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Zanthoxylum

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) AMPK (1) Apoptosis (4) Bacterial (4) ERK (2) FAK (2) Fungal (1) Isotope-Labeled Compounds (1) Monoamine Oxidase (1) NF-κB (2) p38 MAPK (2) Parasite (4) PGE synthase (1) STAT (2) Topoisomerase (2) Tyrosinase (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Infection (7) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N10879

5,7-Dimethoxyflavanone	Others	Others
5,7-Dimethoxyflavanone is an active compound. 5,7-Dimethoxyflavanone can be Isolated from the roots of Zanthoxylum nitidum .

HY-N3139

Ombuin	Bacterial	Infection
Ombuin, isolated from Zanthoxylum armatum, displays broad spectrum antibacterial effect with MIC ranges from 125 to 500 μg/mL .

HY-N6824

Hydroxy-β-sanshool 1 Publications Verification	Others	Others
Hydroxy-β-sanshool is an alkylamide exists in Zanthoxylum bungeanum oil and Zanthoxylum schinifolium oil .

HY-N3700

Decarine Rutaceline	Others	Others
Decarine is a alkaloid which can be isolated from Zanthoxylum simulans .

HY-N8340

Luvangetin	Others	Others
Luvangetin is a coumarin that can be isolated from Zanthoxylum avicennae .

HY-N3123

Oxychelerythrine Dihydrooxochelerythrine	Others	Cancer
Oxychelerythrine is an alkaloid that can be isolated from Zanthoxylum integrifoliolum. Oxychelerythrine exhibits cytotoxicity against P-388 and HT-29 cell lines with ED₅₀s of 3.25 and 5.48 μg/mL, respectively .

HY-N7013

Hydroxy-Epsilon-Sanshool	Others	Neurological Disease
Hydroxy-Epsilon-Sanshool is an alkylamide isolated from Zanthoxylum bungeanum. Hydroxy-Epsilon-Sanshool produces key tingling and numbing chemosensates, and its content is important in determinant the pungency intensity of Zanthoxylum bungeanum .

HY-N11979

Dihydronitidine	Others	Others
Dihydronitidine is an alkaloid can be extracted from Zanthoxylum rhoifolium .

HY-N1053

Zanthobungeanine	Others	Others
Zanthobungeanine is a Alkaloids product that can be isolated from the roots of Zanthoxylum nitidum. .

HY-N8706

Hydrangetin 7-Hydroxy-8-methoxycoumarin	Others	Cardiovascular Disease
Hydrangetin inhibits platelet aggregation. Hydrangetin can be isolated from Zanthoxylum schinifolium .

HY-N3236

Mullilam diol	Others	Others
Mullilam diol is a Monoterpenoids product that can be isolated from the herbs of Zanthoxylum budrunga Wall. .

HY-N1538

(+)-Piperitol-3,3-dimethylallyl ether	Others	Others
(+)-Piperitol-3,3-dimethylallyl ether can be isolated from the roots and the bark of Zanthoxylum usambarense .

HY-N9926

Pluviatolide (-)-Pluviatolide	Others	Others
Pluviatolide ((-)-Pluviatolide) is a lignan that can be found in the bark of Zanthoxylum pluviatile Hartley. Pluviatolide can be used as (-)-Podophyllotoxin precursor .

HY-N2678

5-Hydroxymethyl-7-methoxybenzofuran	Others	Others
5-Hydroxymethyl-7-methoxybenzofuran is a Phenols product that can be isolated from the fruits of Zanthoxylum bungeanum .

HY-N2697

6-Acetonyl-N-methyldihydrodecarine	Monoamine Oxidase	Neurological Disease
6-Acetonyl-N-methyldihydrodecarine is a natural alkaloid that can be isolated from roots of Zanthoxylum rigidum. An inhibitor of monoamine oxidases .

HY-N1906

4-Methoxy-1-methylquinolin-2-one	Others	Others
4-Methoxy-1-methylquinolin-2-one is a Alkaloids product that can be isolated from the herbs of Zanthoxylum nitidum .

HY-N4164

Schinifoline	Apoptosis	Cancer
Schinifoline, a 4-quinolinone derivative isolated from Zanthoxylum schinifolium Sieb, improves radiosensitizing effect, and effects cell cycle and apoptotic-inducing effects in cancer .

HY-138548

4-Ethoxycoumarin	Bacterial	Infection
4-Ethoxycoumarin is an antimicrobial .

HY-129130

Canthin-6-one N-oxide Canthin-6-one 3-oxide	Parasite	Infection
Canthin-6-one N-oxide (Canthin-6-one 3-oxide) is an orally active antiparasitic agent with limited activity .

HY-111880

γ-Sanshool	Acyltransferase	Cardiovascular Disease
γ-Sanshool can be isolated from Zanthoxylum piperitum. γ-Sanshool inhibits human ACAT-1 and ACAT-2 activities with IC₅₀s of 12.0 and 82.6 μM .

HY-121428

Fagaramide	PGE synthase	Others
Fagaramide is a compound extracted from Zanthoxylum bungeanum with anti-inflammatory activity. It is effective against carrageenan foot swelling in rats and mediates its anti-inflammatory effect partly by inhibiting prostaglandin synthesis. Its activity is about 1/20 of that of indomethacin.

HY-N9194

5-Methoxycanthin-6-one	Parasite	Infection
5-Methoxycanthin-6-one is an orally active inhibitor of Leishmania strains. 5-Methoxycanthin-6-one shows cytotoxicity with an IC₅₀ of 5.44 μg/mL against Ailanthus altissima cells .

HY-N1065

Xanthoxyletin	Apoptosis	Inflammation/Immunology Cancer
Xanthoxyletin is a coumarin that can be isolated from Genus Zanthoxylum and Clausena. Xanthoxyletin has antioxidant and anti-inflammatory activities. Xanthoxyletin shows cytotoxic effects to cancer cells, and induces apoptosis and necrosis. Xanthoxyletin can be used for the research of cancer and inflammation .

HY-N7505

Norchelerythrine	Bacterial	Infection
Norchelerythrine is an alkaloid isolated from the roots of Zanthoxylum capense with antibacterial activity against gram-positive and gram-negative bacteria. Norchelerythrine exhibits inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis and Escherichia coli with MIC values >50 µg/mL .

HY-N1063

Xanthoxylin Xanthoxyline	Fungal	Infection Metabolic Disease
Xanthoxylin (Xanthoxyline) can be isolated from Zanthoxylum simulans. Xanthoxylin has antifungal and antioxidant effects. The MIC of Xanthoxylin against Toxoplasma neonatorum and Aspergillus fumigatus were 50 µg/mL and 75 µg/mL, respectively. Xanthoxylin can be used in the study of anti-epileptic diseases .

HY-W017212

Methyl cinnamate 2 Publications Verification Methyl 3-phenylpropenoate	Tyrosinase Bacterial AMPK	Infection Metabolic Disease
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-N0498

Nitidine chloride 3 Publications Verification	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB	Inflammation/Immunology Cancer
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-N8016S2

Nonanal-d2	Isotope-Labeled Compounds	Metabolic Disease
Nonanal-d₂ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-N0498R

Nitidine chloride (Standard)	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB	Inflammation/Immunology Cancer
Nitidine (chloride) (Standard) is the analytical standard of Nitidine (chloride). This product is intended for research and analytical applications. Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10879

5,7-Dimethoxyflavanone	Structural Classification Flavonoids Flavonones Source classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants	Others
5,7-Dimethoxyflavanone is an active compound. 5,7-Dimethoxyflavanone can be Isolated from the roots of Zanthoxylum nitidum .

HY-N3139

Ombuin	Infection Flavonols Flavonoids Classification of Application Fields Source classification Rutaceae Phenols Polyphenols Plants Disease Research Fields Zanthoxylum armatum DC.	Bacterial
Ombuin, isolated from Zanthoxylum armatum, displays broad spectrum antibacterial effect with MIC ranges from 125 to 500 μg/mL .

HY-N6824

Hydroxy-β-sanshool 1 Publications Verification	Zanthoxylum bungeanum Maxim. Alkaloids Classification of Application Fields Source classification Other Diseases Rutaceae Plants Disease Research Fields	Others
Hydroxy-β-sanshool is an alkylamide exists in Zanthoxylum bungeanum oil and Zanthoxylum schinifolium oil .

HY-N3700

Decarine Rutaceline	Structural Classification Alkaloids Source classification Rutaceae Plants Isoquinoline Alkaloids Zanthoxylum simulans Hance	Others
Decarine is a alkaloid which can be isolated from Zanthoxylum simulans .

HY-N8340

Luvangetin	Structural Classification Natural Products Source classification Rutaceae Zanthoxylum avicennae (Lam.) DC. Plants	Others
Luvangetin is a coumarin that can be isolated from Zanthoxylum avicennae .

HY-N3123

Oxychelerythrine Dihydrooxochelerythrine	Zanthoxylum integrifoliolum (Merr.) Merr. Source classification Rutaceae Plants	Others
Oxychelerythrine is an alkaloid that can be isolated from Zanthoxylum integrifoliolum. Oxychelerythrine exhibits cytotoxicity against P-388 and HT-29 cell lines with ED₅₀s of 3.25 and 5.48 μg/mL, respectively .

HY-N7013

Hydroxy-Epsilon-Sanshool	Zanthoxylum bungeanum Maxim. Structural Classification Natural Products Source classification Rutaceae Plants	Others
Hydroxy-Epsilon-Sanshool is an alkylamide isolated from Zanthoxylum bungeanum. Hydroxy-Epsilon-Sanshool produces key tingling and numbing chemosensates, and its content is important in determinant the pungency intensity of Zanthoxylum bungeanum .

HY-N11979

Dihydronitidine	Structural Classification Alkaloids Other Alkaloids Source classification Rutaceae Zanthoxylum rhoifolium Lam. Plants	Others
Dihydronitidine is an alkaloid can be extracted from Zanthoxylum rhoifolium .

HY-N1053

Zanthobungeanine	Structural Classification Alkaloids Other Alkaloids Source classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants	Others
Zanthobungeanine is a Alkaloids product that can be isolated from the roots of Zanthoxylum nitidum. .

HY-N8706

Hydrangetin 7-Hydroxy-8-methoxycoumarin	Structural Classification Zanthoxylum schinifolium Sieb. et Zucc. Source classification Rutaceae Coumarins Phenylpropanoids Plants	Others
Hydrangetin inhibits platelet aggregation. Hydrangetin can be isolated from Zanthoxylum schinifolium .

HY-N3236

Mullilam diol	Zanthoxylum bungeanum Maxim. Structural Classification Other Monoterpenes Terpenoids Source classification Rutaceae Plants	Others
Mullilam diol is a Monoterpenoids product that can be isolated from the herbs of Zanthoxylum budrunga Wall. .

HY-N1538

(+)-Piperitol-3,3-dimethylallyl ether	Structural Classification Natural Products Source classification Rutaceae Plants Zanthoxylum usambarense (Engl.) Kokwaro	Others
(+)-Piperitol-3,3-dimethylallyl ether can be isolated from the roots and the bark of Zanthoxylum usambarense .

HY-N9926

Pluviatolide (-)-Pluviatolide	Zanthoxylum bungeanum Maxim. Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Rutaceae Phenols Plants Disease Research Fields	Others
Pluviatolide ((-)-Pluviatolide) is a lignan that can be found in the bark of Zanthoxylum pluviatile Hartley. Pluviatolide can be used as (-)-Podophyllotoxin precursor .

HY-N2678

5-Hydroxymethyl-7-methoxybenzofuran	Zanthoxylum bungeanum Maxim. Structural Classification Monophenols Source classification Rutaceae Phenols Plants	Others
5-Hydroxymethyl-7-methoxybenzofuran is a Phenols product that can be isolated from the fruits of Zanthoxylum bungeanum .

HY-N2697

6-Acetonyl-N-methyldihydrodecarine	Structural Classification Alkaloids Source classification Zanthoxylum rigidum Humb. & Bonpl. ex Willd. Rutaceae Plants Isoquinoline Alkaloids	Monoamine Oxidase
6-Acetonyl-N-methyldihydrodecarine is a natural alkaloid that can be isolated from roots of Zanthoxylum rigidum. An inhibitor of monoamine oxidases .

HY-N1906

4-Methoxy-1-methylquinolin-2-one	Structural Classification Alkaloids Source classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Quinoline Alkaloids Plants	Others
4-Methoxy-1-methylquinolin-2-one is a Alkaloids product that can be isolated from the herbs of Zanthoxylum nitidum .

HY-N4164

Schinifoline	Zanthoxylum bungeanum Maxim. Alkaloids Classification of Application Fields Source classification Rutaceae Quinoline Alkaloids Plants Disease Research Fields Cancer	Apoptosis
Schinifoline, a 4-quinolinone derivative isolated from Zanthoxylum schinifolium Sieb, improves radiosensitizing effect, and effects cell cycle and apoptotic-inducing effects in cancer .

HY-138548

4-Ethoxycoumarin	Structural Classification Natural Products Source classification Rutaceae Zanthoxylum zanthoxyloides (Lam.) Zepern. & Timler Plants	Bacterial
4-Ethoxycoumarin is an antimicrobial .

HY-129130

Canthin-6-one N-oxide Canthin-6-one 3-oxide	Structural Classification Alkaloids Simaroubaceae Other Alkaloids Source classification Eurycoma harmandiana Pierre Plants	Parasite
Canthin-6-one N-oxide (Canthin-6-one 3-oxide) is an orally active antiparasitic agent with limited activity .

HY-111880

γ-Sanshool	Zanthoxylum bungeanum Maxim. Structural Classification Natural Products Source classification Rutaceae Plants	Acyltransferase
γ-Sanshool can be isolated from Zanthoxylum piperitum. γ-Sanshool inhibits human ACAT-1 and ACAT-2 activities with IC₅₀s of 12.0 and 82.6 μM .

HY-N9194

5-Methoxycanthin-6-one	Infection Alkaloids Classification of Application Fields Source classification Rutaceae Pyridine Alkaloids Zanthoxylum chiloperone var. angustifolium Plants Disease Research Fields Indole Alkaloids	Parasite
5-Methoxycanthin-6-one is an orally active inhibitor of Leishmania strains. 5-Methoxycanthin-6-one shows cytotoxicity with an IC₅₀ of 5.44 μg/mL against Ailanthus altissima cells .

HY-N1065

Xanthoxyletin	Structural Classification Source classification Rutaceae Coumarins Phenylpropanoids Plants Clausena harmandiana (Pierre) Guillaumin	Apoptosis
Xanthoxyletin is a coumarin that can be isolated from Genus Zanthoxylum and Clausena. Xanthoxyletin has antioxidant and anti-inflammatory activities. Xanthoxyletin shows cytotoxic effects to cancer cells, and induces apoptosis and necrosis. Xanthoxyletin can be used for the research of cancer and inflammation .

HY-N7505

Norchelerythrine	Infection Alkaloids Classification of Application Fields Source classification Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Bacterial
Norchelerythrine is an alkaloid isolated from the roots of Zanthoxylum capense with antibacterial activity against gram-positive and gram-negative bacteria. Norchelerythrine exhibits inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis and Escherichia coli with MIC values >50 µg/mL .

HY-N1063

Xanthoxylin Xanthoxyline	Zanthoxylum bungeanum Maxim. Infection Structural Classification Monophenols Classification of Application Fields Rutaceae Phenols Plants Zanthoxylum simulans Hance Disease Research Fields	Fungal
Xanthoxylin (Xanthoxyline) can be isolated from Zanthoxylum simulans. Xanthoxylin has antifungal and antioxidant effects. The MIC of Xanthoxylin against Toxoplasma neonatorum and Aspergillus fumigatus were 50 µg/mL and 75 µg/mL, respectively. Xanthoxylin can be used in the study of anti-epileptic diseases .

HY-W017212

Methyl cinnamate 2 Publications Verification Methyl 3-phenylpropenoate	Structural Classification Microorganisms Classification of Application Fields Simple Phenylpropanols Source classification Rutaceae Metabolic Disease Phenylpropanoids Plants Disease Research Fields Zanthoxylum armatum DC.	Tyrosinase Bacterial AMPK
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-N0498

Nitidine chloride 3 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Source classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-N0498R

Nitidine chloride (Standard)	Alkaloids Structural Classification Source classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Isoquinoline Alkaloids	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
Nitidine (chloride) (Standard) is the analytical standard of Nitidine (chloride). This product is intended for research and analytical applications. Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

Cat. No.	Product Name	Chemical Structure

HY-N8016S2

Nonanal-d2

Nonanal-d₂ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

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Inhibitors & Agonists

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Isotope-Labeled Compounds

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