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hexapeptide

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Amyloid-β (1) Apoptosis (1) ATM/ATR (1) Bacterial (2) c-Myc (1) Complement System (1) CXCR (1) EGFR (1) Endothelin Receptor (1) GHSR (1) HIV Protease (1) Interleukin Related (1) MDM-2/p53 (1) Microtubule/Tubulin (1) Notch (1) Opioid Receptor (2) Oxytocin Receptor (1) PGC-1α (1) Protease Activated Receptor (PAR) (2) Proteasome (1) Reactive Oxygen Species (1) Tau Protein (2) Wnt (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (4) Endocrinology (1) Infection (4) Inflammation/Immunology (2) Metabolic Disease (4) Neurological Disease (8)

By Targets:

Amino Acid Derivatives (1)

Amyloid-β (1)

Apoptosis (1)

ATM/ATR (1)

Bacterial (2)

c-Myc (1)

Complement System (1)

CXCR (1)

EGFR (1)

Endothelin Receptor (1)

GHSR (1)

HIV Protease (1)

Interleukin Related (1)

MDM-2/p53 (1)

Microtubule/Tubulin (1)

Notch (1)

Opioid Receptor (2)

Oxytocin Receptor (1)

PGC-1α (1)

Protease Activated Receptor (PAR) (2)

Proteasome (1)

Reactive Oxygen Species (1)

Tau Protein (2)

Wnt (1)

By Research Areas:

Cancer (4)

Cardiovascular Disease (4)

Endocrinology (1)

Infection (4)

Inflammation/Immunology (2)

Metabolic Disease (4)

Neurological Disease (8)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2096

Hexapeptide-11	Reactive Oxygen Species ATM/ATR MDM-2/p53	Infection
Hexapeptide-11 is a bioactive peptide with anti-aging effect. Hexapeptide-11 protects fibroblasts against oxidative stress-mediated premature cellular senescence by mediating a downregulation of cellular proteins, such as ataxia telangiectasia mutated (ATM) and p53 .

HY-P5225

*Acetyl hexapeptide-38*	PGC-1α	Others
Acetyl hexapeptide-38 is a bioactive peptide with upregulate adipogenesis effect and has been reported used as a cosmetic ingredient .

HY-N6793

Phomopsin A	Microtubule/Tubulin	Cancer
Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to tubulin .

HY-19738

NQTrp	Tau Protein	Neurological Disease
NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide ( ⁴¹GCWMLY ⁴⁶ within the N-terminus of γD-crystallin) as well as full-length γD-crystallin .

HY-N10790

RA-V	Wnt c-Myc Notch	Cancer
RA-V is a cyclic hexapeptide. RA-V has activity against Wnt, Myc and Notch with IC₅₀ values of 50, 75, and 93 ng/mL, respectively. RA-V can be used for the research of cancer-related signaling pathways .

HY-125553

Hexapeptide-10 Serilesine	Amino Acid Derivatives	Others
Hexapeptide-10 is an amino acid derivative .

HY-P5227

*Acetyl hexapeptide-49*	Interleukin Related	Inflammation/Immunology
Acetyl hexapeptide-49 is a bioactive peptide with anti-allergen effect and has been reported used as a cosmetic ingredient .

HY-N10793

RA-XI	Others	Cancer
RA-XI is a bicyclic hexapeptide isolated from Rubia cordifolia with antitumour activity .

HY-P10175

Acetalin-1	Opioid Receptor	Neurological Disease
Acetalin-1 (Ac-RFMWMK-NH2), a hexapeptide, is a μ opioid receptor antagonist with high affinity for μ and κ3 opioid receptor, weak affinity for κ1 receptors and no affinity for κ2 receptors .

HY-P1313A

PAR 4 (1-6) (TFA) GYPGQV TFA	Protease Activated Receptor (PAR)	Others
PAR 4 (1-6) TFA (GYPGQV TFA), a hexapeptide, is a fragment of protease-activated receptor 4 (PAR₄). PAR 4 (1-6) TFA acts as a PAR₄-specific agonist .

HY-P2673

Lys-Arg-Thr-Leu-Arg-Arg KRTLRR	EGFR	Others
Lys-Arg-Thr-Leu-Arg-Arg (KRTLRR) is a hexapeptide. Lys-Arg-Thr-Leu-Arg-Arg is a substrate of protein kinase C from EGF receptor. Lys-Arg-Thr-Leu-Arg-Arg can be used to determine the activity of protein kinase C .

HY-120301

L-366682	Oxytocin Receptor	Endocrinology
L-366682, a cyclic hexapeptide, possesses antagonism of oxytocin .

HY-P1675A

Acetyl-PHF6 amide TFA 1 Publications Verification AcPHF6 TFA; Ac-VQIVYK-NH2 TFA	Tau Protein	Neurological Disease
Acetyl-PHF6 amide TFA (AcPHF6 TFA) is a tau derived hexapeptide.

HY-125567

Antileukinate	CXCR	Inflammation/Immunology
Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury .

HY-P10151

PD 156252	Endothelin Receptor	Cardiovascular Disease
PD 156252 is a hexapeptide that is a highly potent endothelin (ET) antagonist. PD 156252 has enhanced binding affinity for rabbit ETA and rat ETB receptor subtypes with IC50 values of 1.0 and 40 nM, respectively.

HY-P1313

PAR 4 (1-6) (human) GYPGQV	Protease Activated Receptor (PAR)	Others
PAR 4 (1-6) human, a hexapeptide, is a fragment of protease-activated receptor 4 (PAR₄). PAR 4 (1-6) TFA acts as a PAR₄-specific agonist .

HY-P3119

Desotamide Desotamide A	Bacterial	Infection
Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces. It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs=16, 12.5, and 32 μg/mL, respectively).

HY-P10673

KwFwLL-NH2	GHSR	Metabolic Disease
KwFwLL-NH2, a hexapeptide, is a ghrelin receptor ligand. KwFwLL-NH2 can act as a specific inverse agonist at the ghrelin receptor but with moderate potency (EC₅₀=45.6 nM) .

HY-P2054

Mvt-101	HIV Protease	Infection
Mvt-101 is a hexapeptide-based inhibitor of HIV-1 protease. Mvt-101 is also reduced-peptide-bond inhibitor. Mvt-101 inhibits reproduction of the HIV virus by blocking protease action .

HY-P4788

Acetyl-Amyloid β-Protein (1-6) amide	Amyloid-β	Neurological Disease
Acetyl-Amyloid β-Protein (1-6) amide is a hexapeptide that contains a potential copper(II) binding site. Acetyl-Amyloid β-Protein (1-6) amide can be used for research of Alzheimer's disease and related disorders .

HY-P10177

Acetalin-3	Opioid Receptor	Neurological Disease
Acetalin-3 (Ac-RFMWMT-NH2), a hexapeptide, is a μ opioid receptor antagonist with high affinity for μ and κ3 opioid receptor, weak affinity for κ1 receptors and no affinity for κ2 receptors .

HY-P4910

Baceridin	Proteasome Apoptosis	Cancer
Baceridin is a proteasome inhibitor and a cyclic hexapeptide. Baceridin can be isolated from the culture medium of Epiphytic Bacillus. Baceridin can inhibit cell cycle progression and induce tumor cell apoptosis through a p53-independent pathway. Baceridin can be used in cancer research .

HY-E70375

*Fructosyl-peptide* oxidase (FPOX-CE)** Fructosyl-peptide: oxygen oxidoreductase	Others	Others
Fructosyl-peptide oxidase (FPOX-CE) (Fructosyl-peptide: oxygen oxidoreductase) is an enzyme that catalyzes the oxidation of glycopeptides. Fructosyl-peptide oxidase (FPOX-CE) shows high activity against small molecule glycated peptides, but no activity is detected against the glycated hexapeptide standard fVHLTPE used in the study. Fructosyl-peptide oxidase (FPOX-CE) can be used in the study of diabetes monitoring .

HY-P5506

C5a Receptor agonist, W5Cha	Complement System	Others
C5a Receptor agonist, W5Cha (Peptide 1) is a selective complement C5a receptor (C5aR) agonist (EC₅₀=0.2 μM), a hexapeptide derived from the C-terminus of C5a with specific amino acid modifications. C5a Receptor agonist, W5Cha is able to interact with the Arg-206 site of the C5a receptor through its C-terminal arginine, thereby activating the receptor .

HY-P10281

RW3	Bacterial	Infection
RW3 is a small cationic hexapeptide with amphiphilic properties. RW3 targets the plasma membrane of bacteria and works by inhibiting cell respiration and cell wall synthesis. RW3 shows high biological activity against gram-positive bacteria and does not show significant cytotoxic or hemolytic effects in previous studies. RW3 quickly kills 97% of the initial colony forming units (CFU) within 10 minutes at twice the minimum inhibitory concentration (MIC). RW3 can be used in antimicrobial and antifungal studies .

Cat. No.	Product Name	Type

HY-P2823

Trypsinogen	Biochemical Assay Reagents
Trypsinogen, a proenzyme synthesized in the pancreas, is activated to form trypsin by enterokinase upon reaching the small intestine lumen, where it opens a hexapeptide bond at the Lys6 - Ile7 junction, leading to the production of the active enzyme. This single polypeptide chain, composed of 229 amino acids and stabilized by six disulfide bridges, further autocatalytically converts additional trypsinogen into trypsin, which is initially present as β-trypsin before undergoing autolysis at the Lys131 - Ser132 site to form α-trypsin. As a serine protease, trypsin features His46 and Ser183 at its active site and exhibits optimal enzymatic activity at a pH range of 7 to 9.

Trypsinogen

Biochemical Assay Reagents

Trypsinogen, a proenzyme synthesized in the pancreas, is activated to form trypsin by enterokinase upon reaching the small intestine lumen, where it opens a hexapeptide bond at the Lys6 - Ile7 junction, leading to the production of the active enzyme. This single polypeptide chain, composed of 229 amino acids and stabilized by six disulfide bridges, further autocatalytically converts additional trypsinogen into trypsin, which is initially present as β-trypsin before undergoing autolysis at the Lys131 - Ser132 site to form α-trypsin. As a serine protease, trypsin features His46 and Ser183 at its active site and exhibits optimal enzymatic activity at a pH range of 7 to 9.

Cat. No.	Product Name	Target	Research Area

HY-P3163

Hexapeptide-9	Peptides	Others
Hexapeptide-9 is a collagen peptide, with anti-aging activity. Hexapeptide-9 is commonly used as the ingredient in skin care products for improving the appearance of the skin .

HY-P2096

Hexapeptide-11	Reactive Oxygen Species ATM/ATR MDM-2/p53	Infection
Hexapeptide-11 is a bioactive peptide with anti-aging effect. Hexapeptide-11 protects fibroblasts against oxidative stress-mediated premature cellular senescence by mediating a downregulation of cellular proteins, such as ataxia telangiectasia mutated (ATM) and p53 .

HY-P5270

Hexapeptide-12	Peptides	Metabolic Disease
Hexapeptide-12isa bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

HY-66015

*Palmitoyl hexapeptide-12*	Peptides	Others
Palmitoyl hexapeptide-12 is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

HY-125553

Hexapeptide-10 Serilesine	Amino Acid Derivatives	Others
Hexapeptide-10 is an amino acid derivative .

HY-P5222

Hexapeptide-33	Peptides	Others
Hexapeptide-33 is a bioactive peptide and has been reported used as a cosmetic ingredient .

HY-P5223

Hexapeptide-42	Peptides	Others
Hexapeptide-42 is a bioactive peptide and has been reported used as a cosmetic ingredient .

HY-P5254

Hexapeptide-3	Peptides	Metabolic Disease
Hexapeptide-3isa bioactive peptide with repair skin effect and has been reported used as a cosmetic ingredient .

HY-P5268

*Palmitoyl hexapeptide-14* Palmitoyl hexapeptide-6	Peptides	Metabolic Disease
Palmitoyl hexapeptide-14(Palmitoyl hexapeptide-6)isa bioactive peptide withanti-inflammatoryeffect and has been reported used as a cosmetic ingredient .

HY-P5221

*Acetyl hexapeptide-37*	Peptides	Others
Acetyl hexapeptide-37 is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

HY-P5225

*Acetyl hexapeptide-38*	PGC-1α	Others
Acetyl hexapeptide-38 is a bioactive peptide with upregulate adipogenesis effect and has been reported used as a cosmetic ingredient .

HY-P5227

*Acetyl hexapeptide-49*	Interleukin Related	Inflammation/Immunology
Acetyl hexapeptide-49 is a bioactive peptide with anti-allergen effect and has been reported used as a cosmetic ingredient .

HY-P5235

*Myristoyl hexapeptide-16*	Peptides	Others
Myristoyl hexapeptide-16 is a bioactive peptide with stimulate eyelash growth effect and has been reported used as a cosmetic ingredient .

HY-P5220

*Acetyl hexapeptide-1* Melitane	Peptides	Others
Acetyl hexapeptide-1 (Melitane) is a bioactive peptide with anti-wrinkle effect and can be used as a cosmetic ingredient .

HY-P5220A

*Acetyl hexapeptide-1 acetate* Melitane acetate	Peptides	Others
Acetyl hexapeptide-1 acetate (Melitane acetate) is a bioactive peptide with anti-wrinkle effect and can be used as a cosmetic ingredient .

HY-P0033

Argireline Acetyl hexapeptide-3	Peptides	Neurological Disease
Argireline (Acetyl hexapeptide-3) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline significantly inhibits Ca ²⁺ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline has antiwrinkle and anti-aging activity .

HY-P0033A

Argireline acetate Acetyl hexapeptide-3 acetate	Peptides	Neurological Disease
Argireline acetate (Acetyl hexapeptide-3 acetate) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline acetate significantly inhibits Ca ²⁺ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline acetate has antiwrinkle and anti-aging activity .

HY-P10175

Acetalin-1	Opioid Receptor	Neurological Disease
Acetalin-1 (Ac-RFMWMK-NH2), a hexapeptide, is a μ opioid receptor antagonist with high affinity for μ and κ3 opioid receptor, weak affinity for κ1 receptors and no affinity for κ2 receptors .

HY-P1313A

PAR 4 (1-6) (TFA) GYPGQV TFA	Protease Activated Receptor (PAR)	Others
PAR 4 (1-6) TFA (GYPGQV TFA), a hexapeptide, is a fragment of protease-activated receptor 4 (PAR₄). PAR 4 (1-6) TFA acts as a PAR₄-specific agonist .

HY-P2673

Lys-Arg-Thr-Leu-Arg-Arg KRTLRR	EGFR	Others
Lys-Arg-Thr-Leu-Arg-Arg (KRTLRR) is a hexapeptide. Lys-Arg-Thr-Leu-Arg-Arg is a substrate of protein kinase C from EGF receptor. Lys-Arg-Thr-Leu-Arg-Arg can be used to determine the activity of protein kinase C .

HY-P2333

LCKLSL 4 Publications Verification	Peptides	Cardiovascular Disease
LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles .

HY-P2333A

LCKLSL hydrochloride 4 Publications Verification	Peptides	Cardiovascular Disease
LCKLSL hydrochloride is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL hydrochloride potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL hydrochloride also inhibits the generation of plasmin and has anti-angiogenic roles .

HY-120301

L-366682	Oxytocin Receptor	Endocrinology
L-366682, a cyclic hexapeptide, possesses antagonism of oxytocin .

HY-P1675A

Acetyl-PHF6 amide TFA 1 Publications Verification AcPHF6 TFA; Ac-VQIVYK-NH2 TFA	Tau Protein	Neurological Disease
Acetyl-PHF6 amide TFA (AcPHF6 TFA) is a tau derived hexapeptide.

HY-P4239

H-AAAAAA-OH	Peptides	Others
Ala-Ala-Ala-Ala-Ala-Ala is a hexapeptide composed of six alanine amino acid residues .

HY-P1487

Pressinoic Acid	Peptides	Neurological Disease
Pressinoic Acid is a synthetic hexapeptide with potent corticotrophin-releasing activity. Pressinoic Acid is also an oxytocin inhibitor; it induces maternal behavior.

HY-P3834

*Antiarrhythmic peptide* (cattle atrium)**	Peptides	Cardiovascular Disease
Antiarrhythmic peptide (cattle atrium), a hexapeptide, shows a protective effect against experimental agent induced arrhythmias .

HY-125567

Antileukinate	CXCR	Inflammation/Immunology
Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury .

HY-P10151

PD 156252	Endothelin Receptor	Cardiovascular Disease
PD 156252 is a hexapeptide that is a highly potent endothelin (ET) antagonist. PD 156252 has enhanced binding affinity for rabbit ETA and rat ETB receptor subtypes with IC50 values of 1.0 and 40 nM, respectively.

HY-P1313

PAR 4 (1-6) (human) GYPGQV	Protease Activated Receptor (PAR)	Others
PAR 4 (1-6) human, a hexapeptide, is a fragment of protease-activated receptor 4 (PAR₄). PAR 4 (1-6) TFA acts as a PAR₄-specific agonist .

HY-P3119

Desotamide Desotamide A	Bacterial	Infection
Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces. It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs=16, 12.5, and 32 μg/mL, respectively).

HY-P10673

KwFwLL-NH2	GHSR	Metabolic Disease
KwFwLL-NH2, a hexapeptide, is a ghrelin receptor ligand. KwFwLL-NH2 can act as a specific inverse agonist at the ghrelin receptor but with moderate potency (EC₅₀=45.6 nM) .

HY-P2054

Mvt-101	HIV Protease	Infection
Mvt-101 is a hexapeptide-based inhibitor of HIV-1 protease. Mvt-101 is also reduced-peptide-bond inhibitor. Mvt-101 inhibits reproduction of the HIV virus by blocking protease action .

HY-P4788

Acetyl-Amyloid β-Protein (1-6) amide	Amyloid-β	Neurological Disease
Acetyl-Amyloid β-Protein (1-6) amide is a hexapeptide that contains a potential copper(II) binding site. Acetyl-Amyloid β-Protein (1-6) amide can be used for research of Alzheimer's disease and related disorders .

HY-P10177

Acetalin-3	Opioid Receptor	Neurological Disease
Acetalin-3 (Ac-RFMWMT-NH2), a hexapeptide, is a μ opioid receptor antagonist with high affinity for μ and κ3 opioid receptor, weak affinity for κ1 receptors and no affinity for κ2 receptors .

HY-P4651

H-Tyr-Ile-Gly-Ser-Arg-NH2	Peptides	Others
H-Tyr-Ile-Gly-Ser-Arg-NH2 is a hexapeptide that is an essential fragment of laminin responsible for efficient cell adhesion and receptor binding. H-Tyr-Ile-Gly-Ser-Arg-NH2 promotes various epithelial cell adhesion activities .

HY-P4910

Baceridin	Proteasome Apoptosis	Cancer
Baceridin is a proteasome inhibitor and a cyclic hexapeptide. Baceridin can be isolated from the culture medium of Epiphytic Bacillus. Baceridin can inhibit cell cycle progression and induce tumor cell apoptosis through a p53-independent pathway. Baceridin can be used in cancer research .

HY-P5506

C5a Receptor agonist, W5Cha	Complement System	Others
C5a Receptor agonist, W5Cha (Peptide 1) is a selective complement C5a receptor (C5aR) agonist (EC₅₀=0.2 μM), a hexapeptide derived from the C-terminus of C5a with specific amino acid modifications. C5a Receptor agonist, W5Cha is able to interact with the Arg-206 site of the C5a receptor through its C-terminal arginine, thereby activating the receptor .

HY-P10281

RW3	Bacterial	Infection
RW3 is a small cationic hexapeptide with amphiphilic properties. RW3 targets the plasma membrane of bacteria and works by inhibiting cell respiration and cell wall synthesis. RW3 shows high biological activity against gram-positive bacteria and does not show significant cytotoxic or hemolytic effects in previous studies. RW3 quickly kills 97% of the initial colony forming units (CFU) within 10 minutes at twice the minimum inhibitory concentration (MIC). RW3 can be used in antimicrobial and antifungal studies .

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hexapeptide

Inhibitors & Agonists

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