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Results for "

RAW macrophages

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Antibiotic (1) Apoptosis (5) Bacterial (4) Bcl-2 Family (1) Calmodulin (1) Caspase (1) COX (13) Dengue virus (1) Dipeptidyl Peptidase (1) Endogenous Metabolite (2) ERK (1) Flavivirus (1) Fluorescent Dye (1) Fungal (2) GLUT (1) HDAC (2) HIV Protease (1) IKK (2) Interleukin Related (7) JAK (1) JNK (1) Keap1-Nrf2 (3) Lipoxygenase (3) Mitochondrial Metabolism (1) Na+/H+ Exchanger (NHE) (1) nAChR (1) NF-κB (16) NO Synthase (16) NOD-like Receptor (NLR) (1) p38 MAPK (3) PAK (1) Parasite (1) Phosphodiesterase (PDE) (1) PPAR (1) Prostaglandin Receptor (1) PROTACs (1) Reactive Oxygen Species (4) STAT (1) TNF Receptor (11) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (3) Endocrinology (1) Infection (7) Inflammation/Immunology (62) Metabolic Disease (5) Neurological Disease (4)

By Targets:

Adrenergic Receptor (1)

Antibiotic (1)

Apoptosis (5)

Bacterial (4)

Bcl-2 Family (1)

Calmodulin (1)

Caspase (1)

COX (13)

Dengue virus (1)

Dipeptidyl Peptidase (1)

Endogenous Metabolite (2)

ERK (1)

Flavivirus (1)

Fluorescent Dye (1)

Fungal (2)

GLUT (1)

HDAC (2)

HIV Protease (1)

IKK (2)

Interleukin Related (7)

JAK (1)

JNK (1)

Keap1-Nrf2 (3)

Lipoxygenase (3)

Mitochondrial Metabolism (1)

Na+/H+ Exchanger (NHE) (1)

nAChR (1)

NF-κB (16)

NO Synthase (16)

NOD-like Receptor (NLR) (1)

p38 MAPK (3)

PAK (1)

Parasite (1)

Phosphodiesterase (PDE) (1)

PPAR (1)

Prostaglandin Receptor (1)

PROTACs (1)

Reactive Oxygen Species (4)

STAT (1)

TNF Receptor (11)

Toll-like Receptor (TLR) (2)

By Research Areas:

Cancer (6)

Cardiovascular Disease (3)

Endocrinology (1)

Infection (7)

Inflammation/Immunology (62)

Metabolic Disease (5)

Neurological Disease (4)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Targets Recommended: Macrophage migration inhibitory factor (MIF)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2620

Rutaevin	Reactive Oxygen Species	Inflammation/Immunology
Rutaevin is isolated from the fruits of Euodia rutaecarpa. Rutaevin inhibits NO production in LPS-induced RAW 264.7 macrophages .

HY-125531

Dactylorhin A	Others	Others
Dactylorhin A, a succinate derivative ester, is isolated from rhizomes of Gymnadenia conopsea. Dactylorhin A exhibits moderate inhibitory effects on NO production effects in RAW 264.7 macrophage cells .

HY-N0569

Madecassic acid 1 Publications Verification	NO Synthase COX TNF Receptor Interleukin Related	Inflammation/Immunology
Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells .

HY-N1912

Andropanolide	Others	Cancer
Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .

HY-N10297

Curindolizine	Others	Inflammation/Immunology
Curindolizine, indolizine alkaloid , displays an anti-inflammatory action in lipopolyssacharide (LPS)-induced RAW 264.7 macrophages with an IC₅₀ value of 5.31 μM .

HY-N8160

Dehydrocurdione	Keap1-Nrf2 Reactive Oxygen Species	Inflammation/Immunology
Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity .

HY-N10111

Siegesbeckialide I	IKK	Inflammation/Immunology
Siegesbeckialide I most potently inhibits LPS-induced NO production in RAW264.7 murine macrophages by directly binding to IKKα/β.

HY-N2838

Alismol	NO Synthase	Inflammation/Immunology
Alismol is a natural sesquiterpene. Alismol shows promising inhibitory effects on INF-γ-induced nitric oxide production in murine macrophage RAW264.7 cells .

HY-N11544

Inflexuside B	NO Synthase	Inflammation/Immunology
Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages .

HY-N11548

Inflexuside A	NO Synthase	Inflammation/Immunology
Inflexuside A, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO production (NO Synthase) in RAW264.7 macrophages .

HY-W573700

Methyl everninate	Others	Others
Methyl everninate is the major constituent of the deuterochloroform. Methyl everninate, rhodomollosides A and B are the derivatives of Methyl everninate, with cytotoxicity against RAW264.7 cells. Both of they shows inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model .

HY-N12283

NF-κB-IN-13	NF-κB	Inflammation/Immunology
NF-κB-IN-13 (compound 12) can significantly inhibit LPS-induced NF-κB activation and NO production in RAW264.7 macrophages. NF-κB-IN-13 has anti-inflammatory effects .

HY-N3289A

(E)-Methyl 3,4,5-trimethoxycinnamate	Others	Inflammation/Immunology
(E)-Methyl 3,4,5-trimethoxycinnamate is a bioactive natural phenylpropanoid. (E)-Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. (E)-Methyl 3,4,5-trimethoxycinnamate also has antiarrhythmic effect, leads to suppression of triggered activities in rabbit myocytes .

HY-N10114

Hyperectumine	Others	Inflammation/Immunology
Hyperectumine exhibits moderate anti-inflammatory activity via suppression of LPS-activated inflammatory mediators in RAW 264.7 macrophage cells.

HY-N13138

Angulasaponin B	NO Synthase	Inflammation/Immunology
Angulasaponin B, a natural product, can be obtained from Vigna angularis. Angulasaponin B inhibits nitric oxide production in LPS-activated RAW264.7 macrophages with IC₅₀ values ranging from 13 μM to 24 μM .

HY-N9000

Loganic acid 6′-O-β-D-glucoside	TNF Receptor	Inflammation/Immunology
Loganic acid 6′-O-β-D-glucoside, a iridoidal glucoside, is isolated from the whole plant of Gentiana rhodantha (Gentianaceae). Loganic acid 6′-O-β-D-glucoside inhibits LPS-induced NO and TNF-α production in macrophage RAW264.7 cells .

HY-N3383

Ligustroside Ligstroside	Mitochondrial Metabolism	Neurological Disease
Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages .

HY-129151

Ganoderic acid C1	Others	Inflammation/Immunology
Ganoderic acid C1, a natural compound that could be isolated from G. lucidum, suppresses TNF-α production by murine macrophages (RAW 264.7 cells) .

HY-N10865

Chloranthalactone E	NO Synthase	Inflammation/Immunology
Chloranthalactone E (compound 6), a labdane diterpene, can be isolated from the aerial parts of Chloranthus serratus. Chloranthalactone E inhibits NO production in LPS-activated RAW 264.7 macrophages .

HY-N11570

Phaeocaulisin E	Others	Inflammation/Immunology
Phaeocaulisin E (Compound 5) is a guaiane-type sesquiterpene that inhibits LPS HY-(HY-D1056)-induced NO production in RAW 264.7 macrophages with an IC₅₀ of 10.3 μM .

HY-153762

COX-2-IN-32	NO Synthase NF-κB COX	Inflammation/Immunology
COX-2-IN-32 (Compound 2f) is an iNOS and COX-2 inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC₅₀: 11.2 μM) .

HY-P1439A

RS 09 TFA 4 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
RS 09 TFA is a TLR4 agonist. RS 09 TFA promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. RS 09 TFA acts as an adjuvant in vivo; RS 09 TFA enhances X-15 specific antibody serum concentrations, when administered with X-15-KLH in mice.

HY-N6893

Ergolide 2 Publications Verification	NF-κB	Inflammation/Immunology
Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB .

HY-N11058

Damnacanthol	Lipoxygenase NO Synthase	Inflammation/Immunology
Damnacanthol is a natural product that can be isolated from Damnacanthus major . Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells .

HY-N2535

Coniferaldehyde 1 Publications Verification 4-Hydroxy-3-methoxycinnamaldehyde	Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

HY-115770

8-Methylsulfinyloctyl isothiocyanate	Bacterial	Inflammation/Immunology
8-Methylsulfinyloctyl isothiocyanate, an isothiocyanate, has antimicrobial activity and remarkable inhibitory activity against plant growth . 8-Methylsulfinyloctyl isothiocyanate impair COX-2 mediated inflammatory responses in LPS stimulated raw macrophages .

HY-N12767

Salixteroside D	p38 MAPK NF-κB	Inflammation/Immunology
Salixteroside D is a salicin derivative, that exhibits anti-inflammatory activity through inhibition of MAPK and NF-κB signaling pathways .

HY-153330

TNF-α-IN-10	Interleukin Related TNF Receptor	Inflammation/Immunology
TNF-α-IN-10 (compound 8a) is a IL-6 and TNF-α inhibitor. TNF-α-IN-10 shows anti-inflammatory activity .

HY-N0223

Epibetulinic acid	NO Synthase Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC₅₀s of 0.7 and 0.6 μM, respectively. Anti-inflammatory activity .

HY-110247

TRAF-STOP inhibitor 6877002 1 Publications Verification	TNF Receptor NF-κB	Cardiovascular Disease Inflammation/Immunology
TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques .

HY-124508

Lambertellin	Antibiotic Bacterial Fungal p38 MAPK NF-κB	Infection Inflammation/Immunology
Lambertellin is an effective antibiotic that can be used as a bactericide and as a fungicide. Lambertellin exerts its anti-inflammatory effect in LPS (HY-D1056)-stimulated RAW 264.7 macrophage cells by modulating the activation of the MAPK and NF-κB signaling pathways .

HY-128776

Antitumor agent-19	Others	Cancer
Antitumor agent-19 is an antitomor agent targeting *tumor-associated macrophages* (TAMs) to serve as an effective TAMs modulator. The EC₅₀** values of Antitumor agent-19 in the RAW 264.7 cells and the BMDM cells are 17.18 μM and 18.87 μM, respectively .

HY-N3552

Catalposide	NF-κB	Inflammation/Immunology
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .

HY-155820

Anti-inflammatory agent 54	NF-κB NO Synthase TNF Receptor Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 54 (compound 9c) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC₅₀: 2.4 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model .

HY-155821

Anti-inflammatory agent 55	NF-κB NO Synthase TNF Receptor Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC₅₀: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model .

HY-N2535R

Coniferaldehyde (Standard)	Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Coniferaldehyde (Standard) is the analytical standard of Coniferaldehyde. This product is intended for research and analytical applications. Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

HY-N7422

Kauran-16,17-diol ent-Kauran-16β,17-diol	Apoptosis	Inflammation/Immunology Cancer
Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC₅₀ of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages .

HY-126211

KBH-A42	HDAC	Inflammation/Immunology
KBH-A42 is a novel histone deacetylase (HDAC) inhibitor with significant anti-inflammatory properties. KBH-A42 against TNF-α and NO production with IC₅₀ values of 1.10 and 2.71 µM, respectively, in the LPS-induced murine macrophage RAW 264.7 cells .

HY-13982

JSH-23 Maximum Cited Publications 92 Publications Verification	NF-κB	Metabolic Disease Inflammation/Immunology Cancer
JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC₅₀ of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .

HY-129113

α-Chaconine	COX	Inflammation/Immunology
α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N2939

Bis-5,5-Nortrachelogenin	Others	Others
Bis-5,5-Nortrachelogenin is isolated from active extract of root of Wikstroemia indica. Bis-5,5-Nortrachelogenin inhibits nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-γ(IFN-γ) activated murine macrophage-like cell line, RAW 264.7 with an IC₅₀ value of 48.6 mM .

HY-B0386

Flunixin meglumine	COX	Inflammation/Immunology
Flunixin meglumine is a cyclooxygenase (COX) inhibitor with IC₅₀ values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin meglumine shows anti-inflammatory effects .

HY-B0386R

Flunixin meglumine (Standard)	COX	Inflammation/Immunology
Flunixin (meglumine) (Standard) is the analytical standard of Flunixin (meglumine). This product is intended for research and analytical applications. Flunixin meglumine is a cyclooxygenase (COX) inhibitor with IC50 values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin meglumine shows anti-inflammatory effects .

HY-121046

Flunixin Sch 14714	COX	Inflammation/Immunology
Flunixin is a cyclooxygenase (COX) inhibitor with IC₅₀ values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin shows anti-inflammatory effects .

HY-159669

Stercobilin hydrochloride (mixture of isomers)	HIV Protease	Infection Inflammation/Immunology
Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a K_i of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections .

HY-N10156

1,3,5-Trihydroxy-4-prenylxanthone	Na+/H+ Exchanger (NHE) Phosphodiesterase (PDE) NO Synthase	Inflammation/Immunology
1,3,5-Trihydroxy-4-prenylxanthone is a Na ⁺/H ⁺ exchange system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL . 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC₅₀ value of 3.0 μM . 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056))-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities .

HY-N0569R

Madecassic acid (Standard)	NO Synthase COX TNF Receptor Interleukin Related	Inflammation/Immunology
Madecassic acid (Standard) is the analytical standard of Madecassic acid. This product is intended for research and analytical applications. Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells .

HY-105825

Sermetacin SH-G 318AB	Endogenous Metabolite	Inflammation/Immunology
Sermetacin (SH-G 318AB) is an anti-inflammatory agent with biocompatibility and anti-inflammatory activity. Sermetacin is stable in saline and suitable for compound delivery. Sermetacin exhibits good biocompatibility in the RAW 264.7 mouse macrophage cell line. The anti-inflammatory response of sermetacin is comparable to that of its parent compound, indomethacin. Sermetacin may show potential in future applications of self-delivery of compound delivery .

HY-158402

Anti-inflammatory agent 84	Bacterial Fungal	Infection Inflammation/Immunology
Anti-inflammatory agent 84 (Compound 4D) is a derivative of Coumarin (HY-N0709) with antimicrobial and anti-inflammatory activities. Anti-inflammatory agent 84 inhibits E. coli, Candida albicans, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), with MIC of 312, 156, 19 and 316 μg/mL, respectively. Anti-inflammatory agent 84 inhibits biofilm formation of S. aureus, E. coli and MRSA, with IC₅₀ of 185, 321 and 99 μM, respectively. Anti-inflammatory agent 84 inhibits nitric oxide production in Lipopolysaccharide (HY-D1056)-stimulated RAW264.7 macrophage cell .

HY-W082785A

L6H21	TNF Receptor Interleukin Related Toll-like Receptor (TLR) NF-κB NOD-like Receptor (NLR) Apoptosis Caspase Bcl-2 Family Reactive Oxygen Species	Neurological Disease Metabolic Disease Inflammation/Immunology
L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low K_D value of 33.3?μM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages, with IC₅₀ values of 6.58 and 8.59 μM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research .

Cat. No.	Product Name	Type

HY-W013435

1,2-Diaminoanthraquinone	Fluorescent Dyes/Probes
1,2-Diaminoanthraquinone is a sensitivity, specificity and nontoxic nitric oxide (NO) fluorescent probe. 1,2-Diaminoanthraquinone can be used to detect NO productions in live cell and animals with a maximum of absorption at about 540 nm and a detection limit of 5 μM for NO .

Cat. No.	Product Name	Type

HY-159669

Stercobilin hydrochloride (mixture of isomers)

Cell Assay Reagents

Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a K_i of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections .

Cat. No.	Product Name	Target	Research Area

HY-P2624

st-Ht31	PAK	Metabolic Disease
st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage .

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