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BPR1R024 is an orally active and selective colony-stimulatingfactor-1receptor(CSF1R) inhibitor. BPR1R024 has potent CSF1R inhibition activity with an IC50 value of 0.53 nM. BPR1R024 can be used for the research of immuno-oncology .
JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulatingfactor-1receptor(CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis .
c-Fms-IN-10 is the derivative of thieno [3,2-d] pyrimidine, an kinase inhibitor of FMS (Colony stimulatingfactor-1receptor, CSF-1R) with IC50 of 2 nM.
c-Fms-IN-10 has anti-tumor activity .
CSF1R-IN-15 (compound 23) is an inhibitor targeting CSF1R. The colony-stimulatingfactor-1receptor (CSF1R) is a tyrosine kinase embedded in the cell membrane of macrophages. The receptor is activated by colony-stimulatingfactor-1 (CSF-1) and interleukin-34, and signaling via CSF1R is crucial for the differentiation, proliferation, and survival of macrophages .
CSF1R-IN-23 (Compound 7dri) is a selective inhibitor for colony-stimulatingfactor-1receptor(CSF1R), with IC50 of 36.1 nM. CSF1R-IN-23 serves as antineuroinflammatory agent in mouse model. CSF1R-IN-23 is blood brain barrier (BBB) permeable .
BPR1R024 mesylate is an orally active and selective colony-stimulatingfactor-1receptor(CSF1R) inhibitor.
BPR1R024 mesylate is the equivalent of BPR1R024 (HY-132935). BPR1R024 has potent CSF1R inhibition activity with an IC50 value of 0.53 nM. BPR1R024 can be used for the research of immuno-oncology .
CSF1R-IN-18 (Compdound 16t), para-aniline derivative, is a colony-stimulatingfactor 1receptor (CSF1R) inhibitor. CSF1R-IN-18 can be used for the research of cancers, CNS-diseases and bone diseases .
JNJ-28312141 is an inhibitor for colony-stimulatingfactor-1receptor(CSF-1R or FMS), with an IC50 of 0.69 nM. JNJ-28312141 inhibits proliferation of BDBM, MV-4-11, M-o7e, TF-1 with an IC50s of 2.6, 21, 41 and 150 nM, respectively. JNJ-28312141 exhibits anti-inflammatory activity in mouse arthritis model .
Emactuzumab(RG 7155) is a specific monoclonal antibody that inhibits colonystimulatingfactor 1receptor(CSF1R) activation. Emactuzumab has high affinity for CSF-1R with Ki value of 0.2 nM to blocks CSF-1R dimerization. Emactuzumab can be used for the research of several diseases, such as diffuse-type tenosynovial giant cell tumour (dt-GCT) .
AZ683 is a potent and selective 3-amido-4-anilinoquinoline CSF1R inhibitor. AZ683 has high affinity for CSF1R (Ki=8 nM; IC50=6 nM). AZ683 has good oral bioavailability. [ 11C]AZ683 can be used as a positron emission tomography (PET) radiotracer for colony stimulatingfactor 1receptor (CSF1R) .
Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulatingfactor 1receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity .
Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulatingfactor 1receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity .
Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active colony-stimulatingfactor-1receptor(CSF-1R) inhibitor with an IC50 of 3.2 nM. Edicotinib exhibits less inhibitory effects on KIT and FLT3 with IC50 values of 20 nM and 190 nM, respectively . Edicotinib limits microglial expansion and attenuates microglial proliferation and neurodegeneration in mice. Edicotinib has the potential for Alzheimer’s disease and rheumatoid arthritis research .
Edicotinib hydrochloride is a potent, selective, brain penetrant and orally active?colony-stimulatingfactor-1receptor(CSF-1R)?inhibitor with an IC50 of 3.2 nM. Edicotinib hydrochloride exhibits less inhibitory effects on KIT and FLT3 with IC50 values of 20 nM and 190 nM, respectively . Edicotinib hydrochloride limits microglial expansion and attenuates microglial proliferation and neurodegeneration?in mice. Edicotinib hydrochloride has the potential for Alzheimer’s disease and rheumatoid arthritis research .
Emactuzumab(RG 7155) is a specific monoclonal antibody that inhibits colonystimulatingfactor 1receptor(CSF1R) activation. Emactuzumab has high affinity for CSF-1R with Ki value of 0.2 nM to blocks CSF-1R dimerization. Emactuzumab can be used for the research of several diseases, such as diffuse-type tenosynovial giant cell tumour (dt-GCT) .
Emactuzumab(RG 7155) is a specific monoclonal antibody that inhibits colonystimulatingfactor 1receptor(CSF1R) activation. Emactuzumab has high affinity for CSF-1R with Ki value of 0.2 nM to blocks CSF-1R dimerization. Emactuzumab can be used for the research of several diseases, such as diffuse-type tenosynovial giant cell tumour (dt-GCT) .
CSF1R protein is ubiquitously found in mononuclear phagocytes, especially macrophages and monocytes, and is involved in a variety of biological processes. It induces the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammation. CSF1R Protein, Human (HEK293) is the recombinant human-derived CSF1R protein, expressed by HEK293 , with tag free. The total length of CSF1R Protein, Human (HEK293) is 493 a.a., with molecular weight of 80-120 kDa.
The CSF1R protein is a tyrosine protein kinase receptor for CSF1 and IL34 and plays a critical regulatory role in hematopoietic cells, especially mononuclear phagocytes. Its effects span innate immunity, inflammation, osteoclast function, skeletal development, and fertility. CSF1R Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CSF1R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CSF1R Protein, Mouse (HEK293, Fc) is 492 a.a., with molecular weight of ~81.9 kDa.
The CSF1R protein is a tyrosine protein kinase receptor for CSF1 and IL34 and plays a critical regulatory role in hematopoietic cells, especially mononuclear phagocytes. Its effects span innate immunity, inflammation, osteoclast function, skeletal development, and fertility. CSF1R Protein, Mouse (HEK293, His) is the recombinant mouse-derived CSF1R protein, expressed by HEK293 , with C-His labeled tag.
CSF1R Protein is a cell surface receptor with high a affinity for a variety of polypeptide growth factors, cytokines, and hormones. CSF1R Protein participate in PLCG2/PKA/UCP2 signaling pathway to reduce oxidative stress and neuronal apoptosis in rat models with neonatal HIE. The blocking of the CSF1R signal is associated with tumorigenesis. CSF1R Protein, Rat (HEK293, His) is the recombinant rat-derived CSF1R protein, expressed by HEK293 , with C-His labeled tag. The total length of CSF1R Protein, Rat (HEK293, His) is 491 a.a., with molecular weight of 69-89 kDa.
CSF1R protein is ubiquitously found in mononuclear phagocytes, especially macrophages and monocytes, and is involved in a variety of biological processes. It induces the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammation. CSF1R Protein, Human (HEK293, His-Fc) is the recombinant human-derived CSF1R protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of CSF1R Protein, Human (HEK293, His-Fc) is 493 a.a., with molecular weight of 115-125 kDa.
CSF1R Protein is a cell surface receptor with high a affinity for a variety of polypeptide growth factors, cytokines, and hormones. CSF1R Protein participate in PLCG2/PKA/UCP2 signaling pathway to reduce oxidative stress and neuronal apoptosis in rat models with neonatal HIE. The blocking of the CSF1R signal is associated with tumorigenesis. CSF1R Protein, Rat (HEK293, C-His) is the recombinant rat-derived CSF1R, expressed by HEK293 , with C-10*His labeled tag. The total length of CSF1R Protein, Rat (HEK293, C-His) is 491 a.a.,
CSF1R protein is ubiquitously found in mononuclear phagocytes, especially macrophages and monocytes, and is involved in a variety of biological processes. It induces the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammation. CSF1R Protein, Human (HEK293, hFc) is the recombinant human-derived CSF1R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CSF1R Protein, Human (HEK293, hFc) is 493 a.a., with molecular weight of ~81.2 kDa.
CSF1R protein is ubiquitously found in mononuclear phagocytes, especially macrophages and monocytes, and is involved in a variety of biological processes. It induces the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammation. CSF1R Protein, Human (HEK293, mFc) is the recombinant human-derived CSF1R protein, expressed by HEK293 , with C-mFc labeled tag. The total length of CSF1R Protein, Human (HEK293, mFc) is 498 a.a., with molecular weight of ~81.5 kDa.
CSF1R Protein is a cell surface receptor with high a affinity for a variety of polypeptide growth factors, cytokines, and hormones. CSF1R Protein participate in PLCG2/PKA/UCP2 signaling pathway to reduce oxidative stress and neuronal apoptosis in rat models with neonatal HIE. The blocking of the CSF1R signal is associated with tumorigenesis. CSF1R Protein, Rat (HEK293, Fc) is the recombinant rat-derived CSF1R protein, expressed by HEK293 , with C-hFc labeled tag.
The CSF1R protein is a tyrosine protein kinase receptor for CSF1 and IL34 and plays a critical regulatory role in hematopoietic cells, especially mononuclear phagocytes. Its effects span innate immunity, inflammation, osteoclast function, skeletal development, and fertility. CSF1R Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived CSF1R protein, expressed by HEK293 , with C-His labeled tag. The total length of CSF1R Protein, Mouse (Biotinylated, HEK293, His) is 492 a.a., with molecular weight of ~56.8 kDa.
CSF1R protein is ubiquitously found in mononuclear phagocytes, especially macrophages and monocytes, and is involved in a variety of biological processes. It induces the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammation. CSF1R Protein, Human (498a.a, HEK293, His) is the recombinant human-derived CSF1R protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CSF1R Protein, Human (498a.a, HEK293, His) is 498 a.a., with molecular weight of 80-110 kDa.
CSF1R protein is ubiquitously found in mononuclear phagocytes, especially macrophages and monocytes, and is involved in a variety of biological processes. It induces the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammation. CSF1R Protein, Human (271a.a, HEK293, His) is the recombinant human-derived CSF1R protein, expressed by HEK293 , with C-His labeled tag. The total length of CSF1R Protein, Human (271a.a, HEK293, His) is 271 a.a., with molecular weight of ~31.1 kDa.
CSF1R protein is ubiquitously found in mononuclear phagocytes, especially macrophages and monocytes, and is involved in a variety of biological processes. It induces the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammation. CSF1R Protein, Human (214a.a, HEK293, His) is the recombinant human-derived CSF1R protein, expressed by HEK293 , with C-His labeled tag. The total length of CSF1R Protein, Human (214a.a, HEK293, His) is 214 a.a., with molecular weight of ~25.3 kDa.
CSF1R protein is ubiquitously found in mononuclear phagocytes, especially macrophages and monocytes, and is involved in a variety of biological processes. It induces the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammation. CSF1R Protein, Human (430a.a, sf9, His-GST) is the recombinant human-derived CSF1R protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CSF1R Protein, Human (430a.a, sf9, His-GST) is 430 a.a., with molecular weight of ~75 kDa.
The CSF1R protein is a tyrosine protein kinase receptor for CSF1 and IL34 and plays a critical regulatory role in hematopoietic cells, especially mononuclear phagocytes. Its effects span innate immunity, inflammation, osteoclast function, skeletal development, and fertility. CSF1R Protein, Rhesus Macaque (C378R, HEK293, Fc) is the recombinant Rhesus Macaque-derived CSF1R protein, expressed by HEK293 , with C-hFc labeled tag.
The CSF1R protein is a tyrosine protein kinase receptor for CSF1 and IL34 and plays a critical regulatory role in hematopoietic cells, especially mononuclear phagocytes. Its effects span innate immunity, inflammation, osteoclast function, skeletal development, and fertility. CSF1R Protein, Rhesus Macaque (C378R, HEK293, His) is the recombinant Rhesus Macaque-derived CSF1R protein, expressed by HEK293 , with C-His labeled tag.
CSF1R is colony-stimulating factor receptor, a type I transmembrane protein receptor. Binding of CSF1R to CSF-1 or IL-34 activates a cascade of extracellular pro-cell survival kinases, including PI3K, ERK1/2, and JNK. CSF1R also recruits multiple downstream effector proteins/pathways, including PI3K, Grb2, SFK, Src, PKC, etc. CSF1R is involved in embryonic development and tissue repair and is associated with tumorigenesis and cancer progression. CSF1R Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CSF1R protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CSF1R Protein, Cynomolgus (HEK293, His) is 498 a.a., with molecular weight of 80-120 kDa.
CSF1R protein is ubiquitously found in mononuclear phagocytes, especially macrophages and monocytes, and is involved in a variety of biological processes. It induces the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammation. CSF1R Protein, Human (HEK293, His-Flag) is the recombinant human-derived CSF1R protein, expressed by HEK293 , with C-6*His, C-Flag labeled tag. The total length of CSF1R Protein, Human (HEK293, His-Flag) is 493 a.a., with molecular weight of 57.7 kDa.
CSF1R protein is ubiquitously found in mononuclear phagocytes, especially macrophages and monocytes, and is involved in a variety of biological processes. It induces the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammation. CSF1R Protein, Human (HEK293, C-His-Avi) is the recombinant human-derived CSF1R protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of CSF1R Protein, Human (HEK293, C-His-Avi) is 493 a.a., with molecular weight of 75-105 kDa.
CSF1R protein is ubiquitously found in mononuclear phagocytes, especially macrophages and monocytes, and is involved in a variety of biological processes. It induces the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammation. CSF1R Protein, Human (sf9, GST) is the recombinant human-derived CSF1R, expressed by Sf9 insect cells , with GST labeled tag. The total length of CSF1R Protein, Human (sf9, GST) is 435 a.a.,
CSF1R Antibody (YA1189) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1189), targeting CSF1R. CSF1R Antibody (YA1189) can be used for IHC-P experiment in human background.
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