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PurE

" in MedChemExpress (MCE) Product Catalog:

41

Inhibitors & Agonists

2

Fluorescent Dye

2

Biochemical Assay Reagents

2

Peptides

8

Natural
Products

4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-133154
    Carboxyaminoimidazole ribotide
    1 Publications Verification

    CAIR; 4-Carboxy-AIR

    		 Endogenous Metabolite Infection
    Carboxyaminoimidazole ribotide (CAIR) is a metabolite of E. coli. Carboxyaminoimidazole ribotide can be used to detect distinctive features of E. coli PurE active site and synthesis fungal de novo purine .
    Carboxyaminoimidazole ribotide
  • HY-B1194
    Tetramisole hydrochloride

    (±)-Tetramisole hydrochloride; DL-Tetramisole hydrochloride; R-829

    		 Parasite Phosphatase Antibiotic Infection
    Tetramisole hydrochloride inhibits alkaline phosphatase and is a highly pure antiparasitic agent.
    Tetramisole hydrochloride
  • HY-15758
    3,3'-Diindolylmethane
    5+ Cited Publications

    DIM; Arundine; HB 236

    		 Androgen Receptor Autophagy Cancer
    3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.
    3,3'-Diindolylmethane
  • HY-50868
    Bafetinib
    5+ Cited Publications

    INNO-406; NS-187

    		 Bcr-Abl Src Apoptosis Cancer
    Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph + leukemia cells. Bafetinib has antitumor activity .
    Bafetinib
  • HY-16023A
    Acolbifene
    2 Publications Verification

    EM-652; SCH 57068

    		 Estrogen Receptor/ERR Cancer
    Acolbifene (EM-652), the active metabolite of EM800, is an orally active pure antiestrogen and selective estrogen receptor antagonist. Acolbifene (EM-652) inhibits estradiol (E2)-induced transcriptional activity of ERα (IC50 = 2 nM) and ERβ (IC50 = 0.4 nM). Acolbifene (EM-652) possesses potent and pure anticarcinogenic properties .
    Acolbifene
  • HY-D0317
    Chrome Pure Blue BX

    Sunchromine PurE Blue BX

    		 Fluorescent Dye Others
    Chrome Pure Blue BX (Sunchromine Pure Blue BX) is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
    Chrome Pure Blue BX
  • HY-142919
    μ opioid receptor agonist 2

    		Opioid Receptor Neurological Disease
    μ opioid receptor agonist 2 （Compound H-3）is an optically pure oxaspiro ring substituted pyrrolopyrazole derivative, acts as a MOR receptor agonist and can be used for the research of pain and pain related diseases .
    μ opioid receptor agonist 2
  • HY-142918
    μ opioid receptor agonist 1

    		Opioid Receptor Neurological Disease
    μ opioid receptor agonist 1 （Compound H-1a）is an optically pure oxaspiro ring substituted pyrrolopyrazole derivative, acts as a MOR receptor agonist and can be used for the research of pain and pain related diseases .
    μ opioid receptor agonist 1
  • HY-15206A
    Glibenclamide potassium

    Glyburide potassium

    		 Potassium Channel CFTR Others
    Glibenclamide (Glyburide) potassium is a potassium salt of Glibenclamide (HY-15206). Glibenclamid potassium exists in anhydrous and hydrate forms, with higher solubility compared to pure Glibenclamide .
    Glibenclamide potassium
  • HY-B1194R
    Tetramisole (hydrochloride) (Standard)

    		Parasite Phosphatase Antibiotic Infection
    Tetramisole (hydrochloride) (Standard) is the analytical standard of Tetramisole (hydrochloride). This product is intended for research and analytical applications. Tetramisole hydrochloride inhibits alkaline phosphatase and is a highly pure antiparasitic agent.
    Tetramisole (hydrochloride) (Standard)
  • HY-B0162AS
    Ivabradine-d6 hydrochloride

    		Adrenergic Receptor Endocrinology
    Ivabradine-d6 (hydrochloride) is the deuterium labeled Ivabradine hydrochloride. Ivabradine hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent.
    Ivabradine-d6 hydrochloride
  • HY-B0162AS1
    Ivabradine-d3 hydrochloride

    		Adrenergic Receptor Endocrinology
    Ivabradine-d3 (hydrochloride) is the deuterium labeled Ivabradine hydrochloride. Ivabradine hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent.
    Ivabradine-d3 hydrochloride
  • HY-Y1422I
    Lipase AK

    		Lipase Others
    Lipase AK comes from Pseudomonas fluorescens and shows good applicability in ester synthesis of food industry, the biofuel synthesis, the synthesis of enantiomeric pure chiral drugs and so on .
    Lipase AK
  • HY-121418
    Lusianthridin

    		c-Myc Cancer
    Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling .
    Lusianthridin
  • HY-N4309
    Lotusine

    		Others Cardiovascular Disease
    Lotusine is a pure alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn. Lotusine shows effects on the action potentials in myocardium and slow inward current in cardiac Purkinje fibers .
    Lotusine
  • HY-N4309A
    Lotusine hydroxide

    		Others Cardiovascular Disease
    Lotusine (hydroxide) is a pure alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn. Lotusine (hydroxide) shows effects on the action potentials in myocardium and slow inward current in cardiac Purkinje fibers .
    Lotusine hydroxide
  • HY-Y1881A
    Copper sulfate pentahydrate, 99.9%

    		Biochemical Assay Reagents Others
    Copper sulfate pentahydrate, commonly used biochemical reagents. Copper sulfate pentahydrate, 99.9% indicates that it is almost entirely pure, making it suitable for uses in laboratory experiments, chemical synthesis, and some pharmaceutical applications.
    Copper sulfate pentahydrate, 99.9%
  • HY-15758R
    3,3'-Diindolylmethane (Standard)

    		Androgen Receptor Autophagy Cancer
    3,3'-Diindolylmethane (Standard) is the analytical standard of 3,3'-Diindolylmethane. This product is intended for research and analytical applications. 3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.
    3,3'-Diindolylmethane (Standard)
  • HY-P1167
    [Orn5]-URP

    		Urotensin Receptor Cardiovascular Disease
    [Orn5]-URP is a potent and selective pure antagonist of Urotensin-II receptor (UT), with an pEC50 of 7.24. [Orn5]-URP displays no agonist activity .
    [Orn5]-URP
  • HY-P1167A
    [Orn5]-URP TFA

    		Urotensin Receptor Cardiovascular Disease
    [Orn5]-URP TFA is a potent and selective pure antagonist of Urotensin-II receptor (UT), with an pEC50 of 7.24. [Orn5]-URP TFA displays no agonist activity .
    [Orn5]-URP TFA
  • HY-148225
    Fulvestrant 3-β-D-Glucuronide

    		Others Cancer
    Fulvestrant 3-β-D-Glucuronide, a metabolite, is glucuronide and sulfate conjugates of Fulvestrant (HY-13636), a pure anti-estrogenic steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer .
    Fulvestrant 3-β-D-Glucuronide
  • HY-N9506
    Anisatin

    		GABA Receptor Neurological Disease
    Anisatin, a pure toxic substance isolated from the seeds of a Japanese plant (Illicium anisatum) acts as a picrotoxin-like, non-competitive GABA antagonist. Anisatin suppresses GABA-induced currents in a concentration-dependent manner with an EC50 of ~1.10 μM .
    Anisatin
  • HY-12407
    ZK168281
    1 Publications Verification

    		 VD/VDR Metabolic Disease
    ZK168281 is a 25-carboxylic ester 1α,25(OH)2D3 analog and a pure VDR antagonist with a Kd value of 0.1 nM. ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor .
    ZK168281
  • HY-W013812S1
    Ethyl linoleate-d5

    Linoleic Acid ethyl ester-d5; Ethyl linoleate, PurE-d5; Mandenol-d5

    		 Isotope-Labeled Compounds Others Cardiovascular Disease
    Ethyl linoleate-d5 (Linoleic Acid ethyl ester-d5) is deuterium labeled Ethyl linoleate. Ethyl linoleate (Linoleic Acid ethyl ester) inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators .
    .
    Ethyl linoleate-d5
  • HY-D1756
    ROX NHS ester, 6-isomer

    		Fluorescent Dye Others
    ROX NHS ester, 6-isomer is a highly fluorescent, and photostable rhodamine dye for various applications. ROX labeled oligonucleotide probes are often used in qPCR, and qPCR instruments have ROX channel. This is reactive dye for the labeling of amino-groups in peptides, proteins, and amino-oligonucleotides. Pure single isomer.
    ROX NHS ester, 6-isomer
  • HY-109163
    Treprostinil palmitil

    INS-1009

    		 Prostaglandin Receptor Inflammation/Immunology Endocrinology
    Treprostinil palmitil (TP) is the proagent of DP1 and EP2 agonist, Treprostinil (UT-15), whose EC50 values were 0.6 and 6.2 nM, respectively. Treprostinil palmitil is a pure proagent and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors .
    Treprostinil palmitil
  • HY-13636
    Fulvestrant
    Maximum Cited Publications
    86 Publications Verification

    ICI 182780; ZD 9238; ZM 182780

    		 Estrogen Receptor/ERR Autophagy Apoptosis Cancer
    Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy .
    Fulvestrant
  • HY-125263
    OP-1074

    		Estrogen Receptor/ERR Cancer
    OP-1074, a pure anti-estrogen drug, is a selective ER degrader (PA-SERD) with specific anti-estrogenic activity against ERα and ERβ, inhibiting 17β-estradiol (E2)-stimulated transcription with IC50 values of 1.6 and 3.2 nM, respectively.
    OP-1074
  • HY-B1804
    Tricaprilin

    Trioctanoin; Glyceryl trioctanoate

    		 Endogenous Metabolite Neurological Disease Inflammation/Immunology
    Tricaprilin (Trioctanoin) is an orally active and well tolerated ketogenic agent that safely induces ketosis. Tricaprilin restores brain electrical activity and metabolism to help counteract neuroinflammation in migraine. Tricaprilin is promising for research of migraine prevention and Alzheimer’s disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT) .
    Tricaprilin
  • HY-145572
    Imlunestrant

    LY-3484356

    		 Estrogen Receptor/ERR Cancer
    Imlunestrant (LY-3484356) is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC) .
    Imlunestrant
  • HY-145572A
    Imlunestrant tosylate

    LY-3484356 tosylate

    		 Estrogen Receptor/ERR Cancer
    Imlunestrant (LY-3484356) tosylate is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant tosylate results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant tosylate can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC) .
    Imlunestrant tosylate
  • HY-171033
    ASM-IN-3

    		Phospholipase Neurological Disease
    ASM-IN-3 (Compound 21b) is a selective and BBB-penetrating acid sphingomyelinase (ASM) inhibitor (IC50: 3.37 μM for pure human ASM). ASM-IN-3 improves depression-like behaviors by inhibiting ASM activity and increasing neurogenesis in hippocampus in Reserpine (HY-N0480)-induced depressed rats .
    ASM-IN-3
  • HY-13636S
    Fulvestrant-d3

    ICI 182780-d3; ZD 9238-d3; ZM 182780-d3

    		 Isotope-Labeled Compounds Estrogen Receptor/ERR Autophagy Apoptosis Cancer
    Fulvestrant-d3 is the deuterium labeled Fulvestrant. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy[1].
    Fulvestrant-d3
  • HY-13636R
    Fulvestrant (Standard)
    Maximum Cited Publications
    86 Publications Verification

    ICI 182780(Standard); ZD 9238(Standard); ZM 182780 (Standard)

    		 Estrogen Receptor/ERR Autophagy Apoptosis Cancer
    Fulvestrant (Standard) is the analytical standard of Fulvestrant. This product is intended for research and analytical applications. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy .
    Fulvestrant (Standard)
  • HY-125263B
    (R)-OP-1074

    		Estrogen Receptor/ERR Cancer
    (R)-OP-1074 is an isomer of OP-1074 (HY-125263) and can serve as a control compound in experiments. OP-1074, a pure anti-estrogen drug, is a selective ER degrader (PA-SERD) with specific anti-estrogenic activity against ERα and ERβ, inhibiting 17β-estradiol (E2)-stimulated transcription with IC50 values of 1.6 and 3.2 nM, respectively.
    (R)-OP-1074
  • HY-16023
    Acolbifene hydrochloride
    2 Publications Verification

    EM-652 hydrochloride; SCH 57068 hydrochloride

    		 Estrogen Receptor/ERR Cancer
    Acolbifene (EM-652) hydrochloride, an active metabolite of EM800, is an orally active, cancer-preventing selective estrogen receptor modulator (SERM). Acolbifene (EM-652) hydrochloride inhibits estradiol (E2)-induced transcriptional activity of ERα (IC50=2 nM) and ERβ (IC50=0.4 nM). Acolbifene (EM-652) hydrochloride exerts a potent and pure antiestrogenic action in the mammary gland and uterus. Anticarcinogenic properties .
    Acolbifene hydrochloride
  • HY-100981
    MR-16728 hydrochloride

    		Others Neurological Disease
    MR-16728 hydrochloride is a compound that promotes the release of acetylcholine and has activity that enhances the release of acetylcholine. MR-16728 hydrochloride inhibits acetylcholine release induced by KCl depolarization. MR-16728 hydrochloride also inhibits Ca(2+)-ATPase activity in pure presynaptic membranes. The half-maximal effect of MR-16728 hydrochloride occurs at a concentration of 13.5 μM. MR-16728 hydrochloride significantly enhances the release of acetylcholine in the presence of low concentrations of calcium (approximately 10 μM range). Enhanced acetylcholine release was also observed with MR-16728 hydrochloride in proteoliposomes loaded with mediator proteins .
    MR-16728 hydrochloride
  • HY-W250795B
    Maltodextrin, dextrose equivalent 5.0-8.0

    		Endogenous Metabolite Others
    Maltodextrin, dextrose equivalent 5.0-8.0 can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs. Dextrose Equivalent (DE) expresses the number of reducing ends aldehyde groups relative to pure glucose at the same concentration, so that high DE indicates high hydrolytic conversion and lower average molecular mass .
    Maltodextrin, dextrose equivalent 5.0-8.0
  • HY-117063
    LEK 8841 methanesulfonate

    		Others Endocrinology
    LEK 8841 methanesulfonate is a gastrointestinal calming agent with strong selective 5-HT2 receptor antagonist activity. The antipsychotic potential of LEK 8841 has made it the focus of research into alternative medicines. LEK 8841 behaves as a pure competitive antagonist in response to 5-HT and norepinephrine, with pA2 values of 7.93 and 6.45, respectively. The selectivity of LEK 8841 is better than that of the comparative drug ketanserin, making it an important reference value in corresponding receptor research. Studies related to structural modifications have shown that LEK 8841 exhibits high affinity for 5-HT2 receptors and low alpha-adrenergic receptor activity .
    LEK 8841 methanesulfonate
  • HY-15191B
    (S)-Sabutoclax

    (S)-BI-97C1

    		 Bcl-2 Family Cancer
    (S)-Sabutoclax ((S)-BI-97C1), an optically pure apogossypol derivative, is pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (S)-Sabutoclax (Compound II) inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1, and Bfl-1 with IC50 values of 0.31, 0.32, 0.20, and 0.62 μM, respectively. (S)-Sabutoclax also potently inhibits cell growth of human prostate cancer, lung cancer, and lymphoma cell lines with EC50 values of 0.13, 0.56, and 0.049 μM, respectively. (S)-Sabutoclax can be used for the research of apoptosis-based therapies against cancer .
    (S)-Sabutoclax
  • HY-145341
    GNE-149

    		Estrogen Receptor/ERR Cancer
    GNE-149 is an orally bioavailable full antagonist of estrogen receptor α (ERα; IC50=0.053 nM). GNE-149 is a selective estrogen receptor degrader (SERD). GNE-149 can be used for the research of breast cancer .
    GNE-149

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