LYP

By Targets:	Apoptosis (1) Endogenous Metabolite (3) Isotope-Labeled Compounds (2) Liposome (1) NAMPT (1) Notch (1) Phosphatase (6) PKC (1) PROTACs (1) SHP2 (1)
By Research Areas:	Cancer (9) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Phospholipids (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155848

LYP-IN-4	Phosphatase	Cancer
LYP-IN-4 (compound D14) is a reversible and selective inhibitor of lymphotyrosine phosphatase (LYP) (Ki=1.34 μM, IC50=3.52μM). LYP-IN-4 inhibits LYP to regulate TCR signaling, up-regulates PD-1/PD-L1 expression, and enhance anti-tumor immunity. LYP-IN-4 activates T cells and inhibits M2 macrophage polarization, inhibits tumor growth in MC38 isogenic mouse models.

HY-155847

LYP-IN-3	Phosphatase	Cancer
LYP-IN-3 (compound D34) is a selective inhibitor of Lymphoid-tyrosine phosphatase (LYP) (Ki=0.93 μM), and regulates T-cell receptor (TCR) signaling pathway in tumor progress. LYP-IN-3 activates T-cell and inhibits M2 macrophage polarization, but upregulates PD-1/PD-L1 expression. LYP-IN-3 can be leveraged with PD-1/PD-L1 inhibitor, for futher cancer immunotherapy .

HY-108944

LYP-IN-1	SHP2 Phosphatase	Inflammation/Immunology
LYP-IN-1 is a potent, selective and specific *LYP* inhibitor with a K_i and an IC₅₀ of 110 nM and 0.259 μM, respectively. LYP-IN-1 also has selectivity for a large panel of PTPs, such as SHP1 (IC₅₀=5 μM) and SHP2 (IC₅₀=2.5 μM). LYP-IN-1 exhibits highly efficacious cellular activity in T- and mast cells. LYP-IN-1 can be used for the study of autoimmune disorders . LYP-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-18667

LTV-1	Phosphatase	Inflammation/Immunology
LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC₅₀ of 508 nM. LTV-1 has the potential for autoimmunity treatment .

HY-124718

p32 Inhibitor M36 M36	PKC	Cancer
p32 inhibitor M36 (M36) is a p32 mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1 .

HY-113010

1-Arachidoyl-sn-glycero-3-phosphocholine	Endogenous Metabolite	Others
1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid (LyP).

HY-138622

24:0 Lyso PC	Liposome	Others
24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-162537

LYP-8	PROTACs NAMPT	Cancer
LYP-8 is a potent and effective NAMPT degrader with maximum degradation of 97% at 0.5 μM in SKOV-3 cells. LYP-8 shows anti-cancer activity in vivo and in vitro(Sturcture Note:(Blue: Cereblon ligand (HY-112078), Black: linker (HY-128801)；Pink: Nampt inhibitor Nampt-IN-11 (HY-158689)) .

HY-156659

NC1	Phosphatase	Others
NC1 is a noncompetitive and allosteric lymphoid-specific tyrosine phosphatase (LYP) inhibitor, with a K_i value 4.3 μM. NC1 inhibits LYP by restricting the movement of the WPD-loop. NC1 inhibits LYP-mediated TCR signaling in T cells .

HY-164238

LysoPC(18:3)	Others	Cancer
LysoPC(18:3) is a lysophospholipid (LyP). LysoPC(18:3) can be used as a lipid biomarker in the diagnosis of breast cancer .

HY-113123

LysoPC(14:0/0:0) 14:0 Lyso PC; 1-myristoyl-sn-glycero-3-phosphatidylcholine	Endogenous Metabolite	Neurological Disease Metabolic Disease
LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .

HY-138622S1

24:0 Lyso PC-d4	Isotope-Labeled Compounds	Others
24:0 Lyso PC-d₄4 is the deuterium labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery[1].

HY-138622S

24:0 Lyso PC-13C6	Isotope-Labeled Compounds	Others
24:0 Lyso PC- ¹³C₆ is the ¹³C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery[1].

HY-113010S1

1-Arachidoyl-sn-glycero-3-phosphocholine-d4	Endogenous Metabolite	Others
1-Arachidoyl-sn-glycero-3-phosphocholine-d₄4 is the deuterium labeled 1-Arachidoyl-sn-glycero-3-phosphocholine. 1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid (LyP).

HY-123931

ZLDI-8 1 Publications Verification	Notch Phosphatase Apoptosis	Cancer
ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC₅₀ of 31.6 μM and a K_i of 26.22 μM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC₅₀ of 5.32 μM .

Cat. No.	Product Name	Type

HY-138622

24:0 Lyso PC	Drug Delivery
24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

Cat. No.	Product Name	Target	Research Area

HY-P2526A

LyP-1 TFA 1 Publications Verification	Peptides	Cancer
LyP-1 TFA is a cyclic 9 amino acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells .

HY-P4088

LyP-2	Peptides	Cancer
LyP-2 is a peptide that homes to tumor lymphatics. LyP2 homes to lymphatics of C8161 melanomas and cervical carcinomas and K14-HPV16 skin, but not to MDA-MB435 tumors, showing heterogeneity in the molecular markers of tumor cells and lymphatics .

HY-P2526

LyP-1	Peptides	Cancer
LyP-1 is a cyclic 9‐amino‐acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113010

1-Arachidoyl-sn-glycero-3-phosphocholine	Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid (LyP).

HY-113123

LysoPC(14:0/0:0) 14:0 Lyso PC; 1-myristoyl-sn-glycero-3-phosphatidylcholine	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .

Cat. No.	Product Name	Chemical Structure

HY-138622S

24:0 Lyso PC-13C6
24:0 Lyso PC- ¹³C₆ is the ¹³C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery[1].

HY-138622S1

24:0 Lyso PC-d4
24:0 Lyso PC-d₄4 is the deuterium labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery[1].

HY-113010S1

1-Arachidoyl-sn-glycero-3-phosphocholine-d4
1-Arachidoyl-sn-glycero-3-phosphocholine-d₄4 is the deuterium labeled 1-Arachidoyl-sn-glycero-3-phosphocholine. 1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid (LyP).

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82205

	SH2D1A Antibody (YA1950) LYP; SAP; XLP; DSHP; EBVS; IMD5; XLPD; MTCP1; XLPD1; SAP/SH2D1A	WB	Human, Mouse, Rat
	SH2D1A Antibody (YA1950) is a biotin-conjugated non-conjugated IgG antibody, targeting SH2D1A, with a predicted molecular weight of 14 kDa (observed band size: 14 kDa). SH2D1A Antibody (YA1950) can be used for WB experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-138622

24:0 Lyso PC		Phospholipids
24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-113123

LysoPC(14:0/0:0) 14:0 Lyso PC; 1-myristoyl-sn-glycero-3-phosphatidylcholine		Phospholipids
LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .

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LYP

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