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Results for "

YAP1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (1) Arp2/3 Complex (1) Endogenous Metabolite (1) Small Interfering RNA (siRNA) (3) YAP (6)
By Research Areas:	Cancer (6) Infection (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138565

K-975 10+ Cited Publications	YAP	Cancer
K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between *YAP1/TAZ* and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma ^[1].

HY-161573

BAY-593	YAP	Cancer
BAY-593 is an orally active GGTase-I inhibitor. BAY-593 has anti-tumor activity and blocks YAP1/TAZ signaling in vivo ^[1].

HY-125269

TED-347 5+ Cited Publications	YAP	Cancer
TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC₅₀ of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a K_i of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity ^[1].

HY-161573A

(7S)-BAY-593	YAP	Cancer
(7S)-BAY-593 is the S-enantiomer of BAY-593 (HY-161573). BAY-593 is an orally active GGTase-I inhibitor. BAY-593 has anti-tumor activity and blocks YAP1/TAZ signaling in vivo ^[1].

HY-RS15911

YAP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
YAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for YAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

YAP1 Human Pre-designed siRNA Set A YAP1 Human Pre-designed siRNA Set A

HY-RS15912

Yap1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Yap1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Yap1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Yap1 Mouse Pre-designed siRNA Set A Yap1 Mouse Pre-designed siRNA Set A

HY-RS15913

Yap1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Yap1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Yap1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Yap1 Rat Pre-designed siRNA Set A Yap1 Rat Pre-designed siRNA Set A

HY-156024

TEAD-IN-6	YAP	Others
TEAD-IN-6 (Example 11-1) is a TEAD modulator that blocks the interaction between *YAP1/TAZ* and TEAD. TEAD-IN-6 can be used in cancer research ^[1].

HY-E70293

N-Acetylgalactosaminyltransferase 12 GALNT12	Endogenous Metabolite	Cancer
N-Acetylgalactosaminyltransferase 12 (GALNT12) belongs to the uridine diphosphate N-acetylgalactosamine gene family and is involved in the biological processes of many diseases, such as tumor progression. N-Acetylgalactosaminyltransferase 12 is a potential biomarker for fibrosarcoma, and its high expression level is closely related to the yes1-associated transcriptional regulator (YAP1) signaling pathway ^[1].

HY-163622

USP10-IN-3	Apoptosis	Cancer
USP10-IN-3 (compound D1) is a potent USP10 inhibitor with an IC₅₀ value of 7.2 µM. USP10-IN-3 inhibits cell proliferation. USP10-IN-3 induces apoptosis and cell cycle arrest at S-phase ^[1].

HY-N6682

Cytochalasin D Maximum Cited Publications 45 Publications Verification Zygosporin A; NSC 209835	Arp2/3 Complex Antibiotic YAP	Infection
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6682

Cytochalasin D 40+ Cited Publications Zygosporin A; NSC 209835	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Arp2/3 Complex Antibiotic YAP
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80864

	*Phospho-YAP1* (Ser127) Antibody (YA136)** YAP1; YAP65; Yorkie homolog; 65 kDa Yes-associated protein; YAP65	WB, IHC-P	Human, Mouse, Rat
	Phospho-YAP1 (Ser127) Antibody (YA136) is a non-conjugated and Rabbit origined monoclonal antibody about 54 kDa, targeting to Phospho-YAP1 (Ser127). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80374

	YAP1 Antibody	WB, ICC/IF, IHC-P, IP, FC	Human
	YAP1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 54 kDa, targeting to YAP1. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human.

HY-P80481

	*Phospho-YAP1* (Ser127) Antibody (YA137)**	WB, IHC-P	Human, Mouse
	Phospho-YAP1 (Ser127) Antibody (YA137) is a non-conjugated and Rabbit origined monoclonal antibody about 54 kDa, targeting to Phospho-YAP1 (S127). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse.

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YAP1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
YAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for YAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Yap1 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Yap1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Yap1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Yap1 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Yap1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Yap1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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