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Results for "

androgenic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5 alpha Reductase (9) Akt (1) Aldehyde Dehydrogenase (ALDH) (1) AMPK (1) Androgen Receptor (30) Apoptosis (1) Autophagy (1) Bacterial (2) Cytochrome P450 (3) Drug Derivative (1) Drug Metabolite (1) Endogenous Metabolite (6) Estrogen Receptor/ERR (10) Fungal (4) Isotope-Labeled Compounds (7) Ligands for Target Protein for PROTAC (1) Mitochondrial Metabolism (1) mTOR (1) Progesterone Receptor (6) Prostaglandin Receptor (1) PROTACs (1) TGF-β Receptor (2) Thyroid Hormone Receptor (2)
By Research Areas:	Cancer (11) Cardiovascular Disease (2) Endocrinology (30) Infection (3) Inflammation/Immunology (5) Metabolic Disease (12) Neurological Disease (1)
Click Chemistry:	Alkynes (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123047

Tibolone	Progesterone Receptor Androgen Receptor Estrogen Receptor/ERR	Endocrinology
Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research .

HY-125970

CRTh2 antagonist 2	Prostaglandin Receptor	Endocrinology
CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC₅₀ of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia .

HY-118528A

TP0427736 hydrochloride 1 Publications Verification	TGF-β Receptor	Endocrinology
TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC₅₀ of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC₅₀=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC₅₀ value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA) .

HY-17462

Adrenosterone (+)-Adrenosterone	Androgen Receptor Endogenous Metabolite	Endocrinology Cancer
Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-13635

Finasteride 4 Publications Verification MK-906	5 alpha Reductase	Cancer
Finasteride (MK-906) is an orally active and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-W013172

Norgestimate	Progesterone Receptor	Endocrinology
Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive . Norgestimate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-123047R

Tibolone (Standard)	Progesterone Receptor Androgen Receptor Estrogen Receptor/ERR	Endocrinology
Tibolone (Standard) is the analytical standard of Tibolone. This product is intended for research and analytical applications. Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research .

HY-B1234R

Octinoxate (Standard)	Androgen Receptor Estrogen Receptor/ERR	Others
Octinoxate (Standard) is the analytical standard of Octinoxate. This product is intended for research and analytical applications. Octinoxate (Octyl methoxycinnamate) is an organic compound that is an ingredient in some sunscreens and lip balms, primarily used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage and can be used to reduce the appearance of scars. Octinoxate also has a complex *androgenic* and estrogenic effect .

HY-B1234A

(E)-Octinoxate (E)-Octyl methoxycinnamate	Estrogen Receptor/ERR Androgen Receptor	Endocrinology
(E)-Octinoxate is the isomer of Octinoxate (HY-B1234). Octinoxate is an organic compound that is an ingredient in some sunscreens and lip balms, primarily used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage and can be used to reduce the appearance of scars. Octinoxate also has a complex androgenic and estrogenic effect .

HY-13635A

Finasteride acetate MK-906 acetate	5 alpha Reductase	Cancer
Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-W744216

Trestolone acetate	Androgen Receptor	Metabolic Disease
Trestolone acetate is a synthetic anabolic androgenic steroid.

HY-I0352

Epiandrosterone 3β-Androsterone; trans-Androsterone; iso-Androsterone	Androgen Receptor Endogenous Metabolite	Endocrinology
Epiandrosterone is a steroid hormone with weak androgenic activity.

HY-B2044

Bromopropylate	Androgen Receptor	Endocrinology
Bromopropylate is a pesticide with moderate *anti-androgenic* activities .

HY-W411296

6α-Chloro testosterone	Androgen Receptor	Metabolic Disease
6α-Chloro testosterone is an anabolic androgenic steroid.

HY-U00052

Silandrone Testosterone trimethylsilyl ether	Androgen Receptor	Metabolic Disease
Silandrone is a synthetic, orally active anabolic-androgenic steroid (AAS).

HY-113233

19-Noretiocholanolone	Androgen Receptor	Metabolic Disease
19-Noretiocholanolone is an anabolic androgenic steroid metabolite of Nandrolone .

HY-123698

Mebolazine Dimethazine	Androgen Receptor	Endocrinology
Mebolazine binds to the androgen receptor and produce androgenic and anabolic activity .

HY-114744

6α-Hydroxy metandienone	Androgen Receptor	Endocrinology
6α-Hydroxy metandienone is an androgenic anabolic steroid metabolite of Metandienone.

HY-138151

3'-Hydroxy stanozolol	Androgen Receptor	Endocrinology
3'-Hydroxy stanozolol is a major metabolite of the anabolic androgenic steroid Stanozolol .

HY-137236

6β-Hydroxy metandienone	Drug Metabolite	Metabolic Disease
6β-Hydroxy metandienone is an anabolic androgenic steroid metabolite of Metandienone .

HY-101734

Trestolone 7α-Methylnandrolone	Androgen Receptor	Metabolic Disease
Trestolone is a synthetic anabolic-androgenic steroid (AAS) of the nandrolone (19-nortestosterone) group.

HY-118608

2α-Methyl androsterone	Drug Derivative	Metabolic Disease
2α-Methyl androsterone is an anabolic androgenic steroid metabolite of mesterolone and drostanolone .

HY-B0141A

Alpha-Estradiol Alfatradiol; Epiestradiol; Epiestrol	5 alpha Reductase Endogenous Metabolite Bacterial	Inflammation/Immunology
Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-B2044R

Bromopropylate (Standard)	Androgen Receptor	Endocrinology
Bromopropylate (Standard) is the analytical standard of Bromopropylate. This product is intended for research and analytical applications. Bromopropylate is a pesticide with moderate anti-androgenic activities .

HY-B0487

Ethisterone Pregneninolone; 17α-Ethynyltestosterone	Estrogen Receptor/ERR	Endocrinology
Ethisterone (Pregneninolone), a synthetic steroidal estrogen, is an orally active steroidal contraceptive agent. Ethisterone is reported for androgenic activity, used for the research of the gynecological disorders .

HY-123047S

Tibolone-d5	Isotope-Labeled Compounds Estrogen Receptor/ERR Progesterone Receptor Androgen Receptor	Endocrinology
Tibolone-d₅ is deuterium labeled Tibolone. Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research .

HY-W016645

4-Diethylaminobenzaldehyde 2 Publications Verification	Aldehyde Dehydrogenase (ALDH)	Cancer
4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenases (ALDHs) inhibitor, with a K_i of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC₅₀= 1.71μM) .

HY-W653723

N-Nitrosodicyclohexylamine NDCHA	Androgen Receptor	Endocrinology
N-Nitrosodicyclohexylamine (NDCHA) is a N-nitrosocompound with anti-androgenic activities. N-Nitrosodicyclohexylamine shows the competitive binding to androgen receptor (AR) against 5α-dihydrotestosterone and decreased the level of AR protein .

HY-B0141AS

Alpha-Estradiol-d3 Alfatradiol-d₃; Epiestradiol-d₃; Epiestrol-d₃	5 alpha Reductase Endogenous Metabolite	Inflammation/Immunology
Alpha-Estradiol-d₃ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-W698952S

3β hydroxy Tibolone-d5	Isotope-Labeled Compounds	Endocrinology
3β hydroxy Tibolone-d₅ is deuterium labeled Tibolone. Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research .

HY-B0141AS1

Alpha-Estradiol-d2 Alfatradiol-d₂; Epiestradiol-d₂; Epiestrol-d₂	5 alpha Reductase Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Alpha-Estradiol-d₂ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia[1].

HY-B0487R

Ethisterone (Standard)	Estrogen Receptor/ERR	Endocrinology
Ethisterone (Standard) is the analytical standard of Ethisterone. This product is intended for research and analytical applications. Ethisterone (Pregneninolone), a synthetic steroidal estrogen, is an orally active steroidal contraceptive agent. Ethisterone is reported for androgenic activity, used for the research of the gynecological disorders .

HY-W013172R

Norgestimate (Standard)	Progesterone Receptor	Endocrinology
Norgestimate (Standard) is the analytical standard of Norgestimate. This product is intended for research and analytical applications. Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive .

HY-B0141AR

Alpha-Estradiol (Standard) Alfatradiol(Standard); Epiestradiol(Standard); Epiestrol (Standard)	5 alpha Reductase Endogenous Metabolite Bacterial	Inflammation/Immunology
Alpha-Estradiol (Standard) is the analytical standard of Alpha-Estradiol. This product is intended for research and analytical applications. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-107043

7β-Hydroxy-epi-androsterone 7β-Hydroxy-EpiA	Estrogen Receptor/ERR	Neurological Disease Inflammation/Immunology
7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) can bind to ERβ and has anti-inflammatory and neuroprotective properties. 7β-Hydroxy-epi-androsterone is an endogenous androgenic derivative of dehydroepiandrosterone .

HY-170448

PROTAC AR Degrader-9	PROTACs Androgen Receptor	Endocrinology
PROTAC AR Degrader-9 (Compound c6) is a PROTAC degrader for androgen receptor, that degrades AR in human hair follicle papilla cells (HDPCs) with a DC₅₀ of 262.38 nM. PROTAC AR Degrader-9 promotes the expressions of paracrine factors, such as TGF-β1 and β-catenin, exhibits hair regenerating efficacy in mouse models . (Pink: ligand for target protein AR ligand-38 (HY-170450); Black: linker; Blue: ligand for E3 ligase Cereblon (HY-170449))

HY-170450

AR ligand-38	Androgen Receptor Ligands for Target Protein for PROTAC	Endocrinology
AR ligand-38 is the ligand for androgen receptor, that can be used for synthesis of PROTAC AR Degrader-9 (HY-170448) .

HY-171048

GTx-027	Androgen Receptor	Cancer
GTx-027 is a non-steroidal selective androgen receptor modulator (SARM). GTx-027 shows androgen receptor (AR) Transactivation with the EC₅₀ of 2.8765 nM. GTx-027 acts selectively increase muscle weight (anabolic) without affecting secondary sexual organs (androgenic) .

HY-W653723R

N-Nitrosodicyclohexylamine (Standard)	Androgen Receptor	Endocrinology
N-Nitrosodicyclohexylamine (Standard) is the analytical standard of N-Nitrosodicyclohexylamine. This product is intended for research and analytical applications. N-Nitrosodicyclohexylamine (NDCHA) is a N-nitrosocompound with anti-androgenic activities. N-Nitrosodicyclohexylamine shows the competitive binding to androgen receptor (AR) against 5α-dihydrotestosterone and decreased the level of AR protein .

HY-152094

SRD5A1-IN-1	5 alpha Reductase	Endocrinology
SRD5A1-IN-1 (Compound 4) is a competitive and covalent steroid 5α-reductase type 1 (SRD5A1) inhibitor with an IC₅₀ of 1.44 µM. SRD5A1-IN-1 modulates SRD5A1 function, leading to a lower level of dihydrotestosterone (DHT) production and SRD5A1 protein suppression .

HY-139244S

Norgestimate-d6	Isotope-Labeled Compounds Progesterone Receptor	Endocrinology
Norgestimate-d₆ is the deuterium labeled Norgestimate. Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2]. Norgestimate-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-118528

TP0427736	TGF-β Receptor	Cancer
TP0427736 is a selective inhibitor of ALK5 with an IC₅₀ of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells .

HY-13635S

Finasteride-d9 MK-906-d₉	Isotope-Labeled Compounds 5 alpha Reductase	Cancer
Finasteride-d₉ is deuterium labeled Finasteride. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].

HY-13635R

Finasteride (Standard) MK-906 (Standard)	5 alpha Reductase	Cancer
Finasteride (Standard) is the analytical standard of Finasteride. This product is intended for research and analytical applications. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-N12124

Monascuspiloin Monascinol	Akt mTOR AMPK Androgen Receptor Apoptosis Autophagy	Cancer
Monascuspiloin (Monascinol) exhibits anti-androgenic activity with an IC₅₀ of 7 μM. Monascuspiloin inhibits viability of PC-3 and LNCaP with IC₅₀ of 45 and 47 μM. Monascuspiloin induces apoptosis in LNCaP through inhibition of Akt/mTOR signaling pathway, induces autophagy through activation AMPK signaling pathway and arrest cell cycle at G2/M phase in PC-3. Monascuspiloin exhibits antitumor efficacy in mice .

HY-116214

Cyprodinil	Fungal Androgen Receptor	Infection Endocrinology
Cyprodinil is an anilinopyrimidine broad-spectrum fungicide that inhibits the biosynthesis of methionine in phytopathogenic fungi. Cyprodinil inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC₅₀s=0.44, 4.8, and 0.03 µM, respectively). Cyprodinil acts as an androgen receptor (AR) agonist (EC₅₀=1.91 µM) in the absence of the AR agonist DHT and inhibits the androgenic effect of DHT (IC₅₀=15.1 µM).

HY-100186

GSK-2881078 4 Publications Verification	Androgen Receptor	Cardiovascular Disease Others Metabolic Disease Inflammation/Immunology Endocrinology Cancer
GSK-2881078 is an orally active and nonsteroidal selective androgen receptor modulator (SARM) which act as partial AR agonists in androgenic tissues while mainly as complete AR agonists in synthetic metabolic tissues,induces AR-mediated transcriptional activation in PC3(AR)₂ cells (EC₅₀ = 3.99 nM) and the effect can be inhibited by the non-steroidal AR antagonist Bicalutamide. GSK-2881078 can be used in research of muscle weakness and cachexia associated with both chronic and acute illness .

HY-116214S1

Cyprodinil-13C6	Isotope-Labeled Compounds Fungal Androgen Receptor	Infection Endocrinology
Cyprodinil- ¹³C₆ is the ¹³C₆ labeled Cyprodinil. Cyprodinil is an anilinopyrimidine broad-spectrum fungicide that inhibits the biosynthesis of methionine in phytopathogenic fungi. Cyprodinil inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC₅₀s=0.44, 4.8, and 0.03 µM, respectively). Cyprodinil acts as an androgen receptor (AR) agonist (EC50=1.91 µM) in the absence of the AR agonist DHT and inhibits the androgenic effect of DHT (IC50=15.1 µM).

HY-116214R

Cyprodinil (Standard)	Fungal Androgen Receptor	Infection Endocrinology
Cyprodinil (Standard) is the analytical standard of Cyprodinil. This product is intended for research and analytical applications. Cyprodinil is an anilinopyrimidine broad-spectrum fungicide that inhibits the biosynthesis of methionine in phytopathogenic fungi. Cyprodinil inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC₅₀s=0.44, 4.8, and 0.03 µM, respectively). Cyprodinil acts as an androgen receptor (AR) agonist (EC₅₀=1.91 µM) in the absence of the AR agonist DHT and inhibits the androgenic effect of DHT (IC₅₀=15.1 µM).

HY-B1234

Octinoxate Octyl methoxycinnamate	Androgen Receptor Estrogen Receptor/ERR Thyroid Hormone Receptor Cytochrome P450	Metabolic Disease Endocrinology
Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and *anti-androgenic* effect in vitro and in vivo .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17462

Adrenosterone (+)-Adrenosterone	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Androgen Receptor Endogenous Metabolite
Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-I0352

Epiandrosterone 3β-Androsterone; trans-Androsterone; iso-Androsterone	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Androgen Receptor Endogenous Metabolite
Epiandrosterone is a steroid hormone with weak androgenic activity.

HY-B0141A

Alpha-Estradiol Alfatradiol; Epiestradiol; Epiestrol	Structural Classification Monophenols Classification of Application Fields Anti-aging Source classification Disease markers Phenols Endocrine diseases Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	5 alpha Reductase Endogenous Metabolite Bacterial
Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-B0141AR

Alpha-Estradiol (Standard) Alfatradiol(Standard); Epiestradiol(Standard); Epiestrol (Standard)	Structural Classification Classification of Application Fields Anti-aging Source classification Disease markers Phenols Endocrine diseases Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	5 alpha Reductase Endogenous Metabolite Bacterial
Alpha-Estradiol (Standard) is the analytical standard of Alpha-Estradiol. This product is intended for research and analytical applications. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-B1234

Octinoxate Octyl methoxycinnamate	Structural Classification Natural Products other families Classification of Application Fields Source classification Other Diseases Cosmetic Research Plants Disease Research Fields	Androgen Receptor Estrogen Receptor/ERR Thyroid Hormone Receptor Cytochrome P450
Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and *anti-androgenic* effect in vitro and in vivo .

HY-B1234R

Octinoxate (Standard)	Structural Classification Natural Products other families Source classification Plants	Androgen Receptor Estrogen Receptor/ERR
Octinoxate (Standard) is the analytical standard of Octinoxate. This product is intended for research and analytical applications. Octinoxate (Octyl methoxycinnamate) is an organic compound that is an ingredient in some sunscreens and lip balms, primarily used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage and can be used to reduce the appearance of scars. Octinoxate also has a complex *androgenic* and estrogenic effect .

HY-N12124

Monascuspiloin Monascinol	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Akt mTOR AMPK Androgen Receptor Apoptosis Autophagy
Monascuspiloin (Monascinol) exhibits anti-androgenic activity with an IC₅₀ of 7 μM. Monascuspiloin inhibits viability of PC-3 and LNCaP with IC₅₀ of 45 and 47 μM. Monascuspiloin induces apoptosis in LNCaP through inhibition of Akt/mTOR signaling pathway, induces autophagy through activation AMPK signaling pathway and arrest cell cycle at G2/M phase in PC-3. Monascuspiloin exhibits antitumor efficacy in mice .

HY-145751

7α-Hydroxy-DHEA 7α-Hydroxydehydroepiandrosterone; 3β,7α-Dihydroxy-Δ5-androsten-17-one	Structural Classification Source classification Endogenous metabolite Steroids	Cytochrome P450 Mitochondrial Metabolism
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA (HY-14650), catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma .

Cat. No.	Product Name	Chemical Structure

HY-B0141AS1

Alpha-Estradiol-d2
Alpha-Estradiol-d₂ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia[1].

HY-13635S

Finasteride-d9

Finasteride-d₉ is deuterium labeled Finasteride. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].

HY-123047S

Tibolone-d5
Tibolone-d₅ is deuterium labeled Tibolone. Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research .

HY-B0141AS

Alpha-Estradiol-d3
Alpha-Estradiol-d₃ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-W698952S

3β hydroxy Tibolone-d5
3β hydroxy Tibolone-d₅ is deuterium labeled Tibolone. Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research .

HY-139244S

Norgestimate-d6

Norgestimate-d₆ is the deuterium labeled Norgestimate. Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2]. Norgestimate-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-116214S1

Cyprodinil-13C6

Cyprodinil- ¹³C₆ is the ¹³C₆ labeled Cyprodinil. Cyprodinil is an anilinopyrimidine broad-spectrum fungicide that inhibits the biosynthesis of methionine in phytopathogenic fungi. Cyprodinil inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC₅₀s=0.44, 4.8, and 0.03 µM, respectively). Cyprodinil acts as an androgen receptor (AR) agonist (EC50=1.91 µM) in the absence of the AR agonist DHT and inhibits the androgenic effect of DHT (IC50=15.1 µM).

HY-116214S

Cyprodinil-d5

Cyprodinil-d₅ is the deuterium labeled Cyprodinil (HY-116214) . Cyprodinil is an anilinopyrimidine broad-spectrum fungicide that inhibits the biosynthesis of methionine in phytopathogenic fungi. Cyprodinil inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC₅₀s=0.44, 4.8, and 0.03 μM, respectively). Cyprodinil acts as an androgen receptor (AR) agonist (EC₅₀=1.91 μM) in the absence of the AR agonist DHT and inhibits the androgenic effect of DHT (IC₅₀=15.1 μM) .

HY-B1234S

Octinoxate-13C,d3

Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

Cat. No.	Product Name		Classification

HY-W013172

Norgestimate		Alkynes
Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive . Norgestimate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139244S

Norgestimate-d6		Alkynes
Norgestimate-d₆ is the deuterium labeled Norgestimate. Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2]. Norgestimate-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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