibits IL4-mediated cell proliferation and IL-5 up-regulation by T-cells. IL-4R alpha/CD124, Human (M26-Q231) is produced in HEK293 cells with a C-Terminal mFc-tag.

HY-P73217

	IL-4R alpha/CD124 Protein, Rat (HEK293, His) Interleukin-4 receptor subunit alpha; IL-4R-alpha; IL-4RA; CD124; IL4-BP; IL4R	Rat	HEK293
	IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Rat consists of 801 amino acids (M1-S801), exerts IL-4 binding function and results the phosphorylation of C-terminal tyrosine residues. IL-4R alpha/CD124, Rat has an immunoreceptor tyrosine inhibitor motif (ITIM) (698-703 a.a), which can bind to the SH2 domain of some phosphatases by phosphorylating ITIM. IL-4R alpha/CD124, Rat has a soluble form (1-229 a.a) and a transmembrane domain (233-256 a.a). The soluble IL-4R (sIL4R) inhibits IL4-induced spleen cell proliferation. IL-4R alpha/CD124 Protein, Rat is produced in HEK293 cells, including a Fibronectin typr III domain (125-223 a.a) and a C-Terminal His-tag.

HY-P70305

	IL-4R alpha/CD124 Protein, Mouse (HEK293, Fc) rMuInterleukin-4 receptor subunit alpha/IL-4RA, Fc; Interleukin-4 receptor subunit alpha; IL-4R-alpha; CD124; IL4-BP; Soluble IL-4R-alpha; IL-4RA	Mouse	HEK293
	IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, exerts IL-4 binding function and results the phosphorylation of C-terminal tyrosine residues. IL-4R alpha/CD124, Mouse has an immunoreceptor tyrosine inhibitor motif (ITIM) (707-712 a.a), which can bind to the SH2 domain of some phosphatases by phosphorylating ITIM. IL-4R alpha/CD124 Protein, Mouse (HEK293, Fc) has a transmembrane domain (234-257 a.a). IL-4R alpha/CD124 Protein, Mouse is produced in HEK293 cells, including a Fibronectin typr III domain and a C-terminal hFC-tag.

HY-P70186

	IL-4R alpha/CD124 Protein, Cynomolgus (HEK293, His) rCynInterleukin-4 receptor subunit alpha/IL-4Ra, His; Interleukin-4 receptor subunit alpha; IL-4R-alpha; CD124; IL4-BP; Soluble IL-4R-alpha; IL-4RA	Cynomolgus	HEK293
	IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Cynomolgus consists of 825 amino acids (M1-S825). IL-4R alpha/CD124 Protein, Cynomolgus (M26-R232) is produced in HEK293 cells, including a Fibronectin typr III domain (125-224 a.a) and a C-Terminal His-tag.

HY-P72541

	IL-4R alpha/CD124 Protein, Mouse (HEK293, His) Interleukin-4 receptor subunit alpha; IL-4RA; IL-4R-alpha; CD124; IL4-BP	Mouse	HEK293
	IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Mouse exerts IL-4 binding function and results the phosphorylation of C-terminal tyrosine residues. IL-4R alpha/CD124, Mouse has an immunoreceptor tyrosine inhibitor motif (ITIM), which can bind to the SH2 domain of some phosphatases by phosphorylating ITIM. IL-4R alpha/CD124, Mouse has a transmembrane domain. IL-4R alpha/CD124 Protein, Mouse is produced in HEK293 cells, including a Fibronectin typr III domainand a C-terminal His-tag.

HY-P7220

	IL-4R alpha/CD124 Protein, Human (HEK293) 1 Publications Verification rHuIL-4R; IL4R; IL-4RA; CD124	Human	HEK293
	IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Human consists of 825 amino acids (M1-S825) with a transmembrane domain (233-256 a.a) and a soluble form (1-227 a.a). Soluble IL-4R (sIL-4R) inhibits IL4-mediated cell proliferation and IL-5 up-regulation by T-cells. IL-4R alpha/CD124, Human (G24-H232) is produced in HEK293 cells with a full length of 209 amino acids.

HY-P77009

	IL-4R Protein, Cynomolgus (HEK293, Fc) Interleukin-4 receptor subunit alpha; IL4R alpha; IL4R; CD124	Cynomolgus	HEK293
	IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Cynomolgus consists of 825 amino acids (M1-S825). IL-4R alpha/CD124 Protein, Cynomolgus is produced in HEK293 cells, including a Fibronectin typr III domain (125-224 a.a) and a C-Terminal hFc-tag.

HY-P77010

	IL-4R Protein, Cynomolgus (HEK293, His) Interleukin-4 receptor subunit alpha; IL4R alpha; IL4R; CD124	Cynomolgus	HEK293
	IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Cynomolgus consists of 825 amino acids (M1-S825). IL-4R alpha/CD124 Protein, Cynomolgus is produced in HEK293 cells, including a Fibronectin typr III domain (125-224 a.a) and a C-Terminal His-tag.

HY-P78855

	IL-4R alpha/CD124 Protein, Human (Biotinylated, HEK293, His-Avi) IL4R; CD124; IL4RA	Human	HEK293
	IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Human consists of 825 amino acids (M1-S825) with a transmembrane domain (233-256 a.a) and a soluble form (1-227 a.a). Soluble IL-4R (sIL-4R) inhibits IL4-mediated cell proliferation and IL-5 up-regulation by T-cells. IL-4R alpha/CD124, Human (M26-H232) is produced in HEK293 cells with a C-Terminal Avi-tag and a C-Terminal His-tag.

HY-P74801

	IL-4R alpha/CD124 Protein, Rat (HEK293, Fc) Interleukin-4 receptor subunit alpha; IL4R alpha; IL4R	Rat	HEK293
	IL-4R alpha is a subunit alpha shared by IL-4 and IL-13 receptors, found in leukocytes originally. IL-4R alpha couples to the JAK1/2/3-STAT6 pathway and involves in promoting Th2 differentiation. IL-4R alpha/CD124, Rat consists of 801 amino acids (M1-S801), exerts IL-4 binding function and results the phosphorylation of C-terminal tyrosine residues. IL-4R alpha/CD124, Rat has an immunoreceptor tyrosine inhibitor motif (ITIM) (698-703 a.a), which can bind to the SH2 domain of some phosphatases by phosphorylating ITIM. IL-4R alpha/CD124, Rat has a a soluble form (1-229 a.a) and a transmembrane domain (233-256 a.a). The soluble IL-4R (sIL4R) inhibits IL4-induced spleen cell proliferation. IL-4R alpha/CD124, Rat is produced in HEK293 cells, including a Fibronectin typr III domain (125-223 a.a) and a C-Terminal hFc-tag.

HY-P70750G

	*GMP IL-4* Protein, Human (HEK293)** 1 Publications Verification Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4	Human	HEK293
	GMP IL-4 Protein, Human (HEK293) is a recombinant GMP-grade protein produced by HEK293 cells with C-His tag. IL-4 is an anti-inflammatory cytokine acting as a pleiotropic regulator of numerous immune and inflammatory processes.

HY-P700248AF

	*Animal-Free IL-4* Protein, Pig (His)** 2 Publications Verification rPoIL-4; BSF-1; IL4	Pig	E. coli
	IL-4 protein is actively involved in the activation process of B cells and various cell types, acting as a costimulator of DNA synthesis. It induces expression of MHC class II molecules by resting B cells and enhances IgE and IgG1 secretion and cell surface expression. Animal-Free IL-4 Protein, Pig (His) is the recombinant pig-derived animal-FreeIL-4 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-4 Protein, Pig (His) is 109 a.a., with molecular weight of ~13.5 kDa.

HY-P78549

	*GMP IL-4* Protein, Human** 3 Publications Verification Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4	Human	E. coli
	The IL-4 protein is primarily secreted by mast cells, T cells, eosinophils, and basophils and is critical for antibody production, hematopoiesis, and immune responses. It induces MHC class II expression on B cells, enhances IgE and IgG1 secretion, and modulates CD23 and IL31RA expression. GMP IL-4 Protein, Human is the recombinant human-derived IL-4 protein, expressed by E. coli , with tag free.

HY-P700130AF

	*Animal-Free IL-4* Protein, Human (His)** Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4	Human	E. coli
	The IL-4 protein is primarily secreted by mast cells, T cells, eosinophils, and basophils and is critical for antibody production, hematopoiesis, and immune responses. It induces MHC class II expression on B cells, enhances IgE and IgG1 secretion, and modulates CD23 and IL31RA expression. Animal-Free IL-4 Protein, Human (His) is the recombinant human-derived animal-FreeIL-4 protein, expressed by E. coli , with C-His labeled tag.

HY-P71337

	STAT6 Protein, Human (His) Signal Transducer and Activator of Transcription 6; IL-4 Stat; STAT6	Human	E. coli
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (His) is the recombinant human-derived STAT6 protein, expressed by E. coli , with C-6*His labeled tag. The total length of STAT6 Protein, Human (His) is 211 a.a., with molecular weight of ~30.0 kDa.

HY-P700214AF

	*Animal-Free IL-4* Protein, Mouse (His)** rMuIL-4; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra	Mouse	E. coli
	Interleukin 4 (IL-4) Protein is a pleiotropic cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses.IL-4 participates in STAT6 signaling and regulates the expression of MHC II, IgE, IgG1 amd CD23.Animal-Free IL-4 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-4 protein, expressed by E.coli , with C-His labeled tag.

HY-P702835A

	STAT6 Protein, Human (536a.a, His) Signal Transducer and Activator of Transcription 6; IL-4 Stat; STAT6	Human	E. coli
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (536a.a, His) is the recombinant human-derived STAT6 protein, expressed by E. coli , with N-His labeled tag.

HY-P703579

	STAT6 Protein, Human (sf9, His, Strep) Signal Transducer and Activator of Transcription 6; IL-4 Stat; STAT6	Human	Sf9 insect cells
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (sf9, His, Strep) is the recombinant human-derived STAT6 protein, expressed by Sf9 insect cells , with C-His; C-Strep labeled tag.

HY-P702835

	STAT6 Protein, Human (Phosphorylated, 536a.a, His) Signal Transducer and Activator of Transcription 6; IL-4 Stat; STAT6	Human	E. coli
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (Phosphorylated, 536a.a, His) is the recombinant human-derived STAT6 protein, expressed by E. coli , with N-His labeled tag.

HY-P700200AF

	Animal-Free IL-24 Protein, Mouse (His) Interleukin-24; IL-4-induced secreted protein; Melanoma differentiation-associated gene 7 protein (MDA-7); Th2-specific cytokine FISP; IL24; Mda7	Mouse	E. coli
	IL-24 Protein, a crucial immune regulatory cytokine, plays a pivotal role in modulating immune responses. Animal-Free IL-24 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-24 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-24 Protein, Mouse (His) is 155 a.a., with molecular weight of ~18.94 kDa.

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HY-P80722

	IL-4 Antibody (YA343) IL4; Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra	WB	Human, Mouse, Rat
	IL-4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 17 kDa, targeting to IL-4. It can be used for WB assays with tag free, in the background of Transfected.

HY-P80347

	STAT6 Antibody 12S1644 antibody; D12S1644 antibody; IL 4 STAT antibody; IL-4 Stat antibody; IL4 STAT antibody; Interleukin 4 Induced antibody; Interleukin 4 Induced Transcription Factor IL4 STAT antibody; Signal transducer and activator of transcription 6 antibody; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced antibody; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1 antibody; Signal transducer and activator of transcription 6, interleukin 4 induced antibody; STAT 6 antibody; STAT interleukin4 induced antibody; STAT, interleukin4 induced antibody; Stat6 antibody; STAT6_HUMAN antibody; STAT6B antibody; STAT6C antibody; Transcription factor IL 4 STAT antibody;	WB, ICC/IF, IHC-P, IP	Human, Mouse
	STAT6 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 94 kDa, targeting to STAT6. It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human, Mouse.

HY-P81480

	IL-4I1/LAO Antibody (YA1225) IL4I1; FIG1 ; UNQ636/PRO1265 ; L-amino-acid oxidase ; Interleukin-4-induced protein 1; hIL4I1 ; Protein Fig-1 ; LAAO; LAO	IHC-P	Human
	IL-4I1/LAO Antibody (YA1225) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1225), targeting IL-4I1/LAO. IL-4I1/LAO Antibody (YA1225) can be used for IHC-P experiment in human background.