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Results for "

NPRs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Natriuretic Peptide Receptor (NPR) (9) Endothelin Receptor (2) FGFR (2) Guanylate Cyclase (1) Histamine Receptor (2) Small Interfering RNA (siRNA) (5)
By Research Areas:	Cancer (3) Cardiovascular Disease (7) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (3)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (3) siRNAs (5)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Oligonucleotides

Targets Recommended: Natriuretic Peptide Receptor (NPR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0003

Nesiritide Brain Natriuretic Peptide-32 human; BNP-32	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease Cancer
Nesiritide (Brain Natriuretic Peptide-32 human) is an agonist of natriuretic peptide receptors (NPRs), with K_d values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Nesiritide can be used for the research of heart failure .

HY-P1419

AP 811	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a K_i of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation .

HY-143316

NPR-C activator 1	Guanylate Cyclase	Neurological Disease
NPR-C activator 1 (Compound 1) is a potent activator of natriuretic peptide receptor C (NPR-C). C-type natriuretic peptide (CNP) is involved in the regulation of vascular homeostasis. NPR-C activator 1 is identified as a potent agonist (EC₅₀ ∼ 1 μM) with promising in vivo pharmacokinetic properties .

HY-P0003A

Nesiritide acetate Brain Natriuretic Peptide-32 human acetate; BNP-32 acetate	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease Cancer
Nesiritide (Brain Natriuretic Peptide-32 human) acetate is an agonist of natriuretic peptide receptors (NPRs), with K_d values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Nesiritide acetate can be used for the research of heart failure .

HY-P1419A

AP 811 acetate	Endothelin Receptor	Cardiovascular Disease
AP 811 acetate is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a K_i of 0.48 nM. AP 811 acetate displays >20000-fold selectivity for NPR3 over NPR1. AP 811 acetate abolishes ANP-induced pump stimulation .

HY-RS18627

Npr1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Npr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Npr1 Mouse Pre-designed siRNA Set A Npr1 Mouse Pre-designed siRNA Set A

HY-RS09499

NPR3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NPR3 Human Pre-designed siRNA Set A contains three designed siRNAs for NPR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NPR3 Human Pre-designed siRNA Set A NPR3 Human Pre-designed siRNA Set A

HY-RS09498

NPR2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NPR2 Human Pre-designed siRNA Set A contains three designed siRNAs for NPR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NPR2 Human Pre-designed siRNA Set A NPR2 Human Pre-designed siRNA Set A

HY-RS09497

NPR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NPR1 Human Pre-designed siRNA Set A contains three designed siRNAs for NPR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NPR1 Human Pre-designed siRNA Set A NPR1 Human Pre-designed siRNA Set A

HY-RS19149

Npr3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Npr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Npr3 Mouse Pre-designed siRNA Set A Npr3 Mouse Pre-designed siRNA Set A

HY-P990921

Imelciment	Natriuretic Peptide Receptor (NPR)	Inflammation/Immunology
HY-P990921 is an *NPR1*-targeting half-IG G4 -κ/h-CH2-CH3 type human antibody .

HY-P990951

Vixticibart	Natriuretic Peptide Receptor (NPR)	Inflammation/Immunology
HY-P990951 is an *NPR1*-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P3503A

Vosoritide acetate BMN 111 acetate	FGFR	Others
Vosoritide (BMN 111) acetate is a natriuretic peptide receptor 2 (NPR2) agonist that acts on the proliferation and differentiation of chondrocytes to promote bone growth .

HY-P1526

ANP [Des18-22] 4-23 amide (rat)	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
ANP [Des18-22] 4-23 amide rat is a polypeptide fragment of rat atrial natriuretic peptide (ANP) that specifically binds *NPR-C* .

HY-153650

JS11	Natriuretic Peptide Receptor (NPR)	Others
JS11 is an inhibitor for natriuretic polypeptide receptor 1 (Npr1) with an IC₅₀ of 1.9 μM for hNpr1. JS11 ameliorates the pruritus in mouse models .

HY-P991121

Baloncibart	Natriuretic Peptide Receptor (NPR)	Inflammation/Immunology
Baloncibart is a human IgG4K antibody targeting *NPR1*. The corresponding isotype control is: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P3503

Vosoritide BMN 111	FGFR	Others
Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to *NPR-B* (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research .

HY-P1237

C-Type Natriuretic Peptide (CNP) (1-22), human 2 Publications Verification	Histamine Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
C-Type Natriuretic Peptide (CNP) (1-22), human, a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .

HY-P1237A

C-Type Natriuretic Peptide (CNP) (1-22), human TFA 2 Publications Verification	Histamine Receptor Endothelin Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .

HY-P10869

dCNP	Natriuretic Peptide Receptor (NPR)	Inflammation/Immunology Cancer
dCNP binds to NPR-B/C receptor, activates cGMP signaling pathway, and regulates vascular function. dCNP exhibits anti-hypoxia property through downregulation of hypoxia-related genes expressions like HIF1α and HIF2α. dCNP inhibits the induction of tumor stroma and exhibits anti-fibrosis activity. dCNP upregulates CTLs, NK cells, and conventional type 1 dendritic cells in tumors, and activates immune responses .

Cat. No.	Product Name	Target	Research Area