Iron transport

By Targets:	Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Bacterial (2) Biochemical Assay Reagents (4) Drug Derivative (1) Fluorescent Dye (1) Fungal (1) Heme Oxygenase (HO) (1) Transferrin Receptor (4)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (1) Metabolic Disease (2)

Targets Recommended: FATP Ferroportin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3267

Holo-Bovine Transferrin 2 Publications Verification	Transferrin Receptor	Others
Holo-Bovine Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Holo-Bovine Transferrin can bind to and mediate the transport of iron .

HY-103708

Nezukone C2-deoxyhinokitiol; 4-Isopropyltropone	Drug Derivative	Others
Nezukone is a derivative of hinokitiol. Hinokitiol can restore iron transports, however, Nezukone cannot bind or transport iron.

HY-NP011

Holo-Human transferrin Holo-TRF	Transferrin Receptor	Others
Holo-Human transferrin is a glycoprotein with a branched sugar chain that mediates the transport of iron from plasma to cells .

HY-P990051

Delpacibart	Transferrin Receptor	Cancer
Delpacibart is a humanized IgG1κ antibody targeting TFRC. TFRC is the most important membrane protein that regulates intracellular iron transport processes .

HY-W127813

Iron(III) octaethylporphine chloride Chloro(octaethylporphyrinato)Iron	Biochemical Assay Reagents	Others
Iron(III) octaethylporphine chloride is a coordination complex containing iron and porphyrin ligands. It is often used as a model compound to study the electronics and magnetism of heme proteins, which play important roles in various biological processes such as oxygen transport and metabolism. Iron(III) octaethylporphine chloride has a variety of applications in biochemical and biophysical research, including as a probe to study protein-ligand interactions and as a catalyst for oxidation reactions. In addition, it can be used as a photosensitizer in photodynamic therapy for the improvement of cancer and other diseases.

HY-P2232

Conalbumin Ovotransferrin	Fungal	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Conalbumin (Ovotransferrin), also known as ovotransferrin, is a monomeric glycoprotein consisting of 686 amino acids, encoded by the avian transferrin gene in the oviduct, and a prominent component of chicken egg white. Exhibiting a unique glycosylation pattern that differentiates it from serum transferrin, Conalbumin is a potent iron binder that plays a crucial role in iron transport to developing embryos. Additionally, it possesses a range of biological activities, including antimicrobial, antifungal, antiviral, anticancer, antioxidative, antihypertensive, and immunoregulatory properties, making it valuable in numerous applications such as infant formula ingredients, food additives, and agents for enhancing animal health.

HY-P2995

Hemoglobin	Biochemical Assay Reagents Heme Oxygenase (HO)	Others
Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin is an inducer of HO-1. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant .

HY-N14935

Agrobactin	Biochemical Assay Reagents	Infection
Agrobactin is a catechol-type siderophore (microbial iron transport compound) .

HY-121858

Nicotianamine	Angiotensin-converting Enzyme (ACE)	Metabolic Disease
Nicotianamine can be isolated from the leaves of Nicotiana Tabacum L.. Nicotianamine is a key biosynthetic precursor of phytosiderophores. Nicotianamine is an iron chelating agent and can promote the transport of iron. Nicotianamine is an angiotensin-converting enzyme (ACE) inhibitor with IC₅₀ values of 76 nM and 59 nM for rhACE2 and rhACE, respectively. Nicotianamine is vital in metal nutrition and metal homeostasis of flowering plants .

HY-P2120

Pseudobactin A	Bacterial	Others
Pseudobactin A is a non-fluorescent extracellular iron carrier produced by the plant growth-promoting bacterium Pseudomonas B10 .

HY-W073080

Coproporphyrin I dihydrochloride	Biochemical Assay Reagents	Others
Coproporphyrin I dihydrochlorideIt is an organic compound belonging to the class of porphyrins. It is a derivative of heme, an iron-containing molecule found in hemoglobin and other proteins. Coproporphyrin I dihydrochlorideOften used as a biomarker in the assessment of certain liver and metabolic diseases, especially those related to bile synthesis and transport. It can also be used as a reference standard for analytical chemistry and pharmacological research.

HY-D2426

Cy3-Transferrin	Fluorescent Dye Transferrin Receptor	Cardiovascular Disease
Cy3-Transferrin is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye and Transferrin (HY-P3267). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrin can bind to and mediate the transport of iron .

HY-151944

Antibacterial agent 128	Bacterial Antibiotic	Infection
Antibacterial agent 128 is a siderophore analog-Ciprofloxacin (Ciprofloxacin (HY-B0356)) conjugate with a cleavable linker. Antibacterial agent 128 shows antibiotic activities against *P. aeruginosa* (MIC values of 0.25-64 μg/mL) and *B. pseudomallei* (MIC values of 1-32 μg/mL) .

Cat. No.	Product Name

HY-L045

Oxygen Sensing Compound Library	3,147 compounds
Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival. HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation. MCE offers a unique collection of 3,147 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Oxygen Sensing Compound Library

3,147 compounds

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.

HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.

MCE offers a unique collection of 3,147 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Cat. No.	Product Name	Type

HY-D2426

Cy3-Transferrin	Fluorescent Dyes/Probes
Cy3-Transferrin is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye and Transferrin (HY-P3267). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrin can bind to and mediate the transport of iron .

Cy3-Transferrin

Fluorescent Dyes/Probes

Cy3-Transferrin is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye and Transferrin (HY-P3267). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrin can bind to and mediate the transport of iron .

Cat. No.	Product Name	Type

HY-P3267

Holo-Bovine Transferrin 2 Publications Verification	Native Proteins
Holo-Bovine Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Holo-Bovine Transferrin can bind to and mediate the transport of iron .

HY-NP011

Holo-Human transferrin Holo-TRF	Native Proteins
Holo-Human transferrin is a glycoprotein with a branched sugar chain that mediates the transport of iron from plasma to cells .

HY-W127813

Iron(III) octaethylporphine chloride Chloro(octaethylporphyrinato)Iron	Biochemical Assay Reagents
Iron(III) octaethylporphine chloride is a coordination complex containing iron and porphyrin ligands. It is often used as a model compound to study the electronics and magnetism of heme proteins, which play important roles in various biological processes such as oxygen transport and metabolism. Iron(III) octaethylporphine chloride has a variety of applications in biochemical and biophysical research, including as a probe to study protein-ligand interactions and as a catalyst for oxidation reactions. In addition, it can be used as a photosensitizer in photodynamic therapy for the improvement of cancer and other diseases.

Iron(III) octaethylporphine chloride

Chloro(octaethylporphyrinato)Iron

Biochemical Assay Reagents

Iron(III) octaethylporphine chloride is a coordination complex containing iron and porphyrin ligands. It is often used as a model compound to study the electronics and magnetism of heme proteins, which play important roles in various biological processes such as oxygen transport and metabolism. Iron(III) octaethylporphine chloride has a variety of applications in biochemical and biophysical research, including as a probe to study protein-ligand interactions and as a catalyst for oxidation reactions. In addition, it can be used as a photosensitizer in photodynamic therapy for the improvement of cancer and other diseases.

HY-P2232

Conalbumin Ovotransferrin	Native Proteins
Conalbumin (Ovotransferrin), also known as ovotransferrin, is a monomeric glycoprotein consisting of 686 amino acids, encoded by the avian transferrin gene in the oviduct, and a prominent component of chicken egg white. Exhibiting a unique glycosylation pattern that differentiates it from serum transferrin, Conalbumin is a potent iron binder that plays a crucial role in iron transport to developing embryos. Additionally, it possesses a range of biological activities, including antimicrobial, antifungal, antiviral, anticancer, antioxidative, antihypertensive, and immunoregulatory properties, making it valuable in numerous applications such as infant formula ingredients, food additives, and agents for enhancing animal health.

Conalbumin

Ovotransferrin

Native Proteins

Conalbumin (Ovotransferrin), also known as ovotransferrin, is a monomeric glycoprotein consisting of 686 amino acids, encoded by the avian transferrin gene in the oviduct, and a prominent component of chicken egg white. Exhibiting a unique glycosylation pattern that differentiates it from serum transferrin, Conalbumin is a potent iron binder that plays a crucial role in iron transport to developing embryos. Additionally, it possesses a range of biological activities, including antimicrobial, antifungal, antiviral, anticancer, antioxidative, antihypertensive, and immunoregulatory properties, making it valuable in numerous applications such as infant formula ingredients, food additives, and agents for enhancing animal health.

HY-P2995

Hemoglobin	Native Proteins
Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin is an inducer of HO-1. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant .

HY-W073080

Coproporphyrin I dihydrochloride	Biochemical Assay Reagents
Coproporphyrin I dihydrochlorideIt is an organic compound belonging to the class of porphyrins. It is a derivative of heme, an iron-containing molecule found in hemoglobin and other proteins. Coproporphyrin I dihydrochlorideOften used as a biomarker in the assessment of certain liver and metabolic diseases, especially those related to bile synthesis and transport. It can also be used as a reference standard for analytical chemistry and pharmacological research.

Coproporphyrin I dihydrochloride

Biochemical Assay Reagents

Coproporphyrin I dihydrochlorideIt is an organic compound belonging to the class of porphyrins. It is a derivative of heme, an iron-containing molecule found in hemoglobin and other proteins. Coproporphyrin I dihydrochlorideOften used as a biomarker in the assessment of certain liver and metabolic diseases, especially those related to bile synthesis and transport. It can also be used as a reference standard for analytical chemistry and pharmacological research.

Cat. No.	Product Name	Target	Research Area

HY-P2120

Pseudobactin A	Bacterial	Others
Pseudobactin A is a non-fluorescent extracellular iron carrier produced by the plant growth-promoting bacterium Pseudomonas B10 .

Cat. No.	Product Name	Target	Research Area

HY-P990051

Delpacibart	Transferrin Receptor	Cancer
Delpacibart is a humanized IgG1κ antibody targeting TFRC. TFRC is the most important membrane protein that regulates intracellular iron transport processes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N14935

Agrobactin	Structural Classification Natural Products Microorganisms Source classification	Biochemical Assay Reagents
Agrobactin is a catechol-type siderophore (microbial iron transport compound) .

HY-121858

Nicotianamine	Structural Classification Nicotiana tabacum L. Ketones, Aldehydes, Acids Source classification Solanaceae Plants	Angiotensin-converting Enzyme (ACE)
Nicotianamine can be isolated from the leaves of Nicotiana Tabacum L.. Nicotianamine is a key biosynthetic precursor of phytosiderophores. Nicotianamine is an iron chelating agent and can promote the transport of iron. Nicotianamine is an angiotensin-converting enzyme (ACE) inhibitor with IC₅₀ values of 76 nM and 59 nM for rhACE2 and rhACE, respectively. Nicotianamine is vital in metal nutrition and metal homeostasis of flowering plants .

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Screening Libraries

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Iron transport

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Natural
Products