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Taste Receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Taste Receptor (8) 5-HT Receptor (1) Bacterial (3) Biochemical Assay Reagents (1) Cannabinoid Receptor (1) Endogenous Metabolite (1) Fluorescent Dye (1) P2X Receptor (1) Parasite (3)
By Research Areas:	Endocrinology (1) Infection (3) Inflammation/Immunology (2) Metabolic Disease (4)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: Taste Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100047

Nα,Nα-Bis(carboxymethyl)-L-lysine	Taste Receptor	Others
Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of *bitter taste* receptor 4, with an IC₅₀** of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .

HY-139091

FEMA 4774	Taste Receptor	Others
FEMA 4774 is a positive allosteric modulator of taste receptors T1R2 and T1R3, two subunits of the human sweet taste receptor. FEMA 4774 is also used as a sucrose sweetness enhancer .

HY-N2084

Perillartine DL-Perillartine	Endogenous Metabolite	Others
Perillartine is a sweetener, which activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner.

HY-W030796A

Lactisole	Taste Receptor	Metabolic Disease
Lactisole is a canonical antagonist of sweet **taste receptor, selectively targeting to T1R3** subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets .

HY-N0742

Absinthin	Others	Others
Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca ²⁺-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .

HY-136352

Adenosine 5'-succinate	Taste Receptor	Others
Adenosine 5'-succinate is a chemically AMP-related compound and potently inhibits Denatonium benzoate/taste receptor activation of transducin .

HY-19158

Org 13011	5-HT Receptor	Others
Org 13011 is a central nervous system-active 5-HT1A receptor agonist that induces conditioned taste aversion.

HY-W030796

Lactisole free acid	Taste Receptor	Metabolic Disease
Lactisole free acid is a canonical antagonist of sweet **taste receptor, selectively targeting to T1R3** subunit, a glucose-sensing receptor. Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets .

HY-117868

NC-174 CP-Dpm-GA	Fluorescent Dye	Others
NC-174 is a super-strong guanidine compound that is sweeter than sucrose. NC-174 is more than 300,000 times sweeter than sucrose and has the potential to be a probe for sweet taste receptors .

HY-124956

GIV3727	Taste Receptor	Others
GIV3727 is a bitter taste receptor hTAS2R antagonist, which can inhibit the activation of hTAS2R31 by saccharin and acesulfame potassium, and can effectively reduce the bitter quality of food, beverage and medicine .

HY-D0887

Disodium 5'-inosinate 1 Publications Verification IMP disodium salt; Disodium inosinate	Biochemical Assay Reagents	Metabolic Disease
Disodium 5'-inosinate (IMP disodium salt) is a nucleotide-based umami agent. Disodium 5'-inosinate can bind to umami receptors and stimulate taste nerves, allowing the brain to perceive umami. In addition, Disodium 5'-inosinate produces a transient behavioral excitement in mice .

HY-N0742R

Absinthin (Standard)	Others	Others
Absinthin (Standard) is the analytical standard of Absinthin. This product is intended for research and analytical applications. Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca2+-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .

HY-136026

Camlipixant BLU-5937	P2X Receptor	Inflammation/Immunology
Camlipixant (BLU-5937) a potent, selective, non-competitive and orally active P2X3 homotrimeric receptor antagonist with an IC₅₀ of 25 nM against hP2X3 homotrimeric. Camlipixant shows potent anti-tussive effect and no taste alteration. Camlipixant can be used for the research of unexplained, refractory chronic cough .

HY-B1146

Denatonium benzoate 1 Publications Verification THS-839	Taste Receptor	Inflammation/Immunology Endocrinology
Denatonium benzoate (THS-839) is known as the most bitter compound and is commonly used as a deterrent (bittering agent) to activate different types of bitter taste receptors (TAS2Rs) with oral activity. Denatonium benzoate can enhance insulin secretion, has anti-inflammatory effects, and promotes allergy susceptibility .

HY-136429

Ethylhydrocupreine Optochin	Bacterial Parasite	Infection
Ethylhydrocupreine (Optochin) is a quinine derivate with antimicrobial activity against *S. pneumoniae. Ethylhydrocupreine also possesses antimalarial activity against Plasmodium falciparum, with an IC₅₀* of 25.75 nM. Ethylhydrocupreine is a **Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7**) agonist .

HY-136429A

Ethylhydrocupreine hydrochloride Optochin hydrochloride	Bacterial Parasite	Infection
Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against *S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC₅₀* of 25.75 nM. Ethylhydrocupreine hydrochloride is a **Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7**) agonist .

HY-136429AR

Ethylhydrocupreine (hydrochloride) (Standard)	Bacterial Parasite	Infection
Ethylhydrocupreine (hydrochloride) (Standard) is the analytical standard of Ethylhydrocupreine (hydrochloride). This product is intended for research and analytical applications. Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC₅₀ of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist .

HY-153264

TAS2R14 agonist-1	Taste Receptor	Others
TAS2R14 agonist is a potent TAS2R14 partial agonist with an EC₅₀ of 116.6 ±23.6 nM .

HY-110206

AM6545	Cannabinoid Receptor	Metabolic Disease
AM6545 is a highly selective, brain-free (peripherally active) CB1 receptor antagonist (K_i=1.7 nM). AM6545 inhibits endocannabinoid signaling by competitively antagonizing CB1 receptors, inhibiting CB1-mediated appetite stimulation and inflammatory responses without affecting cAMP levels. AM6545 significantly reduces food intake and body weight in mice, while improving metabolic syndrome-related renal impairment (such as proteinuria, fibrosis) and insulin resistance. AM6545 can be used in the study of obesity and its complications .

Cat. No.	Product Name	Target	Research Area

HY-100047

Nα,Nα-Bis(carboxymethyl)-L-lysine	Taste Receptor	Others
Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of *bitter taste* receptor 4, with an IC₅₀** of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .

Perillartine DL-Perillartine	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Sweeteners Food Research	Endogenous Metabolite
Perillartine is a sweetener, which activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner.

Absinthin	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Plants Acacia confusa Merr. Compositae Disease Research Fields	Others
Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca ²⁺-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .

Disodium 5'-inosinate 1 Publications Verification IMP disodium salt; Disodium inosinate	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Disease Research Fields Food Research	Biochemical Assay Reagents
Disodium 5'-inosinate (IMP disodium salt) is a nucleotide-based umami agent. Disodium 5'-inosinate can bind to umami receptors and stimulate taste nerves, allowing the brain to perceive umami. In addition, Disodium 5'-inosinate produces a transient behavioral excitement in mice .

Absinthin (Standard)	Triterpenes Structural Classification Terpenoids Source classification Plants Acacia confusa Merr. Compositae	Others
Absinthin (Standard) is the analytical standard of Absinthin. This product is intended for research and analytical applications. Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca2+-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .

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Taste Receptor

Inhibitors & Agonists

Peptides

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Natural
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