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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

drug coupling

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (10) Drug-Linker Conjugates for ADC (1) Radionuclide-Drug Conjugates (RDCs) (1) ADC Cytotoxin (1) Biochemical Assay Reagents (5) Cathepsin (1) Liposome (1)
By Research Areas:	Cancer (9) Inflammation/Immunology (1)
Click Chemistry:	ADC Synthesis (1) DBCO (1)
Oligonucleotides:	Cholesterol (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Click Chemistry

Oligonucleotides

Targets Recommended: Drug Intermediate Drug Isomer Drug Derivative Drug Metabolite Antibody-Drug Conjugates (ADCs) Peptide-Drug Conjugates (PDCs) Radionuclide-Drug Conjugates (RDCs) Drug-Linker Conjugates for ADC ADC Linker

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W250574

NOTA-bis(tBu)ester NOTA-bis(t-Butyl ester)	Radionuclide-Drug Conjugates (RDCs) Biochemical Assay Reagents	Cancer
NOTA-bis(tBu)ester (NOTA-bis(t-Butyl ester)), a NOTA derivative, is a bifunctional chelator that can be used for drug coupling .

HY-W011556

N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate TCFH	Biochemical Assay Reagents	Others
N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate is a kind of biological coupling reagent, can be used for antitumor drugs sulphur alkali before medicine research .

HY-W090940

H-Gly-Gly-Phe-OH	ADC Linker	Cancer
H-Gly-Gly-Phe-OH is a tripeptide linker that may be used in the creation of antibody drug conjugates (ADCs). The N-terminal of the glycine tripeptide is free to perform a variety of reactions such as couplings with carboxylic acids or NHS esters.

HY-132180A

Seco-DUBA	ADC Cytotoxin	Inflammation/Immunology Cancer
Seco-DUBA is a duocarmycin (DUBA) prodrug containing two hydroxyl groups, which can each be used for coupling to an antibody via a linker. Seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-114362

DL-alpha-Tocopherol methoxypolyethylene glycol succinate TPGS-750-M	Biochemical Assay Reagents	Others
DL-alpha-Tocopherol methoxypolyethylene glycol succinate (TPGS-750-M) is an amphiphile, acts as a surfactant. DL-alpha-Tocopherol methoxypolyethylene glycol succinate has a positive effect on Suzuki-Miyaura cross coupling. DL-alpha-Tocopherol methoxypolyethylene glycol succinate increases the styrene titer. DL-alpha-Tocopherol methoxypolyethylene glycol succinate is used in the stability test of NPYM-modified drugs in biological fluids .

HY-P4565

Phe-Arg-Arg-Gly	Cathepsin	Others
Phe-Arg-Arg-Gly is a polypeptide that can be used for agent coupling .

HY-W004650

TETA hydrochloride hydrate	Biochemical Assay Reagents	Others
TETA hydrochloride hydrate is an effective selective chelating agent for copper (II). TETA hydrochloride hydrate can be used for drug coupling .

HY-158709

Cho-es-Lys	Biochemical Assay Reagents Liposome	Others
Cho-es-Lys is a cationic lipid synthesized by coupling natural cholesterol and amino acids, which has high gene transfection efficiency. Cho-es-Lys can be used in drug delivery research .

HY-W800622

Fmoc-PEG4-Val-Cit-PAB-OH	ADC Linker	Cancer
Fmoc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Fmoc protecting group may be removed with piperidine to reveal a primary amine which may be used in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell.

HY-W800625

Boc-PEG4-Val-Cit-PAB-OH	ADC Linker	Cancer
Boc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Boc protecting group may be removed with acid to reveal a primary amine which may be used in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell.

HY-W800621

Fmoc-PEG2-Val-Cit-PAB-OH	ADC Linker	Cancer
Fmoc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Fmoc protecting group may be removed with piperidine to reveal a primary amine for use in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell.

HY-W800623

Fmoc-PEG6-Val-Cit-PAB-OH	ADC Linker	Cancer
Fmoc-PEG6-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Fmoc protecting group may be removed with piperidine to reveal a primary amine which may be used in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell.

HY-W800624

Boc-PEG2-Val-Cit-PAB-OH	ADC Linker	Cancer
Boc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Boc protecting group may be removed with acid to reveal a primary amine which may be used in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell.

HY-147363

DIBAC-GGFG-NH2CH2-Dxd	Drug-Linker Conjugates for ADC	Others
DIBAC-GGFG-NH2CH2-Dxd (compound LP4), a Camptothecin (HY-16560) derivative, is a linker-payload of protein-agent conjugates . Dxd (HY-13631D) can be used as a payload for the antibody-coupling drug ADC (DS-8201a).DIBAC-GGFG-NH2CH2-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .

HY-W800618

NH2-PEG3-Val-Cit-PAB-OH	ADC Linker	Others
NH2-PEG3-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.

HY-W800617

NH2-PEG1-Val-Cit-PAB-OH	ADC Linker	Cancer
NH2-PEG1-Val-Cit-PAB-OH is a cleavable ADC linker intermediate featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.

HY-W800619

NH2-PEG4-Val-Cit-PAB-OH	ADC Linker	Others
NH2-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.

HY-W800620

NH2-PEG6-Val-Cit-PAB-OH	ADC Linker	Others
NH2-PEG6-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.

Cat. No.	Product Name	Type

HY-W250574

NOTA-bis(tBu)ester NOTA-bis(t-Butyl ester)	Chelators
NOTA-bis(tBu)ester (NOTA-bis(t-Butyl ester)), a NOTA derivative, is a bifunctional chelator that can be used for drug coupling .

HY-W011556

N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate TCFH	Biochemical Assay Reagents
N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate is a kind of biological coupling reagent, can be used for antitumor drugs sulphur alkali before medicine research .

HY-W004650

TETA hydrochloride hydrate	Chelators
TETA hydrochloride hydrate is an effective selective chelating agent for copper (II). TETA hydrochloride hydrate can be used for drug coupling .

HY-158709

Cho-es-Lys	Drug Delivery
Cho-es-Lys is a cationic lipid synthesized by coupling natural cholesterol and amino acids, which has high gene transfection efficiency. Cho-es-Lys can be used in drug delivery research .

Phe-Arg-Arg-Gly	Cathepsin	Others
Phe-Arg-Arg-Gly is a polypeptide that can be used for agent coupling .

Cat. No.	Product Name		Classification

HY-147363

DIBAC-GGFG-NH2CH2-Dxd		DBCO ADC Synthesis
DIBAC-GGFG-NH2CH2-Dxd (compound LP4), a Camptothecin (HY-16560) derivative, is a linker-payload of protein-agent conjugates . Dxd (HY-13631D) can be used as a payload for the antibody-coupling drug ADC (DS-8201a).DIBAC-GGFG-NH2CH2-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .

Cat. No.	Product Name		Classification

HY-158709

Cho-es-Lys		Cholesterol
Cho-es-Lys is a cationic lipid synthesized by coupling natural cholesterol and amino acids, which has high gene transfection efficiency. Cho-es-Lys can be used in drug delivery research .

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