Search Result

Results for "

miR-21

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) DNA/RNA Synthesis (3) Drug Derivative (1) MicroRNA (24) PPAR (2) Programmed Cell Death 4 (PDCD4) (2) PROTACs (2) PTEN (1) TGF-beta/Smad (1)
By Research Areas:	Cancer (28)
Oligonucleotides:	miRNA mimics (5) miRNA agomirs (5) miRNA antagomirs (5) MicroRNAs (20) miRNA inhibitors (5)

Inhibitors & Agonists

Oligonucleotides

Targets Recommended: PAK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151516

microRNA-21-IN-2	MicroRNA	Cancer
microRNA-21-IN-2 is a potential *miR-21* inhibitor with an AC₅₀ value of 3.29 μM. microRNA-21-IN-2 can be used for the research of cancer .

HY-164053

MicroRNA modulator-1	MicroRNA	Cancer
MicroRNA modulator-1 (TABLE4 compound 1) is an oxadiazole *miR-21* inhibitor with AC₅₀ of 14.64 μM .

HY-164054

MicroRNA modulator-2	MicroRNA	Cancer
MicroRNA modulator-2 (TABLE4 compound 2) is an oxadiazole *miR-21* inhibitor with AC₅₀ of 16.48 μM .

HY-153534

microRNA-21-IN-3	MicroRNA	Cancer
microRNA-21-IN-3 (compound 45) can specifically bind to the precursor of oncogenic and pro-inflammatory microRNA-21 with medium nanomolar affinity, reduce cancer cell proliferation and miR-21 levels, and can be used in antitumor research .

HY-130487

miR-21-IN-2	Drug Derivative	Others
miR-21-IN-2 is an active compound.

HY-143208

HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt	DNA/RNA Synthesis	Cancer
HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt has inhibitory activity against pre-miR-21 RNA. HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt has the potential for the research of neoplastic disease such as cancer and especially cancers expressing miR-21 (extracted from patent WO2021087084A1, compound 25) .

HY-170791

CIB-L43	PTEN TGF-beta/Smad Akt	Cancer
CIB-L43 is an orally active TRBP inhibitor (K_D = 4.78 nM) and enhances disruption of TRBP-Dicer interactions (IC₅₀ = 2.34 μM). CIB-L43 suppresses oncogenic miR-21 biosynthesis, increasing PTEN and Smad7 expression and inhibiting AKT and TGF-β signaling, thereby reducing HCC cell proliferation and migration .

HY-R02843

*mmu-miR-21b mimic*	MicroRNA	Cancer
mmu-miR-21b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-21b mimic mmu-miR-21b mimic

HY-R02844

*mmu-miR-21c mimic*	MicroRNA	Cancer
mmu-miR-21c mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-21c mimic mmu-miR-21c mimic

HY-R00444

*hsa-miR-21-3p mimic*	MicroRNA	Cancer
hsa-miR-21-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-21-3p mimic hsa-miR-21-3p mimic

HY-R00449

*hsa-miR-21-5p mimic*	MicroRNA	Cancer
hsa-miR-21-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-21-5p mimic hsa-miR-21-5p mimic

HY-R02842

*mmu-miR-21a-3p mimic*	MicroRNA	Cancer
mmu-miR-21a-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-21a-3p mimic mmu-miR-21a-3p mimic

HY-RI02843

*mmu-miR-21b inhibitor*	MicroRNA	Cancer
mmu-miR-21b inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-21b inhibitor mmu-miR-21b inhibitor

HY-RI02844

*mmu-miR-21c inhibitor*	MicroRNA	Cancer
mmu-miR-21c inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-21c inhibitor mmu-miR-21c inhibitor

HY-RI00449

*hsa-miR-21-5p inhibitor*	MicroRNA	Cancer
hsa-miR-21-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-21-5p inhibitor hsa-miR-21-5p inhibitor

HY-RI00444

*hsa-miR-21-3p inhibitor*	MicroRNA	Cancer
hsa-miR-21-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-21-3p inhibitor hsa-miR-21-3p inhibitor

HY-R02844A

*mmu-miR-21c agomir*	MicroRNA	Cancer
mmu-miR-21c agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-21c agomir mmu-miR-21c agomir

HY-R02843A

*mmu-miR-21b agomir*	MicroRNA	Cancer
mmu-miR-21b agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-21b agomir mmu-miR-21b agomir

HY-RI02842

*mmu-miR-21a-3p inhibitor*	MicroRNA	Cancer
mmu-miR-21a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-21a-3p inhibitor mmu-miR-21a-3p inhibitor

HY-R00449A

*hsa-miR-21-5p agomir*	MicroRNA	Cancer
hsa-miR-21-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-21-5p agomir hsa-miR-21-5p agomir

HY-R00444A

*hsa-miR-21-3p agomir*	MicroRNA	Cancer
hsa-miR-21-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-21-3p agomir hsa-miR-21-3p agomir

HY-RI02844A

*mmu-miR-21c antagomir*	MicroRNA	Cancer
mmu-miR-21c antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-21c antagomir mmu-miR-21c antagomir

HY-RI02843A

*mmu-miR-21b antagomir*	MicroRNA	Cancer
mmu-miR-21b antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-21b antagomir mmu-miR-21b antagomir

HY-R02842A

*mmu-miR-21a-3p agomir*	MicroRNA	Cancer
mmu-miR-21a-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-21a-3p agomir mmu-miR-21a-3p agomir

HY-RI00449A

*hsa-miR-21-5p antagomir*	MicroRNA	Cancer
hsa-miR-21-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-21-5p antagomir hsa-miR-21-5p antagomir

HY-RI00444A

*hsa-miR-21-3p antagomir*	MicroRNA	Cancer
hsa-miR-21-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-21-3p antagomir hsa-miR-21-3p antagomir

HY-RI02842A

*mmu-miR-21a-3p antagomir*	MicroRNA	Cancer
mmu-miR-21a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-21a-3p antagomir mmu-miR-21a-3p antagomir

HY-139682

Dovitinib-RIBOTAC	PROTACs DNA/RNA Synthesis PPAR Programmed Cell Death 4 (PDCD4)	Cancer
Dovitinib RIBOTAC is an RNA-targeting RIBOTAC degrader that can specifically bind to and degrade *pre-miR-21*. Dovitinib RIBOTAC can inhibit the metastasis of breast cancer and has anti-tumor activity .

HY-139682A

Dovitinib-RIBOTAC TFA	PROTACs DNA/RNA Synthesis PPAR Programmed Cell Death 4 (PDCD4)	Cancer
Dovitinib RIBOTAC TFA is an RNA-targeting RIBOTAC degrader that can specifically bind to and degrade *pre-miR-21*. Dovitinib RIBOTAC TFA can inhibit the metastasis of breast cancer and has anti-tumor activity .

Cat. No.	Product Name		Classification