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Results for "

mPGES-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (1) Isotope-Labeled Compounds (1) Lipoxygenase (5) NO Synthase (1) PGE synthase (20) Progesterone Receptor (3)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Endocrinology (4) Infection (1) Inflammation/Immunology (19) Neurological Disease (1)

Inhibitors & Agonists

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Products

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-118282

mPGES1-IN-7	PGE synthase	Endocrinology
mPGES-1-IN-2 (compound III) is a benzimidazole-based *mPGES-1* inhibitor that also inhibits adipophysin PGD synthase (I-PGDS) (5 μM, IR=60 %). mPGES-1-IN-2 reduces PGE2 production and tends to reduce levels of other prostaglandins. mPGES-1-IN-2 effectively inhibits acute inflammation in an air sac model stimulated by Carrageenan (HY-125474) in mice ^[1].

HY-13475

mPGES1-IN-8	PGE synthase	Inflammation/Immunology
mPGES1-IN-8, is a novel microsomal prostaglandin E synthase 1 (mPGES1) inhibitor ^[1].

HY-100864

mPGES1-IN-3	PGE synthase	Inflammation/Immunology
mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC₅₀: 8 nM), cell (A549 IC₅₀: 16.24 nM) and human whole blood potency (IC₅₀: 249.9 nM) ^[1].

HY-144238

mPGES1-IN-6	PGE synthase	Inflammation/Immunology
MPGES-1 is considered as a promising therapeutic target of the next generation anti-inflammatory drugs in the research of inflammatory diseases. The < b > IC < sub > 50 < / sub > < / b > value of mPGES1-IN-6 is 0.03 μ M。

HY-139364

mPGES1-IN-4	Others	Others
mPGES1-IN-4 (compound 32) is a polysubstituted pyrimidine compound and a submicromolar PGE2 production inhibitor. It exerts its anti-inflammatory effect mainly by inhibiting mPGES-1 and has a significant inhibitory effect on the acute inflammation model in vivo.

HY-139365

mPGES1-IN-5	Others	Others
mPGES1-IN-5 (compound 18) is a polysubstituted pyrimidine compound and a submicromolar PGE2 production inhibitor. It exerts its anti-inflammatory effect mainly by inhibiting mPGES-1 and has a significant inhibitory effect on the acute inflammation model in vivo.

HY-163736

mPGES-1/5-LOX-IN-1	Lipoxygenase PGE synthase	Inflammation/Immunology
mPGES-1/5-LOX-IN-1 (compound 3j) is a potent and orally active *mPGES-1* and 5-LOX dual inhibitor with IC₅₀ values of 0.92, 1.89 µM, respectively. mPGES-1/5-LOX-IN-1 shows anti-inflammatory impact ^[1].

HY-126898

*5-LO/mPGES1-IN-1*	Lipoxygenase PGE synthase	Inflammation/Immunology
5-LO/mPGES1-IN-1 (Compound 16) is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO). IC₅₀ values are 0.3 and 0.4 μM, respectively. 5-LO/mPGES1-IN-1 has anti-inflammatory activity ^[1].

HY-162166

*COX-2/15-LOX/mPGES1-IN-1*	COX Lipoxygenase	Inflammation/Immunology
COX-2/15-LOX/mPGES1-IN-1 (Compound 2c) is an inhibitor of COX-2, 15-LOX, and *mPGES-1* enzymes with IC₅₀ values of 0.057, 2.39, and 2.8 μM, respectively. COX-2/15-LOX/mPGES1-IN-1 possesses anti-inflammatory activity and can inhibit rat paw edema in vivo experiments ^[1].

HY-164358

α-Gracinoic acid	PGE synthase	Inflammation/Immunology
α-Gracinoic acid is an *mPGES-1* inhibitor with anti-inflammatory activity ^[1].

HY-125415

PF-4693627	PGE synthase	Inflammation/Immunology
PF-4693627 is a potent, selective and orally bioavailable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC₅₀=3 nM) for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA) ^[1].

HY-19622

PF-9184	PGE synthase	Inflammation/Immunology
PF-9184 is a potent and highly selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), with an IC₅₀ of 16.5 nM. PF-9184 inhibits IL-1β-induced PGE₂ synthesis in vitro ^[1].

HY-125975

1-Naphthyl 3,5-dinitrobenzoate	Lipoxygenase	Inflammation/Immunology
1-Naphthyl 3,5-dinitrobenzoate is a potent 5-lipoxygenase inhibitor with IC₅₀ values of 1.04 µM and 3.6 µM for 5-LOX and mPGES-1, respectively. 1-Naphthyl 3,5-dinitrobenzoate has strong inhibition activity in the human whole blood (HWB) assay with an IC₅₀ value of 8.6 μM. 1-Naphthyl 3,5-dinitrobenzoate can be used in research of inflammation ^[1].

HY-13283

MF63 1 Publications Verification	PGE synthase	Inflammation/Immunology
MF63 is a selective and orally active inhibitor of *mPGES-1. MF63 reduces the accumulation of PGE₂, relieves pyresis, hyperalgesia, and inflammatory pain by inhibiting mPGES-1* ^[1].

HY-156612

Friluglanstat	PGE synthase	Inflammation/Immunology
Friluglanstat is a prostaglandin E synthase (mPGES-1) inhibitor, with anti-inflammatory activity ^[1].

HY-111140

YS121	PGE synthase Lipoxygenase	Inflammation/Immunology
YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC₅₀=3.4 μM) and 5-lipoxygenase (5-LOX; IC₅₀=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC₅₀=12 μM in IL-1β-stimulated A549 cells ^[1].

HY-N9814

Shanciol B	NO Synthase	Inflammation/Immunology
Shanciol B, isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricate Hook, inhibits nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity ^[1]. Shanciol B is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with anti-inflammatory activity .

HY-144237

BRP-201	PGE synthase	Inflammation/Immunology
Brp-201 is considered as a promising therapeutic target for the next generation of anti-inflammatory drugs in the research of inflammatory diseases. It is a new, effective and selective inhibitor of mPGES-1 with an IC₅₀ value of 0.42 μM.

HY-139589

Zaloglanstat ISC-27864; GRC-27864	PGE synthase	Neurological Disease Inflammation/Immunology
Zaloglanstat (ISC-27864) is the inhibitor of the microsomal prostaglandin E synthase-1 (mPGES-1), and can be used to study asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases, etc ^[1].

HY-147416

Vipoglanstat BI 1029539; GS-248; OX-MPI	PGE synthase	Infection
Vipoglanstat (BI 1029539), a carboxamide, is a potent and selective, non-peptide and orally active small molecular inhibitor of human prostaglandin E synthase 1 *(mPGES-1)*. Vipoglanstat also has anti-inflammatory activity ^[1] .

HY-117008

CAY10589	PGE synthase	Inflammation/Immunology
CAY10589 is an inhibitor of *mPGES-1*, an enzyme induced during inflammatory responses. CAY10589 has no significant effect on the differentiation of BM myeloid precursor cells into M2-like TAMs ^[1] .

HY-118119

CAY10526	PGE synthase	Cancer
CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC₅₀<5 μM) in three melanoma cell lines expressing mPGES1 ^[1].

HY-162387

UK4b	PGE synthase	Cardiovascular Disease Inflammation/Immunology Cancer
UK4b is a highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. UK4b possesses anti-inflammatory and analgesic effects. UK4b can block the growth of abdominal aortic aneurysms in mice ^[1].

HY-149202

UT-11	PGE synthase	Inflammation/Immunology
UT-11 is a potent and brain-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC₅₀s of 0.10 μM and 2.00 μM for inhibiting PGE₂ production in human (SK-N-AS) and murine (BV2) cells, respectively ^[1].

HY-B0084

Dienogest 1 Publications Verification STS 557	Progesterone Receptor	Endocrinology
Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, *mPGES-1* and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia ^[1] .

HY-118184

AF3485	PGE synthase	Cancer
AF3485 is a human mPGES-1 inhibitor that exhibits antitumor activity in vitro and in vivo. AF3485 inhibits tumor-associated angiogenesis by reducing PGE2 production, inhibiting EGFR signaling, and decreasing VEGF and FGF-2 expression. AF3485 reduced tumor growth in mice bearing human A431 xenograft tumors by subchronic administration.

HY-B0084R

Dienogest (Standard)	Progesterone Receptor	Endocrinology
Dienogest (Standard) is the analytical standard of Dienogest. This product is intended for research and analytical applications. Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, *mPGES-1* and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia ^[1] .

HY-B0084S4

Dienogest-13C,15N,d4 STS 557-¹³C,¹⁵N,d₄	Isotope-Labeled Compounds Progesterone Receptor	Endocrinology
Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, *mPGES-1* and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia ^[1] .

HY-122064

FR20	Others	Others
FR20 acts as an inhibitor of human microsomal prostaglandin synthase 1 (mPGES 1).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9814

Shanciol B	Pholidota imbricata Hook. Classification of Application Fields Orchidaceae Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	NO Synthase
Shanciol B, isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricate Hook, inhibits nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity ^[1]. Shanciol B is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with anti-inflammatory activity .

Cat. No.	Product Name	Chemical Structure

HY-B0084S4

Dienogest-13C,15N,d4
Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, *mPGES-1* and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia ^[1] .

Dienogest-13C,15N,d4

Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia ^[1] .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81996

	Prostaglandin E Synthase Antibody (YA1741) PGES; mPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1	WB	Human, Mouse, Rat
	Prostaglandin E Synthase Antibody (YA1741) is a biotin-conjugated non-conjugated IgG antibody, targeting Prostaglandin E Synthase, with a predicted molecular weight of 17 kDa (observed band size: 17 kDa). Prostaglandin E Synthase Antibody (YA1741) can be used for WB experiment in human, mouse, rat background.

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