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NSC-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>2</sub>

" in MedChemExpress (MCE) Product Catalog:

20

Inhibitors & Agonists

20

Isotope-Labeled Compounds

2

Click Chemistry

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N1150S9
    Thymidine-15N2

    DThyd-<sup>15sup>N<sub>2sub>; NSC-<sup>15sup>N<sub>2sub>

    		 DNA/RNA Synthesis Endogenous Metabolite Orthopoxvirus Cancer
    Thymidine- 15N2 is the 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].
    Thymidine-15N2
  • HY-W779017
    Thymidine-13C5

    DThyd-<sup>13sup>C<sub>5sub>; NSC 21548-<sup>13sup>C<sub>5sub>

    		 Orthopoxvirus Endogenous Metabolite DNA/RNA Synthesis Isotope-Labeled Compounds Others
    Thymidine- 13C5 (DThyd- 13C5; NSC 21548- 13C5) is 13C-labeled Thymidine (HY-N1150) .
    Thymidine-13C5
  • HY-N1150S8
    Thymidine-13C10,15N2

    DThyd-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>2sub>; NSC-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>2sub>

    		 DNA/RNA Synthesis Endogenous Metabolite Orthopoxvirus Cancer
    Thymidine- 13C10, 15N2 is the 13C and 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].
    Thymidine-13C10,15N2
  • HY-N1150S11
    Thymidine-13C10

    DThyd-<sup>13sup>C<sub>10sub>; NSC 21548-<sup>13sup>C<sub>10sub>

    		 Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite Orthopoxvirus Cancer
    Thymidine- 13C10 (DThyd- 13C10; NSC 21548- 13C10) is 13C-labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
    Thymidine-13C10
  • HY-A0161S
    Chlophedianol-13C6

    Clofedanol-<sup>13sup>C<sub>6sub>; Calmotusin-<sup>13sup>C<sub>6sub>; NSC 113595-<sup>13sup>C<sub>6sub>

    		 Isotope-Labeled Compounds Infection
    Chlophedianol- 13C6 is the 13C labeled Chlophedianol (HY-A0161). Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs)[1][2][3].
    Chlophedianol-13C6
  • HY-12008S1
    Erlotinib-13C6 hydrochloride

    CP-358774-<sup>13sup>C<sub>6sub> hydrochloride; NSC 718781-<sup>13sup>C<sub>6sub> hydrochloride; OSI-774-<sup>13sup>C<sub>6sub> hydrochloride

    		 EGFR Autophagy Cancer
    Erlotinib- 13C6 (hydrochloride) is the 13C labeled Erlotinib Hydrochloride[1]. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM[2]. Erlotinib-13C6 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Erlotinib-13C6 hydrochloride
  • HY-50896S1
    Erlotinib-13C6

    CP-358774-<sup>13sup>C<sub>6sub>; NSC 718781-<sup>13sup>C<sub>6sub>; OSI-774-<sup>13sup>C<sub>6sub>

    		 Isotope-Labeled Compounds EGFR Autophagy Cancer
    Erlotinib- 13C6 is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].
    Erlotinib-13C6
  • HY-B0139AS
    Flucytosine-15N3 hydrochloride

    5-Fluorocytosine-<sup>15sup>N<sub>3sub> hydrochloride; NSC 103805-<sup>15sup>N<sub>3sub> hydrochloride; Ro 2-9915-<sup>15sup>N<sub>3sub> hydrochloride

    		 Isotope-Labeled Compounds Others
    Flucytosine- 15N3 hydrochloride is 15N labeled Flucytosine.
    Flucytosine-15N3 hydrochloride
  • HY-12033S1
    2-Methoxyestradiol-13C6

    2-ME2-<sup>13sup>C<sub>6sub>; NSC-659853-<sup>13sup>C<sub>6sub>

    		 Isotope-Labeled Compounds Microtubule/Tubulin Reactive Oxygen Species Apoptosis Autophagy Endogenous Metabolite Cancer
    2-Methoxyestradiol- 13C6 is the 13C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].
    2-Methoxyestradiol-13C6
  • HY-W653882
    Carbamazepine-d2,15N

    CBZ-d<sub>2sub>,<sup>15sup>N; NSC 169864-d<sub>2sub>,<sup>15sup>N

    		 Isotope-Labeled Compounds Others
    Carbamazepine-d2,15N is a deuterated labeled Carbamazepine-d2,15N .
    Carbamazepine-d2,15N
  • HY-118560S
    Tricyclodecenyl acetate-13C2

    NSC 6598-<sup>13sup>C<sub>2sub>; Herbaflorat-<sup>13sup>C<sub>2sub>; Greenyl acetate-<sup>13sup>C<sub>2sub>; Verdyl acetate-<sup>13sup>C<sub>2sub>

    		 Isotope-Labeled Compounds Others
    Tricyclodecenyl acetate- 13C2 is 13C labeled 2-Acetylthiazole.
    Tricyclodecenyl acetate-13C2
  • HY-N0055S
    Chlorogenic acid-13C3

    3-O-Caffeoylquinic acid-<sub>13sub>C<sup>3sup>; Heriguard-<sub>13sub>C<sup>3sup>; NSC-407296-<sub>13sub>C<sup>3sup>

    		 Isotope-Labeled Compounds Cancer
    Chlorogenic acid- 13C3 (Heriguard- 13C3; NSC-407296- 13C3) is 13C- and 15N-labeled Chlorogenic acid (HY-N0055). Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb.. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension .
    Chlorogenic acid-13C3
  • HY-14655S1
    Sulfasalazine-d3,15N

    NSC 667219-d<sub>3sub>,<sup>15sup>N

    		 Antibiotic Autophagy NF-κB Apoptosis Bacterial Ferroptosis Isotope-Labeled Compounds Infection Inflammation/Immunology Cancer
    Sulfasalazine-d3, 15N is 15N and deuterated labeled Sulfasalazine (HY-14655). Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .
    Sulfasalazine-d3,15N
  • HY-B0457S2
    Clomipramine-13C,d3 hydrochloride

    Chlorimipramine-<sup>13sup>C,d<sub>3sub> hydrochloride; G-34586-<sup>13sup>C,d<sub>3sub> hydrochloride; NSC-169865-<sup>13sup>C,d<sub>3sub> hydrochloride

    		 Isotope-Labeled Compounds Serotonin Transporter Neurological Disease
    Clomipramine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Clomipramine (hydrochloride). Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].
    Clomipramine-13C,d3 hydrochloride
  • HY-A0004S
    Decitabine-13C5

    5-Aza-2'-deoxycytidine-<sup>13sup>C<sub>5sub>; 5-AZA-CdR-<sup>13sup>C<sub>5sub>; NSC 127716-<sup>13sup>C<sub>5sub>

    		 Isotope-Labeled Compounds DNA Methyltransferase Nucleoside Antimetabolite/Analog Apoptosis Cancer
    Decitabine- 13C5 (5-Aza-2'-deoxycytidine- 13C5) is 13C labeled Decitabine. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity .
    Decitabine-13C5
  • HY-N6746S1
    Citrinin-13C13

    NSC 186-<sup>13sup>C<sub>13

    		 Isotope-Labeled Compounds Apoptosis Bacterial Autophagy Infection Neurological Disease Cancer
    Citrinin- 13C13 (NSC 186- 13C13) is the 13C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .
    Citrinin-13C13
  • HY-N1393S
    2-Methoxybenzoic acid-13C6

    NSC 3778-<sup>13sup>C<sub>6sub>; O-Methylsalicylic acid-<sup>13sup>C<sub>6sub>; Salicylic acid methyl ether-<sup>13sup>C<sub>6sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Cancer
    2-Methoxybenzoic acid- 13C6 is the 13C-labeled 2-Methoxybenzoic acid. 2-Methoxybenzoic acid (NSC 3778) is used as an internal standard of salicylic acid and its putative biosynthetic precursors in cucumber leaves. Another known use is in the synthesis of Benextramine.
    2-Methoxybenzoic acid-13C6
  • HY-B0139S
    Flucytosine-13C,15N2

    5-Fluorocytosine-<sup>13sup>C,15sup>N<sub>2sub>; NSC 103805-<sup>13sup>C,15sup>N<sub>2sub>; Ro 2-9915-<sup>13sup>C,15sup>N<sub>2sub>

    		 Isotope-Labeled Compounds Antibiotic Fungal Infection
    Flucytosine- 13C, 15N2 (NSC 103805- 13C, 15N2; Ro 2-9915- 13C, 15N2) is a 13C- and 15N-labeled Flucytosine (HY-B0139).
    Flucytosine-13C,15N2
  • HY-B0094S3
    Artemisinin-13C,d4

    Qinghaosu-<sup>13sup>C,d<sub>4sub>; NSC 369397-13C,d<sub>4sub>

    		 Ferroptosis Akt Parasite HCV Isotope-Labeled Compounds Infection Neurological Disease Cancer
    Artemisinin- 13C,d4 is 13C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
    Artemisinin-13C,d4
  • HY-Y1250S6
    Fmoc-Gly-OH-13C2,15N

    Fmoc glycine-<sup>13sup>C<sub>2sub>,<sup>15sup>N; N-(9-Fluorenylmethoxycarbonyl)glycine-<sup>13sup>C<sub>2sub>,<sup>15sup>N; N-Fluorenylmethoxycarbonylglycine-<sup>13sup>C<sub>2sub>,<sup>15sup>N; NPC 14692-<sup>13sup>C<sub>2sub>-<sup>15sup>N; NSC 334288-<sup>13sup>C<sub>2sub>,<sup>15sup>N; [[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]acetic acid-<sup>13sup>C<sub>2sub>,<sup>15sup>N

    		 Isotope-Labeled Compounds Influenza Virus Bacterial Infection
    Fmoc-Gly-OH- 13C2, 15N is a 15N-labeled and 13C-labled Crystal Violet. Crystal violet (Basic Violet 3) is a triarylmethane dye. Crystal Violet (Gentian Violet) has antiviral effects against H1N1 and also has prominent bactericidal activities.
    Fmoc-Gly-OH-13C2,15N

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