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Results for "

antiosteoporosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Autophagy (4) Bcl-2 Family (2) Caspase (2) Endogenous Metabolite (1) ERK (2) Interleukin Related (1) JAK (2) MMP (1) NF-κB (7) p38 MAPK (4) PARP (2) PI3K (1) PPAR (1) RANKL/RANK (2) STAT (2) TNF Receptor (1) Wnt (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (2) Endocrinology (3) Inflammation/Immunology (13) Metabolic Disease (4) Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-49069

Anti-osteoporosis agent-7	Others	Others
Anti-osteoporosis agent-7 (Compound 133) is a potential anti-osteoporosis agent showing high inhibition of osteoclast formation.

HY-N11514

Anti-osteoporosis agent-2	Others	Inflammation/Immunology
Anti-osteoporosis agent-2 (Compound 10) is an anti-osteoporosis agent. Anti-osteoporosis agent-2 inhibits differentiation on osteoclast induced by RANKL .

HY-149852

Anti-osteoporosis agent-3	Others	Inflammation/Immunology
Anti-osteoporosis agent-3 (Compound 11), a PMSA derivative, is an anti-osteoporosis agent. Anti-osteoporosis agent-3 inhibits osteoclastogenesis with an IC₅₀ value of 322.9 nM in vitro. Anti-osteoporosis agent-3 also blocks the formation of F-action belts and bone resorption .

HY-155985

Anti-osteoporosis agent-6	Others	Metabolic Disease
Anti-osteoporosis agent-6 (compound 174) is an anti-osteoporosis agent. Anti-osteoporosis agent-6 has 14.11% inhibition rate against osteoclast formation at 10 μM .

HY-169070

Anti-osteoporosis agent-10	PPAR	Others
Anti-osteoporosis agent-10 is an osteoporosis inhibitor. Anti-osteoporosis agent-10 can suppress the generation of osteoclasts, with an IC₅₀ of 0.042 μM. Anti-osteoporosis agent-10 also has antagonistic activity on PPARγ, with an EC₅₀ value of 0.75 μM .

HY-149472

Anti-osteoporosis agent-4	NF-κB PI3K	Inflammation/Immunology
Anti-osteoporosis agent-4 (Compound 11h) inhibits differentiation of primary osteoclasts. Anti-osteoporosis agent-4 attenuates RANKL-induced osteoclastogenesis. Anti-osteoporosis agent-4 inhibits osteoclast formation with an IC₅₀ value of 358.29 nM. Anti-osteoporosis agent-4 inhibits PI3K/AKT and IκBα/NF-κB signaling pathway activation .

HY-168090

Anti-osteoporosis agent-11	p38 MAPK NF-κB RANKL/RANK	Endocrinology
Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. Anti-osteoporosis agent-11 has the most significant inhibitory effect on osteoclast differentiation, with an IC₅₀ value of 0.36 μM. In addition, Anti-osteoporosis agent-11 inhibits osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking rankl-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways .

HY-155977

Anti-osteoporosis agent-5	Others	Others
Anti-osteoporosis agent-5 (compound 189) is a potent inhibitor of the formation of osteoclasts .

HY-158311

Anti-osteoporosis agent-8	RANKL/RANK p38 MAPK NF-κB	Endocrinology
Anti-osteoporosis agent-8 (Compound 4aa) is an inhibitor for RANKL, which inhibits RANKL-induced osteoclastogenesis and osteoclast differentiation (IC₅₀ is 2.41 μM) in cells RAW264.7. Anti-osteoporosis agent-8 ameliorates bone loss in an ovariectomized (OVX) mice model .

HY-145896

Anti-osteoporosis agent-1	Apoptosis	Inflammation/Immunology
Anti-osteoporosis agent-1 (comp 4aa) is a potent replication protein A (RPA) inhibitor (IC₅₀=18 µM) .

HY-163847

Anti-osteoporosis agent-9	Others	Inflammation/Immunology
Anti-osteoporosis agent-9 (compound 5b) 是一种 N-环丙基-4-((磺酰哌嗪-1-基)甲基)苯酰胺衍生物，显示出抗破骨细胞活性。

HY-162847

S24–14	Others	Metabolic Disease
S24–14 is a potent antiosteoporosis agent. S24–14 inhibits osteoclastogenesis with an IC₅₀ value of 0.40 µM. S24–14 induces osteoblast differentiation. S24–14 suppresses bone loss .

HY-N10370

Morusignin L	Others	Cancer
Morusignin L is an active compound that shows anti-osteoporosis activities .

HY-N2290

Baohuoside VII	Others	Metabolic Disease
Baohuoside VII is a flavonoid isolated from Herba Epimedii, with anti-osteoporosis activities .

HY-W009208

Calcium L-Threonate	Endogenous Metabolite	Metabolic Disease
Calcium L-Threonate is an anti-osteoporosis agent, and widely used as a calcium supplement . Calcium L-Threonate also stimulates the uptake of ascorbic acid .

HY-163513

AACA	Wnt	Endocrinology
AACA is an inhibitor for sclerostin, that binds sclerostin on loop3 region with K_d of 15.4 nM. AACA exhibits anti-osteoporosis activity through Wnt signaling pathway .

HY-N0705

Curculigoside Maximum Cited Publications 6 Publications Verification	JAK STAT NF-κB	Neurological Disease Inflammation/Immunology Cancer
Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

HY-N0824

Syringin 1 Publications Verification Eleutheroside B	Autophagy	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Syringin (Eleutheroside B) is an active natural phenolic glycoside possessing various pharmacological activities, including anti-inflammatory, anti-irradiation, anti-osteoporosis and anticancer activities. Syringin also can be used to enhance memory, relieve fatigue, improve human cognition and protect ischemia heart against cerebrovascular damage, etc .

HY-N0705R

Curculigoside (Standard)	JAK STAT NF-κB	Neurological Disease Inflammation/Immunology Cancer
Curculigoside (Standard) is the analytical standard of Curculigoside. This product is intended for research and analytical applications. Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

HY-N0213

Peiminine 4 Publications Verification Verticinone; Raddeanine	Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis	Inflammation/Immunology Cancer
Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .

HY-155960

SH491	Others	Inflammation/Immunology
SH491 (Compound 33) is an antiosteoporosis agent. SH491 inhibits RANKL-induced osteoclast differentiation on bone-marrow-derived monocytes (BMMs) (IC₅₀: 11.8 nM). SH491 inhibits the expression of osteoclastogenesis-related marker genes (TRAP, CTSK, MMP-9, and ATPase v0d2) and proteins (TRAP, CTSK, MMP-9) .

HY-N0824R

Syringin (Standard)	Autophagy	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Syringin (Standard) is the analytical standard of Syringin. This product is intended for research and analytical applications. Syringin (Eleutheroside B) is an active natural phenolic glycoside possessing various pharmacological activities, including anti-inflammatory, anti-irradiation, anti-osteoporosis and anticancer activities. Syringin also can be used to enhance memory, relieve fatigue, improve human cognition and protect ischemia heart against cerebrovascular damage, etc .

HY-N0213R

Peiminine (Standard)	Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis	Inflammation/Immunology Cancer
Peiminine (Standard) is the analytical standard of Peiminine. This product is intended for research and analytical applications. Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .

HY-N1940

β-Anhydroicaritin 1 Publications Verification Cycloicaritin	Interleukin Related TNF Receptor MMP	Inflammation/Immunology Cancer
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

Calcium L-Threonate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Calcium L-Threonate is an anti-osteoporosis agent, and widely used as a calcium supplement . Calcium L-Threonate also stimulates the uptake of ascorbic acid .

Curculigoside Maximum Cited Publications 6 Publications Verification	Curculigo orchioides Gaertn. Structural Classification Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Plants Amaryllidaceae Disease Research Fields Cancer	JAK STAT NF-κB
Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

Syringin 1 Publications Verification Eleutheroside B	Cardiovascular Disease Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Disease Research Fields Araliaceae	Autophagy
Syringin (Eleutheroside B) is an active natural phenolic glycoside possessing various pharmacological activities, including anti-inflammatory, anti-irradiation, anti-osteoporosis and anticancer activities. Syringin also can be used to enhance memory, relieve fatigue, improve human cognition and protect ischemia heart against cerebrovascular damage, etc .

Peiminine 4 Publications Verification Verticinone; Raddeanine	Alkaloids Piperidine Alkaloids Structural Classification Fritillaria thunbergii Miq. Liliaceae Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis
Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .

Anti-osteoporosis agent-2	Structural Classification Terpenoids Sesquiterpenes Source classification Bituminaria morisiana (Pignatti & Metlesics) Greuter Plants Compositae	Others
Anti-osteoporosis agent-2 (Compound 10) is an anti-osteoporosis agent. Anti-osteoporosis agent-2 inhibits differentiation on osteoclast induced by RANKL .

Morusignin L	Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Morus alba L. Plants Moraceae Disease Research Fields Cancer	Others
Morusignin L is an active compound that shows anti-osteoporosis activities .

Baohuoside VII	Flavonols Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields	Others
Baohuoside VII is a flavonoid isolated from Herba Epimedii, with anti-osteoporosis activities .

Curculigoside (Standard)	Curculigo orchioides Gaertn. Structural Classification Monophenols Source classification Phenols Plants Amaryllidaceae	JAK STAT NF-κB
Curculigoside (Standard) is the analytical standard of Curculigoside. This product is intended for research and analytical applications. Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

Syringin (Standard)	Structural Classification Simple Phenylpropanols Source classification Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae	Autophagy
Syringin (Standard) is the analytical standard of Syringin. This product is intended for research and analytical applications. Syringin (Eleutheroside B) is an active natural phenolic glycoside possessing various pharmacological activities, including anti-inflammatory, anti-irradiation, anti-osteoporosis and anticancer activities. Syringin also can be used to enhance memory, relieve fatigue, improve human cognition and protect ischemia heart against cerebrovascular damage, etc .

Peiminine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Fritillaria thunbergii Miq. Liliaceae Source classification Plants	Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis
Peiminine (Standard) is the analytical standard of Peiminine. This product is intended for research and analytical applications. Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .

β-Anhydroicaritin 1 Publications Verification Cycloicaritin	Flavonols Structural Classification Flavonoids Classification of Application Fields Plants Burseraceae Inflammation/Immunology Disease Research Fields Boswellia carterii	Interleukin Related TNF Receptor MMP
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

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antiosteoporosis

Inhibitors & Agonists

NaturalProducts

Natural
Products