Search Result
Results for "
R-L3
" in MedChemExpress (MCE) Product Catalog:
4
Biochemical Assay Reagents
16
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-108591
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R-L3
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Potassium Channel
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Cardiovascular Disease
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L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes .
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- HY-152581
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Cannabinoid Receptor
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Inflammation/Immunology
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CB2R antagonist 3 is a selective antagonist of cannabinoid type 2 receptor (CB2R). CB2R antagonist 3 has high affinity for human CB2R and specific selectivity for CB1R. CB2R antagonist 3 can be combined with CB65 (HY-110047), the activator of CB2R. CB2R antagonist 3 effectively up-regulates the expression of anti-inflammatory cytokines and down-regulates the expression of pro-inflammatory cytokines .
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- HY-156667
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Histamine Receptor
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Inflammation/Immunology
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H4R antagonist 3 (Example 18) is a histamine-4 receptor antagonist with an EC50 of <10 mM. H4R antagonist 3 can be used for the research of prevention of inflammatory, autoimmune, allergic, and ocular diseases .
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- HY-W008507S3
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- HY-W008507S2
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- HY-W008507S
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-
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- HY-W040185S
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Isotope-Labeled Compounds
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Others
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(R)-2,3-Bis(tetradecanoyloxy)propyl phosphate-d54 (sodium) is deuterium labeled (R)-2,3-Bis(tetradecanoyloxy)propyl phosphate.
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- HY-107518
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(R,S)-3,4-DCPG
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iGluR
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Neurological Disease
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(R,S)-3,4-Dicarboxyphenylglycine ((RS)-3,4-DCPG) is an AMPA receptor antagonist. (R,S)-3,4-Dicarboxyphenylglycine antagonizes AMPA-mediated depolarization of motor neurons in neonatal rats. (R,S)-3,4-Dicarboxyphenylglycine can be used in the study of neurological diseases .
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- HY-W140713
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- HY-153805
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Others
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Cancer
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Z-NCTS is an RNA mismatch binding molecule that recognizes the 5’-r(XGG)-3’/5’-r(XGG)-3’ sequence (X=U or A) and acts as a molecular glue for RNA .
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- HY-60256
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-
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- HY-W008507
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-
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- HY-N12486A
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Others
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Neurological Disease
Metabolic Disease
Cancer
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(3S,8R,9R)-Isofalcarintriol is a natural polyacetylene compound found in carrot root parts. (3S,8R,9R)-Isofalcarintriol is a potent longevity promoter that improves glucose metabolism and has anti-tumor activity. (3S,8R,9R)-Isofalcarintriol can affect cellular respiration, interact with the α subunit of mitochondrial ATP synthase, and promote mitochondrial biogenesis. (3S,8R,9R)-Isofalcarintriol can be used in the study of neurodegenerative diseases, metabolic diseases, and aging .
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- HY-77490
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- HY-133872
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-
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- HY-144034
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GCGR
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Metabolic Disease
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GLP-1R agonist 3 is a potent agonist of GLP-1R. GLP-1R agonist 3 is a thickened imidazole derivative compound. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 3 has the potential for the research of diabetes (extracted from patent WO2021197464A1, compound 1) .
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- HY-14664F
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(3R,5S)-XU 62-320
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HMG-CoA Reductase (HMGCR)
Autophagy
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Cancer
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(3R,5S)-Fluvastatin ((3R,5S)-XU 62-320) sodium is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway [3].
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- HY-W012864S1
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- HY-W012864S2
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- HY-135406
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- HY-139990
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c-Fms
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Cancer
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CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity .
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- HY-W010507
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Methyl (R)-(-)-3-hydroxybutyrate
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Biochemical Assay Reagents
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Others
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(R)-Methyl 3-hydroxybutanoate, (R)-Methyl 3-hydroxybutanoate is an enantiomer, from the perspective of the methyl (-CH3) group, the hydroxyl (-OH) group on the third carbon atom The group faces to the right, a colorless transparent liquid, soluble in organic solvents such as ethanol and ether, insoluble in water, (R)-Methyl 3-hydroxybutanoate is usually used to synthesize various organic compounds (including drugs, agricultural chemicals and flavoring agents) It can also be used as a chiral auxiliary in asymmetric synthetic reactions involving the formation of chemical bonds in a stereoselective manner.
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- HY-165859
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- HY-B0590B
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(+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine
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Monoamine Transporter
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Cancer
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(+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.
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- HY-158790
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Ferroptosis
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Cancer
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(R)-HTS-3 is an lysophosphatidylcholine acyltransferase 3 (LPCAT3) inhibitor, with an IC50 of 0.09 μM. (R)-HTS-3 suppresses the C20:4 content of PE, PC, and PS, while promoting a correspondingelevation in C22:4 phospholipids and a paradoxical increase in C20:4 phosphatidylinositol (PI) lipids .
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- HY-W338294S3
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Deoxycytidine-d2 (monohydrate); Cytosine deoxyriboside-d2 (monohydrate); Deoxyribose cytidine-d2 (monohydrate)
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Isotope-Labeled Compounds
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Others
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2'-Deoxycytidine-d2 (monohydrate) is the deuterium labeled (R)-2,3-Dihydroxypropanal[1].
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- HY-Z0790
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- HY-157398
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EGFR
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Cancer
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EGFR T790M/L858R-IN-3 (compound B1) is a EGFR L858R/T790M inhibitor with IC50 value of 13?nM. EGFR T790M/L858R-IN-3 shows anti-tumour activity in H1975 cells with an IC50 value of 0.087 μΜ. EGFR T790M/L858R-IN-3 inhibits cell migration in A549 cells and induces apoptosis in H1975 cells .
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- HY-40354D
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JAK
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Inflammation/Immunology
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(3R,4S)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC50 of 1 nM.
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- HY-60263
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PROTAC Linkers
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Others
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(3R)-3-Pyrrolidinemethanol is a molecular building block and the linker of NRX-0492 (HY-153357).
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- HY-116463A
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Sigma Receptor
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Neurological Disease
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(2R,3S)-E1R (Compound 2c) is an enantiomer of E1R. (2R,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders .
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- HY-116463B
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Sigma Receptor
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Neurological Disease
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(2S,3S)-E1R (Compound 2d) is an enantiomer of E1R. (2S,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders .
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- HY-116463C
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Sigma Receptor
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Neurological Disease
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(2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders .
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- HY-W001294
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Biochemical Assay Reagents
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Others
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(R)-(-)-Boc-3-pyrrolidinol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-14664B
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(3R,5S)-XU 62-320 free acid
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HMG-CoA Reductase (HMGCR)
Autophagy
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Cardiovascular Disease
Cancer
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(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway [3].
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- HY-159090
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Calcium Channel
Angiotensin Receptor
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Cardiovascular Disease
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AT1R antagonist 3 (Compound 1) is an antagonist for angiotensin II type 1 receptor (AT1R) and an inhibitor for calcium channel type-L CaV1.2 (IC50=0.57 μM). AT1R antagonist 3 exhibits vasodilation efficacy in solated rat aorta (10 μM, 88.7%) and antihypertensive efficacy in rat models .
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- HY-W008507S1
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- HY-N10167
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Others
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Others
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7-(6'R-Hydroxy-3',7'-dimethylocta-2',7'-dienyloxy)coumarin is a natural product .
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- HY-163150
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5-HT Receptor
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Neurological Disease
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5-HT6R antagonist 3 (compound 15) is a potent, selective and brain-penetrant 5-HT6R antagonist with Ki values of 14 nM, 3533 nM, 35 nM, 1449 nM for 5-HT6, 5-HT1A, 5-HT2A, 5-HT7, respectively. 5-HT6R antagonist 3 shows anxiolytic-like and properties neuroprotective and procognitive-like effects. 5-HT6R antagonist 3 has the potential for the research of Alzheimer’s Disease .
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- HY-159942
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5-HT Receptor
Dopamine Receptor
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Neurological Disease
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5-HT7R antagonist 3 (Compound 6.4) is a selective 5-HT7R antagonist (Ki: 8 nM), with Ki of 511 nM (D2), 8930 nM (5-HT1A) and 5786 nM (5-HT2A), respectively. 5-HT7R antagonist 3 possesses antidepressant and anxiolytic effects in mice .
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- HY-N8186
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Bacterial
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Infection
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(3R)-7,4’-Dihydrohomoisoflavanone is a natural product with antibacterial activities against S. aureus and methicillin-resistant Staphylococcus aureus (MRSA) .
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- HY-124242
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Others
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Cancer
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(S)-α-Methylbenzyl ricinoleamide (compound (R,S)-3d) is a fatty acid amide. (S)-α-Methylbenzyl ricinoleamide shows antiproliferative activity .
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- HY-N12992
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Others
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Others
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(3R)-3′,8-Dihydroxyvestitol (compound DO-9) is an isoflavonoid monomer that can be isolated from Dalbergia odorifera. I .
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- HY-N1976
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(3R,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol
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Bacterial
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Infection
Inflammation/Immunology
Cancer
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(+)-(3R,8S)-Falcarindiol is a polyacetylene found in carrots, has antimycobacterial activity, with an IC50 of 6 μM and MIC of 24 μM against Mycobacterium tuberculosis H37Ra . Antineoplastic and anti-inflammatory activity . (+)-(3R,8S)-Falcarindiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-146210
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EGFR
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Cancer
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EGFR-IN-50 (Compound 9h) is a potent EGFR inhibitor against L858R resistance mutation (TEL-EGFR-L858R-BaF3: GI50=8 nM, TEL-EGFR-T790M-L858R-BaF3: GI50=6.03 μM). EGFR-IN-50 shows anti-proliferative activity to cancer cells .
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- HY-W028142
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5-HT Receptor
SARS-CoV
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Neurological Disease
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Quipazine is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine behaves as a 5-HT3R agonist in peripheral models. Quipazine can be used for neurological disease research [3] .
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- HY-N0894A
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(3R,5R)-Hexahydrobisdemethoxycurcumin
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Drug Metabolite
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Neurological Disease
Inflammation/Immunology
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(3R,5R)-Octahydrocurcumin (Compound 7) is gut microbial metabolite of Curcumin (HY-N0005). (3R,5R)-Octahydrocurcumin exhibits neuroprotective efficacy against Aβ25-35-induced cell damage in SH-SY5Y, and anti-inflammatory activity against LPS-stimulated mouse microglial BV-2 .
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- HY-W125501
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-
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- HY-W336015
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(2R)-2,3-bis(heptadecanoyloxy)propyl hydrogen phosphate sodium
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Biochemical Assay Reagents
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Metabolic Disease
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1,2-Diheptadecanoyl-sn-glycero-3-phosphatidic acid (sodium) ((2R)-2,3-bis(heptadecanoyloxy)propyl hydrogen phosphate (sodium)) is an ester product.
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- HY-W440986S
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DSPS-d70 sodium
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Isotope-Labeled Compounds
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Others
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Distearoylphosphatidylserine-d70 (sodium) is deuterium labeled (S)-2-amino-2-carboxyethyl ((R)-2,3-bis(stearoyloxy)propyl) phosphate.
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- HY-149644
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- HY-108539A
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Ras
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Metabolic Disease
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(R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 μM). (R)-CE3F4 is more potent than racemic CE3F4 and (S)-CE3F4 .
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- HY-101046
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Quipazine dimaleate
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5-HT Receptor
SARS-CoV
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Neurological Disease
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Quipazine dimaleate is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine dimaleate shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine dimaleate behaves as a 5-HT3R antagonist in peripheral models. Quipazine dimaleate can be used for neurological disease research [3] .
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- HY-161366
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PI3K
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Cancer
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OMS14 is exhibits inhibitory activity for phosphoinositide 3-kinase γ (PI3Kγ) and PIK3CD/PIK3R1, which inhibits 19% PI3Kγ and 65% PIK3CD/PIK3R1 activity at 100 μM. OMS14 exhibits anticancer efficacy in various cancer cells .
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- HY-161567
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- HY-Z5058S
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- HY-W012864S
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- HY-W002421
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Biochemical Assay Reagents
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Others
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tert-butyl N-[(3R)-pyrrolidin-3-yl]carbamate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W344927
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(2R)-2,3-Bis(heptadecanoyloxy)propyl 2,3-dihydroxypropyl phosphate sodium
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Biochemical Assay Reagents
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Metabolic Disease
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1,2-Diheptadecanoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) ((2R)-2,3-Bis(heptadecanoyloxy)propyl 2,3-dihydroxypropyl phosphate (sodium)) is an ester product.
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- HY-100218C
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Drug Isomer
Ferroptosis
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Cancer
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(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .
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- HY-17504C
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HMG-CoA Reductase (HMGCR)
Potassium Channel
Autophagy
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Cardiovascular Disease
Metabolic Disease
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(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM . Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM . Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels [3].
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- HY-128720
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Endogenous Metabolite
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Metabolic Disease
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Diethyl oxalpropionate is an intermediate for poly((R,S)-3,3-dimethylmalic acid) (PDMMLA) derivative synthesis. PDMMLA derivative can be used in synthesis of nanoparticles and study of warfarin encapsulation and controlled release .
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- HY-169499
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Acyltransferase
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Metabolic Disease
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(R)-2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic Acid is an intermediate in the synthesis of the diacylglycerol acyltransferase 2 (DGAT-2) inhibitor Ervogastat.
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- HY-N9533
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Others
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Others
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16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid is a lanostanoid that can be found in the Sri Lankan basidiomycete Ganoderma applanatum .
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- HY-162506
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IGF-1R
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Cancer
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IGF-1R inhibitor-3 (Compound C11) is an allosteric inhibitor for insulin-like growth factor receptor 1 kinase (IGF-1R), with an IC50 of 0.2 μM .
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- HY-N12128
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Others
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Cancer
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Ophiopogonin R (compound 3) is a steroid saponin. Ophiopogonin R was isolated and purified from natural ophiopogonin. Ophiopogonin R was not cytotoxic to five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela) .
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- HY-N2207
-
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Others
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Others
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rel-(8R,8'R)-Dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan is a chemical constituent of the fruit of Myristica fragrans.
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- HY-W242887S2
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- HY-151663
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Fmoc-Abu(3-N3)-OH (2R,3R)
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ADC Linker
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Others
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Fmoc-Abu(3-N3) (Fmoc-Abu(3-N3)-OH) (2R,3R) is a click chemistry reagent containing an azide group. Fmoc-Abu(3-N3) (2R,3R) can be used for the research of various biochemical . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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- HY-W242887S3
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- HY-W735205
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Serotonin Transporter
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Neurological Disease
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(1R,4R)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride is a metabolite of the selective serotonin reuptake inhibitor (SSRI) Sertraline (HY-B0176A).
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- HY-N11983
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Others
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Others
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(25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside (compound 1) is a steroidal saponin , can be isolated from the roots of Ophiopogon japonicus .
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- HY-117272A
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Endogenous Metabolite
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Others
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(2R,3R)-2,3,4-Trihydroxybutanoic acid, also known as erythronic acid, is a naturally occurring organic acid found in the aqueous humor of the eye, as well as in urine, plasma, cerebrospinal fluid, and synovial fluid, prevalent in both healthy adults and children; it is produced through the oxidation of GlcNAc.
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- HY-135374
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Drug Metabolite
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Metabolic Disease
Inflammation/Immunology
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(3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively [3].
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- HY-103558
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mGluR
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Neurological Disease
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LY379268 is a potent, selective and brain-penetrant mGlu2/3R agonist with EC50 values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3). LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects .
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- HY-109022A
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- HY-153333
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Adenosine Receptor
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Cardiovascular Disease
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A1/A3 AR antagonist 3 is an A1R/A3R dual antagonist with high affinity at low-micromolar to low-nanomolar. A1/A3 AR antagonist 3 can be used for the research of chronic heart diseases .
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- HY-163452
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Others
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Metabolic Disease
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Squalene synthase-IN-2 (comppund isomer A-(1S, 3R)-14i) is an orally active squalene synthase inhibitor with IC50 values of 3.4, 99 nM for squalene synthase and cholesterol synthesis, respectively. Squalene synthase-IN-2 reduces plasma cholesterol and triglyceride .
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- HY-78746A
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Amino Acid Derivatives
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Others
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D-Proline, 3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-, (3S,4R,5S)-rel- is a proline derivative .
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- HY-100218A
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RSL3
Maximum Cited Publications
257 Publications Verification
(1S,3R)-RSL3
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p62
Glutathione Peroxidase
Ferroptosis
Reactive Oxygen Species
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Cancer
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RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .
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- HY-W654002
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
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(3R)-3-Hydroxybutyric acid-1- 13C is 13C labeled (R)-3-Hydroxybutanoic acid. (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones [3].
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- HY-B0072
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- HY-13326
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ASP3026
5 Publications Verification
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Anaplastic lymphoma kinase (ALK)
Apoptosis
ROS Kinase
Caspase
PARP
IGF-1R
STAT
Akt
JNK
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Cancer
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ASP3026 is a selective and orally active inhibitor of anaplastic lymphoma kinase (ALK). ASP3026 is a selective and oral active anaplastic lymphoma kinase (ALK) inhibitor with a IC50 value of 3.5 nM. ASP3026 can inhibit the phosphorylation of IGF-1R, STAT3, AKT and JNK proteins, and induce the cleavage of caspase 3 and PARP. It also inhibited ROS and ACK. ASP3026 can be used in anti-tumor research [3] .
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- HY-136057
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Ferroptosis
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Cancer
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iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A) .
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- HY-100218B
-
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Others
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Cancer
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(1R,3S)-RSL3 is the less active (1R,3S)-enantiomer of RSL3 ((1S,3R)-RSL3). (1R,3S)-RSL3 and RSL3 induce cell death in HT22 wild-type cells with EC50 values of 5.2 µM and 0.004 µM, rspectively .
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- HY-W414824
-
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Endogenous Metabolite
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Neurological Disease
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3β,7β-Dihydroxy-5-cholestenoic acid is a C27 acid that displays elevated levels in Niemann-Pick type C and Niemann-Pick type B diseases, contributing to toxicity in oculomotor neurons. It is synthesized from 3β-hydroxy-7-oxocholest-5-en-(25R)26-oic acid (3βH,7O-CA) through the enzymatic action of hydroxysteroid 11-β dehydrogenase 1.
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- HY-B0072S
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- HY-137390A
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Others
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Cardiovascular Disease
Metabolic Disease
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(3S,5R)-Fluvastatin (potassium) is a synthetic hypolipidemic drug that inhibits HMG-CoA reductase activity. (3S,5R)-Fluvastatin (potassium) has similar antioxidative effects on copper ion-induced LDL oxidation compared to its 3R,5S enantiomer. (3S,5R)-Fluvastatin (potassium) and its metabolites demonstrate a potential to exhibit anti-atherosclerotic effects through their antioxidative activities. (3S,5R)-Fluvastatin (potassium) is clinically utilized as part of a racemic mixture for reducing plasma cholesterol levels.
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- HY-10624
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THIQ
1 Publications Verification
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Melanocortin Receptor
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Metabolic Disease
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THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2 nM, EC50=2.1 nM) and rMC4R (IC50=0.6 nM, EC50=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants .
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- HY-144451
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Trk Receptor
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Cancer
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TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRK G595R IC50 = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC50 = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC50 = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line .
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- HY-Z4561S
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Isotope-Labeled Compounds
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Others
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Bortezomib trimer-d15 is deuterium labeled N,N',N''-((2S,2'S,2''S)-(((1R,1'R,1''R)-(1,3,5,2,4,6-Trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(1-oxo-3-phenylpropane-1,2-diyl))tris(pyrazine-2-carboxamide)(Bortezomib Impurity).
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- HY-10847B
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SB-277011A hydrochloride
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Dopamine Receptor
5-HT Receptor
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Neurological Disease
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SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally bioavailable and brain penetrate?dopamine D3?receptor (D3R)?antagonist with Ki values of 10.7?nM and?11.2 nM?at?rodent and human?D3R, respectively. SB-277011 hydrochloride displays 80- to 100-fold selectivity over other dopamine receptors with?pKis of 8.0, 6.0, <5.2, and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively .
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- HY-153357
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PROTACs
Btk
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Cancer
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NRX-0492 is an orally active PROTAC-class BTK degrader. NRX-0492 catalyzes BTK ubiquitination and proteasome degradation (DC50 ≤ 0.2 nM, DC90 ≤ 0.5 nM) . NRX-0492 inhibits B cell receptor (BCR) mediated signaling, transcription programs, and chemokine secretion. NRX-0492 can bind non-covalently to the BTK binding domain and cereblon, which is an adapter protein in the E3 ubiquitin ligase complex . NRX-0492 consists of a target protein ligand (red part) BTK-IN-40 (HY-170324), an E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383), and a PROTAC linker (black part) (3R)-3-Pyrrolidinemethanol (HY-60263). E3 ubiquitin ligase and linker can form Thalidomide 5-pyrrolidine-CHO (HY-49372A); the active control for the target protein ligand is BTK ligand 12 (HY-49421).
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- HY-162812
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Apoptosis
Cholinesterase (ChE)
Tau Protein
Ferroptosis
Histamine Receptor
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Neurological Disease
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H3R antagonist 4 (compound 11L) was a dual inhibitor of cholinesterase and histamine receptor (H3R), with corresponding IC50 of 7.04 μM (eeAChE), 9.73 μM (hAChE)(reversible) and 1.09 nM (H3R) , respectively. H3R antagonist 4 inhibited the aggregation of Aβ1-42 induced by itself and Cu 2+ (95.48% and 88.63%) , and degraded the Aβ1-42 fibrils induced by itself and Cu 2+ (80.16% and 89.30%) . H3R antagonist 4 chelate biometals such as Cu 2+, Zn 2+, Al 3+, and Fe 2+. H3R antagonist 4 significantly reduced tau protein hyperphosphorylation induced by Aβ1-42 and inhibited RSL-3-induced apoptosis and ferroptosis in PC12 cells. H3R antagonist 4 had the best blood-brain barrier permeability and intestinal absorption in hCMEC/D3 and hPepT1-MDCK cells.H3R antagonist 4 ameliorates learning and memory impairment in a mouse model of Alzheimer's disease induced by scopolamine (HY-N0296) .
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Cat. No. |
Product Name |
Type |
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- HY-W010507
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Methyl (R)-(-)-3-hydroxybutyrate
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Drug Delivery
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(R)-Methyl 3-hydroxybutanoate, (R)-Methyl 3-hydroxybutanoate is an enantiomer, from the perspective of the methyl (-CH3) group, the hydroxyl (-OH) group on the third carbon atom The group faces to the right, a colorless transparent liquid, soluble in organic solvents such as ethanol and ether, insoluble in water, (R)-Methyl 3-hydroxybutanoate is usually used to synthesize various organic compounds (including drugs, agricultural chemicals and flavoring agents) It can also be used as a chiral auxiliary in asymmetric synthetic reactions involving the formation of chemical bonds in a stereoselective manner.
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- HY-W001294
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Biochemical Assay Reagents
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(R)-(-)-Boc-3-pyrrolidinol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W002421
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Biochemical Assay Reagents
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tert-butyl N-[(3R)-pyrrolidin-3-yl]carbamate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W008507
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Cat. No. |
Product Name |
Target |
Research Area |
Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P99401
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OMP-131R10
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Inhibitory Antibodies
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Cancer
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Rosmantuzumab (OMP-131R10) is an anti-R-spondin 3 (RSPO3) humanized monoclonal antibody. Rosmantuzumab can be used for the research of advanced telapsed and refractory solid tumors .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
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- HY-77490
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- HY-N1976
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- HY-128720
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- HY-N12486A
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Structural Classification
Natural Products
Source classification
Umbelliferae
Plants
Mentha suaveolens Ehrh.
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Others
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(3S,8R,9R)-Isofalcarintriol is a natural polyacetylene compound found in carrot root parts. (3S,8R,9R)-Isofalcarintriol is a potent longevity promoter that improves glucose metabolism and has anti-tumor activity. (3S,8R,9R)-Isofalcarintriol can affect cellular respiration, interact with the α subunit of mitochondrial ATP synthase, and promote mitochondrial biogenesis. (3S,8R,9R)-Isofalcarintriol can be used in the study of neurodegenerative diseases, metabolic diseases, and aging .
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- HY-133872
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- HY-N10167
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- HY-N8186
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- HY-N12992
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- HY-N0894A
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- HY-N9533
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- HY-N12128
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- HY-N2207
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- HY-N11983
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Cat. No. |
Product Name |
Chemical Structure |
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- HY-W012864S2
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(2S,3R)-2,3,4-Trihydroxybutanal- 13C-2 is the 13C labeled (2S,3R)-2,3,4-Trihydroxybutanal[1].
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- HY-W008507S3
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(R)-2,3-Dihydroxypropanal-d is the deuterium labeled (R)-2,3-Dihydroxypropanal[1].
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- HY-W008507S2
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(R)-2,3-Dihydroxypropanal-d4 is the deuterium labeled (R)-2,3-Dihydroxypropanal[1].
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- HY-W008507S
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(R)-2,3-Dihydroxypropanal-3- 13C is the 13C labeled (R)-2,3-Dihydroxypropanal[1].
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- HY-W040185S
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(R)-2,3-Bis(tetradecanoyloxy)propyl phosphate-d54 (sodium) is deuterium labeled (R)-2,3-Bis(tetradecanoyloxy)propyl phosphate.
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- HY-W012864S1
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(2S,3R)-2,3,4-Trihydroxybutanal- 13C-1 is the 13C labeled (2S,3R)-2,3,4-Trihydroxybutanal[1].
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- HY-W338294S3
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2'-Deoxycytidine-d2 (monohydrate) is the deuterium labeled (R)-2,3-Dihydroxypropanal[1].
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- HY-W008507S1
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(R)-2,3-Dihydroxypropanal-d2 is the deuterium labeled 3-O-Methyl-D-glucopyranose[1].
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- HY-W440986S
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Distearoylphosphatidylserine-d70 (sodium) is deuterium labeled (S)-2-amino-2-carboxyethyl ((R)-2,3-bis(stearoyloxy)propyl) phosphate.
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- HY-Z5058S
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(3R,5S)-Fluvastatin-d7 (sodium) is the deuterium labeled (3R,5S)-Fluvastatin sodium[1].
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- HY-W012864S
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(2S,3R)-2,3,4-Trihydroxybutanal- 13C is the 13C labeled N-acetyl-D-talosamine[1].
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- HY-W242887S2
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D-Gulose- 13C is the 13C labeled (2R,3R,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal[1].
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- HY-W242887S3
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D-Gulose-1- 13C is the 13C labeled (2R,3R,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal[1].
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- HY-W654002
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(3R)-3-Hydroxybutyric acid-1- 13C is 13C labeled (R)-3-Hydroxybutanoic acid. (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones [3].
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- HY-B0072S
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Tropisetron-d5 (SDZ-ICS-930-d5 (free base)) is deuterium labeled Tropisetron. Tropisetron (SDZ-ICS-930 free base) is an orally active anti-inflammatory and antiemetic agent. Tropisetron is 5-HT3R antagonists with a Ki of 5.3 nM. Tropisetron is also a partial agonist of α7 nicotinic receptor (α7 nAChR) with an EC50 of 1.3 μM. In addition, Tropisetron has antitumor and neuroprotective effects [3] .
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- HY-Z4561S
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Bortezomib trimer-d15 is deuterium labeled N,N',N''-((2S,2'S,2''S)-(((1R,1'R,1''R)-(1,3,5,2,4,6-Trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(1-oxo-3-phenylpropane-1,2-diyl))tris(pyrazine-2-carboxamide)(Bortezomib Impurity).
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Cat. No. |
Product Name |
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Classification |
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- HY-151663
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Fmoc-Abu(3-N3)-OH (2R,3R)
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Azide
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Fmoc-Abu(3-N3) (Fmoc-Abu(3-N3)-OH) (2R,3R) is a click chemistry reagent containing an azide group. Fmoc-Abu(3-N3) (2R,3R) can be used for the research of various biochemical . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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