Phenazine

By Targets:	Antibiotic (2) Apoptosis (2) Bacterial (4) Cholinesterase (ChE) (1) Endogenous Metabolite (1) Fluorescent Dye (3) Fungal (1)
By Research Areas:	Cancer (6) Infection (5) Inflammation/Immunology (1) Metabolic Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-33037

Phenazine-1-carboxylic acid	Fungal	Infection Inflammation/Immunology Cancer
Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation .

HY-D1509

Phenazine ethosulfate	Fluorescent Dye	Others
Phenazine ethosulfate is a cationic dye (Ex=390 nm, Em=530 nm) and an electron acceptor that can be used in dye-linked enzyme assays. Phenazine ethosulfate is an intermediate for detecting nitric oxide reducatase (Nors) activity with the presence of ascorbic acid .

HY-W004520

Phenazine methylsulfate 1 Publications Verification 5-Methylphenazinium methylsulfate	Bacterial Antibiotic Apoptosis	Others
Phenazine methylsulfate is a free radical generator, can be used as an electron transfer reactant in cell viability assays. Phenazine methylsulfate induces ssDNA break formation in the presence of the reducing agent NADPH. Phenazine methylsulfate also induces oxidative DNA damage and apoptosis .

HY-W016477

*Phenazine*	Bacterial	Infection
Phenazine is an electron shuttles, which modulates the redox state of cells and the downstream gene expression related to biofilm formation and bacterial survival. Phenazines is a biocontrol agents, which affects the growth of plants and induces the systemic resistance in plants .

HY-121414

Phenazine oxide Phenazine N-oxide; N-OxyPhenazine	Others	Infection
Phenazine oxide (Phenazine N-oxide) is a novel and potent fungicide, bactericide, and wood preservative .

HY-W040198

Phenosafranine	Fluorescent Dye	Others
Phenosafranine is a phenazine dye. Phenosafranine has high binding affinity to triplex RNA compared to the parent duplex form, binds through intercalation to both forms of RNA. Phenosafranine can be used for staining plant cells, determination of hemoglobin, dopamine, serotonin and so on .

HY-148766

VU661	Others	Metabolic Disease
VU661, a phenazine carboxamide, is a modulator of circadian rhythms to produce a period lengthening of the circadian rhythm. VU661 is a redox-active small molecule .

HY-W020086

2,3-Diaminophenazine 2,3-Phenazinediamine	Fluorescent Dye	Others
2,3-Diaminophenazine (2,3-Phenazinediamine) is an amino derivative of phenazine with promising luminescence, electrochemical and biochemical applications .

HY-N3561

Cedrelone	Apoptosis	Cancer
Cedrelone, a limonoid, is a Phenazine biosynthesis-like domain-containing protein (PBLD) activator. Cedrelone induces cancer cell apoptosis, and possess antitumor effects .

HY-113578

PD 116152	Antibiotic Bacterial	Infection Cancer
PD 116152 is a phenazine Antibiotic with antimicrobial and antitumor activity. PD 116152 possesses cytotoxic activity against L1210 lymphocytic leukemia and human colon adenocarcinoma (HCT-8) cells with IC₅₀ values of 5.2 x 10 ^-7 M and 7.1 x 10 ^-7 M, respectively. PD 116152 is promising for research of P388 lymphocytic leukemia .

HY-129503

2-Heptyl-4-quinolone	Others	Others
2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .

HY-129734

Aeruginosin B	Endogenous Metabolite	Others
Aeruginosin B is a phenazine pigment, which can be isolated from Pseudomonas aeruginosa .

HY-118651

Griseoluteic acid	Bacterial	Infection
Griseoluteic acid, a phenazine antibiotic, is originally isolated from S. griseoluteus. Griseoluteic acid is a breakdown product of griseolutein A and B .

HY-121716

Pelagiomicin A Antibiotic 2088A; LL-14I352α	Others	Cancer
Pelagiomicin A is a novel phenazine antibiotic produced by the marine bacterium Pelagiobacter variabilis. The compound is unstable in water and small alcohols. The absolute structure of its major component, Pelagiomicin A, as well as the properties of minor amounts of other structures, were determined by spectroscopic data and synthesis. Pelagiomicin A is active against both Gram-positive and Gram-negative bacteria and exhibits antitumor activity in vitro and in vivo.

HY-W130236

Methylene Violet 3RAX	Cholinesterase (ChE)	Cancer
Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyte AChE and human plasma BChE with an K_is of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy) .

HY-118138

NC-182	Others	Cancer
NC-182 is a novel antitumor compound with a benzo[a]phenazine ring. The interaction mode of the agent with DNA and its effect on DNA conformation were systematically investigated by fluorescence, absorption and circular dichroism spectroscopy as well as viscosity titration measurements, and were compared with those of the DNA minor groove binder distamycin and the DNA base intercalator daunomycin. NC-182 was found to be a strong DNA intercalator, especially for B-form DNA, although without specificity for base pairs. The binding of NC-182 to B-DNA exhibited a biphasic behavior depending on the molar ratio of agent to DNA (r): at relatively low r values, NC-182 made the B-form structure rigid, and at higher r values, promoted the transition from B- to non-B-forms. NC-182 was also shown to promote the unwinding of Z-form DNA into B-form. Viscosity, UV 'melting' and circular dichroism experiments further showed that: (1) NC-182 intercalates to stabilize the DNA double helix structure; (2) NC-182 intercalates into the poly(dA) 2poly(dT) DNA structure to stabilize the triple helix structure, resulting in a melting point close to that of the double helix structure; the melting curves of the triple helix and double helix structures overlap at r > 0.06. These observations make an important contribution to our understanding of the biological properties of this novel benzo[a]phenazine derivative, which is a new antitumor agent suitable for both multiagent-resistant and sensitive tumors.

Cat. No.	Product Name	Type

HY-D1509

Phenazine ethosulfate	Dyes
Phenazine ethosulfate is a cationic dye (Ex=390 nm, Em=530 nm) and an electron acceptor that can be used in dye-linked enzyme assays. Phenazine ethosulfate is an intermediate for detecting nitric oxide reducatase (Nors) activity with the presence of ascorbic acid .

HY-W040198

Phenosafranine	Dyes
Phenosafranine is a phenazine dye. Phenosafranine has high binding affinity to triplex RNA compared to the parent duplex form, binds through intercalation to both forms of RNA. Phenosafranine can be used for staining plant cells, determination of hemoglobin, dopamine, serotonin and so on .

Cat. No.	Product Name	Type

HY-W016477

*Phenazine*	Biochemical Assay Reagents
Phenazine is an electron shuttles, which modulates the redox state of cells and the downstream gene expression related to biofilm formation and bacterial survival. Phenazines is a biocontrol agents, which affects the growth of plants and induces the systemic resistance in plants .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-33037

Phenazine-1-carboxylic acid	Infection Alkaloids Structural Classification Microorganisms Classification of Application Fields Other Alkaloids Marine natural products Source classification Disease Research Fields	Fungal
Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation .

HY-118651

Griseoluteic acid	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial
Griseoluteic acid, a phenazine antibiotic, is originally isolated from S. griseoluteus. Griseoluteic acid is a breakdown product of griseolutein A and B .

HY-N3561

Cedrelone	Triterpenes Structural Classification Terpenoids Source classification Toona ciliata Roem. Plants Meliaceae	Apoptosis
Cedrelone, a limonoid, is a Phenazine biosynthesis-like domain-containing protein (PBLD) activator. Cedrelone induces cancer cell apoptosis, and possess antitumor effects .

HY-129503

2-Heptyl-4-quinolone	Structural Classification Alkaloids Microorganisms Source classification Quinoline Alkaloids	Others
2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .

HY-129734

Aeruginosin B	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Endogenous Metabolite
Aeruginosin B is a phenazine pigment, which can be isolated from Pseudomonas aeruginosa .

HY-121716

Pelagiomicin A Antibiotic 2088A; LL-14I352α	Structural Classification Antibiotics Marine natural products Source classification	Others
Pelagiomicin A is a novel phenazine antibiotic produced by the marine bacterium Pelagiobacter variabilis. The compound is unstable in water and small alcohols. The absolute structure of its major component, Pelagiomicin A, as well as the properties of minor amounts of other structures, were determined by spectroscopic data and synthesis. Pelagiomicin A is active against both Gram-positive and Gram-negative bacteria and exhibits antitumor activity in vitro and in vivo.

Cat. No.	Compare	Product Name	Species	Source

HY-P71144

	PBLD Protein, Human (His) Phenazine Biosynthesis-Like Domain-Containing Protein; MAWD-Binding Protein; MAWDBP; Unknown Protein 32 From 2D-PAGE of Liver Tissue; PBLD; MAWBP	Human	E. coli
	PBLD protein, also known as phenazine biosynthetic domain protein, is a protein involved in a variety of cellular activities. Serval researches indicatethat the PBLD protein interacts with UNRIP/MAWD. PBLD Protein, Human (His) is the recombinant human-derived PBLD protein, expressed by E. coli , with N-6*His labeled tag.

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Phenazine

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

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Recombinant Proteins

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