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Legumain

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By Targets:	Legumain (4) Fluorescent Dye (3) Parasite (1)
By Research Areas:	Cancer (5) Infection (1) Inflammation/Immunology (1)

8

Inhibitors & Agonists

2

Peptides

4

Recombinant Proteins

1

Antibodies

Targets Recommended: Legumain

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Legumain inhibitor 1 1 Publications Verification	Legumain	Cancer
Legumain inhibitor 1 is a potent and selective *Legumain* inhibitor with an IC₅₀ of 3.6 nM. Legumain inhibitor 1 can be used for cancer research .

Z-Ala-Ala-Asn-AMC 3 Publications Verification Cbz-Ala-Ala-Asn-AMC	Fluorescent Dye	Cancer
Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC .

Cbz-Ala-Ala-Asn TFA	Others	Others
Cbz-Ala-Ala-Asn TFA is a peptide that designed based on the sequence of the substrate of legumain. Legumain is a cysteine protease. Cbz-Ala-Ala-Asn TFA can be applied as a scaffold for drug delivery .

RR-11a analog 4 Publications Verification	Parasite Legumain	Infection
RR-11a analog is a potent and irreversible inhibitor of **Schistosoma mansoni legumain, with an IC₅₀** of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor .

LE 28	Fluorescent Dye Legumain	Inflammation/Immunology Cancer
LE 28 is a selective and activity-dependent *legumain* probe. LE 28 becomes fluorescent only upon binding active legumain. LE 28 can be used for research of cancers and inflammatory diseases .

HCy-AAN-Bio	Others	Cancer
HCy-AAN-Bio is a tumor-targeted hemicyanine (HCy) probe for Fluorescent/photoacoustic (FL/PA) imaging of legumain in vivo. Legumain can specifically cleave HCy-AAN-Bio with the generation of FL/PA signal. HCy-AAN-Bio is a powerful tool for early diagnosis of associated cancer .

Z-VAN-AMC	Fluorescent Dye	Others
Z-VAN-AMC is a fluorogenic substrate. Z-VAN-AMC can be hydrolysed by a phytophagous mite of legumain-like activity .

RR-11a	Legumain	Cancer
RR-11a is a synthetic enzyme inhibitor of *Legumain* (IC₅₀=31-55 nM). RR-11a can be used for the research of cancer and acute myocardial infarction (AMI) .

Cat. No.	Product Name	Target	Research Area

Z-Ala-Ala-Asn-AMC 3 Publications Verification Cbz-Ala-Ala-Asn-AMC	Fluorescent Dye	Cancer
Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC .

Z-VAN-AMC	Fluorescent Dye	Others
Z-VAN-AMC is a fluorogenic substrate. Z-VAN-AMC can be hydrolysed by a phytophagous mite of legumain-like activity .

Species:	Human (2) Mouse (1) Pig (1)
Tag:	His (4)
Source:	HEK293 (4)

Cat. No.	Compare	Product Name	Species	Source

	Legumain Protein, Pig (416a.a, HEK293, His) Legumain; Asparaginyl Endopeptidase; Protease Cysteine 1; LGMN; PRSC1	Pig	HEK293
	Legumain proteins can slowly cleave aspartyl bonds, especially under acidic conditions. Legumain Protein, Pig (416a.a, HEK293, His) is the recombinant pig-derived Legumain protein, expressed by HEK293 , with N-His labeled tag. The total length of Legumain Protein, Pig (416a.a, HEK293, His) is 416 a.a., with molecular weight of ~52.5 kDa.

	Legumain Protein, Human (HEK293, C-His) Legumain; Asparaginyl Endopeptidase; Protease Cysteine 1; LGMN; PRSC1	Human	HEK293
	Legumain proteins can slowly cleave aspartyl bonds, especially under acidic conditions.Legumain Protein, Human (HEK293, C-His) is the recombinant human-derived Legumain protein, expressed by HEK293 , with C-6*His labeled tag.

	Legumain Protein, Mouse (HEK293, C-His) rMuLegumain/Asparaginyl Endopeptidase, His; Legumain; Lgmn; Asparaginyl endopeptidase; Protease cysteine 1; Prsc1	Mouse	HEK293
	Legumain proteins can slowly cleave aspartyl bonds, especially under acidic conditions.Legumain Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived Legumain protein, expressed by HEK293 , with C-10*His labeled tag.

	LGMN Protein, Human (HEK293, His) Legumain; Asparaginyl endopeptidase; AEP; Protease; cysteine 1; LGMN	Human	HEK293

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	Legumain Antibody (YA2469) AEP; cysteine 1; Legumain; LGMN; LGMN1; PRSC1	WB	Human, Mouse, Rat
	Legumain Antibody (YA2469) is a biotin-conjugated non-conjugated IgG antibody, targeting Legumain, with a predicted molecular weight of 49 kDa (observed band size: 36,57 kDa). Legumain Antibody (YA2469) can be used for WB experiment in human, mouse, rat background.

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