Search Result

Results for "

Interleukin-1 receptor associated kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IRAK (24) Cyclic GMP-AMP Synthase (1) Ligands for Target Protein for PROTAC (1) NF-κB (1) PROTACs (4) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (8) Infection (2) Inflammation/Immunology (18)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Targets Recommended: Interleukin Related IRAK Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111101

AZ1495	IRAK	Cancer
AZ1495, a weak base, is a potent orally active interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor. AZ1495 has a favorable physicochemical and kinase selectivity for IRAK4 and IRAK1 with IC₅₀ values of 0.005 μM and 0.023 μM, respectively. AZ1495 has IRAK4 inhibition with a K_d value of 0.0007 μM. AZ1495 can be used for the research of diffuse large B-cell lymphoma (DLBCL) .

HY-13276

IRAK inhibitor 2	IRAK	Inflammation/Immunology
IRAK inhibitor 2 is IRAK4 (interleukin-1 receptor associated kinase 4) inhibitor .

HY-13278

IRAK inhibitor 4 1 Publications Verification	IRAK	Inflammation/Immunology
IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor.

HY-13280

IRAK inhibitor 6	IRAK	Inflammation/Immunology
IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor associated kinase 4 (IRAK-4) with IC₅₀ of 160 nM.

HY-101922

IRAK4-IN-1	IRAK	Inflammation/Immunology
IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC₅₀ of 7 nM.

HY-13277

IRAK inhibitor 3 1 Publications Verification	IRAK	Inflammation/Immunology
IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.

HY-123854

PF-06426779	IRAK	Inflammation/Immunology
PF-06426779 is a potent and selective inhibitor of interleukin‑1 receptor associated kinase 4 (IRAK4), with an IC₅₀ of 0.3 nM .

HY-13278A

IRAK inhibitor 4 (trans)	IRAK	Inflammation/Immunology
IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor 4. IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor.

HY-13329

IRAK-1-4 Inhibitor I Maximum Cited Publications 8 Publications Verification IRAK-1/4 Inhibitor I	IRAK	Inflammation/Immunology
IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC₅₀s of 0.2 μM and 0.3 μM, respectively.

HY-150593

IRAK4-IN-16	IRAK	Cancer
IRAK4-IN-16 (compound 4) is a potent IRAK4 (interleukin-1 receptor associated kinase 4) inhibitor, with an IC₅₀ of 2.5 nM. IRAK4-IN-16 shows cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC₅₀ values of 0.2, 0.2, 0.6, and 2.7 μM, respectively .

HY-103017

JH-X-119-01 hydrochloride 3 Publications Verification	IRAK	Infection
JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice .

HY-139315

PROTAC IRAK4 degrader-4	PROTACs IRAK	Cancer
PROTAC IRAK4 degrader-4 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-127 .

HY-139317

PROTAC IRAK4 degrader-6	PROTACs IRAK	Cancer
PROTAC IRAK4 degrader-6 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-172 .

HY-77048

IRAK-4 protein kinase inhibitor 2	IRAK	Inflammation/Immunology
IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC₅₀ of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders .

HY-129967

PROTAC IRAK4 ligand-1	Ligands for Target Protein for PROTAC	Cancer
PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4 (IRAK4). PROTAC IRAK4 ligand-1 can be used in the synthesis of PROTAC IRAK4 degrader-1 (HY-129966) .

HY-109585

IRAK4-IN-7	IRAK	Inflammation/Immunology Cancer
IRAK4-IN-7 is a selective, potent and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, extracted from patent WO2015104688 (example 1). IRAK4-IN-7 has the potential for cancer and inflammatory diseases treatment .

HY-19836

Zimlovisertib 5+ Cited Publications PF-06650833	IRAK	Inflammation/Immunology
Zimlovisertib (PF-06650833) is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC₅₀s of 0.2 and 2.4 nM in the cell and PBMC assay, respectively. Zimlovisertib is used to treat diseases such as rheumatoid arthritis, lupus, and lymphomas .

HY-169057

BI1543673	IRAK Toll-like Receptor (TLR)	Inflammation/Immunology
BI1543673 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor. BI1543673 can reduce the inflammatory response stimulated by TLR4 and TLR7/8 in human lung tissue. BI1543673 can decrease inflammatory signaling in a mouse model of lung inflammation induced by LPS .

HY-114181

IRAK4-IN-4 1 Publications Verification	IRAK Cyclic GMP-AMP Synthase	Inflammation/Immunology
IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC₅₀ of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC₅₀ of 2.1 nM .

HY-129966

PROTAC IRAK4 degrader-1 1 Publications Verification	PROTACs IRAK	Cancer
PROTAC IRAK4 degrader-1 is a Cereblon-based PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively .

HY-103017A

JH-X-119-01 3 Publications Verification	IRAK	Infection Inflammation/Immunology Cancer
JH-X-119-01 is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 ameliorates LPS-induced sepsis in mice . JH-X-119-01 inhibits IRAK1 biochemically with an apparent IC₅₀ of 9 nM while exhibiting no inhibition of IRAK4 at concentrations up to 10 μM .

HY-150732

IRAK4-IN-18	IRAK	Inflammation/Immunology
IRAK4-IN-18 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC₅₀ value of 15 nM. IRAK4-IN-18 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-18 can be used for researching arthritis disease .

HY-150733

IRAK4-IN-19	IRAK	Inflammation/Immunology
IRAK4-IN-19 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC₅₀ value of 4.3 nM. IRAK4-IN-19 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-19 can be used for researching arthritis disease .

HY-162538

LC-MI-3	NF-κB IRAK PROTACs	Inflammation/Immunology
LC-MI-3 is an orally active and potent interleukin-1 receptor-associated kinase 4 (IRAK4) PROTAC degrader, with a DC₅₀ of 47.3 nM. LC-MI-3 effectively inhibits the activation of downstream NF-κB signaling. LC-MI-3 can be used for the research of acute and chronic inflammatory skin. (Blue: VHL ligand, Black: linker, Pink: CRBN ligand (HY-14658)) .

HY-148238

GNE-2256	IRAK	Inflammation/Immunology
GNE-2256 (molecule 19) is an orally active IRAK4 (Interleukin 1 receptor associated kinase 4) inhibitor (IRAK4 K_i=1.4 nM; IL-6 IC₅₀=190 nM) .

Cat. No.	Product Name	Target	Research Area

HY-P5432

IRAK-4 Peptide substrate IRAK-1 (360-380)	Peptides	Others
IRAK-4 Peptide substrate (IRAK-1 (360-380)) is a biological active peptide. (This is a substrate peptide for Interleukin-1 Receptor-Associated Kinase (IRAK) 4)

Species:	Human (5) Mouse (1)
Tag:	His (4) GST (2)
Source:	Sf9 insect cells (4) P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P73255

	IRAK4 Protein, Human (sf9, His) Interleukin-1 receptor-associated kinase 4; IPD1; IRAK4; NY-REN-64; REN64	Human	Sf9 insect cells
	IRAK4 Protein, a serine/threonine-protein kinase, is pivotal in initiating innate immune responses via Toll-like receptor (TLR) and IL-1R signaling pathways. Upon TLR activation, it rapidly forms the Myddosome with IRAK2. IRAK4 phosphorylates IRAK1, promoting its autophosphorylation, and phosphorylates Pellino proteins to facilitate IRAK1 polyubiquitination. This leads to NF-kappa-B activation and regulates immune responses during microbial infections. Additionally, it phosphorylates TIRAP, influencing its ubiquitination and degradation. IRAK4 Protein, Human (sf9, His) is the recombinant human-derived IRAK4 protein, expressed by Sf9 insect cells , with N-10*His labeled tag. The total length of IRAK4 Protein, Human (sf9, His) is 460 a.a., with molecular weight of ~48 kDa.

HY-P700624

	RIPK2 Protein, Human (P. pastoris, His) receptor-interacting serine-threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2; CARD3; CARDIAK; RICK; RIP2; RIP-2; CARD-carrying kinase; growth-inhibiting gene 30; tyrosine-protein kinase RIPK2; receptor interacting protein 2; receptor-interacting protein 2; RIP-like-interacting CLARP kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing Interleukin-1 beta-converting enzyme-associated kinase; CARD-containing Interleukin-1 beta-converting enzyme (ICE)-associated kinase; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; CCK; GIG30	Human	P. pastoris
	RIPK2 is a multifunctional serine/threonine/tyrosine protein kinase that coordinates innate and adaptive immune responses. It is activated by bacterial peptidoglycan to form filaments in the NOD1 and NOD2 pathways, undergoing autophosphorylation and polyubiquitination. RIPK2 Protein, Human (P. pastoris, His) is the recombinant human-derived RIPK2 protein, expressed by P. pastoris , with C-6His, C-6His labeled tag. The total length of RIPK2 Protein, Human (P. pastoris, His) is 540 a.a., with molecular weight of 66 kDa.

HY-P701789

	IRAK1 Protein, Human (Sf9, GST) IRAK1; Interleukin-1 receptor-associated kinase 1; IRAK-1	Human	Sf9 insect cells
	IRAK1 is a serine/threonine protein kinase that initiates innate immune responses against pathogens through Toll-like receptor (TLR) and IL-1R signaling. After TLR activation, IRAK1 is recruited by MYD88 and undergoes IRAK4 phosphorylation, autophosphorylation, and kinase activation. IRAK1 Protein, Human (Sf9, GST) is the recombinant human-derived IRAK1 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of IRAK1 Protein, Human (Sf9, GST) is 519 a.a., .

HY-P703078

	IRAK4 Protein, Mouse (His) Interleukin-1 receptor-associated kinase 4; IRAK-4; EC:2.7.11.1	Mouse	E. coli
	IRAK4 Protein, Mouse (His) is the recombinant mouse-derived IRAK4, expressed by E. coli , with N-6*His labeled tag. ,

HY-P703010

	IRAK3 Protein, Human (sf9, GST) Interleukin-1 receptor-associated kinase 3; IRAK-3; IL-1 receptor-associated kinase M (IRAK-M); Inactive IL-1 receptor-associated kinase 3; IRAK3	Human	Sf9 insect cells
	IRAK3 Protein, Human (sf9, GST) is the recombinant human-derived IRAK3, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P702732

	IRAK4 Protein, Human (307a.a, sf9, His) Interleukin-1 receptor-associated kinase 4; IPD1; IRAK4; NY-REN-64; REN64	Human	Sf9 insect cells
	The IRAK4 protein is a serine/threonine protein kinase that is critical for initiating the innate immune response through the Toll-like receptor (TLR) and IL-1R signaling pathways. After TLR is activated, it rapidly forms the Myddosome with IRAK2. IRAK4 Protein, Human (307a.a, sf9, His) is the recombinant human-derived IRAK4, expressed by Sf9 insect cells , with His labeled tag. ,

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82122

	IRAK2 Antibody (YA1867) Interleukin 1 receptor associated kinase 2; IRAK 2; Irak2	WB, IP, FC	Human
	IRAK2 Antibody (YA1867) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1867), targeting IRAK2, with a predicted molecular weight of 69 kDa (observed band size: 69 kDa). IRAK2 Antibody (YA1867) can be used for WB, IP, FC experiment in human background.

HY-P83307

	IRAKM Antibody (YA3052) IRAK3; Interleukin-1 receptor-associated kinase 3; IRAK-3; IL-1 receptor-associated kinase M; IRAK-M	WB, IP	Human
	IRAKM Antibody (YA3052) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3052), targeting IRAKM, with a predicted molecular weight of 68 kDa (observed band size: 68 kDa). IRAKM Antibody (YA3052) can be used for WB, IP experiment in human background.

HY-P83370

	IRAK4 Antibody (YA3115) IL-1 receptor-associated kinase 4; Interleukin 1 receptor associated kinase 4 mutant form 1; IPD1; IRAK4; LOC 51135; NY REN 64; REN64	WB, IHC-F, IHC-P, ICC/IF	Human
	IRAK4 Antibody (YA3115) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3115), targeting IRAK4, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). IRAK4 Antibody (YA3115) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: