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Results for "

TTK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aurora Kinase (2) CDK (1) Histone Acetyltransferase (1) JAK (1) Ligands for Target Protein for PROTAC (2) Mps1 (15) Polo-like Kinase (PLK) (1) PROTACs (4) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (18) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116673

TTK21	Histone Acetyltransferase	Neurological Disease
TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 passes the blood–brain barrier, induces no toxicity, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP). TTK21 has beneficial implications for the brain functions of neurogenesis and long-term memory ^[1].CSP-TTK21 can ameliorate Aβ-impaired long-term potentiation (LTP). CSP-TTK21 may enhance the transcription of genes that promote synaptic health and cognitive function . CSP-TTK21 is orally effective and leads to improvements in motor functions, histone acetylation dynamics in a spinal injury rat model .

HY-143904

*PROTAC TTK* degrader-1**	PROTACs	Cancer
PROTAC TTK degrader-1 is a potent *TTK* (threonine tyrosine kinase) PROTAC degrader, with DC₅₀ values of 1.7 and 5.8 nM in COLO-205 and HCT-116 cell, respectively. PROTAC TTK degrader-1 exhibits target degradation and anticancer efficacy in a xenograft mouse model of COLO-205 human colorectal cancer cells .

HY-132884

TTK inhibitor 3	Mps1	Cancer
TTK inhibitor 3 is a potent and selective *TTK* (an essential spindle assembly checkpoint enzyme) inhibitor with an IC₅₀ value of 3.0 nM.

HY-168542

TTK ligand 2	Mps1 Ligands for Target Protein for PROTAC	Cancer
TTK ligand 2 is a monopolar spindle 1 (TTK) ligand that can be used in the synthesis of PROTACT (HY-168540) .

HY-168545

TTK ligand 3	Ligands for Target Protein for PROTAC Mps1	Cancer
TTK ligand 3 (Compound 5) is a ligand of monopolar spindle 1 (Mps1, TTK) that can be used in the synthesis of PROTAC (HY-168543) .

HY-162156

TTK inhibitor 4	Mps1	Cancer
TTK inhibitor 4 (compound 16) is a potent inhibitor of threonine tyrosine kinase (TTK), with the IC₅₀ value of 0.016 μM, that has anti-tumor activity .

HY-164955

TTK/PLK1-IN-1	Mps1 Polo-like Kinase (PLK)	Cancer
TTK/PLK1-IN-1 (Formula I) is the inhibitor for threonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1) with IC₅₀ of 7 nM and 72 nM. TTK/PLK1-IN-1 regulates spindle assembly checkpoint (SAC), and exhibits antitumor efficacy against TNBC .

HY-RS15226

TTK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TTK Human Pre-designed siRNA Set A contains three designed siRNAs for TTK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TTK Human Pre-designed siRNA Set A TTK Human Pre-designed siRNA Set A

HY-143905

*PROTAC TTK* degrader-2**	PROTACs	Cancer
PROTAC TTK degrader-2 is a potent *TTK* (threonine tyrosine kinase) PROTAC degrader, with DC₅₀ values of 3.1 and 12.4 nM in COLO-205 and HCT-116 cell, respectively. PROTAC TTK degrader-2 exhibits target degradation and anticancer efficacy in a xenograft mouse model of COLO-205 human colorectal cancer cells .

HY-144308

RMS-07	Mps1	Others
RMS-07 is a covalent Monopolar Spindle Kinase 1 (MPS1/TTK) inhibitor, with an apparent IC₅₀ of 13.1 nM. RMS-07 targets a poorly conserved cysteine in the kinase's hinge region .

HY-123675

CFI-400936	Mps1	Cancer
CFI-400936 is a potent *TTK* inhibitor with an IC₅₀ of 3.6 nM. CFI-400936 has antitumor activity .

HY-168543

PROTAC MPS1 degrader 2	PROTACs Aurora Kinase Mps1	Cancer
PROTAC MPS1 degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA and AURKB, with DC₅₀s of 42.0, 2.1 and 154.0 nM, respectively. PROTAC MPS1 degrader 1 can be used for the research of acute myeloid leukemia. (Pink: ligand for target protein (HY-168545); Black: linker (HY-N0420); Blue: ligand for E3 ligase (HY-10984) .

HY-168540

PROTAC MPS1 degrader 1	PROTACs Mps1 Aurora Kinase	Cancer
PROTAC MPS1 degrader 1 (Compound 19) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA and AURKB, with DC₅₀s of 17.7, 108.7 and 570.3 nM, respectively. PROTAC MPS1 degrader 1 can be used for the research of acute myeloid leukemia. (Pink: ligand for target protein (HY-168542); Black: linker (HY-W141926); Blue: ligand for E3 ligase (HY-10984) .

HY-101340A

Luvixasertib hydrochloride Maximum Cited Publications 6 Publications Verification CFI-402257 hydrochloride	Mps1	Cancer
CFI-402257 hydrochloride is a highly selective and orally bioavailable *TTK/Mps1* inhibitor with an IC₅₀ of 1.7 nM for TTK in vitro. CFI-402257 hydrochloride has anti-cancer activity .

HY-101340

Luvixasertib Maximum Cited Publications 6 Publications Verification CFI-402257	Mps1	Cancer
CFI-402257 is a highly selective and orally bioavailable *TTK/Mps1* inhibitor with an IC₅₀ of 1.7 nM for TTK in vitro. CFI-402257 has anti-cancer activity .

HY-108709

CC-671 1 Publications Verification	CDK	Cancer
CC-671 is a dual TTK protein kinase/CDC2-like kinase (CLK2) inhibitor with IC₅₀s of 0.005 and 0.006 μM for TTK and CLK2, respectively.

HY-14710

AZ3146 Maximum Cited Publications 6 Publications Verification	Mps1	Cancer
AZ3146 is a reasonably potent Mps1 and TTK inhibitor, with IC₅₀ of 35 nM for Mps1 ^Cat.

HY-160419

Mps1-IN-8	Mps1	Cancer
Mps1-IN-8 is a Mps1 inhibitor. Mps1-IN-8 can be used in the study of various tumors .

HY-100024

NTRC 0066-0	Mps1	Cancer
NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC₅₀=0.9 nM). NTRC 0066-0 can be used for the research of cancer .

HY-19544

JAK3-IN-1	JAK	Cancer
JAK3-IN-1 is a potent, selective and orally active JAK3 inhibitor with an IC₅₀ of 4.8 nM. JAK3-IN-1 shows over 180-fold more selective for JAK3 than JAK1 (IC₅₀ of 896 nM) and JAK2 (IC₅₀ of 1050 nM) .

HY-110347

Mps1-IN-1 dihydrochloride	Mps1	Cancer
Mps1-IN-1 dihydrochloride is a potent and ATP-competitive Mps1 kinase inhibitor with an IC₅₀ of 367 nM. Mps1-IN-1 dihydrochloride inhibit Mps1 mitotic kinase activity and abrogates spindle assembly checkpoint (SAC) function. Mps1-IN-1 dihydrochloride decreases the viability of both cancer and ‘normal’ cells .

Species:	Human (2)
Tag:	GST (1) Flag (2)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701653

	TTK Protein, Human (Sf9, GST, FLAG) TTK; Dual specificity protein kinase TTK; Phosphotyrosine picked threonine-protein kinase; PYT	Human	Sf9 insect cells
	The TTK protein is a highly efficient kinase that phosphorylates proteins on serine, threonine, and tyrosine residues, potentially regulating fundamental cellular processes. Notably, it phosphorylates MAD1L1, promoting mitotic checkpoint signaling, which is critical for accurate chromosome segregation. TTK Protein, Human (Sf9, GST, FLAG) is the recombinant human-derived TTK protein, expressed by Sf9 insect cells , with C-Flag, N-GST labeled tag and K857G, , , , mutation. The total length of TTK Protein, Human (Sf9, GST, FLAG) is 857 a.a., .

HY-P701654

	TTK Protein, Human (K857G, Sf9, FLAG) TTK; Dual specificity protein kinase TTK; Phosphotyrosine picked threonine-protein kinase; PYT	Human	Sf9 insect cells
	The TTK protein is a highly efficient kinase that phosphorylates proteins on serine, threonine, and tyrosine residues, potentially regulating fundamental cellular processes. Notably, it phosphorylates MAD1L1, promoting mitotic checkpoint signaling, which is critical for accurate chromosome segregation. TTK Protein, Human (K857G, Sf9, FLAG) is the recombinant human-derived TTK protein, expressed by Sf9 insect cells , with C-Flag labeled tag and K857G mutation.

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TTK Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TTK Human Pre-designed siRNA Set A contains three designed siRNAs for TTK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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