Search Result

Results for "

carboxylases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (30) ADC Cytotoxin (3) AMPK (4) Antibiotic (4) Apoptosis (3) Autophagy (3) Bacterial (6) Endogenous Metabolite (6) Guanylate Cyclase (1) HBV (3) HIV (3) HMG-CoA Reductase (HMGCR) (1) Isotope-Labeled Compounds (1) Mitophagy (3) NF-κB (1) PROTACs (1) Reactive Oxygen Species (1) Topoisomerase (3)
By Research Areas:	Cancer (11) Cardiovascular Disease (1) Endocrinology (1) Infection (8) Inflammation/Immunology (3) Metabolic Disease (20) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Acetyl-CoA Carboxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-142684

*Pyruvate Carboxylase-IN-1*	Others	Cancer
Pyruvate Carboxylase-IN-1 (compound 37) is a potent pyruvate carboxylase inhibitor with antiproliferative activity. The IC₅₀ values of pyruvate carboxylase-IN-1 against PC in cell lysates and cells are 0.204 and 0.104 μM, respectively .

HY-B0511

Biotin 5+ Cited Publications Vitamin B7; Vitamin H; D-Biotin	Endogenous Metabolite	Metabolic Disease
Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-B0511R

Biotin (Standard) Vitamin B7 (Standard); Vitamin H (Standard); D-Biotin (Standard)	Endogenous Metabolite	Metabolic Disease
Biotin (Standard) is the analytical standard of Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-111223

Tralkoxydim PP604; ICIA 0604; FD-4026	Acetyl-CoA Carboxylase	Others
Tralkoxydim is a cyclohexanedione herbicide that inhibits Acetyl-CoA Carboxylase in corn .

HY-161679S

*Pyruvate Carboxylase-IN-3*	Isotope-Labeled Compounds	Cancer
Pyruvate Carboxylase-IN-3 (Compd 36) is a potent Pyruvate Carboxylase inhibitor. Pyruvate Carboxylase-IN-3 inhibits hepatocellular carcinoma cells activity with an IC₅₀ of 4.3 μM .

HY-161680

*Pyruvate Carboxylase-IN-4*	Others	Cancer
Pyruvate Carboxylase-IN-4 (Compd 8V) is a potent and competitive Pyruvate Carboxylase inhibitor with an IC₅₀ of 4.3 μM .

HY-111223R

Tralkoxydim (Standard)	Acetyl-CoA Carboxylase	Others
Tralkoxydim (Standard) is the analytical standard of Tralkoxydim. This product is intended for research and analytical applications. Tralkoxydim is a cyclohexanedione herbicide that inhibits Acetyl-CoA Carboxylase in corn .

HY-161681

Formycin triphosphate	Guanylate Cyclase	Metabolic Disease
Formycin triphosphate is a fluorescent analogue of ATP which on binding to enzyme active sites exhibits enhanced fluorescence. Formycin triphosphate is an ATP-competitive chicken liver pyruvate carboxylase inhibitor. Formycin triphosphate potentiates atrial natriuretic factor (ANF)-stimulated guanylate cyclase activity with an EC₅₀ at about 90 μM and inhibits ATP-stimulated guanylate cyclase activity with an IC₅₀ at about 100 μM .

HY-134425

β-Methylcrotonyl coenzyme A lithium	Endogenous Metabolite	Metabolic Disease
β-Methylcrotonyl coenzyme A lithium is an intermediate in leucine metabolism and can be used as a substrate to study the specificity and kinetics of β-methylcrotonyl coenzyme A carboxylase (MCCase) .

HY-B0511A

Biotin sodium Vitamin B7 sodium; Vitamin H sodium; D-Biotin sodium	Endogenous Metabolite	Metabolic Disease
Biotin (Vitamin B7) sodium is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin sodium is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-16946

CP-610431	Acetyl-CoA Carboxylase	Metabolic Disease
CP-610431 is a reversible, ATP-uncompetitive, isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor. CP-610431 inhibits ACC1 and ACC2 with IC₅₀s of ~50 nM. CP-610431 can be used for the research of metabolic syndrome .

HY-B1856

Haloxyfop	Acetyl-CoA Carboxylase	Metabolic Disease
Haloxyfop is an aryloxyphenoxypropionic acid herbicide and is widely used in grass weeds in broad-leaf crops . Haloxyfop inhibits the acetyl coenzyme A carboxylase (EC 6.4.1.2) from corn seedling chloroplasts with an IC₅₀ of 0.5 μM, but has no effect on this enzyme in pea .

HY-147004

A-908292	Acetyl-CoA Carboxylase	Metabolic Disease
A-908292 is a potent and selective *acetyl-CoA carboxylase* 2 (ACC2) inhibitor, with an IC₅₀** of 23 nM for human ACC2. A-908292 can be used for the research of fatty acid metabolism . A-908292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139134

S-2E	HMG-CoA Reductase (HMGCR) Acetyl-CoA Carboxylase	Cardiovascular Disease
S-2E is an orally active and noncompetitive HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. S-2E has an anti-hyperlipidemic action. S-2E has the potential for familial hypercholesterolemia and mixed hyperlipidemia research .

HY-B1856R

Haloxyfop (Standard)	Acetyl-CoA Carboxylase	Metabolic Disease
Haloxyfop (Standard) is the analytical standard of Haloxyfop. This product is intended for research and analytical applications. Haloxyfop is an aryloxyphenoxypropionic acid herbicide and is widely used in grass weeds in broad-leaf crops . Haloxyfop inhibits the acetyl coenzyme A carboxylase (EC 6.4.1.2) from corn seedling chloroplasts with an IC50 of 0.5 μM, but has no effect on this enzyme in pea .

HY-147376

hACC2-IN-1	Acetyl-CoA Carboxylase	Metabolic Disease
hACC2-IN-1 is a potent *acetyl-CoA carboxylase* 2 (ACC2) inhibitor, with an IC₅₀ value of 2.5 μM (hACC2**). hACC2-IN-1 could be used for obesity research .

HY-152117

*Acetyl-CoA Carboxylase-IN-1*	Acetyl-CoA Carboxylase Bacterial	Infection
Acetyl-CoA Carboxylase-IN-1 is a potent *acetyl-CoA carboxylase* (ACC) inhibitor with an IC₅₀** value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity .

HY-E70015

*Phosphoenolpyruvate carboxylase, Microorganism* PEPC	Others	Others
Phosphoenolpyruvate carboxylase, Microorganism (PEPC) is a carbon dioxide fixing enzyme that in an irreversible manner and in the presence of Mg ²⁺, converts phosphoenolpyruvate and bicarbonate into oxaloacetate and inorganic phosphorus. Phosphoenolpyruvate carboxylase catalyses the primary assimilation of CO(2) in Crassulacean acid metabolism plants. Phosphoenolpyruvate carboxylase plays a major role in setting the day-night pattern of metabolism in plants .

HY-163771

*Pyruvate Carboxylase-IN-5*	Others	Metabolic Disease
Pyruvate Carboxylase-IN-5 (compound 6m) is a pyruvate carboxylase inhibitor with high selectivity and permeability. Pyruvate carboxylase is a mitochondrial enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, a process that plays an important role in maintaining steady-state levels of Krebs cycle intermediates, which are precursors for the synthesis of biomacromolecules such as amino acids, fatty acids, and glucose .

HY-117262

Propaquizafop	Acetyl-CoA Carboxylase	Others
Propaquizafop is a phenoxyisopropionic acid herbicide and an acetyl-coA carboxylase inhibitor .

HY-17641

Olumacostat glasaretil DRM01	Acetyl-CoA Carboxylase	Others
Olumacostat glasaretil (DRM01) is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC).

HY-142870

ZY-444	Others	Cancer
ZY-444 is a small molecule that suppresses breast cancer progression by targeting pyruvate carboxylase.

HY-P2989

Pyruvate carboxylase	Endogenous Metabolite	Metabolic Disease
Pyruvate carboxylase is a biotin-containing enzyme that catalyzes the HCO3 ⁻ and MgATP dependent carboxylation of pyruvate to form oxaloacetate. Pyruvate carboxylase plays an essential role in controlling whole-body energetics through regulation of gluconeogenesis in the liver, synthesis of fatty acids in adipocytes, and insulin secretion in pancreatic β cells .

HY-B2007

Fluazifop-P-butyl	Acetyl-CoA Carboxylase	Metabolic Disease
Fluazifop-P-butyl, a graminicide from arylophenoxypropionate group, is a *acetyl-CoA carboxylase* (ACCase)** inhibitor .

HY-135753

Sethoxydim BAS 9052	Acetyl-CoA Carboxylase	Others
Sethoxydim is a postemergent herbicide. Sethoxydim inhibits plant acetyl-coenzyme A carboxylase (ACCase) activity .

HY-B0861

Cyhalofop-butyl	Others	Others
Cyhalofop-butyl is a post-emergence herbicide. Cyhalofop-butyl inhibits acetyl-coenzyme A carboxylase (ACCase) biosynthesis .

HY-101068

TOFA 5+ Cited Publications RMI14514; MDL14514	Acetyl-CoA Carboxylase	Cancer
TOFA (RMI14514;MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA ).

HY-P2744

Ribulose bisphosphate carboxylase Ribulose 1,5-bisphosphate carboxylase	Others	Others
Ribulose bisphosphate carboxylase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-16901A

Firsocostat (S enantiomer) ND-630 (S enantiomer); GS-0976 (S enantiomer); NDI-010976 (S enantiomer)	Acetyl-CoA Carboxylase	Others
Firsocostat S enantiomer (ND-630 S enantiomer) is the less active S enantiomer of Firsocostat. Firsocostat is an acetyl-CoA carboxylase (ACC) inhibitor.

HY-107709

MK-4074 4 Publications Verification	Acetyl-CoA Carboxylase	Metabolic Disease
MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC₅₀ values of approximately 3 nM.

HY-16943

Moiramide B	Bacterial Acetyl-CoA Carboxylase	Infection
Moiramide B is a potent *acetyl-CoA carboxylase* (ACC) inhibitor with an IC₅₀** value of 6 nM. Moiramide B has antibacterial activity .

HY-15259A

CP-640186 hydrochloride 5+ Cited Publications	Acetyl-CoA Carboxylase	Metabolic Disease
CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation .

HY-15259

CP-640186 5+ Cited Publications	Acetyl-CoA Carboxylase	Metabolic Disease
CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation .

HY-169009

(Rac)-Spirotetramat-enol	Acetyl-CoA Carboxylase	Infection
(Rac)-Spirotetramat-enol (Compound 8) is a ligand of acetyl-CoA carboxylase that can be used to synthesize PROTAC ADC degrader (HY-169008) .

HY-117262R

Propaquizafop (Standard)	Acetyl-CoA Carboxylase	Others
Propaquizafop (Standard) is the analytical standard of Propaquizafop. This product is intended for research and analytical applications. Propaquizafop is a phenoxyisopropionic acid herbicide and an acetyl-coA carboxylase inhibitor .

HY-158246

QPP-I-6	Acetyl-CoA Carboxylase	Others
QPP-I-6 is an inhibitor for acetyl-coenzyme A carboxylase (ACCase). QPP-I-6 exhibits herbicidal activity through induction of cell membrane permeability .

HY-135753R

Sethoxydim (Standard)	Acetyl-CoA Carboxylase	Others
Sethoxydim (Standard) is the analytical standard of Sethoxydim. This product is intended for research and analytical applications. Sethoxydim is a postemergent herbicide. Sethoxydim inhibits plant acetyl-coenzyme A carboxylase (ACCase) activity .

HY-101842

ND-646 5+ Cited Publications	Acetyl-CoA Carboxylase	Cancer
ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC₅₀s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.

HY-B0861R

Cyhalofop-butyl (Standard)	Others	Others
Cyhalofop-butyl (Standard) is the analytical standard of Cyhalofop-butyl. This product is intended for research and analytical applications. Cyhalofop-butyl is a post-emergence herbicide. Cyhalofop-butyl inhibits acetyl-coenzyme A carboxylase (ACCase) biosynthesis .

HY-B2007R

Fluazifop-P-butyl (Standard)	Acetyl-CoA Carboxylase	Metabolic Disease
Fluazifop-P-butyl (Standard) is the analytical standard of Fluazifop-P-butyl. This product is intended for research and analytical applications. Fluazifop-P-butyl, a graminicide from arylophenoxypropionate group, is a acetyl-CoA carboxylase (ACCase) inhibitor .

HY-16901

Firsocostat 10+ Cited Publications ND-630; GS-0976; NDI-010976	Acetyl-CoA Carboxylase	Metabolic Disease
Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC₅₀ values of 2.1 and 6.1 nM, respectively.

HY-123307

Quizalofop Xylafop	Acetyl-CoA Carboxylase	Others
Quizalofop (Xylafop) is a herbicide that inhibits acetyl-CoA carboxylase (ACCase) to reduce the synthesis of fatty acids. Quizalofop can be used to screen EMS (HY-W015854) mutated microalgae for research on improving the performance of microalgae biofuel production .

HY-12942

PF-05175157 2 Publications Verification	Acetyl-CoA Carboxylase	Metabolic Disease
PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively.

HY-W015273

3-Indoleacrylic acid	Reactive Oxygen Species	Others
3-Indoleacrylic acid is a high-efficient antialgal agent. 3-Indoleacrylic acid increases reactive oxygen species (ROS) production, and inhibits the functions of all the nutrient assimilating genes, down-regulated ribulose-1,5-bisphosphate carboxylase/oxygenase II, and cytochrome f genes in P. donghaiense .

HY-135981

CMS-121 1 Publications Verification	Acetyl-CoA Carboxylase	Neurological Disease Inflammation/Immunology
CMS-121 is a quinolone derivative and an orally active *acetyl-CoA carboxylase* 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC₅₀** values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities .

HY-15142

Doxorubicin hydrochloride Maximum Cited Publications 422 Publications Verification Hydroxydaunorubicin hydrochloride; ADR	Topoisomerase ADC Cytotoxin AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial	Infection Cancer
Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-144701

SABA1	Antibiotic Bacterial	Infection Inflammation/Immunology
SABA1 possesses antibacterial properties against Pseudomonas aeruginosa and Escherichia coli, with an IC₅₀ of 4.0 µM against E. coli ACC .

HY-137912

trans-Resveratrol-3-O-β-D-Glucuronide	Others	Endocrinology Cancer
trans-Resveratrol-3-O-β-D-Glucuronide is an active metabolite of trans-resveratrol. trans-Resveratrol-3-O-β-D-Glucuronide reduces the proliferation of several intestinal cancer cell line. trans-Resveratrol-3-O-β-D-Glucuronide increases pyruvate production in livers .

HY-169008

PROTAC ACC degrader-1	PROTACs Acetyl-CoA Carboxylase	Infection
PROTAC ACC degrader-1 (Compound 9b) is a Acetyl-CoA Carboxylase degrader. PROTAC ACC degrader-1 exhibits superior potency against Aphis craccivora (IC₅₀ = 107.8 μg/mL). (Srtucture Note: Pink, Target protein ligand (HY-169009); Blue, E3 ligand (HY-10984); Black, linker (HY-W007559) .

HY-112083

BAY-3827 5 Publications Verification	AMPK	Cancer
BAY-3827 is a potent and selective AMPK inhibitor with IC₅₀ values of 1.4 nM at low (10 µM ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines .

Cat. No.	Product Name

HY-L091

Lipid Metabolism Compound Library

656 compounds

Lipids are a fundamental class of organic molecules implicated in a wide range of biological processes, and based on this can be broadly classified into five categories: fatty acids, triacylglycerols (TAGs), phospholipids, sterol lipids and sphingolipids. Lipids play a crucial role in different metabolic pathways and cellular functions. Lipid metabolism is an important physiological process that is related to nutrient adjustment, hormone regulation, and homeostasis. Lipid metabolism dysregulation is associated with many diseases such as obesity, liver disease, aging and inflammation.

MCE offers a unique collection of 656 compounds related to lipid metabolism, which target relevant targets in the process of lipid metabolism, such as ATGL, MAGL, FAAH, acetyl-Coa Carboxylase, FASN, etc. MCE lipid metabolism compound library is a useful tool for research lipid metabolism and drug discovery of diseases related to lipid metabolism.

Cat. No.	Product Name	Type

HY-134425

β-Methylcrotonyl coenzyme A lithium	Enzyme Substrates
β-Methylcrotonyl coenzyme A lithium is an intermediate in leucine metabolism and can be used as a substrate to study the specificity and kinetics of β-methylcrotonyl coenzyme A carboxylase (MCCase) .

Cat. No.	Product Name	Target	Research Area

HY-P4557

H-Phe-Leu-Glu-Glu-Leu-OH	Peptides	Others
H-Phe-Leu-Glu-Glu-Leu-OH is a synthetic pentapeptide, which can be used as the substrate of vitamin K dependent carboxylase, and a glutamyl residue in the generated product is carboxylated .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0511

Biotin 5+ Cited Publications Vitamin B7; Vitamin H; D-Biotin	Structural Classification Immune System Disorder Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Metabolic Disease Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-B0511R

Biotin (Standard) Vitamin B7 (Standard); Vitamin H (Standard); D-Biotin (Standard)	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Biotin (Standard) is the analytical standard of Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-16943

Moiramide B	Microorganisms Source classification	Bacterial Acetyl-CoA Carboxylase
Moiramide B is a potent *acetyl-CoA carboxylase* (ACC) inhibitor with an IC₅₀** value of 6 nM. Moiramide B has antibacterial activity .

HY-15142

Doxorubicin hydrochloride Maximum Cited Publications 422 Publications Verification Hydroxydaunorubicin hydrochloride; ADR	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Disease Research Fields	Topoisomerase ADC Cytotoxin AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial
Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-N11200

3-Hydroxyisovalerylcarnitine	Structural Classification Natural Products Microorganisms Source classification	Endogenous Metabolite
3-Hydroxyisovalerylcarnitine is a carnitine derivative. 3-Hydroxyisovaleryl carnitine in plasma may serve as a novel biomarker of biotin deficiency in humans, with its concentration increasing with biotin deficiency. Biotin deficiency reduces the activity of biotin-dependent 3-methylcrotonyl-CoA carboxylase, hinders the conversion of 3-methylcrotonyl-CoA into 3-methylglutaconyl-CoA, and impairs the leucine catabolism pathway; resulting in plasma 3-Hydroxyisovalerylcarnitine concentrations rise .

HY-15142R

Doxorubicin hydrochloride (Standard) 1 Publications Verification	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Topoisomerase ADC Cytotoxin AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial
Doxorubicin (hydrochloride) (Standard) is the analytical standard of Doxorubicin (hydrochloride). This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-134425

β-Methylcrotonyl coenzyme A lithium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
β-Methylcrotonyl coenzyme A lithium is an intermediate in leucine metabolism and can be used as a substrate to study the specificity and kinetics of β-methylcrotonyl coenzyme A carboxylase (MCCase) .

HY-B0511A

Biotin sodium Vitamin B7 sodium; Vitamin H sodium; D-Biotin sodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Biotin (Vitamin B7) sodium is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin sodium is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-15142A

Doxorubicin Hydroxydaunorubicin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	ADC Cytotoxin Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV
Doxorubicin (Hydroxydaunorubicin), a broad-spectrum anthracycline antibiotic with cytotoxic properties, is an anti-cancer chemotherapy agent. Doxorubicin has fluorescence properties. Doxorubicin inhibits topoisomerase II with an IC₅₀ of 2.67 μM, thus stopping DNA replication. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy . Doxorubicin inhibits human DNA topoisomerase I with an IC₅₀ of 0.8 μM .

Cat. No.	Product Name	Chemical Structure

HY-161679S

*Pyruvate Carboxylase-IN-3*
Pyruvate Carboxylase-IN-3 (Compd 36) is a potent Pyruvate Carboxylase inhibitor. Pyruvate Carboxylase-IN-3 inhibits hepatocellular carcinoma cells activity with an IC₅₀ of 4.3 μM .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

carboxylases

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products