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Results for "

MPC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (1) Autophagy (1) Bacterial (1) Calcium Channel (2) Fungal (1) HSP (2) Insulin Receptor (2) Liposome (1) MAP3K (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (7) Monocarboxylate Transporter (1) PPAR (2) RAR/RXR (1) Small Interfering RNA (siRNA) (2) Virus Protease (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Endocrinology (1) Infection (2) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (4)
Oligonucleotides:	Phospholipids (1) Human Pre-designed siRNA Sets (2) siRNAs (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14907

Verubulin MPC 6827	Microtubule/Tubulin Apoptosis	Cancer
Verubulin (MPC-6827) is a microtubule-disrupting agent with potent and broad-spectrum in vitro and in vivo cytotoxic activities, and acts as a promising candidate for the treatment of multiple cancer types .

HY-12098

Verubulin hydrochloride MPC-6827 hydrochloride	Microtubule/Tubulin	Cancer
Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. Verubulin hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. Verubulin hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types .

HY-13301

MPC-3100	HSP	Cancer
MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with potential antineoplastic activity .

HY-U00212

Aranidipine MPC1304	Calcium Channel	Cardiovascular Disease
Aranidipine (MPC1304) is a Ca ²⁺ channel antagonist with potent and long-lasting antihypertensive effects.

HY-N0842

Bevirimat 1 Publications Verification PA-457; MPC-4326; YK FH312	Virus Protease	Infection
Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies .

HY-10291

Tarenflurbil 3 Publications Verification (R)-Flurbiprofen; MPC7869	RAR/RXR Autophagy	Neurological Disease Inflammation/Immunology Cancer
Tarenflurbil ((R)-Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R)-Flurbiprofen) inhibits the binding of [ ³H]9-cis-RA to RXRα LBD with IC₅₀ of 75 μM. Tarenflurbil can be used for Alzheimer's disease research.

HY-115499

MPC-0767	HSP	Cancer
MPC-0767 is a potent, selective, and orally active hsp90 inhibitor. MPC-0767 is an L-alanine ester proagent of MPC-3100 with improved chemical stability .

HY-162831

MPC-IN-1	Mitochondrial Metabolism	Others
MPC-IN-1 (compound 4i) is a cyanocinnamate-based, mitochondrial pyruvate transporter (MPC) inhibitor, and is a derivative of UK-5099 (HY-15475). MPC inhibitors promote the development of hair follicle stem cells without affecting normal cells. MPC-IN-1 promotes cellular lactate production and promotes significant hair growth in mice, and has the potential to be used to inhibit hair loss .

HY-RS08607

MPC2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MPC2 Human Pre-designed siRNA Set A contains three designed siRNAs for MPC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MPC2 Human Pre-designed siRNA Set A MPC2 Human Pre-designed siRNA Set A

HY-RS08606

MPC1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MPC1 Human Pre-designed siRNA Set A contains three designed siRNAs for MPC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MPC1 Human Pre-designed siRNA Set A MPC1 Human Pre-designed siRNA Set A

HY-138559

GW604714X	Mitochondrial Metabolism	Neurological Disease
GW604714X is a potent inhibitor of mitochondrial respiration supported by pyruvate but not other substrates. GW604714X is a highly specific mitochondrial pyruvate carrier (MPC) inhibitor with a K_i <0.1 nM. GW604714X also inhibits L-lactate transport by the plasma membrane monocarboxylate transporter (MCT1), but at concentrations more than 4 orders of magnitude greater than the MPC .

HY-108022

Azemiglitazone MSDC-0602	Mitochondrial Metabolism PPAR	Neurological Disease Metabolic Disease Inflammation/Immunology
Azemiglitazone (MSDC-0602) is an orally active thiazolidinedione (TZD) -like molecule, which binds to PPARγ with low binding and activating affinity. Azemiglitazone inhibits mitochondrial pyruvate carrier (MPC), which inhibits Alzheimer’s disease and diminishes nonalcoholic steatohepatitis (NASH) caused liver injury .

HY-100550

MSDC 0160 2 Publications Verification Mitoglitazone; CAY10415	Insulin Receptor Mitochondrial Metabolism	Neurological Disease Endocrinology
MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT)-modulating insulin sensitizer and a modulator of mitochondrial pyruvate carrier (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has the potential for Alzheimer′s disease .

HY-157871

TAK1-IN-5	MAP3K	Cancer
TAK1-IN-5 (Compound 26) is an inhibitor of the transforming growth factor-β activated kinase (TAK1) with an IC₅₀ value of 55 nM. TAK1-IN-5 can inhibit the growth of MPC-11 and H929 cells with a GI₅₀ lower than 30 nM. TAK1-IN-5 can be used in the study of multiple myeloma .

HY-U00212R

Aranidipine (Standard)	Calcium Channel	Cardiovascular Disease
Aranidipine (Standard) is the analytical standard of Aranidipine. This product is intended for research and analytical applications. Aranidipine (MPC1304) is a Ca ²⁺ channel antagonist with potent and long-lasting antihypertensive effects.

HY-15475

UK-5099 Maximum Cited Publications 33 Publications Verification PF-1005023	Mitochondrial Metabolism	Cancer
UK-5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier (MPC). UK-5099 (PF-1005023) inhibits pyruvate-dependent O₂ consumption with an IC₅₀ of 50 nM.

HY-170571

BE2647	Mitochondrial Metabolism	Metabolic Disease Inflammation/Immunology
BE2647 is a selective inhibitor for mitochondrial pyruvate carrier (MPC) with an EC₅₀ of 70 nM. BE2647 exhibits good metabolic stability in mouse liver microsomes. BE2647 can be used in research of metabolic diseases, non-alcoholic fatty liver disease (MASLD), or non-alcoholic steatohepatitis (MASH) .

HY-142988

1-Stearoyl-2-myristoyl-sn-glycero-3-PC 1S-2M-PC	Liposome	Others
1-Stearoyl-2-myristoyl-sn-glycero-3-PC (1S-2M-PC) belongs to the class of asymmetric phospholipids. 1-Stearoyl-2-myristoyl-sn-glycero-3-PC is abundant in biological membranes .

HY-121349

Aerothionin	Bacterial Fungal Antibiotic	Infection Cancer
Aerothionin is an antibiotic with potent antimicrobial efficacy against bacteria and fungi. Aerothionin exhibits antitumor efficacy against adrenal pheochromocytomas and extra-adrenal paragangliomas (PPGLs) .

HY-D0713

7ACC2 5+ Cited Publications	Monocarboxylate Transporter Mitochondrial Metabolism	Cancer
7ACC2 is a potent monocarboxylate transporter (MCT) inhibitor with an IC₅₀ of 11 nM for inhibition of [ ¹⁴C]-lactate influx. 7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport. 7ACC2 is an anticancer agent through inhibition of lactate flux .

HY-W854727

N-Methylfulleropyrrolidine	Others	Others
N-Methylfulleropyrrolidine serves as an electron acceptor molecule characterized by its fullerene core and a nitrogen-free lone pair associated with the pyrrolidine ring. This compound can act as an intermediate in the synthesis of various functionalized fullerenes and plays a significant role in the development of opto-electronic devices. Comprehensive studies have been conducted on the photoinduced energy and electron transfer processes between oligothienylenevinylenes and N-Methylfulleropyrrolidine (MP-C60).

HY-108022A

Azemiglitazone potassium MSDC-0602K	Insulin Receptor PPAR	Metabolic Disease
Azemiglitazone potassium (MSDC-0602K), a PPARγ-sparing thiazolidinedione (Ps-TZD), binds to PPARγ with the IC₅₀ of 18.25 μM . Azemiglitazone potassium modulates the mitochondrial pyruvate carrier (MPC). Azemiglitazone potassium can be used for the research of fatty liver including dysfunctional lipid metabolism, inflammation, and insulin resistance . Azemiglitazone potassium, an insulin sensitizer, improves insulinemia and fatty liver disease in mice, alone and in combination with Liraglutide .

Cat. No.	Product Name	Type

HY-142988

1-Stearoyl-2-myristoyl-sn-glycero-3-PC 1S-2M-PC	Drug Delivery
1-Stearoyl-2-myristoyl-sn-glycero-3-PC (1S-2M-PC) belongs to the class of asymmetric phospholipids. 1-Stearoyl-2-myristoyl-sn-glycero-3-PC is abundant in biological membranes .

Bevirimat 1 Publications Verification PA-457; MPC-4326; YK FH312	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Myrtaceae Plants Syzygium aromaticum Disease Research Fields	Virus Protease
Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies .

Aerothionin	Structural Classification Antibiotics Marine natural products Source classification Sponge	Bacterial Fungal Antibiotic
Aerothionin is an antibiotic with potent antimicrobial efficacy against bacteria and fungi. Aerothionin exhibits antitumor efficacy against adrenal pheochromocytomas and extra-adrenal paragangliomas (PPGLs) .

MPC2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MPC2 Human Pre-designed siRNA Set A contains three designed siRNAs for MPC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MPC1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MPC1 Human Pre-designed siRNA Set A contains three designed siRNAs for MPC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

1-Stearoyl-2-myristoyl-sn-glycero-3-PC 1S-2M-PC		Phospholipids
1-Stearoyl-2-myristoyl-sn-glycero-3-PC (1S-2M-PC) belongs to the class of asymmetric phospholipids. 1-Stearoyl-2-myristoyl-sn-glycero-3-PC is abundant in biological membranes .

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