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Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC50 values of 4 μM and 3.6 μM, respectively .
Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells .
TM4SF1 Human Pre-designed siRNA Set A contains three designed siRNAs for TM4SF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TM4SF19 Human Pre-designed siRNA Set A contains three designed siRNAs for TM4SF19 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TM4SF20 Human Pre-designed siRNA Set A contains three designed siRNAs for TM4SF20 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TM4SF4 Human Pre-designed siRNA Set A contains three designed siRNAs for TM4SF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TM4SF5 Human Pre-designed siRNA Set A contains three designed siRNAs for TM4SF5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cheilanthifoline, an alkaloid, is isolated from Corydalis calliantha. Cheilanthifoline exhibits antiplasmodial activities against Plasmodium falciparum, with IC50s of 0.90 μg/mL and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively .
Pparδ agonist 7 is a potent agonist of Pparδ. The peroxisome proliferator-activated receptor (PPAR) is a member of the intranuclear receptor transcription factor superfamily that plays a key role in the regulation of metabolic homeostasis, inflammation, cell growth and differentiation in vivo. Pparδ agonist 7 has the potential for the research of non-alcoholic fatty liver disease (NAFLD) (extracted from patent WO2019105234A1, compound TM4) .
DHFR-IN-20 (Compound LA1) is a Plasmodium falciparum dihydrofolate reductase (DHFR) inhibitor, with Kis of 0.16, 0.30, 6.6 nM for PfDHFR-WT, PfDHFR-QM, HsDHFR. DHFR-IN-20 has antimalarial activities (IC50: 1.4 nM and 1.6 μM for P. falciparum carrying the wild-type (TM4/8.2) and the quadruple mutant (V1/S) PfDHFR enzyme .
Flurochloridone (Standard) is the analytical standard of Flurochloridone. This product is intended for research and analytical applications. Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells .
PDdB-Pfp is a cleavable ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1) .
The Anti-TM4SF1 Antibody is a CHO-expressed human antibody that targets TM4SF1. The Anti-TM4SF1 Antibody is equipped with a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-TM4SF1 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC50 values of 4 μM and 3.6 μM, respectively .
Cheilanthifoline, an alkaloid, is isolated from Corydalis calliantha. Cheilanthifoline exhibits antiplasmodial activities against Plasmodium falciparum, with IC50s of 0.90 μg/mL and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively .
The TM4SF2/TSPAN7 protein may be involved in cell proliferation and motility and play a role in regulating these processes, but the specific mechanism remains unclear. Its involvement in proliferation suggests importance for cell growth, while its role in motility suggests a potential contribution to cell motility and migration. TM4SF2/TSPAN7 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TM4SF2/TSPAN7 protein, expressed by HEK293 , with C-His labeled tag. The total length of TM4SF2/TSPAN7 Protein, Mouse (HEK293, His) is 101 a.a., with molecular weight of 23-29 kDa.
TM4SF2/TSPAN7 protein is a highly expressed tetraspanin that is involved in synaptic transmission, neuronal morphogenesis, DCs, and osteoblast morphogenesis. Additionally, it plays a key role in tumorigenesis, promotion, and metastasis. TM4SF2/TSPAN7 Protein, Rat (HEK293, His) is the recombinant rat-derived TM4SF2/TSPAN7 protein, expressed by HEK293 , with N-His labeled tag. The total length of TM4SF2/TSPAN7 Protein, Rat (HEK293, His) is 101 a.a., with molecular weight of ~13.9 kDa.
The TM4SF2/TSPAN7 Protein, a crucial tetraspanin family member, plays an essential role in signal transduction, cell adhesion, and membrane organization. Its study enhances understanding of cell membrane dynamics and offers potential applications in cell biology and cancer research. Classification within the tetraspanin family emphasizes unique contributions to diverse physiological processes. Further exploration promises insights into TM4SF2/TSPAN7's role in both normal physiology and pathological conditions. TM4SF2/TSPAN7 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TM4SF2/TSPAN7 protein, expressed by HEK293, with N-His labeled tag. The total length of TM4SF2/TSPAN7 Protein, Cynomolgus (HEK293, His) is 101 a.a., with molecular weight of 20-28 kDa.
TM4SF2/TSPAN7 Protein is a member of the tetraspanin family. It mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN7 promotes apoptosis and inhibits tumor growth and cell cycle progression in BCa via the regulation of multiple key components of the PTEN/PI3K/AKT pathway. During cell differentiation, TSPAN7 emerges as a master regulator of morphological changes through cytoskeletal remodeling. TM4SF2/TSPAN7 Protein, Human (HEK293, His) is the recombinant human-derived TM4SF2/TSPAN7 protein, expressed by HEK293 , with C-His labeled tag. The total length of TM4SF2/TSPAN7 Protein, Human (HEK293, His) is 101 a.a., with molecular weight of 24-30 kDa.
TSPAN1 Protein is a member of the tetraspanin (TSPAN/TM4SF) family of proteins whose important feature is their ability to aggregate with one another or various other transmembrane receptors, to become TSPAN-enriched microdomains (TEMs). TSPAN1 functions as an oncoprotein in many cancer types, especially digestive malignancies such as hepatocellular carcinoma (HCC), pancreatic, gastric, colorectal, and esophageal cancers. TSPAN1 is a novel positive regulator of macroautophagy/autophagy characterized by decreased LC3-II and SQSTM1/p62 expressions, inhibited puncta formation of GFP-LC3 and autophagic vacuoles. TSPAN1 Protein, Human (HEK293, His) is the recombinant human-derived TSPAN1 protein, expressed by HEK293 , with N-His labeled tag. The total length of TSPAN1 Protein, Human (HEK293, His) is 102 a.a., with molecular weight of ~32 & 27 & 18 & 14 kDa, respectively.
The TM4SF2/TSPAN7 Protein, a crucial tetraspanin family member, plays an essential role in signal transduction, cell adhesion, and membrane organization. Its study enhances understanding of cell membrane dynamics and offers potential applications in cell biology and cancer research. Classification within the tetraspanin family emphasizes unique contributions to diverse physiological processes. Further exploration promises insights into TM4SF2/TSPAN7's role in both normal physiology and pathological conditions. TM4SF2/TSPAN7 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived TM4SF2/TSPAN7 protein, expressed by HEK293, with N-mFc labeled tag. The total length of TM4SF2/TSPAN7 Protein, Cynomolgus (HEK293, Fc) is 101 a.a., with molecular weight of 45-49 kDa.
TM4SF1 Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.
TM4SF1 Protein-VLP, Cynomolgus (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.
TSPAN1 Protein is a member of the tetraspanin (TSPAN/TM4SF) family of proteins whose important feature is their ability to aggregate with one another or various other transmembrane receptors, to become TSPAN-enriched microdomains (TEMs). TSPAN1 functions as an oncoprotein in many cancer types, especially digestive malignancies such as hepatocellular carcinoma (HCC), pancreatic, gastric, colorectal, and esophageal cancers. TSPAN1 is a novel positive regulator of macroautophagy/autophagy characterized by decreased LC3-II and SQSTM1/p62 expressions, inhibited puncta formation of GFP-LC3 and autophagic vacuoles. TSPAN1 Protein, Human (HEK293, rFc) is the recombinant human-derived TSPAN1 protein, expressed by HEK293 , with N-rFc labeled tag. The total length of TSPAN1 Protein, Human (HEK293, rFc) is 102 a.a., with molecular weight of 43-53 kDa.
TSPAN1 Protein is a member of the tetraspanin (TSPAN/TM4SF) family of proteins whose important feature is their ability to aggregate with one another or various other transmembrane receptors, to become TSPAN-enriched microdomains (TEMs). TSPAN1 functions as an oncoprotein in many cancer types, especially digestive malignancies such as hepatocellular carcinoma (HCC), pancreatic, gastric, colorectal, and esophageal cancers. TSPAN1 is a novel positive regulator of macroautophagy/autophagy characterized by decreased LC3-II and SQSTM1/p62 expressions, inhibited puncta formation of GFP-LC3 and autophagic vacuoles. TSPAN1 Protein, Human (HEK293, Fc) is the recombinant human-derived TSPAN1 protein, expressed by HEK293 , with N-mFc labeled tag. The total length of TSPAN1 Protein, Human (HEK293, Fc) is 102 a.a., with molecular weight of ~38.4 KDa.
TSPAN8 is a cell surface glycoprotein that is complexed with integrins and belongs to the four-span protein family. It has four hydrophobic domains. TSPAN8 mediates extracellular signal transduction processes and regulates cell development, activation, growth, and movement. In addition, TSPAN8 is expressed in different cancers and has potential roles in cancer prognosis and targeted therapy. TSPAN8 Protein, Human (HEK293, His) is the recombinant human-derived TSPAN8 protein, expressed by HEK293 , with N-His, N-6*His labeled tag. The total length of TSPAN8 Protein, Human (HEK293, His) is 96 a.a., with molecular weight of ~17 & 13 kDa, respectively.
TSPAN8 is a cell surface glycoprotein that is complexed with integrins and belongs to the four-span protein family. It has four hydrophobic domains. TSPAN8 mediates extracellular signal transduction processes and regulates cell development, activation, growth, and movement. In addition, TSPAN8 is expressed in different cancers and has potential roles in cancer prognosis and targeted therapy. TSPAN8 Protein, Human (HEK293, Fc) is the recombinant human-derived TSPAN8 protein, expressed by HEK293 , with N-mFc labeled tag. The total length of TSPAN8 Protein, Human (HEK293, Fc) is 96 a.a., with molecular weight of ~46 kDa.
TM4SF1 Human Pre-designed siRNA Set A contains three designed siRNAs for TM4SF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TM4SF19 Human Pre-designed siRNA Set A contains three designed siRNAs for TM4SF19 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TM4SF20 Human Pre-designed siRNA Set A contains three designed siRNAs for TM4SF20 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TM4SF4 Human Pre-designed siRNA Set A contains three designed siRNAs for TM4SF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
TM4SF5 Human Pre-designed siRNA Set A contains three designed siRNAs for TM4SF5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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