2. Immunology/Inflammation Cell Cycle/DNA Damage NF-κB Apoptosis Metabolic Enzyme/Protease PI3K/Akt/mTOR
  3. Reactive Oxygen Species ATM/ATR MDM-2/p53
  4. Hexapeptide-11

Hexapeptide-11 is a bioactive peptide with anti-aging effect. Hexapeptide-11 protects fibroblasts against oxidative stress-mediated premature cellular senescence by mediating a downregulation of cellular proteins, such as ataxia telangiectasia mutated (ATM) and p53 .

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Hexapeptide-11 Chemical Structure

Hexapeptide-11 Chemical Structure

CAS No. : 161258-30-6

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Based on 1 publication(s) in Google Scholar

Hexapeptide-11 Related Antibodies

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Description

Hexapeptide-11 is a bioactive peptide with anti-aging effect. Hexapeptide-11 protects fibroblasts against oxidative stress-mediated premature cellular senescence by mediating a downregulation of cellular proteins, such as ataxia telangiectasia mutated (ATM) and p53 [1].

Molecular Weight

676.80

Formula

C36H48N6O7
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Phe-Val-Ala-Pro-Phe-Pro
Sequence Shortening

FVAPFP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (147.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4775 mL 7.3877 mL 14.7754 mL
5 mM 0.2955 mL 1.4775 mL 2.9551 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4775 mL 7.3877 mL 14.7754 mL 36.9385 mL
5 mM 0.2955 mL 1.4775 mL 2.9551 mL 7.3877 mL
10 mM 0.1478 mL 0.7388 mL 1.4775 mL 3.6939 mL
15 mM 0.0985 mL 0.4925 mL 0.9850 mL 2.4626 mL
20 mM 0.0739 mL 0.3694 mL 0.7388 mL 1.8469 mL
25 mM 0.0591 mL 0.2955 mL 0.5910 mL 1.4775 mL
30 mM 0.0493 mL 0.2463 mL 0.4925 mL 1.2313 mL
40 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9235 mL
50 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.7388 mL
60 mM 0.0246 mL 0.1231 mL 0.2463 mL 0.6156 mL
80 mM 0.0185 mL 0.0923 mL 0.1847 mL 0.4617 mL
100 mM 0.0148 mL 0.0739 mL 0.1478 mL 0.3694 mL
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Hexapeptide-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hexapeptide-11161258-30-6Hexapeptide11Hexapeptide 11Reactive Oxygen SpeciesATM/ATRMDM-2/p53Ataxia telangiectasia mutatedATM and RAD3 relateddegenerative aging pathologiesoxidative stresspremature cellularInhibitorinhibitorinhibit

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