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Thyroid-stimulating hormone Receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TSH Receptor (4) Estrogen Receptor/ERR (1)
By Research Areas:	Cancer (1) Endocrinology (5) Metabolic Disease (1)

5

Inhibitors & Agonists

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Peptides

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Recombinant Proteins

1

Antibodies

Targets Recommended: Thyroid Hormone Receptor TSH Receptor Nuclear Hormone Receptor 4A/NR4A PTHR GHR GHSR GnRH Receptor MCHR1 (GPR24) c-Fms

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

VA-K-14 hydrochloride	TSH Receptor	Endocrinology
VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC₅₀= 12.3 μM) .

Org41841	TSH Receptor	Endocrinology
Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC₅₀s of 0.2 and 7.7 μM, respectively.

ADX61623	Estrogen Receptor/ERR	Endocrinology
ADX61623 is a potent *follicle stimulating hormone* (FSH) receptor (FSHR)** negative allosteric modulator (NAM). ADX61623 shows luteinizing hormone receptor (LH-R) activity and is not active on thyroid-stimulating hormone (TSH) receptors. ADX61623 can be used for the study of estrogen dependent disease .

ML-109	TSH Receptor	Metabolic Disease Endocrinology
ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC₅₀ of 40 nM.

NCATS-SM4420	TSH Receptor	Cancer
NCATS-SM4420 (Compound A35) is an orally active thyroid-stimulating hormone receptor (TSHR) ligand that inhibits the proliferation of MDA-T32 and MDA-T85 cells in vitro (IC₅₀ values of 0.71 μM and 0.38 μM, respectively) and suppresses metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds promise for research in the field of thyroid cancer .

Cat. No.	Product Name	Target	Research Area

PGlu-3-methyl-His-Pro-NH2 TFA A-42872 TFA	Peptides	Endocrinology
PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA), the modified thyrotropin-releasing hormone (TRH) peptide, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary. The in vitro permeability of PGlu-3-methyl-His-Pro-NH2 TFA through rat skin is increased in the presence of enhancers Ethanol and Cineole .

Cat. No.	Compare	Product Name	Species	Source

	TSHR Protein, Human (sf9, His) Thyrotropin Receptor; TSH-R; LGR3; CHNG1	Human	Sf9 insect cells
	TSHR, a membrane protein, is a key regulator of thyroid cell metabolism. As a receptor for thyrothropin and thyrostimulin, its activity involves adenylate cyclase. Gene defects contribute to various hyperthyroidism types. The gene exhibits restricted expression in the thyroid (RPKM 104.1). TSHR Protein, Human (sf9, His) is the recombinant human-derived TSHR protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of TSHR Protein, Human (sf9, His) is 393 a.a., with molecular weight (affected by relative charge) of ~60 KDa.

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	TSH Receptor/TSH-R Antibody (YA1252) LGR3; TSHR; Thyrotropin Receptor; Thyroid-stimulating hormone Receptor (TSH-R)	IHC-P	Human
	TSH Receptor/TSH-R Antibody (YA1252) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1252), targeting TSH Receptor/TSH-R. TSH Receptor/TSH-R Antibody (YA1252) can be used for IHC-P experiment in human background.

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