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Lovastatin acid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (1) Autophagy (5) Bacterial (2) Caspase (1) Cytochrome P450 (1) Drug Metabolite (1) Endogenous Metabolite (2) Ferroptosis (4) Fungal (1) HMG-CoA Reductase (HMGCR) (12) Isotope-Labeled Compounds (4)
By Research Areas:	Cancer (7) Cardiovascular Disease (5) Infection (3) Metabolic Disease (7)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Amino acid Transporter Amino Acid Derivatives Amino Acid Decarboxylase Hydroxycarboxylic Acid Receptor (HCAR) Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123672

Lovastatin hydroxy acid sodium Mevinolinic acid sodium	HMG-CoA Reductase (HMGCR)	Metabolic Disease
Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a K_i of 0.6 nM .

HY-N0504R

Lovastatin (Standard) Maximum Cited Publications 24 Publications Verification Mevinolin (Standard)	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Lovastatin (Standard) is the analytical standard of Lovastatin. This product is intended for research and analytical applications. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-N0504

*Lovastatin* Maximum Cited Publications 24 Publications Verification Mevinolin	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-122439

Lovastatin acid Mevinolinic acid; MSD803	HMG-CoA Reductase (HMGCR) Drug Metabolite	Cardiovascular Disease Cancer
Lovastatin acid (Mevinolinic acid), an active metabolite of Lovastatin, is a potent competitive HMG-CoA reductase inhibitor with a K_i of 0.6 nM .

HY-169818

Keto lovastatin	Bacterial HMG-CoA Reductase (HMGCR)	Infection Metabolic Disease
Keto lovastatin is an impurity of Lovastatin (HY-N0504) with antibacterial activity. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol .

HY-N0504S1

Lovastatin-d9	Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Lovastatin-d₉ is the deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-123672S

Lovastatin-d3 hydroxy acid sodium	Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR)	Metabolic Disease
Lovastatin-d₃ hydroxy acid (sodium) is the deuterium labeled Lovastatin hydroxy acid sodium. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].

HY-123672R

Lovastatin hydroxy acid (sodium) (Standard)	HMG-CoA Reductase (HMGCR)	Metabolic Disease
Lovastatin hydroxy acid (sodium) (Standard) is the analytical standard of Lovastatin hydroxy acid (sodium). This product is intended for research and analytical applications. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM .

HY-143802S

Lovastatin hydroxy-d3 ammonium	Isotope-Labeled Compounds	Others
Lovastatin hydroxy-d₃ (ammonium) is the deuterium labeled Lovastatin hydroxy ammonium[1].

HY-N0504S2

Lovastatin-d3 Mevinolin-d₃	Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Lovastatin-d₃ is deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-137371R

Lactonic sophorolipid (Standard)	Bacterial Apoptosis Antibiotic	Infection Cancer
Lovastatin hydroxy acid (sodium) (Standard) is the analytical standard of Lovastatin hydroxy acid (sodium). This product is intended for research and analytical applications. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM .

HY-126237

Acetyllovastatin	Fungal	Infection
Acetyllovastatin, a acetate of Lovastatin, presentes a moderate inhibitory effect against the enzyme acetylcholinesterase with an IC₅₀ of 79 μg/mL. Lovastatin has been found to display antifungal activity, and suppresses proliferation of a number of transformed cell lines .

HY-P1008

Z-VDVAD-FMK 3 Publications Verification Z-VD(OMe)VAD(OMe)-FMK	Caspase	Cancer
Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis .

HY-Z8472

Dihydromevinolin Lovastatin EP impurity E; 4a,5-Dihydromevinolin	Endogenous Metabolite HMG-CoA Reductase (HMGCR)	Metabolic Disease
Dihydromevinolin is a potent hypocholesterolemic metabolite produced by Aspergillus terreus. Dihydromevinolin is a HMG-CoA reductase inhibitor .

HY-104051

Monacolin J Antibiotic MB 530A; Lovastatin diol lactone	HMG-CoA Reductase (HMGCR) Autophagy	Metabolic Disease
Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.

HY-117219

SKF 104976	Cytochrome P450 HMG-CoA Reductase (HMGCR) Endogenous Metabolite	Metabolic Disease
SKF 104976 is a 3,2-carboxylic acid derivative with potent 14-alpha-demethylase (14 alpha DM) inhibitory activity. SKF 104976 inhibited 14 alpha DM activity by 50% at 2 nM in Hep G2 cell extracts. SKF 104976 inhibited the incorporation of [14C]acetate into cholesterol in intact cells at similar concentrations, accompanied by accumulation of lanosterol, and resulted in a 40-70% decrease in 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) activity. SKF 104976 did not affect the uptake and degradation of low-density lipoprotein in Hep G2 cells, indicating that HMGR and low-density lipoprotein receptor activities are not coordinately regulated under these conditions. The inhibitory effect of SKF 104976 on HMGR activity remained unchanged even when the flux of carbon units in the sterol synthesis pathway was reduced by 80%. SKF 104976 did not inhibit HMGR activity under conditions where sterol synthesis was almost completely blocked by lovastatin .

Cat. No.	Product Name	Target	Research Area

HY-P1008

Z-VDVAD-FMK 3 Publications Verification Z-VD(OMe)VAD(OMe)-FMK	Caspase	Cancer
Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0504R

Lovastatin (Standard) 20+ Cited Publications Mevinolin (Standard)	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis
Lovastatin (Standard) is the analytical standard of Lovastatin. This product is intended for research and analytical applications. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-N0504

*Lovastatin* 20+ Cited Publications Mevinolin	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis
Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-Z8472

Dihydromevinolin Lovastatin EP impurity E; 4a,5-Dihydromevinolin	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Endogenous Metabolite HMG-CoA Reductase (HMGCR)
Dihydromevinolin is a potent hypocholesterolemic metabolite produced by Aspergillus terreus. Dihydromevinolin is a HMG-CoA reductase inhibitor .

Cat. No.	Product Name	Chemical Structure

HY-N0504S1

Lovastatin-d9
Lovastatin-d₉ is the deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-123672S

Lovastatin-d3 hydroxy acid sodium
Lovastatin-d₃ hydroxy acid (sodium) is the deuterium labeled Lovastatin hydroxy acid sodium. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].

HY-143802S

Lovastatin hydroxy-d3 ammonium
Lovastatin hydroxy-d₃ (ammonium) is the deuterium labeled Lovastatin hydroxy ammonium[1].

HY-N0504S2

Lovastatin-d3
Lovastatin-d₃ is deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

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Lovastatin acid

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products