Iron transport

By Targets:	Antibiotic (1) Bacterial (1) Biochemical Assay Reagents (1) Transferrin Receptor (2)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (1) Metabolic Disease (1)

Targets Recommended: FATP Ferroportin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3267

Transferrins 1 Publications Verification	Transferrin Receptor	Others
Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrins can bind to and mediate the transport of iron .

HY-103708

Nezukone C2-deoxyhinokitiol; 4-Isopropyltropone	Others	Others
Nezukone is a derivative of hinokitiol. Hinokitiol can restore iron transports, however, Nezukone cannot bind or transport iron.

HY-NP011

Human transferrin (suitable for cell culture) TRF	Transferrin Receptor	Others
Human transferrin (suitable for cell culture) is a glycoprotein with a branched sugar chain that mediates the transport of iron from plasma to cells .

HY-P2995

Hemoglobin	Biochemical Assay Reagents	Others
Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant .

HY-121858

Nicotianamine	Others	Others
Nicotianamine can be isolated from the leaves of Nicotiana Tabacum L.. Nicotianamine is a key biosynthetic precursor of phytosiderophores. Nicotianamine is an iron chelating agent and can promote the transport of iron. Nicotianamine is vital in metal nutrition and metal homeostasis of flowering plants .

HY-P2232

Conalbumin Ovotransferrin	Others	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Conalbumin (Ovotransferrin), also known as ovotransferrin, is a monomeric glycoprotein consisting of 686 amino acids, encoded by the avian transferrin gene in the oviduct, and a prominent component of chicken egg white. Exhibiting a unique glycosylation pattern that differentiates it from serum transferrin, Conalbumin is a potent iron binder that plays a crucial role in iron transport to developing embryos. Additionally, it possesses a range of biological activities, including antimicrobial, antifungal, antiviral, anticancer, antioxidative, antihypertensive, and immunoregulatory properties, making it valuable in numerous applications such as infant formula ingredients, food additives, and agents for enhancing animal health.

HY-151944

Antibacterial agent 128	Bacterial Antibiotic	Infection
Antibacterial agent 128 is a siderophore analog-Ciprofloxacin (Ciprofloxacin (HY-B0356)) conjugate with a cleavable linker. Antibacterial agent 128 shows antibiotic activities against *P. aeruginosa* (MIC values of 0.25-64 μg/mL) and *B. pseudomallei* (MIC values of 1-32 μg/mL) .

Cat. No.	Product Name

HY-L045

Oxygen Sensing Compound Library	2,742 compounds
Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival. HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation. MCE offers a unique collection of 2,742 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Oxygen Sensing Compound Library

2,742 compounds

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.

HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.

MCE offers a unique collection of 2,742 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Cat. No.	Product Name	Type

HY-P3267

Transferrins 1 Publications Verification	Native Proteins
Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrins can bind to and mediate the transport of iron .

HY-NP011

Human transferrin (suitable for cell culture) TRF	Native Proteins
Human transferrin (suitable for cell culture) is a glycoprotein with a branched sugar chain that mediates the transport of iron from plasma to cells .

HY-P2995

Hemoglobin	Native Proteins
Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant .

Cat. No.	Product Name	Target	Research Area

HY-P2120

Pseudobactin A	Peptides	Others
Pseudobactin A is a non-fluorescent extracellular iron carrier produced by the plant growth-promoting bacterium Pseudomonas B10 .

Cat. No.	Product Name	Target	Research Area

HY-P990051

Delpacibart	Inhibitory Antibodies	Cancer
Delpacibart is a humanized IgG1κ antibody targeting TFRC. TFRC is the most important membrane protein that regulates intracellular iron transport processes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-121858

Nicotianamine	Structural Classification Nicotiana tabacum L. Ketones, Aldehydes, Acids Source classification Solanaceae Plants	Others
Nicotianamine can be isolated from the leaves of Nicotiana Tabacum L.. Nicotianamine is a key biosynthetic precursor of phytosiderophores. Nicotianamine is an iron chelating agent and can promote the transport of iron. Nicotianamine is vital in metal nutrition and metal homeostasis of flowering plants .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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