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Natural Products，Cytotoxicity

" in MedChemExpress (MCE) Product Catalog:

40

Inhibitors & Agonists

30

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N8088
    Neolancerin

    		Others Cancer
    Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells .
    Neolancerin
  • HY-122948
    Isogambogenic acid

    		Others Cancer
    Isogambogenic acid is a natural product that can be isolated from Resina Garciniae. Isogambogenic acid has cytotoxicity to cancer cell lines with IC50 values of 0.4327-5.942 μmol/L .
    Isogambogenic acid
  • HY-N8317
    Rubicordifolin

    		Others Cancer
    Rubicordifolin is a natural product that can be isolated from Rubia cordifolia. Rubicordifolin inhibits the growth of sarcoma ascites in mice. Rubicordifolin has significant cytotoxic activity both in vitro and in vivo .
    Rubicordifolin
  • HY-N1266
    Scutebata B

    		Others Others
    Scutebata B (compound 4) is a neoclerodane diterpenoid iaolated from the whole plant of Scutellaria barbata. Scutebata B has cytotoxic activities with IC50 values of 10.27～28.48 μM .
    Scutebata B
  • HY-136689
    Taxin B

    		Others Cancer
    Taxin B is a natural product with cytotoxicity effects .
    Taxin B
  • HY-142007
    Epothilone D1

    		Others Others
    Epothilone D1 is an isolated natural product that shows cytotoxicity against mouse fibroblasts.
    Epothilone D1
  • HY-N2852
    α-Terthienylmethanol

    		Others Others
    α-Terthienylmethanol is a terthiophene isolated from the n-hexane fraction of E. prostrata. α-Terthienylmethanol has potent cytotoxic activity against human endometrial cancer cells (Hec1A and Ishikawa) (IC50 < 1 μM). α-Terthienylmethanol increases the intracellular level of ROS and decreases that of GSH .
    α-Terthienylmethanol
  • HY-N3430
    Kaempferol tetraacetate

    AF33

    		 Others Cancer
    Kaempferol tetraacetate (AF33) is a natural product. Kaempferol tetraacetate shows cytotoxicity .
    Kaempferol tetraacetate
  • HY-133220
    Guajadial E

    		Others Cancer
    Guajadial E is a natural product that can be found in Psidium guajava. Guajadial E shows cytotoxicity .
    Guajadial E
  • HY-133220A
    Guajadial F

    		Others Cancer
    Guajadial F is a natural product that can be found in Psidium guajava. Guajadial F shows cytotoxicity .
    Guajadial F
  • HY-W010533
    (E)-2-Methyl-2-pentenoic acid

    		Others Others
    (E)-2-Methyl-2-pentenoic acid is the component can be used to synthesize the cytotoxic natural product Lactimidomycin .
    (E)-2-Methyl-2-pentenoic acid
  • HY-N1081A
    Viteralone

    (S)-Viteralone

    		 Others Cancer
    Viteralone (compound 5) is a natural product that can be isolated from Vitex negundo. Viteralone is cytotoxic to HL-60 cancer cells .
    Viteralone
  • HY-133223
    Hispidanin B

    		Others Cancer
    Hispidanin B is a natural product that can be extracted from the rhizomes of Isodon hispida. Hispidanin B has cytotoxic activities against cancer cells .
    Hispidanin B
  • HY-142102
    T988C

    (+)-T988C

    		 Others Cancer
    T988C is a heptacyclic epidithiodioxopiperazine (ETP) natural product. T988C shows strong cytotoxicity to cultured P388 leukemia cells .
    T988C
  • HY-117371
    Hemiasterlin

    (-)-Hemiasterlin; Milnamide B

    		 ADC Cytotoxin Cancer
    Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .
    Hemiasterlin
  • HY-143242
    Phidianidine B

    		Others Others
    Phidianidine B is a highly cytotoxic 1,2,4-oxadiazole marine metabolite. Phidianidine B is a natural product that can be isolated from a marine mollusk .
    Phidianidine B
  • HY-N8679
    Physalin C

    		Endogenous Metabolite Cancer
    Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .
    Physalin C
  • HY-N7933
    Tetracosane

    ALKANE C24

    		 Apoptosis Inflammation/Immunology
    Tetracosane (ALKANE C24) is a natural product that can be found in Acrostichum aureum. Tetracosane hows cytotoxicity and induces Apoptosis. Tetracosane has the potential for the research of peptic ulcer .
    Tetracosane
  • HY-N7173
    7-Methoxy-β-carboline-1-propionic acid

    		Parasite Infection
    7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia .
    7-Methoxy-β-carboline-1-propionic acid
  • HY-N3966
    Goniodiol 8-acetate

    		Others Others
    Goniodiol 8-acetate is a styrylpyrones that can be isolated from the leaves of Goniothalamus amuyon. Goniodiol 8-acetate has cytotoxic activity .
    Goniodiol 8-acetate
  • HY-N3916
    Galanolactone

    (+)-Galanolactone

    		 Fungal Infection
    Galanolactone is a natural product that can be isolated from the seeds of Alpinia galanga. Galanolactone shows antifungal activitie. Galanolactone shows cytotoxicity against KB cells with an EC50 of 38.5 µg/ml .
    Galanolactone
  • HY-129148
    Ganoderic acid AM1

    GAAM1

    		 Others Cancer
    Ganoderic acid AM1 (GAAM1) is a natural product that can be found in ganoderma lucidum. Ganoderic acid AM1 shows cytotoxicity with an IC50 value of 19.8 µM for HeLa cells .
    Ganoderic acid AM1
  • HY-N7933R
    Tetracosane (Standard)

    		Apoptosis Inflammation/Immunology
    Tetracosane (Standard) is the analytical standard of Tetracosane. This product is intended for research and analytical applications. Tetracosane (ALKANE C24) is a natural product that can be found in Acrostichum aureum. Tetracosane hows cytotoxicity and induces Apoptosis. Tetracosane has the potential for the research of peptic ulcer .
    Tetracosane (Standard)
  • HY-N1912
    Andropanolide

    		Others Cancer
    Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .
    Andropanolide
  • HY-N8846
    dl-Aloesol

    		Fungal Infection
    dl-Aloesol is a natural product that can be isolated from fungus Aspergillus sp. Aspergillus sp metabolites has cytotoxic, antibacterial, free radical scavenging, anti-parasitic, antiviral and antiproliferative activities, etc .
    dl-Aloesol
  • HY-156186
    Anticancer agent 160

    		Others Cancer
    Anticancer agent 160 (Compound 6) is a natural product derived from Parthenium hysterophorus. Anticancer agent 160 is cytotoxic to HCT-116 cells, IC50=5.0 μM .
    Anticancer agent 160
  • HY-129144
    Dihydrodehydrodiconiferyl alcohol

    		TNF Receptor Cancer
    Dihydrodehydrodiconiferyl alcohol (compound 2) is a kind of neolignan. Dihydrodehydrodiconiferyl alcohol can be isolated from Anogeissus acuminata. Dihydrodehydrodiconiferyl alcohol has specific cytotoxic activity on melanoma cancer cell line .
    Dihydrodehydrodiconiferyl alcohol
  • HY-156089
    Triptoquinone H

    		Others Inflammation/Immunology Cancer
    Triptoquinone H is a class of natural product isolated from traditional Chinese medicine Tripterygium hypoglaucu. Triptoquinone H has strong cytotoxic, immunomodulatory and anti-inflammatory activities. Triptoquinone H can be used for cancer or inflammatory diseases research .
    Triptoquinone H
  • HY-N12142
    Anticancer agent 156

    		Others Cancer
    Anticancer agent 156 (compound 11) is a powerful anticancer agent based on Miliusanes (anticancer lead molecule). Anticancer agent 156 effectively inhibits the growth of human cancer cells and shows significant cytotoxicity to gastric cancer cells .
    Anticancer agent 156
  • HY-N11519
    Polyporusterone C

    		Others Cancer
    Polyporusterone C (Compound 3) is a natural product that can be isolated from Polyporus umbellatus. Polyporusterone C shows cytotoxic activities with IC50s of 37, 26 and 42 μg/mL against L-1210 cells at 3, 5 and 7 days, respectively .
    Polyporusterone C
  • HY-N2445R
    Flavokawain C (Standard)

    		Apoptosis Cancer
    Flavokawain C (Standard) is the analytical standard of Flavokawain C. This product is intended for research and analytical applications. Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC50 of 12.75 μM for HCT 116 cells .
    Flavokawain C (Standard)
  • HY-N11651
    Peganumine A

    		Others Others
    Peganumine A is a natural product that can be found in Peganum harmala. Peganumine A shows cytotoxicity with IC50s of5.8, 38.5, 40.2, 55.4 µM for HL-60, MCF-7, PC-3, and HepG2 cells ,respectively .
    Peganumine A
  • HY-N2228
    (-)-Epigallocatechin-3-(3''-O-methyl) gallate

    (-)-EGCG-3''-O-ME

    		 Others Inflammation/Immunology Cancer
    (-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3''-O-ME) is a natural product that can be isolated from the tea leaf, with strong antioxidative activity. (-)-Epigallocatechin-3-(3''-O-methyl) gallate has a strong cytotoxic activity for rat cancer cells .
    (-)-Epigallocatechin-3-(3''-O-methyl) gallate
  • HY-N3057R
    Pinostrobin chalcone (Standard)

    		Others Cancer
    Pinostrobin chalcone (Standard) is the analytical standard of Pinostrobin chalcone. This product is intended for research and analytical applications. Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC50 = 20.42±2.23 and 22.51±0.42 μg/mL) .
    Pinostrobin chalcone (Standard)
  • HY-N0763R
    Angelicin (Standard)

    		Apoptosis Virus Protease Cancer
    Angelicin (Standard) is the analytical standard of Angelicin. This product is intended for research and analytical applications. Angelicin is a natural tricyclic aromatic hydrocarbon compound that is structurally related to psoralen and has anti-cancer, anti-inflammatory, anti-viral and other activities. Cytotoxic, IC50: 49.56 μM; inhibits MHV-68, IC50: 5.39 μg/ml (28.95 μM).
    Angelicin (Standard)
  • HY-N8270
    Physalin H

    		Hedgehog Endogenous Metabolite Cancer
    Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC50 values of 5.7 and 6.8 μM, respectively .
    Physalin H
  • HY-N0446R
    10-Methoxycamptothecin (Standard)

    		ADC Cytotoxin Cancer
    10-Methoxycamptothecin (Standard) is the analytical standard of 10-Methoxycamptothecin. This product is intended for research and analytical applications. 10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines .
    10-Methoxycamptothecin (Standard)
  • HY-129149
    Ganoderic acid SZ

    		HMG-CoA Reductase (HMGCR) Metabolic Disease
    Ganoderic acid SZ is a natural product with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitory activity. Ganoderic acid SZ shows stronger activity than the positive control atorvastatin in inhibiting HMG-CoA reductase. Ganoderic acid SZ exhibits significant inhibition of yeast-derived α-glucosidase with IC50 values achieved at very low concentrations. Ganoderic acid SZ also exhibits cytotoxicity against K562 cells with IC?? values in the range of 10-20 μM .
    Ganoderic acid SZ
  • HY-W391625
    (Rac)-Dehydrocostus Lactone

    (Rac)-Epiligulyl oxide

    		 Others Cancer
    (Rac)-Dehydrocostus Lactone ((Rac)-Epiligulyl oxide) is a natural product with antiparasitic activity. (Rac)-Dehydrocostus Lactone can significantly inhibit the growth of Trypanosoma brucei rhodesiense. (Rac)-Dehydrocostus Lactone exhibits a broad spectrum of biological effects, including anti-inflammatory, anticancer, antiviral and antimicrobial activities. (Rac)-Dehydrocostus Lactone also has antifungal, antioxidant, antidiabetic, antiulcer and antihelminthic effects. (Rac)-Dehydrocostus Lactone exhibits different IC(50) values in cytotoxicity tests and has a high selectivity index .
    (Rac)-Dehydrocostus Lactone
  • HY-N6954R
    Garcinone C (Standard)

    		ATM/ATR STAT CDK Cancer
    Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time? and dose?dependent manner .
    Garcinone C (Standard)

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