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Results for "

Wee1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Wee1 (23) Apoptosis (3) CDK (1) Checkpoint Kinase (Chk) (1) PROTAC Linkers (1) PROTACs (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (25) Inflammation/Immunology (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Oligonucleotides

Targets Recommended: Wee1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108343

WEE1-IN-4	Wee1	Cancer
WEE1-IN-4 is a potent checkpoint Wee1 kinase inhibitor with an IC₅₀ of 0.011 μM ^[1].

HY-138239

WEE1-IN-3	Wee1	Cancer
WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC₅₀ of <10 nM. WEE1-IN-3 has anticancer activities ^[1].

HY-147054

WEE1-IN-5	Wee1 CDK	Cancer
WEE1-IN-5 is a potent *WEE1* inhibitor with an IC₅₀ value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer ^[1].

HY-168654

WEE1 degrader 1	Wee1	Cancer
WEE1 degrader 1 (Compound 10) is a *Wee1* degrader with a DC₅₀ value of 1.5 nM against *Wee1. WEE1* degrader 1 possesses anti-cancer cell proliferation effects ^[1].

HY-RS15805

WEE1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
WEE1 Human Pre-designed siRNA Set A contains three designed siRNAs for WEE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

WEE1 Human Pre-designed siRNA Set A WEE1 Human Pre-designed siRNA Set A

HY-RS15806

Wee1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Wee1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Wee1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Wee1 Mouse Pre-designed siRNA Set A Wee1 Mouse Pre-designed siRNA Set A

HY-RS15807

Wee1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Wee1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Wee1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Wee1 Rat Pre-designed siRNA Set A Wee1 Rat Pre-designed siRNA Set A

HY-168180

WEE1-IN-11	Wee1	Cancer
WEE1-IN-11 (Compound 13) is a potent CDK2 inhibitor with an IC₅₀ of 2.0 nM. WEE1-IN-11 inhibits NCI–H446, A427, OVCAR3, C33A,and WiDr cells with IC₅₀s of 93.9, 34.5, 86.7, 23.1, and 85 nM, respectively ^[1].

HY-161880

WEE1-IN-10	Wee1	Cancer
WEE1-IN-10 (compound 77) is a *Wee1* kinase inhibitor. WEE1-IN-10 shows inhibitory activity on LOVO cell growth, with an IC₅₀ of 0.524 μM. WEE1-IN-10 can be used for the research of diseases caused by abnormal activity of Wee1 ^[1].

HY-160530

WEE1-IN-6	Wee1	Cancer
WEE1-IN-6 (compound 110) is a orally active *WEE1* inhibitor with an DC₅₀ value of ≦ 100 nM. WEE1-IN-6 inhibits cell proliferation ^[1].

HY-161879

WEE1-IN-9	Wee1	Cancer
WEE1-IN-9 (Compound 1) is a *Wee1* inhibitor that can be used in cancer research ^[1].

HY-163697

WEE1-IN-7	Wee1 Apoptosis	Cancer
WEE1-IN-7 (compound 12h) is a potent and orally activeWEE1 inhibitor with an IC₅₀ value of 2.1 nM. WEE1-IN-7 induces apoptosis and cell cycle arrest at the S phase. WEE1-IN-7 shows antitumor activity ^[1].

HY-161871

WEE1-IN-8	Wee1	Cancer
WEE1-IN-8 (Compound 55) is a selective *WEE1* inhibitor, with an IC₅₀ of 0.98 nM. WEE1-IN-8 (Compound 55) can be used for the research of Pancreatic cancer, Ovarian cancer, Colorectal cancer, Uterine serous carcinoma, etc ^[1].

HY-169946

WEE1/PKMYT1-IN-1	Wee1	Cancer
WEE1/PKMYT1-IN-1 (compound 75) is a potent and orally active *WEE1* and *PKMYT1* inhibitor. WEE1/PKMYT1-IN-1 shows antiproliferation activity ^[1].

HY-112409

WEE1-IN-2	Others	Others
WEE1-IN-2 is an active compound.

HY-144999

LEB-03-146	Wee1	Cancer
LEB-03-146 is a *WEE1* DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a PEG2 linker. LEB-03-146 shows significant *WEE1* stabilization in HEP3B hepatoma cancer cells ^[1].

HY-143342

LEB-03-144	Wee1	Cancer
LEB-03-144 is a *WEE1* DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C3 alkyl linker. LEB-03-144 shows significant *WEE1* stabilization in HEP3B hepatoma cancer cells ^[1].

HY-10993

Adavosertib Maximum Cited Publications 46 Publications Verification AZD1775; MK-1775	Wee1	Cancer
Adavosertib (AZD-1775; MK-1775) is a potent *Wee1* inhibitor with an IC₅₀ of 5.2 nM.

HY-143343

LEB-03-153	Wee1	Cancer
LEB-03-153 is a *WEE1* DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through no linker ^[1].

HY-132295

Azenosertib 1 Publications Verification ZN-c3	Wee1	Cancer
Azenosertib (ZN-c3) is a selective, orally active inhibitor for *Wee1* inhibitor (IC₅₀=3.9 nM). Azenosertib exhibits antitumor activity ^[1].

HY-103029

Bosutinib isomer	Wee1	Cancer
Bosutinib isomer is a ligand or inhibitor with high binding affinity for both *Wee1* and *Wee2, with K_d* values of 43.7 ± 10.0 and 4.7 ± 2.3 nM, respectively ^[1].

HY-10993R

Adavosertib (Standard)	Wee1	Cancer
Adavosertib (Standard) is the analytical standard of Adavosertib. This product is intended for research and analytical applications. Adavosertib (AZD-1775; MK-1775) is a potent *Wee1* inhibitor with an IC₅₀ of 5.2 nM.

HY-143340

LEB-03-145	Wee1	Cancer
LEB-03-145 is a *WEE1* DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C5 alkyl linker ^[1].

HY-13925

PD0166285 5+ Cited Publications	Wee1 Apoptosis	Cancer
PD0166285, a substrate of P-gp, is a *WEE1* inhibitor and a weak *Myt1* inhibitor with IC₅₀ values of 24 and 72 nM, respectively. PD0166285 exhibits an IC₅₀ of 3.433 μM for Chk1 ^[1].

HY-13925A

PD0166285 dihydrochloride	Wee1 Apoptosis	Cancer
PD0166285 dihydrochloride, a substrate of P-gp, is a *WEE1* inhibitor and a weak *Myt1* inhibitor with IC₅₀ values of 24 and 72 nM, respectively. PD0166285 dihydrochloride exhibits an IC₅₀ of 3.433 μM for Chk1 ^[1].

HY-18961

PD 407824	Checkpoint Kinase (Chk) Wee1	Inflammation/Immunology Cancer
PD 407824 is a checkpoint kinase *Chk1* and *WEE1* inhibitor with IC₅₀s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4 ^[1] .

HY-133618

Pomalidomide-C3-adavosertib	Wee1 PROTACs	Cancer
Pomalidomide-C3-adavosertib is a rapid and selective PROTAC *Wee1* degrader (IC₅₀=3.58 nM). Pomalidomide-C3-adavosertib shows anti-cancer cell proliferation activity, and induces apoptosis ^[1].

HY-133702

Aniline-piperazine-C3-NH-Boc	PROTAC Linkers	Cancer
Aniline-piperazine-C3-NH-Boc (Compound Int-3) is a PROTAC linker, and can be used for synthesis of Pomalidomide-C3-adavosertib (HY-133618) and AZD1775 (HY-10993) (a Wee1 inhibitor) ^[1].

HY-148065

FMF-06-098-1	PROTACs	Cancer
FMF-06-098-1 is a multitargeted depressant. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 ^[1].

Species:	Human (3)
Tag:	His (2) Tag Free (1) GST (1)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P701727

	Wee1 Protein, Human (Sf9, His) Wee1; Wee1-like protein kinase; Wee1hu; Wee1A kinase	Human	Sf9 insect cells
	Wee1 Protein acts as a crucial negative regulator of the G2 to M transition, ensuring nuclear protection by phosphorylating CDK1 on 'Tyr-15' and inactivating the cyclin B1-CDK1 complex. Its peak activity in G2 phase decreases as cells progress into M phase, with dynamic regulation, increased phosphorylation during S and G2 phases, and diminished levels during M/G1 phase transition potentially due to degradation. Wee1 Protein, Human (Sf9, His) is the recombinant human-derived Wee1 protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of Wee1 Protein, Human (Sf9, His) is 285 a.a., .

HY-P701729

	WEE2 Protein, Human (Sf9, His, GST) Wee2; Wee1-like protein kinase 2; Wee1-like protein kinase 1B; Wee1B kinase	Human	Sf9 insect cells
	WEE2 protein is an oocyte-specific tyrosine kinase that plays an important role in meiosis during prophase I and metaphase II. It maintains meiotic arrest at the germinal vesicle (GV) stage by phosphorylating CDK1 at 'Tyr-15', inhibiting CDK1 activity and preventing reentry. WEE2 Protein, Human (Sf9, His, GST) is the recombinant human-derived WEE2 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of WEE2 Protein, Human (Sf9, His, GST) is 566 a.a., .

HY-P701726

	Wee1 Protein, Human (Sf9) Wee1; Wee1-like protein kinase; Wee1hu; Wee1A kinase	Human	Sf9 insect cells
	Wee1 Protein acts as a crucial negative regulator of the G2 to M transition, ensuring nuclear protection by phosphorylating CDK1 on 'Tyr-15' and inactivating the cyclin B1-CDK1 complex. Its peak activity in G2 phase decreases as cells progress into M phase, with dynamic regulation, increased phosphorylation during S and G2 phases, and diminished levels during M/G1 phase transition potentially due to degradation. Wee1 Protein, Human (Sf9) is the recombinant human-derived Wee1 protein, expressed by Sf9 insect cells , with tag free. The total length of Wee1 Protein, Human (Sf9) is 285 a.a., .

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WEE1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
WEE1 Human Pre-designed siRNA Set A contains three designed siRNAs for WEE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Wee1 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Wee1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Wee1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Wee1 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Wee1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Wee1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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