MUC5AC

Isoforms Recommended:	MUC5AC

By Targets:	Amino Acid Derivatives (1) Apoptosis (1) CCR (1) COX (1) Dopamine Receptor (2) EGFR (1) IKK (1) Interleukin Related (1) mAChR (1) MMP (1) Mucin (2) NF-κB (5) Small Interfering RNA (siRNA) (1) TNF Receptor (1)
By Research Areas:	Cancer (7) Endocrinology (1) Infection (1) Inflammation/Immunology (5)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0280

MUC5AC motif peptide	Mucin	Inflammation/Immunology Cancer
MUC5AC motif peptide is a 16-amino acid fragment of mucin 5.

HY-P99362

Ensituximab Anti-MUC5AC Reference Antibody (ensituximab); NEO-102	Mucin	Cancer
Ensituximab (NEO-102; NPC-1C) is a chimeric monoclonal IgG1 antibody targeting a variant of *MUC5AC*. Ensituximab shows specificity to colorectal and pancreatic cancer .

HY-B0393

Fudosteine 1 Publications Verification	Amino Acid Derivatives	Inflammation/Immunology
Fudosteine is a cysteine derivative and a mucoactive agent. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression .

HY-N2098

Obtusifolin	NF-κB	Cancer
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway . Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein .

HY-N2609

7,4'-Dihydroxyflavone 1 Publications Verification	COX CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits *MUC5AC* gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

HY-100958

4-DAMP 3 Publications Verification 4-DAMP methiodide	mAChR Apoptosis MMP EGFR Interleukin Related	Inflammation/Immunology Cancer
4-DAMP (4-DAMP methiodide) is a potent and selective antagonist of M3 receptors and also has a high affinity for the closely-related M5 receptors. 4-DAMP combined with 5-Fluorouracil (5-Fu) (HY-90006) could significantly reduce the cell viability and enhance apoptosis in MKN45 and BGC823 gastric cancer cells. 4-DAMP inhibits lipopolysaccharide (LPS)- and tobacco-induced pulmonary inflammation and reduces mucin 5AC (MUC5AC), oligomeric mucus/gel-forming secretion .

HY-RS08844

MUC5AC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MUC5AC Human Pre-designed siRNA Set A contains three designed siRNAs for MUC5AC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MUC5AC Human Pre-designed siRNA Set A MUC5AC Human Pre-designed siRNA Set A

HY-117616

Laurotetanine (+)-Laurotetanine	NF-κB	Cancer
Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating *MUC5AC* and NF-κB signaling pathways .

HY-N2098R

Obtusifolin (Standard)	NF-κB	Cancer
Obtusifolin (Standard) is the analytical standard of Obtusifolin. This product is intended for research and analytical applications. Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway . Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein .

HY-126232

Verproside	NF-κB TNF Receptor IKK	Infection Inflammation/Immunology
Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive and anti-asthmatic activities. Verproside has the potential for the study of chronic obstructive pulmonary disease (COPD) .

HY-120687

A68930	Dopamine Receptor	Cancer
A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis .

HY-103431

A68930 hydrochloride	Dopamine Receptor	Others
A68930 hydrochloride, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis .

Cat. No.	Product Name	Target	Research Area

HY-P0280

MUC5AC motif peptide	Mucin	Inflammation/Immunology Cancer
MUC5AC motif peptide is a 16-amino acid fragment of mucin 5.

HY-P5508

MUC5AC-13	Peptides	Others
MUC5AC-13 is a biological active peptide. (This glycopeptide is an N-acetyl galactosamine (GalNAc)-modified MUC5AC mucin peptide containing the single site of threonine 13 labeled with GalNAc (T). Polypeptide N-acetylgalactosaminyltransferase (ppGaNTase) catalyzes the transfer of GalNAc from the nucleotide sugar UDP-GalNAc to threonine. The MUC5*AC gene is mainly expressed in gastric and tracheo-bronchial mucosae, and some tumors.)

HY-P5512

MUC5AC-3	Peptides	Others
MUC5AC-3 is a biological active peptide. (glycopeptide transferase, ppGaNTase-T9 substrate)

HY-P5511

MUC5AC-3/13	Peptides	Others
MUC5AC-3/13 is a biological active peptide. (glycopeptide transferase, ppGaNTase-T9 substrate)

Cat. No.	Product Name	Target	Research Area

HY-P99362

Ensituximab Anti-MUC5AC Reference Antibody (ensituximab); NEO-102	Mucin	Cancer
Ensituximab (NEO-102; NPC-1C) is a chimeric monoclonal IgG1 antibody targeting a variant of *MUC5AC*. Ensituximab shows specificity to colorectal and pancreatic cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2098

Obtusifolin	Seeds of Cassia tora Linn. Structural Classification Classification of Application Fields Source classification Plants Quinones other families Leguminosae Anthraquinones Phenols Polyphenols Disease Research Fields Cancer	NF-κB
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway . Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein .

HY-N2609

7,4'-Dihydroxyflavone 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Endocrinology	COX CCR NF-κB
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits *MUC5AC* gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

HY-117616

Laurotetanine (+)-Laurotetanine	Structural Classification Alkaloids Aporphine Alkaloids Classification of Application Fields Source classification Plants Lauraceae Isoquinoline Alkaloids Disease Research Fields Lindera aggregata (Sims) Kosterm. Cancer	NF-κB
Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating *MUC5AC* and NF-κB signaling pathways .

HY-N2098R

Obtusifolin (Standard)	Seeds of Cassia tora Linn. Quinones Structural Classification other families Leguminosae Anthraquinones Source classification Phenols Polyphenols Plants	NF-κB
Obtusifolin (Standard) is the analytical standard of Obtusifolin. This product is intended for research and analytical applications. Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway . Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein .

HY-126232

Verproside	Plantaginaceae Infection Structural Classification Iridoids Veronica officinalis L. Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields	NF-κB TNF Receptor IKK
Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive and anti-asthmatic activities. Verproside has the potential for the study of chronic obstructive pulmonary disease (COPD) .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80988

	Mucin 5AC Antibody ApoMUCin; Gastric MUCin; LeB; MUC5AC; MUCin 5AC oligomeric MUCus/gel forming; TBM	WB, IHC-P, ICC/IF	Human
	Mucin 5AC Antibody is an unconjugated, approximately 220-600 kDa, rabbit-derived, anti-Mucin 5AC monoclonal antibody. Mucin 5AC Antibody can be used for: WB, IHC-P, ICC/IF expriments in human background without labeling.

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HY-RS08844

MUC5AC Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MUC5AC Human Pre-designed siRNA Set A contains three designed siRNAs for MUC5AC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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