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Ki67

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By Targets:	Akt (1) Apoptosis (4) Caspase (1) CDK (1) DNA/RNA Synthesis (7) Endogenous Metabolite (2) HDAC (1) Histone Methyltransferase (1) Lipoxygenase (1) mTOR (1) PI3K (1)
By Research Areas:	Cancer (5) Endocrinology (2) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (2)

9

Inhibitors & Agonists

2

Natural
Products

2

Recombinant Proteins

4

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

4-tert-Octylphenol	Endogenous Metabolite Apoptosis DNA/RNA Synthesis	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic agent. 4-tert-Octylphenol is also a biodegradation product of non-ionic surfactants alkylphenol polyethoxylates. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice, which is promising for reserch of immune response, neuro-related diseases and ethology .

CP681301	CDK DNA/RNA Synthesis	Cancer
CP681301 is a potent CDK5 inhibitor. CP681301 shows antiproliferative activity. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs (Glioma stem cells). CP681301 reduces self-renewal in mouse glioma xenografts. CP681301 shows anti-tumor activity in Drosophila .

KTC1101	PI3K Akt mTOR	Cancer
KTC1101 is an orally active pan-PI3K inhibitor. KTC1101 can inhibit the PI3K signaling pathway, reduce downstream AKT and mTOR phosphorylation, and reduces the expression of *Ki67*. The anti-tumor effect of KTC1101 has a dual mechanism of action: directly inhibiting tumor cell growth and dynamically enhancing immune response .

12R-LOX-IN-2	Lipoxygenase DNA/RNA Synthesis	Inflammation/Immunology
12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases .

12R-LOX-IN-1	DNA/RNA Synthesis	Inflammation/Immunology
12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC₅₀: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research .

4-tert-Octylphenol (Standard)	Endogenous Metabolite Apoptosis DNA/RNA Synthesis	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
4-tert-Octylphenol (Standard) is the analytical standard of 4-tert-Octylphenol. This product is intended for research and analytical applications. 4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic agent. 4-tert-Octylphenol is also a biodegradation product of non-ionic surfactants alkylphenol polyethoxylates. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice, which is promising for reserch of immune response, neuro-related diseases and ethology .

anti-TNBC agent-2	Apoptosis DNA/RNA Synthesis	Cancer
anti-TNBC agent-2 (3j) an anti-Triple negative breast cancer (TNBC) purine derivative. anti-TNBC agent-2 induces MDA-MB-231 cells apoptosis, and inhibits its migration and angiogenesis. anti-TNBC agent-2 inhibits tumor growth and metastasis and reduces the expression of Ki67 and CD31 protein in TNBC xenograft models. anti-TNBC agent-2 can be used for Triple negative breast cancer (TNBC) research .

HDAC3-IN-2	HDAC Histone Methyltransferase Caspase Apoptosis DNA/RNA Synthesis	Cancer
HDAC3-IN-2 (compound 4i) is a pyrazinyl hydrazide-based HDAC3 inhibitor (IC₅₀: 14 nM) that efficiently targets triple-negative breast cancer cells. HDAC3-IN-2 is cytotoxic with an IC₅₀ of 0.55 μM against 4T1 and an IC₅₀ of 0.74 μM against MDA-MB-231. HDAC3-IN-2 has anti-tumor efficacy in vivo in tumor-bearing mouse models, selectively increasing the acetylation levels of H3K9, H3K27 and H4K12, increasing the contents of apoptosis-related caspase-3, caspase-7 and cytochrome c, and reducing Proliferation-related Bcl-2, CD44, EGFR, and Ki-67 levels .

DW10075	Others	Cancer
DW10075 is a novel, highly selective VEGFR inhibitor that targets the VEGF/VEGF receptor (VEGFR) pathway, which has been shown to be an effective anti-angiogenic approach for cancer therapy. Studies have found that DW10075 selectively inhibits VEGFR-1, VEGFR-2, and VEGFR-3 among 21 kinases, while having no effect on the other 18 kinases, including FGFR and PDGFR. In human umbilical vein endothelial cells (HUVECs), DW10075 significantly prevented VEGF-induced activation of VEGFR and its downstream signaling, thereby inhibiting VEGF-induced HUVEC proliferation. In addition, DW10075 dose-dependently inhibited VEGF-induced HUVEC migration and tube formation, and suppressed angiogenesis in the rat aortic ring model and the chick embryo chorionic membrane model. DW10075 also exhibited antiproliferative activity against 22 different human cancer cell lines, with IC50 values ranging from 2.2 μmol/L (for U87-MG human glioblastoma cells) to 22.2 μmol/L (for A375 melanoma cells). In the nude mouse U87-MG xenograft tumor model, oral administration of DW10075 significantly inhibited tumor growth and reduced the expression of CD31 and Ki67 in tumor tissues. In summary, DW10075 is a potential anti-tumor angiogenesis agent that deserves further development.

Cat. No.	Product Name	Category	Target	Chemical Structure

4-tert-Octylphenol	Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite Apoptosis DNA/RNA Synthesis
4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic agent. 4-tert-Octylphenol is also a biodegradation product of non-ionic surfactants alkylphenol polyethoxylates. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice, which is promising for reserch of immune response, neuro-related diseases and ethology .

4-tert-Octylphenol (Standard)	Monophenols Source classification Phenols Endogenous metabolite	Endogenous Metabolite Apoptosis DNA/RNA Synthesis
4-tert-Octylphenol (Standard) is the analytical standard of 4-tert-Octylphenol. This product is intended for research and analytical applications. 4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic agent. 4-tert-Octylphenol is also a biodegradation product of non-ionic surfactants alkylphenol polyethoxylates. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice, which is promising for reserch of immune response, neuro-related diseases and ethology .

Species:	Human (1) Mouse (1)
Tag:	His (1) GST (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	Ki67/MKI67 Protein, Human (GST) Antigen Ki-67; Ki-67; KiA; MIB-1; MKi67; Proliferation Marker Protein Ki-67	Human	E. coli
	Ki67/MKI67 is localized on mitotic chromosomes and maintains its dispersion during nuclear envelope disassembly. It covers a large portion of the chromosome surface and prevents chromatin from collapsing into clumps. Ki67/MKI67 Protein, Human (GST) is the recombinant human-derived Ki67/MKI67 protein, expressed by E. coli , with N-GST labeled tag. The total length of Ki67/MKI67 Protein, Human (GST) is 120 a.a., with molecular weight of approximately 36.91 kDa.

	Ki-67(MKI67) Protein, Human (His)	Mouse	E. coli
	Ki67/MKI67 is localized on mitotic chromosomes and maintains its dispersion during nuclear envelope disassembly. It covers a large portion of the chromosome surface and prevents chromatin from collapsing into clumps. Ki-67 (MKI67) Protein, Human (His) is the recombinant mouse-derived Ki-67(MKI67) protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

	Ki-67 Antibody 1 Publications Verification Antigen identified by monoclonal antibody Ki 67; Antigen Ki67; KiA; Ki67; MKi67; Proliferation related Ki 67 antigen; Antigen Ki-67; Ki67_MOUSE.	IHC-P, IHC-F, ICC/IF	Human
	Ki-67 Antibody is an unconjugated, approximately 358 kDa, rabbit-derived, anti-Ki-67 polyclonal antibody. Ki-67 Antibody can be used for: IHC-P, IHC-F, ICC, IF expriments in human background without labeling.

	Ki67 Antibody (YA001) MKi67; Antigen Ki-67	IHC-P, ICC/IF	Human, Mouse
	Ki67 Antibody (YA001) is a non-conjugated and Rat origined monoclonal antibody, targeting to Ki67. It can be used for IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse.

	Ki67 Antibody (YA717)	IHC-P	Human, Mouse
	Ki67 Antibody (YA717) is a non-conjugated and Mouse origined monoclonal antibody about 359 kDa, targeting to Ki67. It can be used for IHC-P assays with tag free, in the background of Human, Mouse.

	Ki67 Antibody (YA322) 1 Publications Verification	IHC-P, IHC-F, ICC/IF, FC	Human, Mouse, Rat
	Ki67 Antibody (YA322) is a non-conjugated and Rabbit origined monoclonal antibody about 345-395 kDa, targeting to Ki67. It can be used for IHC,IF assays with tag free, in the background of Human, Mouse, Rat.

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