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S1P receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Aryl Hydrocarbon Receptor (3) Endogenous Metabolite (2) ERK (1) Fluorescent Dye (1) Isotope-Labeled Compounds (1) Leukotriene Receptor (2) LPL Receptor (58) PAK (1) Smo (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (8) Endocrinology (3) Infection (2) Inflammation/Immunology (40) Metabolic Disease (3) Neurological Disease (15)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101265

Icanbelimod S1P receptor agonist 1	LPL Receptor	Inflammation/Immunology
Icanbelimod (S1p receptor agonist 1) is a potent and orally active S1P receptor agonist, exhibits an activity of inducing S1P1 internalization (EC50=9.83 nM). Icanbelimod has the potential for the study of arthritis and EAE (experimental autoimmune encephalitis). Icanbelimod is extracted from patent WO2015039587A1, Compound 2.

HY-12288

Ozanimod 3 Publications Verification RPC-1063	LPL Receptor	Neurological Disease Inflammation/Immunology
Ozanimod (RPC-1063), a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod has modulate effect for hS1P₁ and hS1P₅ receptor with EC₅₀s of 1.03 nM and 8.6 nM, respectively. Ozanimod can be used for the research of relapsing multiple sclerosis (MS) .

HY-12288A

Ozanimod hydrochloride 3 Publications Verification RPC-1063 hydrochloride	LPL Receptor	Neurological Disease Inflammation/Immunology
Ozanimod (RPC-1063) hydrochloride, a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod hydrochloride has modulate effect for hS1P₁ and hS1P₅ receptor with EC₅₀s of 1.03 nM and 8.6 nM, respectively. Ozanimod hydrochloride can be used for the research of relapsing multiple sclerosis (MS) .

HY-12355

Siponimod 5+ Cited Publications BAF-312	LPL Receptor	Neurological Disease Inflammation/Immunology
Siponimod (BAF-312) is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for *S1P₁* and *S1P₅* over S1P₂, S1P₃, and S1P₄, with EC₅₀s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research ^- .

HY-148115

S1p receptor agonist 2	LPL Receptor	Inflammation/Immunology
S1p receptor agonist 2 (compound 1) is an agonist of **S1P5 receptor, exhibits selectivity over the S1P1 and/or S1P3 receptor*s. S1p* receptor agonist 2 can be used for endogenous SIP signaling system research, and alleviating or preventing CNS disorders research, such as neurodegenerative disorders .

HY-12288R

Ozanimod (Standard)	LPL Receptor	Neurological Disease Inflammation/Immunology
Ozanimod (Standard) is the analytical standard of Ozanimod. This product is intended for research and analytical applications. Ozanimod (RPC-1063), a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod has modulate effect for hS1P₁ and hS1P₅ receptor with EC₅₀s of 1.03 nM and 8.6 nM, respectively. Ozanimod can be used for the research of relapsing multiple sclerosis (MS) .

HY-12355A

Siponimod hemifumarate BAF-312 hemifumarate	LPL Receptor	Neurological Disease Inflammation/Immunology
Siponimod (BAF-312) hemifumarate is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod hemifumarate is selective for *S1P1* and *S1P5* receptors over S1P2, S1P3, and S1P4 (EC₅₀s of 0.39, 0.98, >10000, >1000, and 750 nM, respectively). Siponimod hemifumarate can be used for multiple sclerosis (MS) research .

HY-12355R

Siponimod (Standard)	LPL Receptor	Neurological Disease Inflammation/Immunology
Siponimod (Standard) is the analytical standard of Siponimod. This product is intended for research and analytical applications. Siponimod (BAF-312) is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for *S1P₁* and *S1P₅* over S1P₂, S1P₃, and S1P₄, with EC₅₀s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research ^- .

HY-148801

Tamuzimod	LPL Receptor	Inflammation/Immunology
Tamuzimod is a potent immunomodulator. Tamuzimod has **S1P Receptor modulatory activity with EC₅₀**s <1 μM .

HY-12005R

Fingolimod hydrochloride (Standard) FTY720 (Standard)	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod (hydrochloride) (Standard) is the analytical standard of Fingolimod (hydrochloride). This product is intended for research and analytical applications. Fingolimod hydrochloride (FTY720), an analog of sphingosine, is a potent sphingosine 1-phosphate (S1P) receptors modulator. Fingolimod hydrochloride is phosphorylated by sphingosine kinases, particularly by SK2, and then binds S1PR1, 3, 4, and 5. Fingolimod hydrochloride induces the internalization of S1P1, and consequently, inhibits S1P activity. Fingolimod hydrochloride also is a pak1 activator .

HY-15382

FTY720 (S)-Phosphate 1 Publications Verification (S)-FTY720P; (S)-FTY720 phosphate	LPL Receptor	Inflammation/Immunology
FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

HY-15382A

(S)-FTY720-phosphonate	LPL Receptor	Inflammation/Immunology
FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

HY-16734

Amiselimod MT-1303	LPL Receptor	Inflammation/Immunology
Amiselimod (MT-1303) is a modulator for sphingosine 1-phosphate receptor (S1P *receptor). Amiselimod converses to its active metabolite (S)-amiselimod phosphate by sphingosine kinases (SPHKs), targets S1P1 receptor*, ameliorates the autoimmune disease without causing bradycardia .

HY-158638

NBD-FTY720 phenoxy hydrochloride	Fluorescent Dye	Others
NBD-FTY720 phenoxy hydrochloride is a fluorescently-labeled analog of FTY720. FTY720 (HY-12005) is a potent sphingosine 1-phosphate (S1P) receptors modulator .

HY-108490

VPC 23019	LPL Receptor	Inflammation/Immunology
VPC 23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the *S1P1* and **S1P3 receptors (pK_i= 7.86 and 5.93, respectively) and an agonist at the S1P4 and S1P5** receptors (pEC₅₀= 6.58 and 7.07, respectively) .

HY-12685

Ceralifimod ONO-4641	LPL Receptor	Neurological Disease
Ceralifimod (ONO-4641) is selective, high potent agonist for sphingosine 1-phosphate receptors 1 and 5, with EC₅₀s of 27.3, 334 pM for human S1P receptor 1 and 5, respectively.

HY-119401

CAY10444 1 Publications Verification BML-241	LPL Receptor	Cancer
CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca²⁺ in HeLa cells expressing S1P3 receptors .

HY-135432

Etrasimod arginine APD334 arginine	LPL Receptor	Inflammation/Immunology
Etrasimod arginine is an orally available *S1P* receptor modulator that is a potent full agonist of the *S1P1 receptor* and has partial agonist activity at *S1P*4. Etrasimod arginine reduces inflammation in a CD4 ⁺CD45RB ^high T cell-transferred mouse colitis model .

HY-15381

Fingolimod phosphate 1 Publications Verification FTY720 phosphate	LPL Receptor	Infection Neurological Disease Inflammation/Immunology
Fingolimod phosphate (FTY720 phosphate) is an orally active sphingosine 1-phosphate (S1P) receptor agonist. Fingolimod phosphate can promote the neuroprotective effects of microglia. Fingolimod phosphate can be used for the research of multiple sclerosis and neurologic diseases .

HY-16734A

Amiselimod hydrochloride MT-1303 hydrochloride	LPL Receptor	Cancer
Amiselimod hydrochloride is an orally active novel sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. Amiselimod-P shows potent and high selectivity for *S1P1* and *S1P5* but with minimal agonist activity for *S1P4* and no distinct agonist activity for *S1P2* or *S1P3*. Amiselimod hydrochloride is promising for research of autoimmune diseases .

HY-148292

C16-Sphingosine-1-phosphate	LPL Receptor	Cardiovascular Disease Inflammation/Immunology
C16-Sphingosine-1-phosphate is a derivative of Sphingosine-1-phosphate and also an endogenous ligand for the *EDG/S1P* receptor. C16-Sphingosine-1-phosphate can be used in the research of angiogenesis, inflammation, and cardiovascular diseases .

HY-108496

Sphingosine-1-phosphate 5+ Cited Publications S1P	Endogenous Metabolite LPL Receptor	Endocrinology
Sphingosine-1-phosphate (S1P) is an agonist of **S1P_1-5 receptors** and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca ²⁺ as an extracellular ligand for G protein-coupled receptors . Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids .

HY-12355S

Siponimod-d11 BAF-312-d₁₁	LPL Receptor Isotope-Labeled Compounds	Neurological Disease Inflammation/Immunology
Siponimod-d11 is deuterium labeled Siponimod (HY-12355). Siponimod is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for *S1P₁* and *S1P₅* over *S1P₂, S1P₃, and S1P₄, with EC₅₀s* of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research .

HY-108496S

Sphingosine-1-phosphate-d7 S1P-d₇	Endogenous Metabolite LPL Receptor	Endocrinology
Sphingosine-1-phosphate-d₇ is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].

HY-110291

A-971432	Others	Neurological Disease
A-971432 is a potent, selective and orally active *sphingosine-1-phosphate (S1P) receptor* 5 agonist with IC₅₀*s of .362, >10, 0.006 µM for S1P1, S1P3, S1P*5 respectively. A-971432 protects blood–brain barrier (BBB) homeostasis. A-971432 reverses age-related cognitive decline. A-971432 has the potential for the research of alzheimer’s disease or multiple sclerosis .

HY-113934

L-threo Lysosphingomyelin (d18:1) L-threo-Sphingosylphosphorylcholine	LPL Receptor	Cancer
L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) is an endogenous bioactive sphingolipid. L-threo Lysosphingomyelin (d18:1) is a potent **S1P receptor agonist with EC₅₀**s of 19.3, 131.8, and 313.3 nM for hS1P₁, hS1P₃, and hS1P₂, respectively .

HY-115566

S1PL-IN-1	LPL Receptor Smo	Inflammation/Immunology
S1PL-IN-31 (compound ) is an oral active *sphingosine-1-phosphate (S1P) lyase* inhibitor with the IC₅₀ of 210 nM. S1PL-IN-31 is Smoothened receptor antagonist with the IC₅₀ of 440 nM. S1PL-IN-31 can be used for study of experimental autoimmune encephalomyelitis .

HY-119221A

AUY 954 hydrochloride	Others	Neurological Disease
AUY 954 hydrochloride is a potent and selective sphingosine-1-phosphate (S1P(1)) receptor agonist, exhibiting significant immunomodulatory activity. AUY 954 hydrochloride induces a profound and reversible reduction of circulating lymphocytes upon oral administration. AUY 954 hydrochloride has demonstrated efficacy in prolonging cardiac allograft survival when used in combination with RAD001 in a stringent transplantation model. AUY 954 hydrochloride effectively prevents experimental autoimmune neuritis in rats, showcasing its therapeutic potential in autoimmune conditions.

HY-148198

S1P5 receptor agonist-1	LPL Receptor	Inflammation/Immunology
S1P5 receptor agonist-1 (example 6) is a potent and selective agonist of **S1P₅ receptor with an EC₅₀** value of 20 nM .

HY-100953

CYM-5520	LPL Receptor	Metabolic Disease
CYM-5520 is a selective and allosteric *sphingosine 1-phosphate receptor* 2 (S1PR2) agonist with an EC₅₀** of 480 nM. CYM-5520 does not activate S1PR1, S1PR3, S1PR4 and S1PR5 receptors. CYM-5520 can co-bind in the S1PR2 receptor with S1P. CYM-5520 can be used for osteoporosis research .

HY-W011338

Benzyl butyl phthalate 1 Publications Verification	Aryl Hydrocarbon Receptor	Cancer
Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates *aryl hydrocarbon receptor* (AhR)** in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

HY-143864

S1PR1 agonist 1	LPL Receptor	Inflammation/Immunology
S1PR1 agonist 1 is a potent agonist of S1PR1. Sphingosine-1-phosphate (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 1 has the potential for the research of autoimmune diseases (extracted from patent WO2021175223A1, compound 22) .

HY-143865

S1PR1 agonist 2	LPL Receptor	Inflammation/Immunology
S1PR1 agonist 2 is a potent agonist of S1PR1. Sphingosine-1-phosphate (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 2 has the potential for the research of autoimmune diseases (extracted from patent WO2021175225A1, compound 1) .

HY-19989

MK-571 Maximum Cited Publications 24 Publications Verification L-660711	Leukotriene Receptor LPL Receptor	Inflammation/Immunology
MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D₄ (LTD₄) receptor antagonist, with K_i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release .

HY-14977

CS-0777-P	LPL Receptor	Inflammation/Immunology
CS-0777-P, the phosphorylated form of CS-0777, acts as a potent and selective modulator of the S1P receptor-1 (S1P1). It exhibits approximately 320-fold higher agonist activity for human S1P1 compared to S1P3, with an EC50 of 1.1 nM. In pharmacological studies, CS-0777-P demonstrated significant effects in vitro as an S1P1 and S1P3 agonist, leading to lowered peripheral blood lymphocyte counts and suppressive effects on experimental autoimmune encephalomyelitis (EAE) in rats. Pharmacokinetic studies in rats revealed rapid lymphocyte count reductions following oral administration, making CS-0777 a promising candidate currently undergoing clinical trials for the treatment of multiple sclerosis (MS) .

HY-19989A

MK-571 sodium L-660711 sodium	Leukotriene Receptor LPL Receptor	Inflammation/Immunology
MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D₄ (LTD₄) receptor antagonist, with K_i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release .

HY-W011338S

Benzyl butyl phthalate-d4	Aryl Hydrocarbon Receptor	Cancer
Benzyl butyl phthalate-d₄ is the deuterium labeled Benzyl butyl phthalate[1]. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs)[2][3][4].

HY-W011338R

Benzyl butyl phthalate (Standard)	Aryl Hydrocarbon Receptor	Cancer
Benzyl butyl phthalate (Standard) is the analytical standard of Benzyl butyl phthalate. This product is intended for research and analytical applications. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

HY-108494

CYM50260	LPL Receptor	Cardiovascular Disease
CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonist with an EC₅₀ of 45 nM. CYM50260 displays no activity against S1P₁-R, S1P₂-R, S1P₃-R and S1P₅-R .

HY-19511

GSK2018682	LPL Receptor	Inflammation/Immunology
GSK2018682 is an agonist for *S1P1* and **S1P5 receptor with pEC₅₀*s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P*4. GSK2018682 is used in the research of multiple sclerosis.

HY-19511A

GSK2018682 hydrochloride	LPL Receptor	Inflammation/Immunology
GSK2018682 hydrochloride is an agonist for *S1P1* and **S1P5 receptor with pEC₅₀*s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P*4. GSK2018682 hydrochloride is used in the research of multiple sclerosis.

HY-117213

Ex26 S1P1-IN-Ex26	LPL Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology
Ex26 (S1P1-IN-Ex26) is a potent and selective *sphingosine 1-phosphate receptor* 1** (S1P₁) antagonist (IC₅₀=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P₁ over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach .

HY-120468

GSK2263167	LPL Receptor	Inflammation/Immunology
GSK2263167 is a **S1P1 receptor** agonist

HY-108495

CYM50308 ML248	LPL Receptor	Cardiovascular Disease
CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P₄-R) agonist with an EC₅₀ of 56 nM. CYM50308 displays 37-fold more selective for *S1P₄-R* than S1P₅-R. CYM50308 has no activity at S1P₁-R, S1P₂-R and S1P₃-R subtypes at concentrations up to 25 μM .

HY-115831

SAR247799 S1P1 agonist 3	LPL Receptor	Cardiovascular Disease
SAR247799 (S1P1 agonist 3) is an oral activity, selective G-protein-biased *sphingosine-1 phosphate receptor-1 (S1P1 )* agonist, with EC₅₀s rang from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 can be used for the research of endothelial protection, including type-2 diabetes, metabolic syndrome .

HY-116146

CYM50179	LPL Receptor	Inflammation/Immunology
CYM50179 (compound 22n) is a potent and selective **S1P4-R (Sphingosine-1-phosphate4 receptor) agonist with an EC₅₀** of 46 nM .

HY-10968A

CYM5442 hydrochloride	LPL Receptor	Neurological Disease
CYM5442 hydrochloride is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC₅₀ of 1.35 nM. CYM5442 hydrochloride is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 hydrochloride activates *S1P1*-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 hydrochloride can easily penetrate the central nervous system (CNS) .

HY-10968

CYM5442 1 Publications Verification	LPL Receptor	Neurological Disease
CYM5442 is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC₅₀ of 1.35 nM. CYM5442 is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 activates *S1P1*-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 can easily penetrate the central nervous system (CNS) .

HY-19736

TY-52156 5+ Cited Publications	LPL Receptor	Cardiovascular Disease
TY-52156 is a potent and selective *S1P₃* receptor antagonist with a K_i value of 110 nM .

HY-111021

ASP-4058 1 Publications Verification	LPL Receptor	Inflammation/Immunology
ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 **(S1P₁ and S1P₅)**, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-108496

Sphingosine-1-phosphate 5+ Cited Publications S1P	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite LPL Receptor
Sphingosine-1-phosphate (S1P) is an agonist of **S1P_1-5 receptors** and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca ²⁺ as an extracellular ligand for G protein-coupled receptors . Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids .

Cat. No.	Product Name	Chemical Structure

HY-108496S

Sphingosine-1-phosphate-d7

Sphingosine-1-phosphate-d₇ is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].

HY-W011338S

Benzyl butyl phthalate-d4

Benzyl butyl phthalate-d₄ is the deuterium labeled Benzyl butyl phthalate[1]. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs)[2][3][4].

HY-12355S

Siponimod-d11

Siponimod-d11 is deuterium labeled Siponimod (HY-12355). Siponimod is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P₁ and S1P₅ over S1P₂, S1P₃, and S1P₄, with EC₅₀s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82614

	EDG3 Antibody (YA2359) S1PR3; EDG3; Sphingosine 1-phosphate receptor 3; S1P receptor 3; S1P3; Endothelial differentiation G-protein coupled receptor 3; Sphingosine 1-phosphate receptor Edg-3; S1P receptor Edg-3	WB	Human, Mouse, Rat
	EDG3 Antibody (YA2359) is a biotin-conjugated non-conjugated IgG antibody, targeting EDG3, with a predicted molecular weight of 42 kDa (observed band size: 42 kDa). EDG3 Antibody (YA2359) can be used for WB experiment in human, mouse, rat background.

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