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Indoleamine,2,3-dioxygenase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Indoleamine 2,3-Dioxygenase (IDO) (7)
By Research Areas:	Cancer (8) Infection (1)

9

Inhibitors & Agonists

2

Natural
Products

4

Recombinant Proteins

1

Antibodies

Targets Recommended: Indoleamine 2,3-Dioxygenase (IDO) HPPD TET Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Navoximod 5+ Cited Publications GDC-0919; NLG-919	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Navoximod (GDC-0919; NLG-919) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with K_i/EC₅₀ of 7 nM/75 nM.

BMS-986242 1 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used for the research of cancer .

IDO/TDO-IN-1	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and *tryptophan 2,3-dioxygenase* (TDO) inhibitor with IC₅₀**s of 9.7 and 47 nM, respectively .

TDO-IN-1	Others	Cancer
TDO-IN-1 is an orally active and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), shows excellent selectivity over *indoleamine-2,3-dioxygenase* (IDO), with an IC₅₀ value of 0.62 μM (IDO). TDO-IN-1 reverse the local immune tolerance of tumor tissue to inhibit tumor growth in vivo .

(R)-IDO/TDO-IN-1	Indoleamine 2,3-Dioxygenase (IDO)	Others Cancer
(R)-IDO/TDO-IN-1 (compound 25) is an indoleamine-2,3-dioxygenase (IDO) inhibitor, with good pharmacokinetic properties. (R)-IDO/TDO-IN-1 exhibits anti-tumor activity in MC38 xenograft model. (R)-IDO/TDO-IN-1 shows synergistic effect with anti-PD-1 monoclonal antibody (SHR-1210) .

Entadamide A	Others	Infection
Entadamide A (compound 1) is a tryptophan derivative. Entadamide A prevents tryptophan depletion by inhibiting indoleamine 2, 3-dioxygenase (IDO), thereby inhibiting HIV replication. Entadamide A can be used in drug and neuropsychiatric studies of redesivir [1].

IDO-IN-11	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC₅₀s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 13.

IDO-IN-9	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC₅₀s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 6.

IDO1-IN-7	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC₅₀ of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer .

Species:	Human (3) Mouse (1)
Tag:	His (3) Tag Free (1)
Source:	E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

	IDO-1 Protein, Mouse (His) Indoleamine 2,3-dioxygenase 1; IDO-1; Indoleamine-pyrrole 2,3-dioxygenase; IDO; INDO	Mouse	E. coli
	IDO Protein, an enzyme, is involved in the metabolism of tryptophan. Dysregulation of IDO Protein has been linked to immune escape mechanisms and tumor progression. Targeting IDO Protein may provide potential therapeutic interventions in cancer by modulating tryptophan metabolism, enhancing immune responses, and inhibiting tumor growth. IDO-1 Protein, Mouse (His) is the recombinant mouse-derived IDO protein, expressed by E. coli , with N-6*His labeled tag.

	IDO-2 Protein, Human (His) Indoleamine 2,3-dioxygenase 2; Indoleamine 2,3-dioxygenase-like protein 1; Indoleamine pyrrole 2,3-dioxygenase-like protein 1; IDO2; INDOL1	Human	E. coli
	The IDO-2 protein plays a key role in cellular processes, catalyzing the initial and rate-limiting steps in the catabolism of the essential amino acid tryptophan in the kynurenine pathway. This enzymatic activity has been confirmed in multiple studies, establishing IDO-2 as a key regulator of tryptophan metabolism with important implications for immune regulation. IDO-2 Protein, Human (His) is the recombinant human-derived IDO-2 protein, expressed by E. coli , with C-6*His labeled tag. The total length of IDO-2 Protein, Human (His) is 407 a.a., with molecular weight of ~41.43 kDa.

	IDO-1 Protein, Human (His) Indole 2; 3-dioxygenase; Indoleamine 2; 3-dioxygenase 1; IDO-1; IDO1; IDO; INDO	Human	E. coli
	IDO proteins catalyze the first step in tryptophan catabolism via the kynurenine pathway, which is critical for immune tolerance and homeostasis maintenance. IDO-1 Protein, Human (His) is the recombinant human-derived IDO protein, expressed by E. coli , with N-6*His labeled tag.

	IDO-1 Protein, Human Indoleamine 2; 3-dioxygenase 1; IDO-1; IDO1; IDO; INDO	Human	E. coli
	IDO proteins catalyze the first step in tryptophan catabolism via the kynurenine pathway, which is critical for immune tolerance and homeostasis maintenance. IDO-1 Protein, Human is the recombinant human-derived IDO protein, expressed by E. coli , with tag free.

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	Indoleamine 2,3-dioxygenase Antibody (YA3100) 3-dioxygenase; IDO 1; IDO; IDO1; INDO; indolamine 2; 3 dioxygenase; Indole 2 3 dioxygenase	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Indoleamine 2,3-dioxygenase Antibody (YA3100) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3100), targeting Indoleamine 2,3-dioxygenase, with a predicted molecular weight of 45 kDa (observed band size: 45 kDa). Indoleamine 2,3-dioxygenase Antibody (YA3100) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human background.

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