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Isoforms Recommended:	PDE9

Results for "

PDE9

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (1) Endogenous Metabolite (1) NF-κB (1) Phosphodiesterase (PDE) (21) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cardiovascular Disease (5) Inflammation/Immunology (1) Neurological Disease (15)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-50865

PDE-9 inhibitor	Phosphodiesterase (PDE)	Neurological Disease
PDE-9 inhibitor is useful for neurodegenerative diseases.

HY-126137

PDE9-IN-1	Phosphodiesterase (PDE)	Neurological Disease
PDE9-IN-1 is a potent, selective, and orally bioavailable **phosphodiesterase-9A (PDE9A) Inhibitor with an IC₅₀** of 8.7 nM .

HY-109193

Tovinontrine IMR-687	Phosphodiesterase (PDE)	Cardiovascular Disease
Tovinontrine (IMR-687) is a highly potent and selective **phosphodiesterase-9 (PDE9) inhibitor specifically for the treatment of sickle cell disease. IC₅₀*s are 8.19 nM and 9.99 nM for PDE9A1 and PDE9*A2, respectively .

HY-132821

Irsenontrine E2027	Phosphodiesterase (PDE)	Neurological Disease
Irsenontrine (E2027) is an orally active and selective phosphodiesterase 9 (PDE9) inhibitor. Irsenontrine can be used for the research of neurological diseases .

HY-148625

PDE9-IN-2	Phosphodiesterase (PDE)	Cardiovascular Disease
PDE9-IN-2 (compound 6) is a *PDE9* inhibitor that improves heart failure.

HY-RS10246

PDE9A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PDE9A Human Pre-designed siRNA Set A contains three designed siRNAs for PDE9A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PDE9A Human Pre-designed siRNA Set A PDE9A Human Pre-designed siRNA Set A

HY-RS10248

Pde9a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pde9a Rat Pre-designed siRNA Set A contains three designed siRNAs for Pde9a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pde9a Rat Pre-designed siRNA Set A Pde9a Rat Pre-designed siRNA Set A

HY-RS10247

Pde9a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pde9a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pde9a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pde9a Mouse Pre-designed siRNA Set A Pde9a Mouse Pre-designed siRNA Set A

HY-114643

(Rac)-Tovinontrine (Rac)-IMR-687	Phosphodiesterase (PDE)	Cardiovascular Disease
(Rac)-Tovinontrine ((Rac)-IMR-687) is a phosphodiesterase 9 (PDE9) inhibitor that increases cyclic guanosine monophosphate (cGMP) levels. (Rac)-Tovinontrine is promising for research of thalassemia .

HY-132821A

Irsenontrine maleate E2027 maleate	Phosphodiesterase (PDE)	Neurological Disease
Irsenontrine (E2027) maleate is an orally active and selective phosphodiesterase 9 (PDE9) inhibitor. Irsenontrine maleate can be used for the research of neurological diseases .

HY-124775

(S)-C33	Phosphodiesterase (PDE)	Neurological Disease
(S)-C33 is a potent and selective **PDE9 (phosphodiesterase-9) inhibitor, with an IC₅₀** of 11 nM. (S)-C33 can be used for central nervous system diseases and diabetes research .

HY-132821B

(R)-Irsenontrine (R)-E2027	Phosphodiesterase (PDE)	Neurological Disease
(R)-Irsenontrine ((R)-E2027), the R-enantiomer of Irsenontrine (HY-132821), is a potent phosphodiesterase 9 (PDE9) inhibitor with an IC₅₀ value of 0.041 μM. (R)-Irsenontrine can be used for the research of neurological diseases .

HY-156434

PDE11A4-IN-1	Phosphodiesterase (PDE)	Neurological Disease
PDE11A4-IN-1 (compound 23b) is a potent and selective *PDE11A4* inhibitor with an IC₅₀ of 12 nM. PDE11A4-IN-1 show high selectivity for PDE11A4 over PDE1, PDE2, PDE7, PDE8, and PDE9 .

HY-170435

PDE5-IN-13	Phosphodiesterase (PDE)	Cardiovascular Disease
PDE5-IN-13 (Compound 14b) inhibits phosphodiesterase 5 (PDE5A) with an IC₅₀ of 3 nM. PDE5-IN-13 is a potential candidate for PAH (pulmonary arterial hypertension) research. PDE5-IN-13 has high selectivity for targets over PDE1, PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11. PDE5-IN-13 is orally active .

HY-104028

BAY 73-6691 2 Publications Verification	Phosphodiesterase (PDE)	Neurological Disease
BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selective *PDE9A* inhibitor .

HY-152106

BAY-7081	Phosphodiesterase (PDE)	Cardiovascular Disease
BAY-7081 is a potent, selective, orally active and soluble cyanopyridone-based *PDE9A* inhibitor with an IC₅₀ of 15 nM .

HY-160991

Menabitan SP-204	Phosphodiesterase (PDE)	Others Neurological Disease
Menabitan (SP-204) is an inhibitor for phosphodiesterase 9 (PDE 9), which acts as a non-opioid analgesic agent. Menabitan lowers the intraocular pressure in rabbit model .

HY-12788

PF-04449613	Phosphodiesterase (PDE)	Neurological Disease
PF-04449613 is a selective PDE9A inhibitor with an IC50 of 22 nM[1]. PF-04449613 improved motor learning ability in a mouse model[2].

HY-160991A

Menabitan dihydrochloride SP-204 dihydrochloride	Phosphodiesterase (PDE)	Others Neurological Disease
Menabitan dihydrochloride (SP-204 dihydrochloride) is the dihydrochloride form of Menabitan (HY-160991). Menabitan dihydrochloride is an inhibitor for phosphodiesterase 9 (PDE 9), which acts as a non-opioid analgesic agent. Menabitan dihydrochloride lowers the intraocular pressure in rabbit model .

HY-15441

Edelinontrine 4 Publications Verification PF-04447943	Phosphodiesterase (PDE)	Neurological Disease
Edelinontrine (PF-04447943) is a potent inhibitor of human recombinant *PDE9A* (IC₅₀=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC₅₀>1000 nM).

HY-104028B

(S)-BAY 73-6691	Phosphodiesterase (PDE)	Neurological Disease
(S)-BAY 73-6691 is the isomer of BAY 73-6691 (HY-104028), and can be used as an experimental control. BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selective *PDE9A* inhibitor .

HY-12788A

(S)-PF-04449613	Phosphodiesterase (PDE)	Neurological Disease
(S)-PF-04449613 is the left-handed isomer of PF-04449613 (HY-12788). PF-04449613 is a selective *PDE9A* inhibitor with an IC₅₀ of 22 nM. PF-04449613 improves motor learning ability in a mouse model .

HY-122942

Moracin M 2 Publications Verification	Phosphodiesterase (PDE) Endogenous Metabolite NF-κB Autophagy	Inflammation/Immunology
Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent phosphodiesterase-4 (PDE4) inhibitor with IC₅₀ values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity .

HY-112831

Osoresnontrine 1 Publications Verification BI-409306	Phosphodiesterase (PDE)	Neurological Disease
Osoresnontrine (BI-409306) is a potent and selective *PDE9A* inhibitor, with an IC₅₀ of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC₅₀, 1.4 µM), PDE1C (IC₅₀, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC₅₀ all > 10 μM); Osoresnontrine can be used in the research of memory enhancement in CNS disorders.

Moracin M 2 Publications Verification	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Endogenous metabolite Inflammation/Immunology Disease Research Fields Morus alba Linn.	Phosphodiesterase (PDE) Endogenous Metabolite NF-κB Autophagy
Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent phosphodiesterase-4 (PDE4) inhibitor with IC₅₀ values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity .

Species:	Human (2)
Tag:	His (2) GST (1)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P75963

	PDE9A Protein, Human (His) High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; PDE9A	Human	E. coli
	PDE9A is a phosphodiesterase that uniquely hydrolyzes second messengers with unparalleled specificity, particularly in the regulation of natriuretic peptide-dependent signaling in the heart, which is critical for the control of cardiac hypertrophy. Its specificity rules out effects on nitric oxide-dependent signaling in the heart. PDE9A Protein, Human (His) is the recombinant human-derived PDE9A protein, expressed by E. coli , with N-His labeled tag. The total length of PDE9A Protein, Human (His) is 326 a.a., with molecular weight of ~37 kDa.

HY-P75962

	PDE9A Protein, Human (sf9, His-GST) High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; PDE9A	Human	Sf9 insect cells
	PDE9A is a phosphodiesterase that uniquely hydrolyzes second messengers with unparalleled specificity, particularly in the regulation of natriuretic peptide-dependent signaling in the heart, which is critical for the control of cardiac hypertrophy. Its specificity rules out effects on nitric oxide-dependent signaling in the heart. PDE9A Protein, Human (sf9, His-GST) is the recombinant human-derived PDE9A protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of PDE9A Protein, Human (sf9, His-GST) is 533 a.a., with molecular weight of ~75 kDa.

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PDE9A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PDE9A Human Pre-designed siRNA Set A contains three designed siRNAs for PDE9A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pde9a Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Pde9a Rat Pre-designed siRNA Set A contains three designed siRNAs for Pde9a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pde9a Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Pde9a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pde9a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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