immunomodulating activities

By Targets:	Apoptosis (1) Bacterial (3) Biochemical Assay Reagents (1) CD3 (1) COX (1) Endogenous Metabolite (1) LPL Receptor (1) STAT (3) Syk (2)
By Research Areas:	Cancer (9) Infection (3) Inflammation/Immunology (12)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-109082A

Cevidoplenib dimesylate SKI-O-703 dimesylate	Syk	Inflammation/Immunology
Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities .

HY-W010169

Sodium 4-aminobenzoate 1 Publications Verification	Biochemical Assay Reagents	Others
Sodium 4-aminobenzoate is a biochemical assay reagent. According to its structure, sodium 4-aminobenzoate exhibits antioxidant, anticoagulant, fubrinolytic and immunomodulating activities, and can be utilized as a protective agent against UV-irradiation and in diagnostic tests for the state of the gastrointestinal tract .

HY-14743B

Golotimod hydrochloride SCV 07 hydrochloride; Gamma-D-glutamyl-L-tryptophan hydrochloride	Bacterial STAT	Infection Inflammation/Immunology Cancer
Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride (SCV 07 hydrochloride) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod hydrochloride (SCV 07 hydrochloride) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

HY-119109

Laminaran 1 Publications Verification	Endogenous Metabolite	Cancer
Laminaran is an β-1-3-glucan and a typical ligand for Dectin-1 from Eisenia Bicyclis, has potent immunomodulating, radioprotective, and anticancer activities . Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds . Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy .

HY-P991089

GEN-1044	CD3	Cancer
GEN-1044 is a bispecific CD3 and oncofetal antigen 5T4 antibody. GEN-1044 shows immunomodulating and antineoplastic activities .

HY-N4129

4''-methyloxy-Genistin	Others	Inflammation/Immunology
4''-methyloxy-Genistin, an isoflavone methyl-glycoside, is isolated from Cordyceps militaris grown on germinated soybeans. Isoflavones possess immunomodulating and antiallergic activities .

HY-106050

Tilomisole Wy 18251	COX	Inflammation/Immunology Cancer
Tilomisole (Wy 18251) is a benzimidazothiazole experimental agent with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation .

HY-N4128

4''-methyloxy-Daidzin Daidzein 7-O-Β-D-glucoside 4''-O-methylate	Others	Inflammation/Immunology
4''-methyloxy-Daidzin (Daidzein 7-O-Β-D-glucoside 4''-O-methylate), an isoflavone methyl-glycoside, is isolated from Cordyceps militaris grown on germinated soybeans. Isoflavones possess immunomodulating and antiallergic activities .

HY-12616

ACT-209905	LPL Receptor	Cancer
ACT-209905 is a S1P1 receptor agonist. ACT-209905 can inhibit glioblastoma (GBM) cell growth and migration. ACT-209905 also has immunomodulating activity, and can be used in research of autoimmune diseases .

HY-121619

Jacaric acid	Apoptosis	Inflammation/Immunology Cancer
Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC₅₀ is 11.8 μM), LNCaP (IC₅₀ is 2.2 μM) and DLD-1, induces apoptosis and necrosis . Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma . Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator . Jacaric acid is orally active.

HY-14743

Golotimod SCV 07; Gamma-D-glutamyl-L-tryptophan	Bacterial STAT	Infection Inflammation/Immunology Cancer
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

HY-14743A

Golotimod TFA SCV 07 TFA; Gamma-D-glutamyl-L-tryptophan TFA	Bacterial STAT	Infection Inflammation/Immunology Cancer
Golotimod TFA (SCV 07 TFA), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod TFA (SCV 07 TFA) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod TFA (SCV 07 TFA) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

HY-109082

Cevidoplenib SKI-O-703	Syk	Inflammation/Immunology
Cevidoplenib (SKI-O-703) is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. Cevidoplenib is also the mesylate form of SKI-O-592. Cevidoplenib and SKI-O-592 inhibits BCR-mediated survival, proliferation, and differentiation of B cells. And SKI-O-592 potently inhibits multiple kinases with IC₅₀s of 6.2 nM (Syk), 1.859 μM (Jak2), 5.807 μM (Jak3), 0.412 μM (RET), 0.687 μM (KOR), 1.783 μM (FLT3), 16.96 μM (FGFR1), 5.662 μM (FGFR3), and 0.709 μM (Pyk2), respectively .

Cat. No.	Product Name	Type

HY-W010169

Sodium 4-aminobenzoate 1 Publications Verification	Biochemical Assay Reagents
Sodium 4-aminobenzoate is a biochemical assay reagent. According to its structure, sodium 4-aminobenzoate exhibits antioxidant, anticoagulant, fubrinolytic and immunomodulating activities, and can be utilized as a protective agent against UV-irradiation and in diagnostic tests for the state of the gastrointestinal tract .

Cat. No.	Product Name	Target	Research Area

HY-106765A

Thymotrinan TFA RGH-0205 TFA; TP3 TFA	Peptides	Inflammation/Immunology
Thymotrinan (RGH-0205) TFA is a biologically active fragment of the naturally occurring thymus hormone thymopoietin and a immunomodulating peptide. Thymotrinan TFA exerts similar immunomodulatory activities to TP5 and to affect humoral as well as cellular responses .

HY-14743

Golotimod SCV 07; Gamma-D-glutamyl-L-tryptophan	Bacterial STAT	Infection Inflammation/Immunology Cancer
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

HY-P3315

Onilcamotide RV001	Peptides	Inflammation/Immunology Cancer
Onilcamotide (RV001) is a C-terminal peptide of RhoC protein. Onilcamotide is a cancer vaccine and has potential immunomodulating and antineoplastic activities .

HY-106765

Thymotrinan RGH-0205; TP3	Peptides	Inflammation/Immunology
Thymotrinan (RGH-0205) is a biologically active fragment of the naturally occurring thymus hormone thymopoietin and a immunomodulating peptide. Thymotrinan exerts similar immunomodulatory activities to TP5 and to affect humoral as well as cellular responses .

Cat. No.	Product Name	Target	Research Area

HY-P991089

GEN-1044	CD3	Cancer
GEN-1044 is a bispecific CD3 and oncofetal antigen 5T4 antibody. GEN-1044 shows immunomodulating and antineoplastic activities .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-119109

Laminaran 1 Publications Verification	Structural Classification Polysaccharides Microorganisms other families Classification of Application Fields Source classification Plants Disease Research Fields Saccharides Cancer	Endogenous Metabolite
Laminaran is an β-1-3-glucan and a typical ligand for Dectin-1 from Eisenia Bicyclis, has potent immunomodulating, radioprotective, and anticancer activities . Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds . Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy .

HY-N4129

4''-methyloxy-Genistin	Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Isoflavones	Others
4''-methyloxy-Genistin, an isoflavone methyl-glycoside, is isolated from Cordyceps militaris grown on germinated soybeans. Isoflavones possess immunomodulating and antiallergic activities .

HY-N4128

4''-methyloxy-Daidzin Daidzein 7-O-Β-D-glucoside 4''-O-methylate	Flavonoids Monophenols Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Plants Disease Research Fields Inflammation/Immunology Isoflavones	Others
4''-methyloxy-Daidzin (Daidzein 7-O-Β-D-glucoside 4''-O-methylate), an isoflavone methyl-glycoside, is isolated from Cordyceps militaris grown on germinated soybeans. Isoflavones possess immunomodulating and antiallergic activities .

HY-121619

Jacaric acid	Structural Classification Caprifoliaceae Ketones, Aldehydes, Acids Source classification Plants Centranthus ruber (L.) DC	Apoptosis
Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC₅₀ is 11.8 μM), LNCaP (IC₅₀ is 2.2 μM) and DLD-1, induces apoptosis and necrosis . Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma . Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator . Jacaric acid is orally active.

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immunomodulating activities

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