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Pyridone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (1) ASK1 (1) Bacterial (2) Bcl-2 Family (1) Biochemical Assay Reagents (1) c-Myc (1) Caspase (1) Cholinesterase (ChE) (1) Drug Metabolite (2) Endogenous Metabolite (2) Epigenetic Reader Domain (1) Fungal (1) HIV (1) Influenza Virus (2) Isotope-Labeled Compounds (2) JAK (1) p38 MAPK (1) Pim (1) RET (1) Reverse Transcriptase (1) Sodium Channel (1)
By Research Areas:	Cancer (5) Infection (5) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14435

Pyridone 6 5+ Cited Publications	JAK	Cancer
Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC₅₀s of 1 nM for JAK2 and TYK2, 5 nM for JAK3, and 15 nM for JAK1, while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases.

HY-Y0191

α-Pyridone 2-Pyridone	Endogenous Metabolite	Metabolic Disease
α-Pyridone is an endogenous metabolite.

HY-113472

*N-Methyl-4-pyridone-3-carboxamide*	Drug Metabolite	Others
N-Methyl-4-pyridone-3-carboxamide is a metabolite of coffee pyridines .

HY-Y0191R

*α-Pyridone* (Standard)**	Endogenous Metabolite	Metabolic Disease
α-Pyridone (Standard) is the analytical standard of α-Pyridone. This product is intended for research and analytical applications. α-Pyridone is an endogenous metabolite.

HY-113472S

*N-Methyl-4-pyridone-3-carboxamide-d3*	Isotope-Labeled Compounds	Others
N-Methyl-4-pyridone-3-carboxamide-d₃ is deuterium labeled N-Methyl-4-pyridone-3-carboxamide.

HY-132834S

*5-Carboxy-N-phenyl-2-1H-pyridone-d5*	Isotope-Labeled Compounds	Others
5-Carboxy-N-phenyl-2-1H-pyridone-d₅ is the deuterium labeled 5-Carboxy-N-phenyl-2-1H-pyridone[1].

HY-N10209

Paecilomide	Cholinesterase (ChE)	Others
Paecilomide is a pyridone alkaloid and acetylcholinesterase inhibitor .

HY-149327

Anticancer agent 131	Others	Cancer
HCT-116-IN-1, a γ-lactam-fused pyridone derivative, has anticancer activity and displayed high cytotoxicity against HCT116 cells with an IC₅₀ of 5.59 μM .

HY-143770

Cap-dependent endonuclease-IN-16	Influenza Virus	Infection
Cap-dependent endonuclease-IN-16 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-16 is a pyridone polycyclic derivative. Cap-dependent endonuclease-IN-16 has the potential for the research of influenza (extracted from patent CN112778330A, compound 15A) .

HY-144065

Cap-dependent endonuclease-IN-19	Influenza Virus	Infection
Cap-dependent endonuclease-IN-19 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-19 is a spirocyclic pyridone derivative. Cap-dependent endonuclease-IN-19 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent CN111410661A, compound 1) .

HY-125161

MT0703	Bacterial Antibiotic	Others
MT0703 is an aminothiazolyl glycyl cephalosporin with a 1,5-dihydroxy-4-pyridone-2-carbonyl group and has good anti-Pseudomonas activity.

HY-122643

NITD-916	Bacterial	Infection
NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active and highly lipophilic mycobacterial enoyl reductase InhA inhibitor with an IC₅₀ of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 has potent anti-tuberculosis effects .

HY-113472R

*N-Methyl-4-pyridone-3-carboxamide (Standard)*	Drug Metabolite	Others
3-Methyladenine (Standard) is the analytical standard of 3-Methyladenine. This product is intended for research and analytical applications. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K .

HY-65036

4-Bromo-2-hydroxypyridine 4-Bromo-2-Pyridone	Biochemical Assay Reagents	Others
4-Bromo-2-hydroxypyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-65008

N-Demethylricinine	Others	Others
N-Demethylricinine is a ricinine, can be interconverted with ricinine in senescent and green castor plant leaves. Ricinine, is a α-pyridone alkaloid biosynthetically related to the pyridine nucleotide cycle. The alkaloid catabolism of ricinine is associated with aging process .

HY-18086

TCS PIM-1 1 4 Publications Verification SC 204330	Pim	Cancer
TCS PIM-1 1 (SC 204330) is a potent, selective and ATP-competitive Pim-1 kianse inhibitor with an IC₅₀ of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC₅₀s >20000 nM) .

HY-163110

NNRT-IN-2	HIV Reverse Transcriptase	Infection
NNRT-IN-2 (compound 7w) is an orally available non-nucleoside reverse transcriptase inhibitor (NNRTI) with broad inhibitory effects on wild-type HIV-1 and mutant strains. NNRT-IN-2 inhibits HIV-1 reverse transcriptase with an EC₅₀ of 22 nM. NNRT-IN-2 is insensitive to CYP and hERG and has good safety and pharmacokinetic characteristics .

HY-113863

Rilopirox HOE 351	Fungal	Infection
Rilopirox (HOE 351) is a hydroxy-pyridone compound with antimycotic properties. Rilopirox, a chelating agent, can inhibit catalase. Rilopirox inhibits the respiratory chain. Rilopirox inhibits growth of yeast isolates with a MIC50 of 4 μg/mL. Rilopirox has the potential for vaginal candidosis and oropharyngeal Candida infections research .

HY-147564

RET-IN-18	RET	Neurological Disease Cancer
RET-IN-18 is a pyridone compound. is a potent inhibitor of RET. RET-IN-18 is a potent inhibitor of RET. RET-IN-18 has the potential for the research of diseases related to irritable bowel syndrome (IBS) and other gastrointestinal disorders, as well as cancers, and neurodegenerative diseases (extracted from patent WO2022017524A1, compound 1) .

HY-160851

GDC-3280 AK3287; AKEX0011	ASK1 p38 MAPK	Inflammation/Immunology
GDC-3280 (AK3287; AKEX0011) is an orally active compound based on Pirfenidone (HY-B0673)'s phenyl pyridone scaffold. GDC-3280 alleviates the inflammatory and fibrotic reaction of silicosis by inhibiting the ASK1-p38 MAPK pathway and regulating macrophage polarization. GDC-3280 exhibits anti-inflammatory and anti-fibrotic effects .

HY-161272

Nav1.8-IN-6	Sodium Channel	Neurological Disease
Nav1.8-IN-6 (Compound 2j) is a novel pyridinone amide Nav1.8 channel inhibitor. The IC₅₀ values in the resting state and semi-activated state are 513.33 and 471.81 nM, respectively. Nav1.8-IN-6 has analgesic activity .

HY-143235

BRD4 Inhibitor-15	Epigenetic Reader Domain Apoptosis Bcl-2 Family Caspase c-Myc	Cancer
BRD4 Inhibitor-15 (compound 13) is a potent BRD4 inhibitor, with an IC₅₀ of 18 nM. BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells by regulating Bcl-2/Bax proteins and activating caspase-3 signaling pathway. BRD4 Inhibitor-15 down-regulates the c-Myc level in 22RV1 cells. BRD4 Inhibitor-15 can be used for prostate cancer research .

4-Bromo-2-hydroxypyridine 4-Bromo-2-Pyridone	Biochemical Assay Reagents
4-Bromo-2-hydroxypyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y0191

α-Pyridone 2-Pyridone	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
α-Pyridone is an endogenous metabolite.

HY-65008

N-Demethylricinine	Alkaloids Structural Classification Ricinus communis L. Euphorbiaceae Plants	Others
N-Demethylricinine is a ricinine, can be interconverted with ricinine in senescent and green castor plant leaves. Ricinine, is a α-pyridone alkaloid biosynthetically related to the pyridine nucleotide cycle. The alkaloid catabolism of ricinine is associated with aging process .

HY-Y0191R

*α-Pyridone* (Standard)**	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
α-Pyridone (Standard) is the analytical standard of α-Pyridone. This product is intended for research and analytical applications. α-Pyridone is an endogenous metabolite.

HY-N10209

Paecilomide	Alkaloids Microorganisms Classification of Application Fields Source classification Other Diseases Pyridine Alkaloids Disease Research Fields	Cholinesterase (ChE)
Paecilomide is a pyridone alkaloid and acetylcholinesterase inhibitor .

Cat. No.	Product Name	Chemical Structure

HY-113472S

*N-Methyl-4-pyridone-3-carboxamide-d3*
N-Methyl-4-pyridone-3-carboxamide-d₃ is deuterium labeled N-Methyl-4-pyridone-3-carboxamide.

HY-132834S

*5-Carboxy-N-phenyl-2-1H-pyridone-d5*
5-Carboxy-N-phenyl-2-1H-pyridone-d₅ is the deuterium labeled 5-Carboxy-N-phenyl-2-1H-pyridone[1].

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Pyridone

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products