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Trichothecene

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Antibiotic (2) Apoptosis (3) Bacterial (2) Bcl-2 Family (1) Caspase (1) Cytochrome P450 (1) Drug Metabolite (3) Endogenous Metabolite (1) Fungal (2) Isotope-Labeled Compounds (3) JNK (1) P-glycoprotein (2) p38 MAPK (1) PARP (1) PI3K (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (3) Infection (5) Metabolic Disease (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6799

Neosolaniol	Others	Infection
Neosolaniol is a type A trichothecene mycotoxin from Fusarium sp . Neosolaniol evokes robust anorectic response .

HY-N6684

Deoxynivalenol 5+ Cited Publications Vomitoxin	P-glycoprotein	Metabolic Disease
Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-N6683

15-Acetyl-deoxynivalenol	Drug Metabolite	Cancer
15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals, and a metabolite of deoxynivalenol, exhibits toxicity to HepG2 cells .

HY-N10229

Harzianum A	Fungal	Infection
Harzianum A is a trichothecene compound. Harzianum A has no antibacterial activity against Gram-negative and Gram-positive bacteria, but has antifungal activity. In addition, Harzianum A is cytotoxic to tumor cells .

HY-157474

(-)-Verrucarol	Drug Metabolite	Cancer
(-)-verrucarol is a trichothecene sesquiterpenoid obtained as a hydrolysis product of the naturally occurring Verrucarin A (HY-107426). Verrucarol can be used to study cancers .

HY-N6799R

Neosolaniol (Standard)	Others	Infection
Neosolaniol (Standard) is the analytical standard of Neosolaniol. This product is intended for research and analytical applications. Neosolaniol is a type A trichothecene mycotoxin from Fusarium sp . Neosolaniol evokes robust anorectic response .

HY-N6684R

Deoxynivalenol (Standard)	P-glycoprotein	Metabolic Disease
Deoxynivalenol (Standard) is the analytical standard of Deoxynivalenol. This product is intended for research and analytical applications. Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-123647

Satratoxin H	Apoptosis p38 MAPK	Cancer
Satratoxin H is a trichothecene with cytotoxic activity. Satratoxin H can be used for cytotoxicological studies on lymphoid cell lines .

HY-N6685

3-Acetyldeoxynivalenol	Others	Cardiovascular Disease
3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative , is a blood-brain barrier (BBB) permeable mycotoxin .

HY-N6685R

3-Acetyldeoxynivalenol (Standard)	Others	Cardiovascular Disease
3-Acetyldeoxynivalenol (Standard) is the analytical standard of 3-Acetyldeoxynivalenol. This product is intended for research and analytical applications. 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative , is a blood-brain barrier (BBB) permeable mycotoxin .

HY-N6683R

15-Acetyl-deoxynivalenol (Standard)	Drug Metabolite	Cancer
15-Acetyl-deoxynivalenol (Standard) is the analytical standard of 15-Acetyl-deoxynivalenol. This product is intended for research and analytical applications. 15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals, and a metabolite of deoxynivalenol, exhibits toxicity to HepG2 cells .

HY-W014118S

α-Hexylcinnamaldehyde-d5	Isotope-Labeled Compounds	Cancer
α-Hexylcinnamaldehyde-d₅ is deuterated labeled Diacetoxyscirpenol (HY-N6692). Diacetoxyscirpenol (DAS) is a trichothecene mycotoxin, a secondary metabolite product of fungi. Diacetoxyscirpenol (DAS) consumption induces haematological disorders (neutropenia, aplastic anemia) in human and animals .

HY-131055

Mytoxin B	ADC Cytotoxin PI3K Apoptosis	Cancer
Mytoxin B is an ADC cytotoxin. Mytoxin B is a satratoxin-type trichothecene macrolide and is similar to the effect of LY294002 (HY-10108). Mytoxin B induces cell apoptosis via PI3K/Akt pathway .

HY-N6685S1

3-Acetyldeoxynivalenol-13C17	Isotope-Labeled Compounds	Cardiovascular Disease
3-Acetyldeoxynivalenol- ¹³C₁₇ is the ¹³C labeled 3-Acetyldeoxynivalenol (HY-N6685) . 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative , is a blood-brain barrier (BBB) permeable mycotoxin .

HY-N6683S1

15-Acetyl-deoxynivalenol-13C17	Isotope-Labeled Compounds	Cancer
15-Acetyl-deoxynivalenol- ¹³C₁₇ is the ¹³C labeled 15-Acetyl-deoxynivalenol (HY-N6683) . 15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals, and a metabolite of deoxynivalenol, exhibits toxicity to HepG2 cells .

HY-N11422R

Mycaminosyltylonolide (Standard)	Antibiotic Bacterial	Infection
Deoxynivalenol (Standard) is the analytical standard of Deoxynivalenol. This product is intended for research and analytical applications. Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-N6720

T-2 Triol	Endogenous Metabolite	Metabolic Disease
T-2 Triol is a trichothecene mycotoxin derived by the metabolism of T-2 toxin. It is less toxic than T-2 toxin . T-2 Triol major metabolites are evaluated in broiler chickens with Half-lives (t_1/2λz), Peak plasma concentrations (C_max) and T_max values of 9.6 mins, 563 ng/ml , 2.5 mins, respectively .

HY-N8508

Myrothecine A	Apoptosis Cytochrome P450 PARP JNK Bcl-2 Family Caspase	Cancer
Myrothecine A is a trichothecene mycotoxin found in M. roridum. Myrothecine A induces apoptosis, promotes the cytochrome c release, PARP-cleavage and phosphorylation of JNK, increases Bax and cleaved caspase-3, -5, and -8 levels. Myrothecine A has anticancer activities and promotes the maturation of DC cells in the microenvironment. Myrothecine A inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells with IC₅₀s of 95, 70, 60, and 25 µM, respectively .

HY-N7432

DIMBOA	Antibiotic Bacterial Fungal	Infection
DIMBOA, an antibiotic, has antibacterial properties and inhibits bacteria such as Staphylococcus aureus and the mycotoxin-producing fungus Fusarium graminearum (which causes scab). DIMBOA exhibits strong free radical scavenging activity and weak iron(III) ion reducing activity, and has antioxidant activity. DIMBOA inhibits the biosynthesis and accumulation of toxic trichothecenes by affecting the expression of Tri6 and Tri5. DIMBOA reduces plant susceptibility to scab. DIMBOA also exhibits cytotoxicity to plant cells, causing plasmolysis, cell collapse, and cell rupture .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6799

Neosolaniol	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Others
Neosolaniol is a type A trichothecene mycotoxin from Fusarium sp . Neosolaniol evokes robust anorectic response .

HY-N6684

Deoxynivalenol 5+ Cited Publications Vomitoxin	Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Metabolic Disease Disease Research Fields	P-glycoprotein
Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-N6683

15-Acetyl-deoxynivalenol	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	Drug Metabolite
15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals, and a metabolite of deoxynivalenol, exhibits toxicity to HepG2 cells .

HY-N10229

Harzianum A	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Fungal
Harzianum A is a trichothecene compound. Harzianum A has no antibacterial activity against Gram-negative and Gram-positive bacteria, but has antifungal activity. In addition, Harzianum A is cytotoxic to tumor cells .

HY-157474

(-)-Verrucarol	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Drug Metabolite
(-)-verrucarol is a trichothecene sesquiterpenoid obtained as a hydrolysis product of the naturally occurring Verrucarin A (HY-107426). Verrucarol can be used to study cancers .

HY-N6799R

Neosolaniol (Standard)	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Others
Neosolaniol (Standard) is the analytical standard of Neosolaniol. This product is intended for research and analytical applications. Neosolaniol is a type A trichothecene mycotoxin from Fusarium sp . Neosolaniol evokes robust anorectic response .

HY-N6684R

Deoxynivalenol (Standard)	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	P-glycoprotein
Deoxynivalenol (Standard) is the analytical standard of Deoxynivalenol. This product is intended for research and analytical applications. Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-123647

Satratoxin H	Structural Classification Natural Products Microorganisms Source classification	Apoptosis p38 MAPK
Satratoxin H is a trichothecene with cytotoxic activity. Satratoxin H can be used for cytotoxicological studies on lymphoid cell lines .

HY-N6685

3-Acetyldeoxynivalenol	Cardiovascular Disease Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Others
3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative , is a blood-brain barrier (BBB) permeable mycotoxin .

HY-N6685R

3-Acetyldeoxynivalenol (Standard)	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Others
3-Acetyldeoxynivalenol (Standard) is the analytical standard of 3-Acetyldeoxynivalenol. This product is intended for research and analytical applications. 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative , is a blood-brain barrier (BBB) permeable mycotoxin .

HY-N6683R

15-Acetyl-deoxynivalenol (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Source classification Plants	Drug Metabolite
15-Acetyl-deoxynivalenol (Standard) is the analytical standard of 15-Acetyl-deoxynivalenol. This product is intended for research and analytical applications. 15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals, and a metabolite of deoxynivalenol, exhibits toxicity to HepG2 cells .

HY-N11422R

Mycaminosyltylonolide (Standard)	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research	Antibiotic Bacterial
Deoxynivalenol (Standard) is the analytical standard of Deoxynivalenol. This product is intended for research and analytical applications. Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-N6720

T-2 Triol	Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
T-2 Triol is a trichothecene mycotoxin derived by the metabolism of T-2 toxin. It is less toxic than T-2 toxin . T-2 Triol major metabolites are evaluated in broiler chickens with Half-lives (t_1/2λz), Peak plasma concentrations (C_max) and T_max values of 9.6 mins, 563 ng/ml , 2.5 mins, respectively .

HY-N8508

Myrothecine A	Structural Classification Natural Products Microorganisms Source classification	Apoptosis Cytochrome P450 PARP JNK Bcl-2 Family Caspase
Myrothecine A is a trichothecene mycotoxin found in M. roridum. Myrothecine A induces apoptosis, promotes the cytochrome c release, PARP-cleavage and phosphorylation of JNK, increases Bax and cleaved caspase-3, -5, and -8 levels. Myrothecine A has anticancer activities and promotes the maturation of DC cells in the microenvironment. Myrothecine A inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells with IC₅₀s of 95, 70, 60, and 25 µM, respectively .

HY-N7432

DIMBOA	Infection Structural Classification Zea mays L. Classification of Application Fields Antibiotics Gramineae Source classification Antibacterial Disease Research Plants Disease Research Fields Other Antibiotics	Antibiotic Bacterial Fungal
DIMBOA, an antibiotic, has antibacterial properties and inhibits bacteria such as Staphylococcus aureus and the mycotoxin-producing fungus Fusarium graminearum (which causes scab). DIMBOA exhibits strong free radical scavenging activity and weak iron(III) ion reducing activity, and has antioxidant activity. DIMBOA inhibits the biosynthesis and accumulation of toxic trichothecenes by affecting the expression of Tri6 and Tri5. DIMBOA reduces plant susceptibility to scab. DIMBOA also exhibits cytotoxicity to plant cells, causing plasmolysis, cell collapse, and cell rupture .

Cat. No.	Product Name	Chemical Structure

HY-N6685S1

3-Acetyldeoxynivalenol-13C17
3-Acetyldeoxynivalenol- ¹³C₁₇ is the ¹³C labeled 3-Acetyldeoxynivalenol (HY-N6685) . 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative , is a blood-brain barrier (BBB) permeable mycotoxin .

HY-W014118S

α-Hexylcinnamaldehyde-d5
α-Hexylcinnamaldehyde-d₅ is deuterated labeled Diacetoxyscirpenol (HY-N6692). Diacetoxyscirpenol (DAS) is a trichothecene mycotoxin, a secondary metabolite product of fungi. Diacetoxyscirpenol (DAS) consumption induces haematological disorders (neutropenia, aplastic anemia) in human and animals .

HY-N6683S1

15-Acetyl-deoxynivalenol-13C17
15-Acetyl-deoxynivalenol- ¹³C₁₇ is the ¹³C labeled 15-Acetyl-deoxynivalenol (HY-N6683) . 15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals, and a metabolite of deoxynivalenol, exhibits toxicity to HepG2 cells .

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Trichothecene

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products