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Jagged-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Bacterial (2) Calcium Channel (1) Endogenous Metabolite (3) Fungal (2) Isotope-Labeled Compounds (1) Notch (5)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1846A

Jagged-1 (188-204) (TFA) Maximum Cited Publications 7 Publications Verification	Notch	Cancer
Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells ^[1] .

HY-N0711

Carvacrol 5 Publications Verification Cymophenol	Notch Apoptosis Fungal Endogenous Metabolite Bacterial	Infection Inflammation/Immunology Cancer
Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates *Notch-1, and Jagged-1, and induces apoptosis*. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations ^[1] .

HY-P1846

Jagged-1 (188-204)	Notch	Cancer
Jagged-1 (188-204) is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells ^[1] .

HY-N0711R

Carvacrol (Standard)	Notch Apoptosis Fungal Endogenous Metabolite Bacterial	Infection Inflammation/Immunology Cancer
Carvacrol (Standard) is the analytical standard of Carvacrol. This product is intended for research and analytical applications. Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations ^[1] .

HY-W032013S3

1-Octanol-d5 Octanol-d₅	Calcium Channel Endogenous Metabolite Isotope-Labeled Compounds	Others
1-Octanol-d₅ is deuterated labeled Carvacrol (HY-N0711). Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates *Notch-1, and Jagged-1, and induces apoptosis*. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations ^[1] .

HY-N9790

Procyanidin B2 3,3'-di-O-gallate	Notch	Others
Procyanidin B2, 3,3'-di-O-gallate is an active constituent. Procyanidin B2, 3,3'-di-O-gallate can be isolated from grape seed extract (GSE) procyanidin mix. Procyanidin B2, 3,3' -di-o-gallate target cancer stem cells (CSCs) in prostate cancer (PCa). Procyanidin B2, 3,3'-di-O-gallate targets both unsorted and sorted CSCs at lower doses. Procyanidin B2, 3,3'-di-O-gallate strongly suppresses the constitutive as well as Jagged1 (Notch1 ligand)-induced activated *Notch1* pathway ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P1846A

Jagged-1 (188-204) (TFA) 5+ Cited Publications	Notch	Cancer
Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells ^[1] .

HY-P1849A

JAG-1, scrambled TFA scJag-1 TFA	Peptides	Cardiovascular Disease
JAG-1, scrambled (scJag-1) TFA is a scrambled sequence of JAG-1 (Jagged-1 protein). JAG-1, scrambled TFA has a random sequence of the amino acids that are the same as the active fragment. JAG-1, scrambled TFA is usually used as a negative control ^[1].

HY-P1846

Jagged-1 (188-204)	Notch	Cancer
Jagged-1 (188-204) is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells ^[1] .

HY-P1849

JAG-1, scrambled scJag-1	Peptides	Cardiovascular Disease
JAG-1, scrambled (scJag-1) is a scrambled sequence of JAG-1 (Jagged-1 protein). JAG-1, scrambled has a random sequence of the amino acids that are the same as the active fragment. JAG-1, scrambled is usually used as a negative control ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0711

Carvacrol 5 Publications Verification Cymophenol	Structural Classification Monophenols Preservatives Classification of Application Fields Labiatae Phenols Plants Inflammation/Immunology Disease Research Fields Food Research	Notch Apoptosis Fungal Endogenous Metabolite Bacterial
Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates *Notch-1, and Jagged-1, and induces apoptosis*. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations ^[1] .

HY-N0711R

Carvacrol (Standard)	Structural Classification Monophenols Labiatae Phenols Plants	Notch Apoptosis Fungal Endogenous Metabolite Bacterial
Carvacrol (Standard) is the analytical standard of Carvacrol. This product is intended for research and analytical applications. Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations ^[1] .

HY-N9790

Procyanidin B2 3,3'-di-O-gallate	Structural Classification Source classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae	Notch
Procyanidin B2, 3,3'-di-O-gallate is an active constituent. Procyanidin B2, 3,3'-di-O-gallate can be isolated from grape seed extract (GSE) procyanidin mix. Procyanidin B2, 3,3' -di-o-gallate target cancer stem cells (CSCs) in prostate cancer (PCa). Procyanidin B2, 3,3'-di-O-gallate targets both unsorted and sorted CSCs at lower doses. Procyanidin B2, 3,3'-di-O-gallate strongly suppresses the constitutive as well as Jagged1 (Notch1 ligand)-induced activated *Notch1* pathway ^[1].

Species:	Human (3) Mouse (1)
Tag:	SUMO (1) His (3) Myc (1) Fc (1)
Source:	HEK293 (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71633

	Jagged-1/JAG1 Protein, Mouse (Myc, His-SUMO) 1 Publications Verification Jag1; Protein Jagged-1; Jagged1; CD antigen CD339	Mouse	E. coli
	Jagged-1/JAG1 protein is a multifunctional ligand that binds to multiple Notch receptors and mediates Notch signaling.It influences cell fate decisions during hematopoiesis, spans early and late mammalian cardiovascular development, and regulates myoblast differentiation.Jagged-1/JAG1 Protein, Mouse (Myc, His-SUMO) is the recombinant mouse-derived Jagged-1/JAG1 protein, expressed by E.coli , with C-Myc, N-SUMO, N-10*His labeled tag.

HY-P70399

	Jagged-1/JAG1 Protein, Human (HEK293, Fc) rHuJagged-1/JAG1, Fc; Protein Jagged-1 I; Jagged-1; JAGL1; HJ1; JAG1 and CD339	Human	HEK293
	Jagged-1/JAG1 protein is a ligand for multiple Notch receptors and crucially mediates Notch signaling through interactions with NOTCH1, NOTCH2, and NOTCH3. Its role in hematopoiesis suggests its involvement in the regulation of blood cell development. Jagged-1/JAG1 Protein, Human (HEK293, Fc) is the recombinant human-derived Jagged-1/JAG1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Jagged-1/JAG1 Protein, Human (HEK293, Fc) is 1013 a.a., with molecular weight of 140-200 kDa.

HY-P73258

	Jagged-1/JAG1 Protein, Human (HEK293, His) AGS; Alagille syndrome; AWS; CD339; HJ1; JAG1; Jagged 1; JAGL1	Human	HEK293
	Jagged-1/JAG1 protein is a ligand for multiple Notch receptors and crucially mediates Notch signaling through interactions with NOTCH1, NOTCH2, and NOTCH3. Its role in hematopoiesis suggests its involvement in the regulation of blood cell development. Jagged-1/JAG1 Protein, Human (HEK293, His) is the recombinant human-derived Jagged-1/JAG1 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Jagged-1/JAG1 Protein, Human (HEK293, His) is 1013 a.a., with molecular weight of 150 kDa.

HY-P701016

	Jagged-1/JAG1 Protein, Human (1013a.a, HEK293, His) Jagged1; hJ1; CD339; JAGL1; AGS; AHD; AWS	Human	HEK293
	Jagged-1/JAG1 protein is a ligand for multiple Notch receptors and crucially mediates Notch signaling through interactions with NOTCH1, NOTCH2, and NOTCH3. Its role in hematopoiesis suggests its involvement in the regulation of blood cell development. Jagged-1/JAG1 Protein, Human (1013a.a, HEK293, His) is the recombinant human-derived Jagged-1/JAG1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Jagged-1/JAG1 Protein, Human (1013a.a, HEK293, His) is 1013 a.a., with molecular weight of 120-140 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-W032013S3

1-Octanol-d5
1-Octanol-d₅ is deuterated labeled Carvacrol (HY-N0711). Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates *Notch-1, and Jagged-1, and induces apoptosis*. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations ^[1] .

1-Octanol-d5

1-Octanol-d₅ is deuterated labeled Carvacrol (HY-N0711). Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations ^[1] .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80195

	Jagged1 Antibody	WB, IHC-P	Human, Mouse, Rat
	Jagged1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 134 kDa, targeting to Jagged1. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P83346

	Jagged 1 Antibody (YA3091) JAG1; JAGL1; Protein Jagged-1; Jagged1; hJ1; CD339	WB, IHC-P	Human
	Jagged 1 Antibody (YA3091) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3091), targeting Jagged 1, with a predicted molecular weight of 134 kDa (observed band size: 180 kDa). Jagged 1 Antibody (YA3091) can be used for WB, IHC-P experiment in human background.