2. Anti-infection
  3. Bacterial
  4. Terminolic acid

Terminolic acid is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum. Terminolic acid can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. Terminolic acid also exhibits moderate antibacterial activity.

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Terminolic acid Chemical Structure

Terminolic acid Chemical Structure

CAS No. : 564-13-6

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5 mg USD 130 In-stock
10 mg USD 220 In-stock
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Based on 1 publication(s) in Google Scholar

Terminolic acid Related Antibodies

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Description

Terminolic acid is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum. Terminolic acid can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. Terminolic acid also exhibits moderate antibacterial activity[1][1].

Molecular Weight

504.70

Formula

C30H48O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]1(C[C@H]2O)[C@@](CC=C([C@]3([H])CC4(C)C)[C@]1(CC[C@]3(CC4)C(O)=O)C)([H])[C@]([C@]2([H])[C@@](C)([C@H]5O)CO)(C[C@H]5O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (198.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9814 mL 9.9069 mL 19.8138 mL
5 mM 0.3963 mL 1.9814 mL 3.9628 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.63%

COA (254 KB) RP-HPLC (155 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9814 mL 9.9069 mL 19.8138 mL 49.5344 mL
5 mM 0.3963 mL 1.9814 mL 3.9628 mL 9.9069 mL
10 mM 0.1981 mL 0.9907 mL 1.9814 mL 4.9534 mL
15 mM 0.1321 mL 0.6605 mL 1.3209 mL 3.3023 mL
20 mM 0.0991 mL 0.4953 mL 0.9907 mL 2.4767 mL
25 mM 0.0793 mL 0.3963 mL 0.7926 mL 1.9814 mL
30 mM 0.0660 mL 0.3302 mL 0.6605 mL 1.6511 mL
40 mM 0.0495 mL 0.2477 mL 0.4953 mL 1.2384 mL
50 mM 0.0396 mL 0.1981 mL 0.3963 mL 0.9907 mL
60 mM 0.0330 mL 0.1651 mL 0.3302 mL 0.8256 mL
80 mM 0.0248 mL 0.1238 mL 0.2477 mL 0.6192 mL
100 mM 0.0198 mL 0.0991 mL 0.1981 mL 0.4953 mL
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Terminolic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Terminolic acid564-13-6BacterialpentacyclictriterpenoidglucosideCombretumracemosuminflammatorycytokinesIL-1βIL-6IL-4antibacterialInhibitorinhibitorinhibit

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