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Results for "

irritant

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (2) Antibiotic (1) Bacterial (1) Biochemical Assay Reagents (1) COX (1) Cytochrome P450 (2) Drug Derivative (1) Drug Metabolite (2) Endogenous Metabolite (3) Fungal (2) Histamine Receptor (1) Kallikrein (1) NF-κB (1) Parasite (1) PKC (1) Tyrosinase (1)
By Research Areas:	Cancer (3) Endocrinology (1) Infection (6) Inflammation/Immunology (8) Metabolic Disease (2) Neurological Disease (1)
Oligonucleotides:	Thickeners (1) Emulsifiers (1)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W010056

Diethyl fumarate 1 Publications Verification	Others	Inflammation/Immunology
Diethyl fumarate is a decomposition product of Malathion (an insecticide). Diethyl fumarate is a reputed skin irritant. Diethyl fumarate can causes non-immunologic contact urticaria on skin .

HY-136611

ω-Hydroxy-DEET	Drug Metabolite	Infection
ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes .

HY-130313

Sodium lauroyl glutamate	Amino Acid Derivatives	Inflammation/Immunology
Sodium lauroyl glutamate is an anionic amino acid surfactant. Sodium lauroyl glutamate has the irritant contact dermatitis potential, and possible anti-irritating potential in a surfactant mixture on human skin .

HY-B0544

Sodium Picosulfate Sodium Picosulphate	Others	Metabolic Disease
Sodium Picosulfate (Sodium Picosulphate) is a contact irritant laxative with oral activity. Sodium Picosulfate inhibits the absorption of water and electrolytes, increasing their production. Sodium Picosulfate can be used in colonoscopy applications .

HY-B0705

Desflurane	NF-κB	Neurological Disease
Desflurane is an airway irritant, acts as an anesthesia agent .

HY-161612

Mycosporine 2 glycine	Tyrosinase	Others
Mycosporine 2 glycine is an inhibitor for tyrosinase-related protein 1 (TYRP1), that binds TYRP1 with good affinity and stability. Mycosporine 2 glycine stimulates mild to moderate skin and ocular irritancy. Mycosporine 2 glycine is utilized in sunscreen products to cure hyperpigmentation-related diseases .

HY-123388

SCH 12223 free base	Others	Others Inflammation/Immunology
SCH 12223 free base is an orally available drug that protects the gastric and intestinal epithelium from harmful irritants .

HY-125116

Jatrophane 2	Others	Others
Jatrophane 2 is a kind of jatrophane diterpene polyester that can be isolated from the highly irritant extract of whole fresh plants of E. peplus L. (Euphorbiaceae) .

HY-125115

Jatrophane 3	Others	Others
Jatrophane 3 is a kind of jatrophane diterpene polyester that can be isolated from the highly irritant extract of whole fresh plants of E. peplus L. (Euphorbiaceae) .

HY-126931

Dinophysistoxin 1 DTX 1	Endogenous Metabolite	Cancer
Dinophysistoxin 1 (DTX 1, 35-methylokadaic acid) is a causative agent of diarrhetic shellfish poisoning. Dinophysistoxin 1 exerts tumor-promoting activity, serves as a skin irritant as well .

HY-W017050

2-Hydroxypropyl acrylate	Biochemical Assay Reagents	Others
2-Hydroxypropyl acrylate (HPA) is a severe irritant and corrosive to the skin. 2-Hydroxypropyl acrylate (HPA) is extensively applied in fibre, adhesives, rubber industry, paints and coatings industry .

HY-125648

Euphorbadienol alpha-Euphorbol	Parasite	Infection
Euphorbadienol (alpha-Euphorbol), a triterpenic compound, isolated from the latex of Euphorbia resinifera. The derivatives of Euphorbadienol can be used as elicitors of disease resistance, and has antileishmanial and antitrypanosomal activity .

HY-107793

Picosulfate sodium salt hydrate	Drug Derivative	Metabolic Disease
Picosulfate sodium salt hydrate is the hydrate of Sodium Picosulfate (HY-B0544). Picosulfate sodium salt hydrate is an orally active contact irritant laxative. Picosulfate sodium salt hydrate inhibits the absorption of water and electrolytes, increasing their production. Picosulfate sodium salt hydrate can be used in colonoscopy applications .

HY-129471

Arbaprostil	Endogenous Metabolite	Inflammation/Immunology
Arbaprostil is an orally active PGE1 (HY-B0131) analog. Arbaprostil protects the gastrointestinal mucosa from stomach acid and other irritants, promotes healing rate of gastric ucler through the antisecretory effect .

HY-B1062

Dexchlorpheniramine maleate S-(+)-Chlorpheniramine maleate salt	Histamine Receptor	Inflammation/Immunology Endocrinology
Dexchlorpheniramine maleate is an orally taken anti-histamine that has anti-inflammatory, anti-irritant, anti-allergic, and skin barrier effects. Dexchlorpheniramine maleate inhibits myocardial contraction in rats. Dexchlorpheniramine maleate can be used in studies of allergic rhinitis .

HY-17481A

Bumadizone calcium	Others	Inflammation/Immunology
Bumadizone calcium is the calcium salt of Bumadizone (HY-17481). Bumadizone calcium is a non-steroidal anti-inflammatory drug, that exhibits potential in ameliorating chronic inflammatory diseases. Bumadizone calcium is irritant to the gastric lining, which leads to gastric bleeding and ulceration .

HY-118834

Teleocidin A1 Lyngbyatoxin A	PKC	Cancer
Teleocidin A1 (Lyngbyatoxin A), a highly toxic skin irritant, is a potent activator of protein kinase C (PKC). Teleocidin A1 shows antiproliferative activity against HeLa cancer cells (IC₅₀=9.2 nM) .

HY-130313R

Sodium lauroyl glutamate (Standard)	Amino Acid Derivatives	Inflammation/Immunology
Sodium lauroyl glutamate (Standard) is the analytical standard of Sodium lauroyl glutamate. This product is intended for research and analytical applications. Sodium lauroyl glutamate is an anionic amino acid surfactant. Sodium lauroyl glutamate has the irritant contact dermatitis potential, and possible anti-irritating potential in a surfactant mixture on human skin .

HY-W145518

Pectin	Endogenous Metabolite Bacterial Antibiotic	Infection Cancer
Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of agents. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa .

HY-136611R

ω-Hydroxy-DEET (Standard)	Drug Metabolite	Infection
Carbasalate calcium (Standard) is the analytical standard of Carbasalate calcium. This product is intended for research and analytical applications. Carbasalate calcium is an anti-inflammatory, antipyretic, and analgesic agent.

HY-136063R

Mefentrifluconazole (Standard)	Fungal Cytochrome P450	Infection

HY-136063

Mefentrifluconazole	Fungal Cytochrome P450	Infection
Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (K_d= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC₅₀=0.92 μM) .

HY-167734

Pemedolac AY-30715	COX	Inflammation/Immunology
Pemedolac (AY-30715) is a potent analgesic with significant pain-relief efficacy against chemically induced and inflammatory pain in animal models. Pemedolac displays a notable separation between analgesic effects and anti-inflammatory activity, achieving effective pain relief at much lower doses than those required for anti-inflammatory or gastric irritant effects. Pemedolac also shows low ulcerogenic potential, indicating a safer profile compared to standard NSAIDs while being utilized for the treatment of neurological, skin, and musculoskeletal disorders.

HY-148949A

Kallikrein 5-IN-2 TFA	Kallikrein	Others
Kallikrein 5-IN-2 TFA is the TFA salt form of Kallikrein 5-IN-2 (HY-148949). Kallikrein 5-IN-2 TFA is a selective inhibitor for kallikrein 5 (KLK5) with pIC₅₀ of 7.1. Kallikrein 5-IN-2 TFA is non-phototoxic (100 μg/mL) and non-irritant. Kallikrein 5-IN-2 is stable at pH 4-pH 8 under non-oxidative condition. Kallikrein 5-IN-2 is potent in ameliorating the Netherton syndrome .

Cat. No.	Product Name

HY-L007

Immunology/Inflammation Compound Library	6,061 compounds
The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Inflammation is also the body's attempt at self-protection to remove harmful stimuli and begin the healing process. It’s part of the body's immune response. The immune system recognizes damaged cells, irritants, and pathogens, and inflammation begins the healing process. Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation. MCE designs a unique collection of 6,061 compounds that are useful tool for Immunology/Inflammation research or autoimmune inflammatory diseases drug discovery.

Immunology/Inflammation Compound Library

6,061 compounds

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Inflammation is also the body's attempt at self-protection to remove harmful stimuli and begin the healing process. It’s part of the body's immune response. The immune system recognizes damaged cells, irritants, and pathogens, and inflammation begins the healing process. Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation.

MCE designs a unique collection of 6,061 compounds that are useful tool for Immunology/Inflammation research or autoimmune inflammatory diseases drug discovery.

Diethyl fumarate 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Others
Diethyl fumarate is a decomposition product of Malathion (an insecticide). Diethyl fumarate is a reputed skin irritant. Diethyl fumarate can causes non-immunologic contact urticaria on skin .

Pectin	Infection Structural Classification Polysaccharides Malus pumila Mill. Source classification Rosaceae Plants Saccharides	Endogenous Metabolite Bacterial Antibiotic
Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of agents. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa .

Jatrophane 2	Structural Classification Terpenoids Source classification Euphorbia peplus Linn. Diterpenoids Euphorbiaceae Plants	Others
Jatrophane 2 is a kind of jatrophane diterpene polyester that can be isolated from the highly irritant extract of whole fresh plants of E. peplus L. (Euphorbiaceae) .

Jatrophane 3	Structural Classification Terpenoids Source classification Euphorbia peplus Linn. Diterpenoids Euphorbiaceae Plants	Others
Jatrophane 3 is a kind of jatrophane diterpene polyester that can be isolated from the highly irritant extract of whole fresh plants of E. peplus L. (Euphorbiaceae) .

Euphorbadienol alpha-Euphorbol	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Euphorbia wallichii Euphorbiaceae Plants Disease Research Fields	Parasite
Euphorbadienol (alpha-Euphorbol), a triterpenic compound, isolated from the latex of Euphorbia resinifera. The derivatives of Euphorbadienol can be used as elicitors of disease resistance, and has antileishmanial and antitrypanosomal activity .

Teleocidin A1 Lyngbyatoxin A	Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids Cancer	PKC
Teleocidin A1 (Lyngbyatoxin A), a highly toxic skin irritant, is a potent activator of protein kinase C (PKC). Teleocidin A1 shows antiproliferative activity against HeLa cancer cells (IC₅₀=9.2 nM) .

Cat. No.	Product Name		Classification

HY-W145518

Pectin		Emulsifiers Thickeners
Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of agents. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa .

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