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endometriosis

" in MedChemExpress (MCE) Product Catalog:

41

Inhibitors & Agonists

4

Peptides

1

Natural
Products

5

Isotope-Labeled Compounds

5

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-109093
    Linzagolix

    KLH-2109; OBE-2109

    		 GnRH Receptor Inflammation/Immunology Cancer
    Linzagolix (KLH-2109; OBE-2109) is a potent, non-peptide, and orally active GnRH antagonist. Linzagolix can be used for uterine fibroids, endometriosis, adenomyosis research .
    Linzagolix
  • HY-111539
    BAY-1316957

    		Prostaglandin Receptor Inflammation/Immunology Endocrinology
    BAY-1316957 is a potent, selective and orally active prostaglandin E2 receptor subtype 4 (EP4-R) antagonist with an IC50 of 15.3 nM for human EP4-R. BAY-1316957 has excellent agent metabolism and pharmacokinetics properties, and can be used for endometriosis research .
    BAY-1316957
  • HY-P0056A
    Histrelin acetate

    		GnRH Receptor Cancer
    Histrelin acetate, a GnRH analogue, is a GnRH Receptor agonist. Histrelin acetate increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin acetate can be used in the research of prostate cancer, endometriosis .
    Histrelin acetate
  • HY-B0084
    Dienogest
    1 Publications Verification

    STS 557

    		 Progesterone Receptor Endocrinology
    Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .
    Dienogest
  • HY-124748A
    ENMD-1068 hydrochloride
    2 Publications Verification

    		 Protease Activated Receptor (PAR) Apoptosis Inflammation/Immunology
    ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 hydrochloride reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 hydrochloride also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 hydrochloride can be used in the study of endometriosis and liver fibrosis .
    ENMD-1068 hydrochloride
  • HY-W703425
    17α-Ethynyl-19-nor-Δ-5(6)-androsten-17β-ol-3-one

    delta-5(6)-Norethindrone

    		 Progesterone Receptor Endocrinology
    17α-Ethynyl-19-nor-Δ-5(6)-androsten-17β-ol-3-one (delta-5(6)-Norethindrone), an impurity of Norethindrone, is an anabolic agent. Norethindrone is a progestin athat can be used for endometriosis research .
    17α-Ethynyl-19-nor-Δ-5(6)-androsten-17β-ol-3-one
  • HY-157493
    PR antagonist 1

    		Progesterone Receptor Endocrinology
    PR antagonist 1 (compound 8) is a selective progesterone receptor (PR) antagonist, and can be used for the research of a variety of progesterone-related diseases and disorders such as endometriosis and uterine fibroids .
    PR antagonist 1
  • HY-P0056
    Histrelin

    		GnRH Receptor Cancer
    Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis .
    Histrelin
  • HY-151200
    Steroid sulfatase-IN-4

    		Steroid Sulfatase Endocrinology
    Steroid sulfatase-IN-4 (Compound 16) is an irreversible steroid sulfatase (STS) inhibitor with an IC50 of 25 nM against human STS. Steroid sulfatase-IN-4 can be used for the research of endometriosis .
    Steroid sulfatase-IN-4
  • HY-B0084R
    Dienogest (Standard)

    		Progesterone Receptor Endocrinology
    Dienogest (Standard) is the analytical standard of Dienogest. This product is intended for research and analytical applications. Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .
    Dienogest (Standard)
  • HY-124748
    ENMD-1068

    		Protease Activated Receptor (PAR) Apoptosis Inflammation/Immunology
    ENMD-1068 is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 can be used in the study of endometriosis and liver fibrosis .
    ENMD-1068
  • HY-16474
    Relugolix

    TAK-385

    		 GnRH Receptor Endocrinology Cancer
    Relugolix (TAK-385) is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC50=0.33 nM) and monkey receptor (IC50=0.32 nM) compared with TAK-013 (HY-100209) . Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al .
    Relugolix
  • HY-151201
    Steroid sulfatase/17β-HSD1-IN-3

    		Steroid Sulfatase Cancer
    Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-3 irreversibly inhibits hSTS activity with anIC50 value of 27 nM. Steroid sulfatase/17β-HSD1-IN-3 can be used in the study of endometriosis and other estrogen-dependent diseases .
    Steroid sulfatase/17β-HSD1-IN-3
  • HY-151202
    Steroid sulfatase/17β-HSD1-IN-4

    		Steroid Sulfatase Cancer
    Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC50 value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases .
    Steroid sulfatase/17β-HSD1-IN-4
  • HY-155010
    Steroid sulfatase/17β-HSD1-IN-5

    		Steroid Sulfatase Metabolic Disease
    Steroid sulfatase/17β-HSD1-IN-5 is a irreversible inhibitor of steroid sulfatase (STS) .Steroid sulfatase/17β-HSD1-IN-5 is a reversible and selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), with IC50s of 43 nM and 6.2μM for 17β-HSD1 and 17β-HSD2, respectively. Steroid sulfatase/17β-HSD1-IN-5 can be used for metabolic disease (especially for endometriosis) research .
    Steroid sulfatase/17β-HSD1-IN-5
  • HY-16474R
    Relugolix (Standard)

    		GnRH Receptor Endocrinology Cancer
    Relugolix (Standard) is the analytical standard of Relugolix. This product is intended for research and analytical applications. Relugolix (TAK-385) is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC50=0.33 nM) and monkey receptor (IC50=0.32 nM) compared with TAK-013 (HY-100209) . Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al .
    Relugolix (Standard)
  • HY-14901
    Telapristone

    		Progesterone Receptor Cancer
    Telapristone is a Progesterone antagonist. Telapristone can be used in the study of uterine fibroids and endometriosis .
    Telapristone
  • HY-17447SA
    Tranylcypromine-d5 hydrochloride

    SKF 385-d5 hydrochloride

    		 Monoamine Oxidase Histone Demethylase Neurological Disease
    Tranylcypromine-d5 (hydrochloride) is a deuterium labeled (rel)-Tranylcypromine hydrochloride. Tranylcypromine hydrochloride is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hydrochloride is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis[1][2].
    Tranylcypromine-d5 hydrochloride
  • HY-B1710S
    Norethindrone acetate-d8

    19-Norethindrone acetate-d8

    		 Isotope-Labeled Compounds Progesterone Receptor Cardiovascular Disease Inflammation/Immunology Endocrinology
    Norethindrone acetate-d8 is the deuterium labeled Norethindrone acetate. Norethindrone acetate is a female hormone used for the research of endometriosis[1]. Norethindrone acetate-d8 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Norethindrone acetate-d8
  • HY-134864
    GnRH antagonist 2

    		GnRH Receptor Endocrinology
    GnRH antagonist 2 (formula I) is a GnRH receptor antagonist that can be used for endometriosis research .
    GnRH antagonist 2
  • HY-P2067
    Argtide

    		GnRH Receptor Endocrinology Cancer
    Argtide is a luteinizing hormone-releasing hormone (LHRH) antagonist. Argtide is used in endometriosis and cancer-related research .
    Argtide
  • HY-B0554
    Norethindrone
    1 Publications Verification

    Norethisterone

    		 Progesterone Receptor Bacterial Endocrinology Cancer
    Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.
    Norethindrone
  • HY-U00289
    Opigolix

    ASP-1707

    		 GnRH Receptor Inflammation/Immunology Endocrinology
    Opigolix (ASP-1707) is a Gonadotropin-releasing hormone (GnRH) receptor antagonist, used for the research of endometriosis and rheumatoid arthritis.
    Opigolix
  • HY-B0554R
    Norethindrone (Standard)
    1 Publications Verification

    Norethisterone (Standard)

    		 Progesterone Receptor Bacterial Endocrinology Cancer
    Norethindrone (Standard) is the analytical standard of Norethindrone. This product is intended for research and analytical applications. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.
    Norethindrone (Standard)
  • HY-B1710
    Norethindrone acetate

    19-Norethindrone acetate

    		 Progesterone Receptor Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
    Norethindrone acetate is a female hormone used for the research of endometriosis . Norethindrone acetate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Norethindrone acetate
  • HY-105173
    Teverelix

    EP 24332

    		 GnRH Receptor Histamine Receptor Endocrinology Cancer
    Teverelix (EP 24332) is a GnRH antagonist. Teverelix binds competitively and reversibly to GnRH receptors, thereby suppressing the release of LH and FSH. Teverelix can be used in the research of prostatic hyperplasia, endometriosis, and prostate cancer .
    Teverelix
  • HY-N7748A
    Epi-cryptoacetalide

    		Estrogen Receptor/ERR Prostaglandin Receptor Inflammation/Immunology Endocrinology
    Epi-cryptoacetalide is a natural diterpenoid. Epi-cryptoacetalide reveals high affinity to ER-α and PGE2 receptor (EP2 subtype) with Ki values of 0.3 μM and 1.92 μM, respectively. Epi-cryptoacetalide has anti-endometriosis activities .
    Epi-cryptoacetalide
  • HY-14789
    (R)-Elagolix

    NBI-56418

    		 GnRH Receptor Nuclear Factor of activated T Cells (NFAT) Endocrinology Cancer
    Elagolix is a highly effective, selective, oral-active, short-term, non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (KD = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis. .
    (R)-Elagolix
  • HY-14369
    Elagolix sodium

    NBI-56418 sodium

    		 GnRH Receptor Nuclear Factor of activated T Cells (NFAT) Endocrinology Cancer
    Elagolix sodium is a highly effective, selective, oral-active, short-term, non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (KD = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis. .
    Elagolix sodium
  • HY-101405
    Gestrinone

    R 2323

    		 Estrogen Receptor/ERR Inflammation/Immunology
    Gestrinone (R2323) is a synthetic steroid hormone used to treat endometriosis. It inhibits leiomyoma cells with an IC50 of 43.67 μM. Gestrinone is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Gestrinone
  • HY-32345
    Elocalcitol

    BXL-628; Ro-26-9228

    		 VD/VDR Inflammation/Immunology Cancer
    Elocalcitol (BXL-628) is a selective, orally active vitamin D receptor (VDR) agonist. Elocalcitol shows anti-inflammatory activity. Elocalcitol inhibits growth of prostate cancer cells .
    Elocalcitol
  • HY-B1710R
    Norethindrone acetate (Standard)

    		Progesterone Receptor Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
    Norethindrone acetate (Standard) is the analytical standard of Norethindrone acetate. This product is intended for research and analytical applications. Norethindrone acetate is a female hormone used for the research of endometriosis . Norethindrone acetate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Norethindrone acetate (Standard)
  • HY-B1496
    Tranylcypromine hemisulfate
    4 Publications Verification

    SKF 385 hemisulfate

    		 Monoamine Oxidase Histone Demethylase Neurological Disease
    Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hemisulfate is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Tranylcypromine has antidepressant effects .
    Tranylcypromine hemisulfate
  • HY-B0554S
    Norethindrone-d6

    		Isotope-Labeled Compounds Progesterone Receptor Endocrinology
    Norethindrone-d6 is the deuterium labeled Norethindrone. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea. Norethindrone-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Norethindrone-d6
  • HY-101405R
    Gestrinone (Standard)

    		Estrogen Receptor/ERR Inflammation/Immunology
    Gestrinone (Standard) is the analytical standard of Gestrinone. This product is intended for research and analytical applications. Gestrinone (R2323) is a synthetic steroid hormone used to treat endometriosis. It inhibits leiomyoma cells with an IC50 of 43.67 μM. Gestrinone is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Gestrinone (Standard)
  • HY-B1496R
    Tranylcypromine hemisulfate (Standard)

    		Monoamine Oxidase Histone Demethylase Neurological Disease
    Tranylcypromine (hemisulfate) (Standard) is the analytical standard of Tranylcypromine (hemisulfate). This product is intended for research and analytical applications. Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hemisulfate is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Tranylcypromine has antidepressant effects .
    Tranylcypromine hemisulfate (Standard)
  • HY-120767
    Linzagolix choline

    KLH-2109 choline; OBE-2109 choline

    		 GnRH Receptor Inflammation/Immunology Cancer
    Linzagolix choline (KLH-2109 choline) is a non-peptide gonadotropin-releasing hormone (GnRH) antagonist with oral activity. Linzagolix choline inhibits the release of endogenous gonadotropins such as luteinizing hormone LH and follicle-stimulating hormone FSH by binding to the GnRH receptor within the pituitary gland. This inhibition results in a reduction in the production of sex hormones such as estrogen and progesterone, which in turn affects the course of sex hormone-dependent diseases. Linzagolix choline can be used in the study of sex hormone-dependent diseases such as endometriosis and uterine fibroids .
    Linzagolix choline
  • HY-16474S
    Relugolix-d6

    TAK-385-d6

    		 Isotope-Labeled Compounds GnRH Receptor Endocrinology Cancer
    Relugolix-d6 is deuterium labeled Relugolix. Relugolix (TAK-385) is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC50=0.33 nM) and monkey receptor (IC50=0.32 nM) compared with TAK-013 (HY-100209)[1]. Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al[2].
    Relugolix-d6
  • HY-16290
    Lonaprisan

    ZK 230211; BAY86 5044

    		 Progesterone Receptor Endocrinology
    Lonaprisan (ZK 230211; BAY86 5044) is an antagonist for progesterone receptor, with IC50 of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA (HY-W011845)-induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect .
    Lonaprisan
  • HY-B0084S4
    Dienogest-13C,15N,d4

    STS 557-13C,15N,d4

    		 Isotope-Labeled Compounds Progesterone Receptor Endocrinology
    Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the 13C, 15N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .
    Dienogest-13C,15N,d4
  • HY-136535
    Anizatrectinib

    hTrkA-IN-1

    		 Trk Receptor Inflammation/Immunology
    Anizatrectinib (hTrkA-IN-1) is a potent and orally active inhibitor of TrkA kinase with an IC50 of 1.3 nM, compound 2 extracted from patent WO2015175788. Anizatrectinib can be used for the study of inflammatory disease, such as prostatitis, pelvic, et al .
    Anizatrectinib

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