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Results for "

OATP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (2) Adrenergic Receptor (2) Bacterial (1) BCRP (3) Biochemical Assay Reagents (2) Drug Metabolite (1) Endogenous Metabolite (6) Endothelin Receptor (2) Fluorescent Dye (2) HCV (6) HMG-CoA Reductase (HMGCR) (7) Interleukin Related (1) Isotope-Labeled Compounds (6) Mitochondrial Metabolism (1) MMP (1) NOD-like Receptor (NLR) (1) OAT (4) P-glycoprotein (1) P2X Receptor (1) PPAR (1) Reactive Oxygen Species (7) TNF Receptor (1) β-catenin (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (13) Endocrinology (1) Infection (9) Inflammation/Immunology (8) Metabolic Disease (8)

By Targets:

Acyltransferase (2)

Adrenergic Receptor (2)

Bacterial (1)

BCRP (3)

Biochemical Assay Reagents (2)

Drug Metabolite (1)

Endogenous Metabolite (6)

Endothelin Receptor (2)

Fluorescent Dye (2)

HCV (6)

HMG-CoA Reductase (HMGCR) (7)

Interleukin Related (1)

Isotope-Labeled Compounds (6)

Mitochondrial Metabolism (1)

MMP (1)

NOD-like Receptor (NLR) (1)

OAT (4)

P-glycoprotein (1)

P2X Receptor (1)

PPAR (1)

Reactive Oxygen Species (7)

TNF Receptor (1)

β-catenin (1)

By Research Areas:

Cancer (7)

Cardiovascular Disease (13)

Endocrinology (1)

Infection (9)

Inflammation/Immunology (8)

Metabolic Disease (8)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137888A

Oxidized ATP trisodium salt OATP trisodium salt	P2X Receptor NOD-like Receptor (NLR)	Inflammation/Immunology
Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis .

HY-16278

Pradigastat 2 Publications Verification LCQ-908	Acyltransferase BCRP OAT	Infection Metabolic Disease
Pradigastat (LCQ-908) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC₅₀ at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited *BCRP, OATP1B1, OATP1B3 and OAT3* activities with IC₅₀ of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro .

HY-N3513

Mulberrin 5 Publications Verification Kuwanon C	OAT	Cardiovascular Disease
Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC₅₀ value being 1.8?±1.5 μM.

HY-119695B

Simvastatin acid calcium hydrate 1 Publications Verification Tenivastatin calcium hydrate	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology
Simvastatin acid (Tenivastatin) calcium hydrate is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid calcium hydrate reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid calcium hydrate can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-119695A

Simvastatin acid ammonium 1 Publications Verification Tenivastatin ammonium	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology
Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-16278A

Pradigastat sodium LCQ 908 sodium	Acyltransferase BCRP OAT	Infection Metabolic Disease
Pradigastat sodium (LCQ 908 sodium) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC₅₀ at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited *BCRP, OATP1B1, OATP1B3 and OAT3* activities with IC₅₀ of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro .

HY-163146

TME-HYM (PH Probe)	Fluorescent Dye	Cancer
TME-HYM (PH Probe) is a novel fluorescent probe based on acidic tumor microenvironment (TME) activation and organic anion transporting polypeptide (OATPs, overexpressed on cancer cells), and can be selective uptaken. TME-HYM (PH Probe) can selectively lit up cancer cells and tumor tissues, offering dual tumor selectivity for precise visualization of tumor mass .

HY-155062

IR-251	Mitochondrial Metabolism Reactive Oxygen Species β-catenin Fluorescent Dye PPAR	Cancer
IR-251 is a mitochondrion-targeting NIR fluorescent probe. IR-251 targets mitochondria via OATPs and causes mitochondrial damage in tumor cells. IR-251 IR-251 induced ROS overproduction by inhibiting PPARγ, and then inhibiting the β-catenin signaling pathway and downstream protein molecules related to the cell cycle and metastasis. IR-251 inhibits tumor proliferation and metastasis .

HY-N8497

Leoidin	Bacterial	Infection
Leoidin is an *OATP1B1* and *OATP1B3* inhibitor with K_i values of 0.08 and 1.84 µM, respectively. Leoidin inhibits sodium fluorescein uptake in CHO cells expressing the human OATP1B1 and OATP1B3. Leoidin is an antibacterial agent against both Gram-positive and Gram-negative pathogens. Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) (IC₅₀= 42 µM) and inhibits protein synthesis in bacterial. Leoidin can be isolated from L. gangaleoides .

HY-138142

Euphol acetate	OAT	Metabolic Disease
Euphol acetate is a triterpene that can be isolated from Euphorbia broteri. Euphol acetate is an inhibitor of hepatic transport proteins organic anion-transporting polypeptide 1/3 (OATP1B1/3) .

HY-115292

Simvastatin hydroxy acid sodium 1 Publications Verification Tenivastatin sodium; Simvastatin Impurity A sodium	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology
Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-119695

Simvastatin acid Tenivastatin	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species	Cardiovascular Disease Cancer
Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin (HY-17502), is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-N3513R

Mulberrin (Standard)	Others	Cardiovascular Disease
Mulberrin (Standard) is the analytical standard of Mulberrin. This product is intended for research and analytical applications. Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC₅₀ value being 1.8 ±1.5 μM.

HY-17352

Clazosentan Ro 61-1790; VML 588; AXV-034343	Endothelin Receptor	Cardiovascular Disease
Clazosentan (Ro 61-1790) is a selective endothelin A (ET_A) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction .

HY-17352A

Clazosentan disodium Ro 61-1790 disodium; VML 588 disodium; AXV-034343 disodium	Endothelin Receptor	Cardiovascular Disease
Clazosentan disodium (Ro 61-1790) is a selective endothelin A (ET_A) receptor antagonist. Clazosentan disodium inhibits ET-1-mediated vasoconstriction. Clazosentan disodium prevents cerebral vasospasm, vasospasm-related cerebral infarction .

HY-10466

Daclatasvir Maximum Cited Publications 46 Publications Verification BMS-790052; EBP 883	HCV	Infection
Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC₅₀s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and *OATP1B3* inhibitor with IC₅₀s of 1.5 µM and 3.27 µM, respectively .

HY-119695AR

Simvastatin acid (ammonium) (Standard)	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology
Simvastatin acid (ammonium) (Standard) is the analytical standard of Simvastatin acid (ammonium). This product is intended for research and analytical applications. Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-10465

Daclatasvir dihydrochloride Maximum Cited Publications 46 Publications Verification BMS-790052 dihydrochloride; EBP 883 dihydrochloride	HCV	Infection
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is a potent and orally active HCV NS5A protein inhibitor with EC₅₀s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir dihydrochloride is also an organic anion transporting polypeptide 1B (OATP1B) and *OATP1B3* inhibitor with IC₅₀s of 1.5 µM and 3.27 µM, respectively .

HY-119695AS1

Simvastatin acid-d9 ammonium Tenivastatin-d₉ ammonium	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species Isotope-Labeled Compounds	Cardiovascular Disease Inflammation/Immunology
Simvastatin acid-d₉ ammonium is deuterated labeled Simvastatin acid ammonium (HY-119695A). Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-119695AS

Simvastatin acid-d6 ammonium Tenivastatin-d₆ ammonium	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease
Simvastatin acid-d₆ (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].

HY-W002438

6-Hydroxyindole	Biochemical Assay Reagents Endogenous Metabolite	Inflammation/Immunology
6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting *OATP1B1* inhibitor, and is elevated plasma of the renal failure patients .

HY-125348

6α-Hydroxy paclitaxel	Drug Metabolite	Cancer
6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion–transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of *OATP1B3*. 6α-Hydroxy paclitaxel can be used for the research of cancer .

HY-10466S

Daclatasvir-d6 BMS-790052-d₆; EBP 883-d₆	Isotope-Labeled Compounds HCV	Infection
Daclatasvir-d₆ is deuterium labeled Daclatasvir. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 µM and 3.27 µM, respectively[1][2][3].

HY-10465R

Daclatasvir (dihydrochloride) (Standard)	HCV	Infection
Daclatasvir (dihydrochloride) (Standard) is the analytical standard of Daclatasvir (dihydrochloride). This product is intended for research and analytical applications. Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is a potent and orally active HCV NS5A protein inhibitor with EC₅₀s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir dihydrochloride is also an organic anion transporting polypeptide 1B (OATP1B) and *OATP1B3* inhibitor with IC₅₀s of 1.5 µM and 3.27 µM, respectively .

HY-10466S2

Daclatasvir-d16 BMS-790052-d₁₆; EBP 883-d₁₆	Isotope-Labeled Compounds HCV	Infection
Daclatasvir-d₁₆ is deuterium labeled Daclatasvir. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 µM and 3.27 µM, respectively[1][2][3].

HY-W011819

Tetradecanedioic acid	Endogenous Metabolite	Metabolic Disease
Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid is an endogenous biomarker for assessing the activity of organic anion transporting polypeptides (OATPs) .

HY-W353102

Estradiol 17-(β-D-Glucuronide)	Endogenous Metabolite	Metabolic Disease Endocrinology
Estradiol 17-(β-D-Glucuronide), a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans. Estradiol 17-(β-D-Glucuronide) is a high-affinity substrate for oatp organic anion transporter .

HY-155485

Abi-DZ-1	Others	Cancer
Abi-DZ-1 is a potential multifunctional theranostic agent via the HIF1α/OATPs Pathway. Abi-DZ-1 can be used in the research of tumor-targeted imaging and precision therapy .

HY-125348S

6α-Hydroxy Paclitaxel-d5	Isotope-Labeled Compounds	Cancer
6α-Hydroxy Paclitaxel-d₅ is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion–transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer[1].

HY-W011819R

Tetradecanedioic acid (Standard)	Endogenous Metabolite	Metabolic Disease
Tetradecanedioic acid (Standard) is the analytical standard of Tetradecanedioic acid. This product is intended for research and analytical applications. Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid is an endogenous biomarker for assessing the activity of organic anion transporting polypeptides (OATPs) .

HY-10466S1

Daclatasvir-13C2,d6 BMS-790052-¹³C₂,d₆; EBP 883-¹³C₂,d₆	Isotope-Labeled Compounds HCV	Infection
Daclatasvir- ¹³C2,d₆ (BMS-790052- ¹³C2,d₆) is ¹³C and deuterium labeled Daclatasvir. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC₅₀s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and *OATP1B3* inhibitor with IC₅₀s of 1.5 μM and 3.27 μM, respectively .

HY-W002438R

6-Hydroxyindole (Standard)	Biochemical Assay Reagents Endogenous Metabolite	Inflammation/Immunology
6-Hydroxyindole (Standard) is the analytical standard of 6-Hydroxyindole. This product is intended for research and analytical applications. 6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor, and is elevated plasma of the renal failure patients .

HY-B0804

Nadolol 2 Publications Verification SQ-11725	Adrenergic Receptor	Cardiovascular Disease
Nadolol (SQ-11725) is a non-selective and orally active β-adrenergic receptors blocker and is a substrate of organic anion transporting polypeptide 1A2 (OATP1A2). Nadolol has the the potential for high blood pressure, angina pectoris and vascular headaches research .

HY-155668

HMG-CoA Reductase-IN-1	HMG-CoA Reductase (HMGCR)	Metabolic Disease
HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor. HMG-CoA Reductase-IN-1has high HMGR inhibitory activity and *OATP1B1* affinity with pIC₅₀ and pKm values of 8.54 and 1.98, respectively. HMG-CoA Reductase-IN-1 can be used for the research of hypercholesterolemia .

HY-161821

Antitumor agent-173	Interleukin Related TNF Receptor MMP	Cancer
Antitumor agent-173 (Compound 4b) is a prodrug of Cycloicaritin (HY-N1940). Antitumor agent-173 is a substrate for OATP2B1. Antitumor agent-173 selectively inhibits the growth of tumor Antitumor agent-173 significantly increases the oral bioavailability of Cycloicaritin and exerts good antitumor activity and safety .

HY-B0804R

Nadolol (Standard)	Adrenergic Receptor	Cardiovascular Disease
Nadolol (Standard) is the analytical standard of Nadolol. This product is intended for research and analytical applications. Nadolol (SQ-11725) is a non-selective and orally active β-adrenergic receptors blocker and is a substrate of organic anion transporting polypeptide 1A2 (OATP1A2). Nadolol has the the potential for high blood pressure, angina pectoris and vascular headaches research .

HY-108347

CP-100356 hydrochloride 5+ Cited Publications	P-glycoprotein BCRP	Metabolic Disease
CP-100356 hydrochloride is an orally active dual MDR1 (P-gp)/BCRP inhibitor, with an IC₅₀s of 0.5 and 1.5 µM for inhibiting MDR1-mediated Calcein-AM transport and BCRP-mediated Prazosin transport, respectively. CP-100356 hydrochloride is also a weak inhibitor of *OATP1B1* (IC₅₀=∼66 µM). CP-100356 hydrochloride is devoid of inhibition against MRP2 and major human P450 enzymes (IC₅₀>15 µM) .

Cat. No.	Product Name	Type

HY-W002438

6-Hydroxyindole	Biochemical Assay Reagents
6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting *OATP1B1* inhibitor, and is elevated plasma of the renal failure patients .

HY-W002438R

6-Hydroxyindole (Standard)	Biochemical Assay Reagents
6-Hydroxyindole (Standard) is the analytical standard of 6-Hydroxyindole. This product is intended for research and analytical applications. 6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor, and is elevated plasma of the renal failure patients .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3513

Mulberrin 5 Publications Verification Kuwanon C	Cardiovascular Disease Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields	OAT
Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC₅₀ value being 1.8?±1.5 μM.

HY-119695A

Simvastatin acid ammonium 1 Publications Verification Tenivastatin ammonium	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species
Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-W002438

6-Hydroxyindole	Structural Classification Alkaloids Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Indole Alkaloids	Biochemical Assay Reagents Endogenous Metabolite
6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting *OATP1B1* inhibitor, and is elevated plasma of the renal failure patients .

HY-W011819

Tetradecanedioic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid is an endogenous biomarker for assessing the activity of organic anion transporting polypeptides (OATPs) .

HY-W353102

Estradiol 17-(β-D-Glucuronide)	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
Estradiol 17-(β-D-Glucuronide), a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans. Estradiol 17-(β-D-Glucuronide) is a high-affinity substrate for oatp organic anion transporter .

HY-N8497

Leoidin	Structural Classification Monophenols Microorganisms Source classification Phenols	Bacterial
Leoidin is an *OATP1B1* and *OATP1B3* inhibitor with K_i values of 0.08 and 1.84 µM, respectively. Leoidin inhibits sodium fluorescein uptake in CHO cells expressing the human OATP1B1 and OATP1B3. Leoidin is an antibacterial agent against both Gram-positive and Gram-negative pathogens. Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) (IC₅₀= 42 µM) and inhibits protein synthesis in bacterial. Leoidin can be isolated from L. gangaleoides .

HY-138142

Euphol acetate	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Disease Research Fields	OAT
Euphol acetate is a triterpene that can be isolated from Euphorbia broteri. Euphol acetate is an inhibitor of hepatic transport proteins organic anion-transporting polypeptide 1/3 (OATP1B1/3) .

HY-N3513R

Mulberrin (Standard)	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	Others
Mulberrin (Standard) is the analytical standard of Mulberrin. This product is intended for research and analytical applications. Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC₅₀ value being 1.8 ±1.5 μM.

HY-119695AR

Simvastatin acid (ammonium) (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species
Simvastatin acid (ammonium) (Standard) is the analytical standard of Simvastatin acid (ammonium). This product is intended for research and analytical applications. Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-W011819R

Tetradecanedioic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Tetradecanedioic acid (Standard) is the analytical standard of Tetradecanedioic acid. This product is intended for research and analytical applications. Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid is an endogenous biomarker for assessing the activity of organic anion transporting polypeptides (OATPs) .

HY-W002438R

6-Hydroxyindole (Standard)	Structural Classification Alkaloids Monophenols Source classification Phenols Endogenous metabolite Indole Alkaloids	Biochemical Assay Reagents Endogenous Metabolite
6-Hydroxyindole (Standard) is the analytical standard of 6-Hydroxyindole. This product is intended for research and analytical applications. 6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor, and is elevated plasma of the renal failure patients .

Cat. No.	Compare	Product Name	Species	Source

HY-P702019

	SLC21A3 Protein, Human (Sf9, His, MBP, FLAG) SLCO1A2; Solute carrier organic anion transporter family member 1A2; OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3	Human	Sf9 insect cells
	SLC21A3 is a Na(+)-independent transporter that greatly facilitates cellular uptake of a variety of organic anions, including bile salts necessary for intestinal absorption. SLC21A3 is responsible for transporting substances such as DHEAS, estrone 3-sulfate, and atROL in human retinal pigment epithelial cells to maintain the integrity of the visual cycle. SLC21A3 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC21A3 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC21A3 Protein, Human (Sf9, His, MBP, FLAG) is 669 a.a., .

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Cat. No.	Product Name	Chemical Structure

HY-125348S

6α-Hydroxy Paclitaxel-d5

6α-Hydroxy Paclitaxel-d₅ is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion–transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer[1].

HY-119695AS1

Simvastatin acid-d9 ammonium

Simvastatin acid-d₉ ammonium is deuterated labeled Simvastatin acid ammonium (HY-119695A). Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-119695AS

Simvastatin acid-d6 ammonium

Simvastatin acid-d₆ (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].

HY-10466S

Daclatasvir-d6
Daclatasvir-d₆ is deuterium labeled Daclatasvir. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 µM and 3.27 µM, respectively[1][2][3].

HY-10466S2

Daclatasvir-d16
Daclatasvir-d₁₆ is deuterium labeled Daclatasvir. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 µM and 3.27 µM, respectively[1][2][3].

HY-10466S1

Daclatasvir-13C2,d6

Daclatasvir- ¹³C2,d₆ (BMS-790052- ¹³C2,d₆) is ¹³C and deuterium labeled Daclatasvir. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC₅₀s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC₅₀s of 1.5 μM and 3.27 μM, respectively .

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HY-P82246

	SLCO5A1 Antibody (YA1991) OATPJ; OATP-J; OATP5A1; OATPRP4; OATP-RP4; SLC21A15	WB, IHC-P	Human, Mouse
	SLCO5A1 Antibody (YA1991) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1991), targeting SLCO5A1, with a predicted molecular weight of 92 kDa (observed band size: 92 kDa). SLCO5A1 Antibody (YA1991) can be used for WB, IHC-P experiment in human, mouse background.

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OATP

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