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centrally-acting

" in MedChemExpress (MCE) Product Catalog:

43

Inhibitors & Agonists

1

Natural
Products

10

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1057
    Nefopam hydrochloride
    2 Publications Verification

    Fenazoxine hydrochloride

    		 β-catenin Neurological Disease Cancer
    Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo .
    Nefopam hydrochloride
  • HY-B1057S
    Nefopam-d3 hydrochloride

    Fenazoxine-d3 hydrochloride

    		 β-catenin Neurological Disease
    Nefopam-d3 (hydrochloride) is the deuterium labeled Nefopam hydrochloride. Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo[1][2].
    Nefopam-d3 hydrochloride
  • HY-133115AS
    N-Desmethylnefopam D5 hydrochloride

    		β-catenin Neurological Disease
    N-Desmethylnefopam-d5 (hydrochloride) is a deuterium labeled N-Desmethylnefopam hydrochloride. N-Desmethylnefopam hydrochloride is the main metabolite of Nefopam. N-Desmethylnefopam hydrochloride is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain[1].
    N-Desmethylnefopam D5 hydrochloride
  • HY-133115
    N-Desmethylnefopam

    		β-catenin Neurological Disease
    N-Desmethylnefopam is the main metabolite of Nefopam. N-Desmethylnefopam is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain. Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo .
    N-Desmethylnefopam
  • HY-100294
    Ruzadolane

    UP 26-91

    		 Others Neurological Disease
    Ruzadolane (UP 26-91) is a non-narcotic, centrally-acting analgesic agent.
    Ruzadolane
  • HY-B1057S2
    Nefopam-d3

    Fenazoxine-d3

    		 β-catenin Neurological Disease
    Nefopam-d3 is a deuterium labeled Nefopam (Fenazoxine). Nefopam is a centrally-acting but non-opioid analgesic drug, and Nefopam targets β-catenin protein level in mesenchymal cells[1][2].
    Nefopam-d3
  • HY-B1057S1
    Nefopam-d4 hydrochloride

    Fenazoxine-d4 hydrochloride

    		 Isotope-Labeled Compounds β-catenin Neurological Disease
    Nefopam-d4 (hydrochloride) is deuterium labeled Nefopam (hydrochloride). Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo[1][2].
    Nefopam-d4 hydrochloride
  • HY-100159
    Ipenoxazone

    MLV-6976; NC-1200

    		 Others Neurological Disease
    Ipenoxazone is a potent and centrally acting muscle relaxant.
    Ipenoxazone
  • HY-100159A
    Ipenoxazone hydrochloride

    MLV-6976 hydrochloride; NC-1200 hydrochloride

    		 Others Neurological Disease
    Ipenoxazone (MLV-6976) hydrochloride is a potent and centrally acting muscle relaxant.
    Ipenoxazone hydrochloride
  • HY-B1139A
    Tolperisone

    		Others Neurological Disease
    Tolperisone, a centrally acting muscle relaxant, is utilized for alleviating symptoms of spasticity and muscle spasms.
    Tolperisone
  • HY-B1462
    Chlorzoxazone
    2 Publications Verification

    		 Cytochrome P450 Inflammation/Immunology
    Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort.
    Chlorzoxazone
  • HY-121644
    Viminol

    		Opioid Receptor Neurological Disease
    Viminol is a centrally acting analgesic agent. Viminol also shows antitussive activity .
    Viminol
  • HY-128469
    Inaperisone

    		GABA Receptor Neurological Disease
    Inaperisone is a centrally acting muscle relaxant. Inaperisone can inhibit the micturition reflex by acting indirectly on GABAB receptors in the brainstem .
    Inaperisone
  • HY-155297
    Nebidrazine

    FLA-136

    		 Histamine Receptor Cardiovascular Disease
    Nebidrazine is a centrally-acting hypotensive agent compared to clonidine, demonstrating weaker cardiovascular effects in rats. It induces dose-dependent hypotension and bradycardia when administered intracerebroventricularly (i.c.v.), with significantly lower sedative potential than clonidine in conscious rats. Yohimbine attenuates the cardiovascular effects of both Nebidrazine and clonidine, suggesting involvement of central alpha-autoreceptors sensitive to yohimbine. Unlike clonidine, Nebidrazine does not affect peripheral alpha-adrenoceptors in pithed rats, indicating a selective central mechanism. Chemical sympathectomy reduces Nebidrazine's cardiovascular effects more than clonidine's, and metiamide diminishes responses to both drugs, implicating central histamine receptors. These findings highlight Nebidrazine's distinct pharmacological profile and potential therapeutic application in managing hypertension through central alpha-autoreceptor stimulation .
    Nebidrazine
  • HY-W016221
    6-Hydroxy Chlorzoxazone

    		Drug Metabolite Inflammation/Immunology
    6-Hydroxy Chlorzoxazone is a metabolite of Chlorzoxazone (HY-B1462). Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort .
    6-Hydroxy Chlorzoxazone
  • HY-B1462S1
    Chlorzoxazone-13C

    		Cytochrome P450 Inflammation/Immunology
    Chlorzoxazone- 13C is the 13C labeled Chlorzoxazone[1]. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort[2].
    Chlorzoxazone-13C
  • HY-17001
    Flupirtine Maleate
    1 Publications Verification

    		 Potassium Channel iGluR Neurological Disease
    Flupirtine Maleate is a?brain?penetrant, and orally bioavailable, non-opioid and centrally acting analgesic agent. Flupirtine Maleate is an indirect N-methyl-D-aspartate receptor (NMDAR) antagonist. Neuroprotective properties .
    Flupirtine Maleate
  • HY-101324
    MK-212

    CPP

    		 5-HT Receptor Neurological Disease
    MK-212 (CPP) is a centrally acting 5-HT1C/5-HT2 agonist. MK-212 can stimulate phosphoinositide hydrolysis in cerebral cortex .
    MK-212
  • HY-B1139
    Tolperisone hydrochloride
    1 Publications Verification

    		 Apoptosis Neurological Disease
    Tolperisone hydrochloride is a centrally acting muscle relaxant studied in neurological disorders causing pathological rhabdomyosclerosis (pyramidal tract injury, multiple sclerosis, myelopathy, encephalomyelitis), spastic paralysis, and other muscle dystonia-related Encephalopathy. Tolperisone hydrochloride also has antiviral activity .
    Tolperisone hydrochloride
  • HY-101324A
    MK-212 monohydrochloride

    CPP monohydrochloride

    		 5-HT Receptor Neurological Disease
    MK-212 (CPP) monohydrochloride is a centrally acting 5-HT1C/5-HT2 agonist. MK-212 monohydrochloride can stimulate phosphoinositide hydrolysis in cerebral cortex .
    MK-212 monohydrochloride
  • HY-112074A
    Tiamenidine hydrochloride

    HOE 440 hydrochloride

    		 Adrenergic Receptor Cardiovascular Disease
    Tiamenidine hydrochloride (HOE 440 hydrochloride) is a centrally acting α1-adrenergic receptor antagonist with hypotensive activity. Tiamenidine hydrochloride regulates blood pressure levels by binding to α1 receptors. Tiamenidine hydrochloride can be used in the study of hypertension .
    Tiamenidine hydrochloride
  • HY-107944
    Chlorphenesin carbamate

    Maolate; U 19646

    		 Others Neurological Disease
    Chlorphenesin carbamate is a centrally acting skeletal muscle relaxant. Chlorphenesin carbamate can be used for the research of pain and discomfort related to skeletal muscle trauma and inflammation . Chlorphenesin carbamate is a selective blocker of polysynaptic pathways at the spinal and supra-spinal levels . Antinociceptive effect .
    Chlorphenesin carbamate
  • HY-17001R
    Flupirtine (Maleate) (Standard)

    		Potassium Channel iGluR Neurological Disease
    Flupirtine (Maleate) (Standard) is the analytical standard of Flupirtine (Maleate). This product is intended for research and analytical applications. Flupirtine Maleate is a brain penetrant, and orally bioavailable, non-opioid and centrally acting analgesic agent. Flupirtine Maleate is an indirect N-methyl-D-aspartate receptor (NMDAR) antagonist. Neuroprotective properties .
    Flupirtine (Maleate) (Standard)
  • HY-19231
    DPI-3290

    Org 41793

    		 Opioid Receptor Neurological Disease
    DPI-3290 (Org 41793) is a potent and specific opioid receptors agonist with Ki values of 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively。DPI-3290 is one of a series of novel centrally acting agents with potent antinociceptive activity .
    DPI-3290
  • HY-106888A
    CS-722

    		Endogenous Metabolite Neurological Disease
    CS-722 is a centrally acting muscle relaxant, and has a muscle relaxant activity and depressant effectson the spinal reflex[1]. CS-722 inhibits spontaneous inhibitory postsynaptic currents and excitatory postsynaptic currents in hippocampal cultures probably by an inhibition of both sodium and calcium currents .
    CS-722
  • HY-B1139S
    Tolperisone-d10 hydrochloride

    		Isotope-Labeled Compounds Neurological Disease
    Tolperisone-d10 (hydrochloride) is the deuterium labeled Tolperisone hydrochloride. Tolperisone hydrochloride is a centrally acting muscle relaxant, is indicated for use in the treatment of pathologically increased tone of the cross-striated muscle caused by neurological diseases (damage of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis) and of spastic paralysis and other encephalopathies manifested with muscular dystonia.
    Tolperisone-d10 hydrochloride
  • HY-W016221R
    6-Hydroxy Chlorzoxazone (Standard)

    		Drug Metabolite Inflammation/Immunology
    6-Hydroxy Chlorzoxazone (Standard) is the analytical standard of 6-Hydroxy Chlorzoxazone. This product is intended for research and analytical applications. 6-Hydroxy Chlorzoxazone is a metabolite of Chlorzoxazone (HY-B1462). Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort .
    6-Hydroxy Chlorzoxazone (Standard)
  • HY-B0520A
    Benztropine mesylate
    5 Publications Verification

    Benzatropine mesylate; Benzotropine mesylate; Benztropine methanesulfonate

    		 Dopamine Receptor mAChR Histamine Receptor Neurological Disease Cancer
    Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects .
    Benztropine mesylate
  • HY-106888
    CS-722 Free base

    		Endogenous Metabolite Neurological Disease
    CS-722 Free base is a synthesized centrally acting muscle relaxant, and has a muscle relaxant activity and depressant effectson the spinal reflex . CS-722 Free base inhibits spontaneous inhibitory postsynaptic currents and excitatory postsynaptic currents in hippocampal cultures probably by an inhibition of both sodium and calcium currents .
    CS-722 Free base
  • HY-B1139R
    Tolperisone (hydrochloride) (Standard)

    		Apoptosis Neurological Disease
    Tolperisone (hydrochloride) (Standard) is the analytical standard of Tolperisone (hydrochloride). This product is intended for research and analytical applications. Tolperisone hydrochloride is a centrally acting muscle relaxant studied in neurological disorders causing pathological rhabdomyosclerosis (pyramidal tract injury, multiple sclerosis, myelopathy, encephalomyelitis), spastic paralysis, and other muscle dystonia-related Encephalopathy. Tolperisone hydrochloride also has antiviral activity .
    Tolperisone (hydrochloride) (Standard)
  • HY-133195
    Nefopam

    Fenazoxine

    		 Others Neurological Disease
    Nefopam (Fenazoxine) is an orally active, non-opioid and non-steroidal centrally acting analgesic agent. Nefopam blocks voltage-sensitive sodium channels (IC50=27 μM) and modulates glutamatergic transmission in rodents. Nefopam can be used in studies of neuropathic pain, anticonvulsant, as well as the prevention of postoperative shivering and hiccups .
    Nefopam
  • HY-115895
    Trebenzomine

    CI-686 free base

    		 Others Neurological Disease
    Trebenzomine (CI-686 free base) is a centrally acting psychotropic compound. Trebenzomine has both neuroleptic and stimulant activity. Trebenzomine potentiates Methamphetamine-induced self-stimulation. Trebenzomine reduces septal hyperirritability, suppression of conditioned avoidance behavior, blocks Apomorphine (HY-12723)-induced emesis in dogs .
    Trebenzomine
  • HY-128891
    Eperisone

    		Others Neurological Disease
    Eperisone is an antispastic agent used for treatment of diseases characterized by muscle stiffness and pain. It works by relaxing both skeletal muscles and vascularsmooth muscles, thus demonstrating avariety of effects such as reduction ofmyotonia, improvement of circulationand suppression of the pain reflex. Eperisone is a centrally acting muscle relaxant inhibiting the pain reflex pathway, having a vasodilator effect [2 .
    Eperisone
  • HY-B0520
    Benztropine

    Benzatropine; Benzotropine

    		 Dopamine Receptor mAChR Histamine Receptor Cancer
    Benztropine (Benzatropine; Benzotropine) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research . Benztropine is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects .
    Benztropine
  • HY-B1462S
    Chlorzoxazone-d3

    		Cytochrome P450 Inflammation/Immunology
    Chlorzoxazone-d3 is the deuterium labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.Chlorzoxazone is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans.
    Chlorzoxazone-d3
  • HY-107944R
    Chlorphenesin carbamate (Standard)

    		Others Neurological Disease
    Chlorphenesin carbamate (Standard) is the analytical standard of Chlorphenesin carbamate. This product is intended for research and analytical applications. Chlorphenesin carbamate is a centrally acting skeletal muscle relaxant. Chlorphenesin carbamate can be used for the research of pain and discomfort related to skeletal muscle trauma and inflammation . Chlorphenesin carbamate is a selective blocker of polysynaptic pathways at the spinal and supra-spinal levels . Antinociceptive effect .
    Chlorphenesin carbamate (Standard)
  • HY-101100
    Anpirtoline hydrochloride

    D-16949 hydrochloride

    		 5-HT Receptor Neurological Disease
    Anpirtoline (D-16949) hydrochloride is a centrally acting 5-HT1B receptor agonist, with Kis of 28 nM (5-HT1B), 150 nM (5-HT1A) and 1.49 μM (5-HT2). Anpirtoline hydrochloride has serotonergic, antinociceptive, antidepressant-like effects .
    Anpirtoline hydrochloride
  • HY-101100A
    Anpirtoline

    D-16949

    		 5-HT Receptor Neurological Disease
    Anpirtoline (D-16949) is a centrally acting 5-HT1B receptor agonist, with Kis of 28 nM (5-HT1B), 150 nM (5-HT1A) and 1.49 μM (5-HT2). Anpirtoline has serotonergic, antinociceptive, antidepressant-like effects .
    Anpirtoline
  • HY-B0520AR
    Benztropine (mesylate) (Standard)

    Benzatropine mesylate (Standard); Benzotropine mesylate (Standard); Benztropine methanesulfonate (Standard)

    		 Dopamine Receptor mAChR Histamine Receptor Neurological Disease Cancer
    Benztropine (mesylate) (Standard) is the analytical standard of Benztropine (mesylate). This product is intended for research and analytical applications. Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects .
    Benztropine (mesylate) (Standard)
  • HY-B1901S
    Eperisone-d10 hydrochloride

    		Isotope-Labeled Compounds Neurological Disease
    Eperisone-d10 (hydrochloride) is the deuterium labeled Eperisone hydrochloride. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is an antispastic agent used for treatment of diseases characterized by muscle stiffness and pain. It works by relaxing both skeletal muscles and vascularsmooth muscles, thus demonstrating avariety of effects such as reduction ofmyotonia, improvement of circulationand suppression of the pain reflex. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is a centrally acting muscle relaxant inhibiting the pain reflex pathway, having a vasodilator effect[1][2 [3].
    Eperisone-d10 hydrochloride
  • HY-B0520AS1
    Benztropine-d3 mesylate

    		Dopamine Receptor Histamine Receptor mAChR Cancer
    Benztropine-d3 (mesylate) is the deuterium labeled Benztropine mesylate[1]. Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[2][3].
    Benztropine-d3 mesylate
  • HY-B0520AS
    Benztropine-13C,d3 mesylate

    		Isotope-Labeled Compounds Dopamine Receptor mAChR Histamine Receptor Neurological Disease Cancer
    Benztropine- 13C,d3 (mesylate) is the 13C- and deuterium labeled Benztropine (mesylate). Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[1][2].
    Benztropine-13C,d3 mesylate
  • HY-127004
    Silperisone hydrochloride

    RGH-5002

    		 Sodium Channel Others
    Silperisone hydrochloride is an organosilicone compound similar to tolperisone that has centrally acting muscle relaxant properties. Silperisone (hydrochloride) is a sodium channel protein type 2 alpha channel blocker that blocks sodium and calcium channels in cells, reduces muscle cell excitability and contraction, reduces peripheral tone, and acts as a muscle relaxant and peripheral vascular dilator. Silperisone (hydrochloride) is used to study recurrent painful myoclonus due to spinal cord injury, abnormal hypertonia due to cerebrovascular disease, myotonia symptoms, pyramidal tonia syndrome, multiple sclerosis myospasm, and myelitis .
    Silperisone hydrochloride

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