cystathionine

By Targets:	Apoptosis (5) Bacterial (2) Biochemical Assay Reagents (2) Calcium Channel (1) Endogenous Metabolite (7) Influenza Virus (1) Isotope-Labeled Compounds (3) MicroRNA (1) P2X Receptor (1) Topoisomerase (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (3) Infection (3) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (1)
Click Chemistry:	Azide (1) Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70078

Cystathionine β-synthase	Biochemical Assay Reagents	Others
Cystathionine β-synthase is an enzyme that catalyzes the condensation of serine and homocysteine to water and cystathionine. Cystathionine β-synthase is a prominent enzyme for the production of hydrogen sulfide (H₂S) .

HY-E70079

Cystathionine β-lyase, Recombinant Microorganisms CBL	Biochemical Assay Reagents	Infection
Cystathionine β-lyase, Recombinant Microorganisms (CBL) is an enzyme that catalyzes the breakdown of cystathionine to homocysteine, the penultimate step in methionine biosynthesis. Cystathionine β-lyase is important for bacterial virulence .

HY-W009749A

DL-Cystathionine	Others	Others
DL-Cystathionine is a mixture of 4 isomers of cystathionine and allocystathionine. DL-Cystathionine also is an intermediate in the biosynthesis of amino acid cysteine .

HY-W009749

L-Cystathionine	Endogenous Metabolite Apoptosis	Cardiovascular Disease
L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection .

HY-W009749C

*L-Cystathionine* dihydrochloride**	Endogenous Metabolite Apoptosis	Cardiovascular Disease
L-Cystathionine (dihydrochloride) is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine (dihydrochloride) protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine (dihydrochloride) plays an important role in cardiovascular protection .

HY-W009749CS

*(S)-Cystathionine-d4*	Apoptosis Endogenous Metabolite Isotope-Labeled Compounds	Others
(S)-Cystathionine-d₄ is the deuterium labeled (S)-Cystathionine[1].

HY-W007926

2-Oxobutanoic acid 1 Publications Verification 2-Ketobutyrate	Endogenous Metabolite	Others
2-Oxobutanoic acid is a product in the enzymatic cleavage of cystathionine.

HY-E70344

Cystathionine γ-lyase	Endogenous Metabolite	Others
Cystathionine γ-lyase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .

HY-W009749B

*DL-Cystathionine* dihydrochloride**	Others	Others
DL-Cystathionine dihydrochloride is a mixture of 4 isomers of cystathionine and allocystathionine. DL-Cystathionine dihydrochloride also is an intermediate in the biosynthesis of amino acid cysteine .

HY-W009749AS

*DL-Cystathionine-d4*	Apoptosis Endogenous Metabolite Isotope-Labeled Compounds	Others
DL-Cystathionine-d₄ is the deuterium labeled Pencycuron[1].

HY-B1148AS

Furaltadone-d5 Altafur-d₅	Bacterial Isotope-Labeled Compounds	Others
Furaltadone-d₅ is the deuterium labeled DL-Cystathionine[1].

HY-N3540

Caraphenol A	Others	Inflammation/Immunology
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits *human cystathionine* β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC₅₀**s of 5.9 μM and 12.1 μM, respectively .

HY-158973

bCSE-IN-1	Bacterial	Infection
bCSE-IN-1 (Compound 3i) is an inhibitor of *Bacterial Cystathionine* γ-lyase. bCSE-IN-1 has antibacterial** activity .

HY-W007926R

2-Oxobutanoic acid (Standard) 2-Ketobutyrate (Standard)	Endogenous Metabolite	Others
2-Oxobutanoic acid (Standard) is the analytical standard of 2-Oxobutanoic acid. This product is intended for research and analytical applications. 2-Oxobutanoic acid is a product in the enzymatic cleavage of cystathionine.

HY-169212

I194496	Others	Cancer
I194496 is a potent cystathionine γ-lyase (CSE) inhibitor, with an IC₅₀ of 0.79 mM. I194496 can inhibit the growth of human TNBC cells via the dual targeting PI3K/Akt and Ras/Raf/ERK pathway and suppress the metastasis of human TNBC cells via down-regulating Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways .

HY-N7690

3,5,7,3′,4′-Pentamethoxyflavone	Calcium Channel	Cardiovascular Disease Metabolic Disease
3,5,7,3’,4’-Pentamethoxyflavone is a Ca ²⁺ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases .

HY-122575

Aurintricarboxylic acid 1 Publications Verification	P2X Receptor Influenza Virus Topoisomerase MicroRNA Apoptosis	Infection Neurological Disease Inflammation/Immunology
Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC₅₀s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively . Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase . Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis . Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway . Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC₅₀ of 0.6 μM . Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC₅₀ of 0.47 µM .

Cat. No.	Product Name	Type

HY-E70078

Cystathionine β-synthase	Biochemical Assay Reagents
Cystathionine β-synthase is an enzyme that catalyzes the condensation of serine and homocysteine to water and cystathionine. Cystathionine β-synthase is a prominent enzyme for the production of hydrogen sulfide (H₂S) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W009749

L-Cystathionine	Cardiovascular Disease Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis
L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection .

HY-W009749C

*L-Cystathionine* dihydrochloride**	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis
L-Cystathionine (dihydrochloride) is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine (dihydrochloride) protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine (dihydrochloride) plays an important role in cardiovascular protection .

HY-W007926

2-Oxobutanoic acid 1 Publications Verification 2-Ketobutyrate	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-Oxobutanoic acid is a product in the enzymatic cleavage of cystathionine.

HY-N3540

Caraphenol A	Leguminosae Phenols Polyphenols Plants Caragana sinica (Buchoz) Rehd.	Others
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits *human cystathionine* β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC₅₀**s of 5.9 μM and 12.1 μM, respectively .

HY-N7690

3,5,7,3′,4′-Pentamethoxyflavone	Structural Classification Flavonoids Classification of Application Fields Flavones Metabolic Disease Plants Disease Research Fields Zingiberaceae	Calcium Channel
3,5,7,3’,4’-Pentamethoxyflavone is a Ca ²⁺ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases .

HY-W007926R

2-Oxobutanoic acid (Standard) 2-Ketobutyrate (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite	Endogenous Metabolite
2-Oxobutanoic acid (Standard) is the analytical standard of 2-Oxobutanoic acid. This product is intended for research and analytical applications. 2-Oxobutanoic acid is a product in the enzymatic cleavage of cystathionine.

Species:	Human (2) E.coli (1)
Tag:	His (2) Tag Free (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P72118

	CBS Protein, Human (His) AI047524; AI303044; Beta thionase; Beta-thionase; Cbs; Cbs cystathionine beta-synthase; CBS_HUMAN; cystathionine beta synthase; cystathionine beta-synthase; EC 4.2.1.22; HIP 4; HIP4; Methylcysteine synthase; MGC18856; MGC18895; MGC37300; OTTHUMP00000109416; OTTHUMP00000109418; Serine sulfhydrase	Human	E. coli
	CBS, a hydro-lyase, initiates the transsulfuration pathway by catalyzing the beta-replacement reaction, converting L-serine to L-cystathionine using L-homocysteine. This process eliminates L-methionine and the potentially harmful metabolite L-homocysteine. CBS, beyond its catabolic role, contributes to hydrogen sulfide production, serving as a gasotransmitter with signaling and cytoprotective effects, particularly on neurons. CBS Protein, Human (His) is the recombinant human-derived CBS protein, expressed by E. coli , with N-6*His labeled tag. The total length of CBS Protein, Human (His) is 550 a.a., with molecular weight of ~64.5 kDa.

HY-P70025

	Cystathionine gamma-lyase/CTH Protein, Human rHucystathionine gamma-lyase/CTH; cystathionine Gamma-Lyase; Cysteine-Protein Sulfhydrase; Gamma-Cystathionase; CTH	Human	E. coli
	CTH protein is a cysteine protein sulfatase that catalyzes the final step of the transsulfuration pathway in a PLP-dependent manner. Cystathionine gamma-lyase/CTH Protein, Human is the recombinant human-derived Cystathionine gamma-lyase/CTH protein, expressed by E. coli , with tag free. The total length of Cystathionine gamma-lyase/CTH Protein, Human is 405 a.a., with molecular weight of ~50.0 kDa.

HY-P71694

	MetC Protein, E.coli (E. coli, His) metC; b3008; JW2975cystathionine beta-lyase MetC; CBL; CL; CD; EC 4.4.1.28; Cysteine lyase MetC; Cysteine-S-conjugate beta-lyase MetC	E.coli	E. coli
	MetC protein is a multifunctional enzyme that catalyzes the cleavage of cystathionine to homocysteine, pyruvate, and ammonia, which is essential for methionine biosynthesis. It also acts as a cysteine desulfurase, converting cysteine into sulfide. MetC Protein, E.coli (E. coli, His) is the recombinant E. coli-derived MetC protein, expressed by E. coli , with N-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W009749CS

*(S)-Cystathionine-d4*
(S)-Cystathionine-d₄ is the deuterium labeled (S)-Cystathionine[1].

HY-W009749AS

*DL-Cystathionine-d4*
DL-Cystathionine-d₄ is the deuterium labeled Pencycuron[1].

HY-B1148AS

Furaltadone-d5
Furaltadone-d₅ is the deuterium labeled DL-Cystathionine[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82707

	Cystathionase Antibody (YA2452) CTH; cystathionine gamma lyase; Cysteine desulfhydrase; Gamma cystathionase; Homoserine deaminase	WB, IP	Human
	Cystathionase Antibody (YA2452) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2452), targeting Cystathionase, with a predicted molecular weight of 45 kDa (observed band size: 42 kDa). Cystathionase Antibody (YA2452) can be used for WB, IP experiment in human background.

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Cat. No.	Product Name		Classification

HY-136211

Cystathionine-γ-lyase-IN-1		Alkynes
Cystathionine-γ-lyase-IN-1 is a selective cystathionine γ-lyase (CSE) enzyme inhibitor with an IC₅₀ of 6.3 μM . Cystathionine-γ-lyase-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-119323

7-Azido-4-methylcoumarin		Azide
7-Azido-4-methylcoumarin is a fluorescent hydrogen sulfide (H2S) probe. 7-Azido-4-methylcoumarin serves as a highly sensitive assay for cystathionine β-synthase activity . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

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cystathionine

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