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Results for "

LYP

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

1

Biochemical Assay Reagents

3

Peptides

2

Natural
Products

3

Isotope-Labeled Compounds

1

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-155848

    Phosphatase Cancer
    LYP-IN-4 (compound D14) is a reversible and selective inhibitor of lymphotyrosine phosphatase (LYP) (Ki=1.34 μM, IC50=3.52μM). LYP-IN-4 inhibits LYP to regulate TCR signaling, up-regulates PD-1/PD-L1 expression, and enhance anti-tumor immunity. LYP-IN-4 activates T cells and inhibits M2 macrophage polarization, inhibits tumor growth in MC38 isogenic mouse models.
    LYP-IN-4
  • HY-155847

    Phosphatase Cancer
    LYP-IN-3 (compound D34) is a selective inhibitor of Lymphoid-tyrosine phosphatase (LYP) (Ki=0.93 μM), and regulates T-cell receptor (TCR) signaling pathway in tumor progress. LYP-IN-3 activates T-cell and inhibits M2 macrophage polarization, but upregulates PD-1/PD-L1 expression. LYP-IN-3 can be leveraged with PD-1/PD-L1 inhibitor, for futher cancer immunotherapy .
    LYP-IN-3
  • HY-108944

    SHP2 Phosphatase Inflammation/Immunology
    LYP-IN-1 is a potent, selective and specific LYP inhibitor with a Ki and an IC50 of 110 nM and 0.259 μM, respectively. LYP-IN-1 also has selectivity for a large panel of PTPs, such as SHP1 (IC50=5 μM) and SHP2 (IC50=2.5 μM). LYP-IN-1 exhibits highly efficacious cellular activity in T- and mast cells. LYP-IN-1 can be used for the study of autoimmune disorders . LYP-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    LYP-IN-1
  • HY-18667

    Phosphatase Inflammation/Immunology
    LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM. LTV-1 has the potential for autoimmunity treatment .
    LTV-1
  • HY-124718

    M36

    PKC Cancer
    p32 inhibitor M36 (M36) is a p32 mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1 .
    p32 Inhibitor M36
  • HY-113010

    Endogenous Metabolite Others
    1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid (LyP).
    1-Arachidoyl-sn-glycero-3-phosphocholine
  • HY-138622

    Liposome Others
    24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .
    24:0 Lyso PC
  • HY-162537

    PROTACs NAMPT Cancer
    LYP-8 is a potent and effective NAMPT degrader with maximum degradation of 97% at 0.5 μM in SKOV-3 cells. LYP-8 shows anti-cancer activity in vivo and in vitro(Sturcture Note:(Blue: Cereblon ligand (HY-112078), Black: linker (HY-128801);Pink: Nampt inhibitor Nampt-IN-11 (HY-158689)) .
    LYP-8
  • HY-156659

    Phosphatase Others
    NC1 is a noncompetitive and allosteric lymphoid-specific tyrosine phosphatase (LYP) inhibitor, with a Ki value 4.3 μM. NC1 inhibits LYP by restricting the movement of the WPD-loop. NC1 inhibits LYP-mediated TCR signaling in T cells .
    NC1
  • HY-164238

    Others Cancer
    LysoPC(18:3) is a lysophospholipid (LyP). LysoPC(18:3) can be used as a lipid biomarker in the diagnosis of breast cancer .
    LysoPC(18:3)
  • HY-113123

    14:0 Lyso PC; 1-myristoyl-sn-glycero-3-phosphatidylcholine

    Endogenous Metabolite Neurological Disease Metabolic Disease
    LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .
    LysoPC(14:0/0:0)
  • HY-138622S1

    Isotope-Labeled Compounds Others
    24:0 Lyso PC-d44 is the deuterium labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery[1].
    24:0 Lyso PC-d4
  • HY-138622S

    Isotope-Labeled Compounds Others
    24:0 Lyso PC- 13C6 is the 13C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery[1].
    24:0 Lyso PC-13C6
  • HY-113010S1

    Endogenous Metabolite Others
    1-Arachidoyl-sn-glycero-3-phosphocholine-d44 is the deuterium labeled 1-Arachidoyl-sn-glycero-3-phosphocholine. 1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid (LyP).
    1-Arachidoyl-sn-glycero-3-phosphocholine-d4
  • HY-123931
    ZLDI-8
    1 Publications Verification

    Notch Phosphatase Apoptosis Cancer
    ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC50 of 31.6 μM and a Ki of 26.22 μM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC50 of 5.32 μM .
    ZLDI-8

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