heterogeneous

By Targets:	Anaplastic lymphoma kinase (ALK) (1) Apoptosis (1) Biochemical Assay Reagents (1) c-Myc (2) Cholinesterase (ChE) (1) Dopamine Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (1) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124811

IRES-C11	c-Myc	Cancer
IRES-C11 is a spectfic c-MYC internal ribosome entry site (IRES) translation inhibitor. IRES-C11 blocks the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleoprotein A1, with its IRES. IRES-C11 does not inhibits BAG-1, XIAP and p53 IRESes .

HY-131768

2'-O-Succinyl-cAMP	Cholinesterase (ChE)	Others
2'-O-Succinyl-cAMP is a cAMP analog that can be covalently coupled to acetylcholinesterase. 2'-O-Succinyl-cAMP conjugate has been used as tracers in a classical heterogeneous competitive enzyme immunoassay allowing the determination of cAMP .

HY-135691

hnRNPK-IN-1	c-Myc Apoptosis	Cancer
hnRNPK-IN-1 is a heterogeneous nuclear ribonucleoprotein K (hnRNPK) binding ligand with K_d values of 4.6 μM and 2.6 μM measured with SPR and MST, respectively. hnRNPK-IN-1 inhibits c-myc transcription by disrupting the binding of hnRNPK and c-myc promoter. hnRNPK-IN-1 induces Hela cells apoptosis and has strongly anti-tumor activities .

HY-D1056

Lipopolysaccharides, from E. coli O55:B5 200+ Cited Publications LPS	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides, from E. coli O55:B5 is an endotoxin extracted from E. coli O55:B5, consisting of an antigen-specific chain, A core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activates TLR-4 of immune cells. Lipopolysaccharides, from E. coli O55:B5 can induce the change of body temperature in rats with dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 caused a heterogeneous and dose-independent increase in body temperature in rats .

HY-137265

Aminomethyltrioxsalen hydrochloride	Biochemical Assay Reagents	Others
Aminomethyltrioxsalen hydrochloride is a derivative of Psoralen (HY-N0053). Aminomethyltrioxsalen hydrochloride penetrate intact cells and form interstrand crosslinks between pyrimidine residues of nucleic acid helices upon irradiation with ultraviolet light as a bifunctional nucleic acid intercalating agent, which can be used as a probe for double-stranded regions in heterogeneous nuclear RNA (hnRNA) to detect the secondary structure of hnRNA .

HY-161910

SH-E4A-66	Anaplastic lymphoma kinase (ALK)	Cancer
SH-E4A-66 is a C ²-COUPLr (COvalent Protein Ligator) with carbazole scaffold barring heterogeneous cysteine reactive warheads (acrylamide and chloroacetamide). SH-E4A-66 is capable of coupling with EML4-ALK (EC₅₀=1.5 μM) and inhibiting the activity of EML4-ALK kinase (IC₅₀=2.3 µM) .

HY-P10405

TAT-D1 peptide	Dopamine Receptor	Neurological Disease
TAT-D1 peptide is a selective D1-D2 heterogeneous antagonist. TAT-D1 peptide destroys the heterodimer of the D1-D2 receptor by interacting with the specific domain of the D2 receptor through its unique amino acid sequence, in particular the two glutamate residues at the C terminal of the D1 receptor. TAT-D1 peptide can be used to study the role of D1-D2 receptor heterodimers in the regulation of depressive and anxiety-like behaviors .

Cat. No.	Product Name

HY-L074

Anti-Breast Cancer Compound Library	2,123 compounds
Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC). Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer. MCE supplies a unique collection of 2,123 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Anti-Breast Cancer Compound Library

2,123 compounds

Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC).

Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer.

MCE supplies a unique collection of 2,123 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Cat. No.	Product Name	Type

HY-D1056

Lipopolysaccharides, from E. coli O55:B5 200+ Cited Publications LPS	Carbohydrates
Lipopolysaccharides, from E. coli O55:B5 is an endotoxin extracted from E. coli O55:B5, consisting of an antigen-specific chain, A core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activates TLR-4 of immune cells. Lipopolysaccharides, from E. coli O55:B5 can induce the change of body temperature in rats with dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 caused a heterogeneous and dose-independent increase in body temperature in rats .

Lipopolysaccharides, from E. coli O55:B5

200+ Cited Publications

LPS

Carbohydrates

Lipopolysaccharides, from E. coli O55:B5 is an endotoxin extracted from E. coli O55:B5, consisting of an antigen-specific chain, A core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activates TLR-4 of immune cells. Lipopolysaccharides, from E. coli O55:B5 can induce the change of body temperature in rats with dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 caused a heterogeneous and dose-independent increase in body temperature in rats .

Cat. No.	Product Name	Target	Research Area

HY-P10405

TAT-D1 peptide	Dopamine Receptor	Neurological Disease
TAT-D1 peptide is a selective D1-D2 heterogeneous antagonist. TAT-D1 peptide destroys the heterodimer of the D1-D2 receptor by interacting with the specific domain of the D2 receptor through its unique amino acid sequence, in particular the two glutamate residues at the C terminal of the D1 receptor. TAT-D1 peptide can be used to study the role of D1-D2 receptor heterodimers in the regulation of depressive and anxiety-like behaviors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-D1056

Lipopolysaccharides, from E. coli O55:B5 200+ Cited Publications LPS	Structural Classification Polysaccharides Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Saccharides	Toll-like Receptor (TLR)
Lipopolysaccharides, from E. coli O55:B5 is an endotoxin extracted from E. coli O55:B5, consisting of an antigen-specific chain, A core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activates TLR-4 of immune cells. Lipopolysaccharides, from E. coli O55:B5 can induce the change of body temperature in rats with dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 caused a heterogeneous and dose-independent increase in body temperature in rats .

Species:	Human (7) Mouse (1)
Tag:	His (7) SUMO (3) Myc (1) GST (2) B2M (1)
Source:	HEK293 (1) Sf9 insect cells (1) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P72229

	HNRNPA1 Protein, Human (His) HNRNPA 1; Helix destabilizing protein; Helix-destabilizing protein; heterogeneous nuclear ribonucleoprotein A1; heterogeneous nuclear ribonucleoprotein A1B protein; heterogeneous nuclear ribonucleoprotein B2 protein; heterogeneous nuclear ribonucleoprotein core protein A1; hnRNP A1; hnRNP core protein A1; HNRNPA1; HNRPA1	Human	E. coli
	The HNRNPA1 protein is complexly involved in multiple RNA processing functions, packaging pre-mRNA into hnRNP particles, promoting Poly(A) mRNA transport, and regulating splice site selection. Crucially, it binds inhibitoryly to sequences flanking PKM exon 9, favoring the inclusion of exon 10 in pyruvate kinase PKM splicing, thereby generating the PKM M2 isoform. HNRNPA1 Protein, Human (His) is the recombinant human-derived HNRNPA1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72233

	HNRNPH1 Protein, Human (His-SUMO) DKFZp686A15170; heterogeneous nuclear ribonucleoprotein H; heterogeneous nuclear ribonucleoprotein H1 H; ; heterogeneous nuclear ribonucleoprotein H1; HNRH1_HUMAN; hnRNP H; hnRNPH; Hnrnph1; HNRPH 1; HNRPH; HNRPH1 protein; N-terminally processed	Human	E. coli
	The HNRNPH1 protein is an important component of the hnRNP complex and plays a key role in pre-mRNA processing events leading to mRNA conversion in the cytoplasm. Functionally, it cooperates with CUGBP1 to regulate alternative splicing of pre-mRNA, specifically inhibiting the inclusion of insulin receptor (IR) pre-mRNA exon 11 in myoblasts. HNRNPH1 Protein, Human (His-SUMO) is the recombinant human-derived HNRNPH1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of HNRNPH1 Protein, Human (His-SUMO) is 448 a.a., with molecular weight of ~65.1 kDa.

HY-P72231

	HNRNPA2B1 Protein, Human (GST) Hnrnpa2b1; Hnrpa2b1; heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1	Human	E. coli
	Heterogeneous nuclear ribonucleoproteins A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. Heterogeneous nuclear ribonucleoproteins A2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. HNRNPA2B1 Protein, Human (GST) is the recombinant human-derived HNRNPA2B1 protein, expressed by E. coli , with N-GST labeled tag. The total length of HNRNPA2B1 Protein, Human (GST) is 249 a.a., with molecular weight of ~64 kDa.

HY-P72232

	HNRNPA2B1 Protein, Mouse (His-SUMO, Myc) Hnrnpa2b1; Hnrpa2b1; heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1	Mouse	E. coli
	The HNRNPA2B1 protein is an important heterogeneous nuclear ribonucleoprotein (hnRNP) that plays a key role in RNA processing and transport. It forms hnRNP particles that compact and stabilize transcripts to influence various cellular functions, including transcription, mRNA processing, nuclear export, localization, translation, and mRNA stability. HNRNPA2B1 Protein, Mouse (His-SUMO) is the recombinant mouse-derived HNRNPA2B1 protein, expressed by E. coli , with N-10*His, N-SUMO, C-Myc labeled tag. The total length of HNRNPA2B1 Protein, Mouse (His-SUMO) is 353 a.a., with molecular weight of ~57.4 kDa.

HY-P72230

	HNRNPA2B1 Protein, Human (His-B2M) Hnrnpa2b1; Hnrpa2b1; heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1	Human	E. coli
	Heterogeneous nuclear ribonucleoproteins A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. Heterogeneous nuclear ribonucleoproteins A2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. HNRNPA2B1 Protein, Human (His-B2M) is the recombinant human-derived HNRNPA2B1 protein, expressed by E. coli , with N-6*His, B2M labeled tag. The total length of HNRNPA2B1 Protein, Human (His-B2M) is 249 a.a., with molecular weight of ~42.4 kDa.

HY-P73920

	HNRNPR Protein, Human (sf9, His-GST) heterogeneous nuclear ribonucleoprotein R; hnRNP R; HNRNPR	Human	Sf9 insect cells
	hnRNP-R Protein, a constituent of ribonucleosomes, participates in precursor mRNA processing within the nucleus. It's part of the spliceosome C complex and involved in IGF2BP1-dependent mRNP granule complexes containing untranslated mRNAs. Additionally, hnRNP-R interacts with GTPBP1. HNRNPR Protein, Human (sf9, His-GST) is the recombinant human-derived hnRNP-R protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P702591

	PTBP1 Protein, Human (HEK293, His) Polypyrimidine tract-binding protein 1; PTB; 57 kDa RNA-binding protein PPTB-1; heterogeneous nuclear ribonucleoprotein I (hnRNP I)	Human	HEK293
	PTBP1 Protein, Human (HEK293, His) is the recombinant human-derived PTBP1, expressed by HEK293 , with N-10*His labeled tag. ,

HY-P72234

	HNRNPM Protein, Human (His-SUMO) CEA receptor; CEAR; heterogeneous nuclear ribonucleoprotein M; Heterogenous nuclear ribonucleoprotein M4; hnRNA binding protein M4; hnRNP M; Hnrnpm; HNRNPM4; HNRPM; HNRPM_HUMAN; HNRPM4; HTGR1; M3; M4; M4 protein; N-acetylglucosamine receptor 1; NAGR1	Human	E. coli
	The HNRNPM protein is a key pre-mRNA binding protein that exhibits strong affinity for poly(G) and poly(U) RNA homopolymers. It is central to the splicing process, complexly regulates RNA maturation, and serves as a receptor for carcinoembryonic antigen in Kupffer cells. HNRNPM Protein, Human (His-SUMO) is the recombinant human-derived HNRNPM protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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Source
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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80874

	PRMT1 Antibody (YA686) ANM 1; ANM1; ANM1_HUMAN; complete cds; HCP 1; HCP1; heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2; heterogeneous nuclear ribonucleoproteins methyltransferase like 2; heterogeneous nuclear ribonucleoproteins methyltransferase like2; Hi	WB	Human
	PRMT1 Antibody (YA686) is a non-conjugated and Mouse origined monoclonal antibody about 42 kDa, targeting to PRMT1 (4E9). It can be used for WB assays with tag free, in the background of Human.

HY-P82129

	hnRNP C1/C2 Antibody (YA1874) HNRNPC; HNRPC; heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1/C2	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	hnRNP C1/C2 Antibody (YA1874) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1874), targeting hnRNP C1/C2, with a predicted molecular weight of 34 kDa (observed band size: 40 kDa). hnRNP C1/C2 Antibody (YA1874) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

HY-P81449

	hnRNP K Antibody (YA1194) HNRNPK; HNRPK; heterogeneous nuclear ribonucleoprotein K; hnRNP K; Transformation up-regulated nuclear protein; TUNP	IHC-P	Human
	hnRNP K Antibody (YA1194) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1194), targeting hnRNP K. hnRNP K Antibody (YA1194) can be used for IHC-P experiment in human background.

HY-P83284

	hnRNP G Antibody (YA3029) RBMX; HNRPG; RBMXP1; RNA-binding motif protein; X chromosome; Glycoprotein p43; heterogeneous nuclear ribonucleoprotein G; hnRNP G	WB, IHC-F, IHC-P, ICC/IF	Human
	hnRNP G Antibody (YA3029) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3029), targeting hnRNP G, with a predicted molecular weight of 42 kDa (observed band size: 42 kDa). hnRNP G Antibody (YA3029) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.

HY-P81279

	hnRNP U Antibody (YA979) heterogeneous nuclear ribonucleoprotein U; hnRNP U protein; HNRNPU; hnRNPU protein; HNRPU; HNRPU_HUMAN; p120; p120 nuclear protein; SAF A; SAF-A; SAFA; Scaffold attachment factor A; U21.1.	WB	Human
	hnRNP U Antibody (YA979) is a biotin-conjugated non-conjugated IgG1 antibody, targeting hnRNP U, with a predicted molecular weight of 91 kDa (observed band size: 110 kDa). hnRNP U Antibody (YA979) can be used for WB experiment in human background.

HY-P81279A

	hnRNP U Antibody (YA980) heterogeneous nuclear ribonucleoprotein U; hnRNP U protein; HNRNPU; hnRNPU protein; HNRPU; HNRPU_HUMAN; p120; p120 nuclear protein; SAF A; SAF-A; SAFA; Scaffold attachment factor A; U21.1.	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	hnRNP U Antibody (YA980) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA980), targeting hnRNP U, with a predicted molecular weight of 91 kDa (observed band size: 120 kDa). hnRNP U Antibody (YA980) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

HY-P82093

	hnRNP Q Antibody (YA1838) SYNCRIP; HNRPQ; NSAP1; heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protein 1; Synaptotagmin-binding; cytoplasmic RNA-interacting protein	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	hnRNP Q Antibody (YA1838) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1838), targeting hnRNP Q, with a predicted molecular weight of 70 kDa (observed band size: 65-82 kDa). hnRNP Q Antibody (YA1838) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.

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Inhibitors & Agonists

Screening Libraries

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Peptides

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heterogeneous

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Antibodies

Natural
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