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hirudin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Thrombin (3)
By Research Areas:	Cancer (1) Cardiovascular Disease (5) Metabolic Disease (1)

3

Inhibitors & Agonists

8

Peptides

1

Natural
Products

1

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

*Hirudin*	Thrombin Apoptosis	Cardiovascular Disease Cancer
Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others .

*Succinyl-(Pro58,D-Glu65)-Hirudin* (56-65) (sulfated)**	Thrombin	Cardiovascular Disease
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a K_D < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM .

Desirudin CGP 39393; Revasc	Thrombin	Cardiovascular Disease
Desirudin (CGP 39393) is a thrombin inhibitor. Desirudin can inhibit the formation of blood clots and venous stasis thrombosis, which is used for the research of thrombocytopenia or platelet dysfunction .

Cat. No.	Product Name	Target	Research Area

*Hirudin*	Thrombin Apoptosis	Cardiovascular Disease Cancer
Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others .

Hirugen	Peptides	Others
Hirugen is a derivative of hirudin, an anticoagulant protein found in leeches .

Hirudin (54-65)	Peptides	Cardiovascular Disease
Hirudin (54-65) is a fragment of Hirudin with anticoagulant effects. Hirudin is a thrombin inhibitor with blood anticoagulant property .

Hirudin (55-65) (sulfated)	Peptides	Others
Hirudin (55-65) (sulfated) is a fragment of Hirudin with anticoagulant effects. Hirudin is a thrombin inhibitor with blood anticoagulant property.

Hirudin (54-65) (TFA)	Peptides	Cardiovascular Disease
Hirudin (54-65) TFA is a fragment of Hirudin with anticoagulant effects. Hirudin is a thrombin inhibitor with blood anticoagulant property .

*Acetyl-Hirudin* (55-65) (sulfated)**	Peptides	Others
Acetyl-Hirudin (55-65) (sulfated) is a Acetyl-fragment of Hirudin. Hirudin is a thrombin inhibitor with blood anticoagulant property .

*Succinyl-(Pro58,D-Glu65)-Hirudin* (56-65) (sulfated)**	Thrombin	Cardiovascular Disease
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a K_D < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM .

*Acetyl-Hirudin* (54-65) (sulfated)**	Peptides	Metabolic Disease
Acetyl-Hirudin (54-65) (sulfated) is a acetyl-fragment of Hirudin which binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex .

Cat. No.	Compare	Product Name	Species	Source

	Hirudin Protein, Poecilobdella viridis (P. pastoris) hirudin	Others	P. pastoris
	Hirudin Protein, a powerful thrombin-specific protease inhibitor, forms a stable non-covalent complex with alpha-thrombin, effectively preventing fibrinogen cleavage. This interaction underscores hirudin's critical role in regulating key coagulation cascade steps. Its specific thrombin inhibition emphasizes hirudin's significance as a therapeutic agent, particularly for precise blood clotting regulation. Hirudin Protein, Poecilobdella viridis (P. pastoris) is the recombinant Hirudin protein, expressed by P. pastoris , with tag free. The total length of Hirudin Protein, Poecilobdella viridis (P. pastoris) is 63 a.a., with molecular weight of ~6.7 kDa.

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