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minor metabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Metabolite (9) Endogenous Metabolite (4) FLT3 (1) Fungal (1) Microtubule/Tubulin (1) Parasite (2) Prostaglandin Receptor (2)
By Research Areas:	Cancer (4) Endocrinology (1) Infection (5) Metabolic Disease (5) Neurological Disease (2)

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Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Metabolite Endogenous Metabolite

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-133787

Levofloxacin N-oxide	Drug Metabolite	Infection
Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria .

HY-119663

Averantin	Fungal	Infection
Averantin is the minor metabolite of the fungus Cercospora arachidicola . Averantin is an aflatoxin B1 precursor that can be used in the biosynthetic pathway .

HY-113367

Suberylglycine	Endogenous Metabolite	Metabolic Disease
Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid.

HY-I0177

Vilazodone carboxylic acid	Drug Metabolite	Others
Vilazodone carboxylic acid is a vilazodone metabolite observed in both urine (major) and plasma (minor) .

HY-113085

3-Hydroxyhippuric acid	Endogenous Metabolite	Others
3-Hydroxyhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids.

HY-133794

Dasatinib N-oxide	Drug Metabolite	Cancer
Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor .

HY-N8853

Victoxinine	Others	Others
Victoxinine is a metabolite of Bipolaris sp. Victoxinine has minor phytotoxic .

HY-W701936

2-O-Desmethyl cisapride	Drug Metabolite	Neurological Disease
2-O-Desmethyl cisapride is a minor Cisapride metabolite .

HY-W011239

Fenbendazole sulfone Oxfendazole sulfone; FBZ-SO2	Parasite	Infection
Fenbendazole sulfone (Oxfendazole sulfone;FBZ-SO2) is a minor metabolite of Fenbendazole in plasma and is a benzimidazole anthelmintic agent .

HY-113367S1

Suberylglycine-d2	Endogenous Metabolite	Metabolic Disease
Suberylglycine-d₂ is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid[1][2].

HY-113367S

Suberylglycine-d4	Endogenous Metabolite	Metabolic Disease
Suberylglycine-d₄ is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid[1][2].

HY-118614

β-Nicotyrine	Drug Metabolite	Neurological Disease
β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid .

HY-139105

20-O-Demethyl-AP3	Microtubule/Tubulin	Infection Cancer
20-O-Demethyl-AP3 is a minor metabolite of Ansamitocin P-3. Ansamitocin P-3, a microtubule inhibitor, is a macrocyclic antitumor antibiotic .

HY-145461

Hydroxy lenalidomide 5-Hydroxy lenalidomide	Others	Others
Hydroxy lenalidomide (5-Hydroxy lenalidomide) is a metabolite of lenalidomide that is present as a minor component in plasma and excreta, accounting for less than 5% of the total radioactivity, following oral administration of lenalidomide in healthy male subjects.

HY-N11485

(25R)-12α-Hydroxyspirost-4-en-3-one	Drug Metabolite	Others
(25R)-12α-Hydroxyspirost-4-en-3-one is a minor metabolite produced by the action of Nocardia globerula on Hecogenin (HY-N1422) .

HY-133794S

Dasatinib N-oxide-d8	Drug Metabolite	Cancer
Dasatinib N-oxide-d₈ is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor[1][2].

HY-W011239R

Fenbendazole sulfone (Standard)	Parasite	Infection
Fenbendazole sulfone (Standard) is the analytical standard of Fenbendazole sulfone. This product is intended for research and analytical applications. Fenbendazole sulfone (Oxfendazole sulfone;FBZ-SO2) is a minor metabolite of Fenbendazole in plasma and is a benzimidazole anthelmintic agent .

HY-137158

16-Phenoxy tetranor Prostaglandin E2 16-Phenoxy tetranor PGE2	Prostaglandin Receptor	Metabolic Disease
16-phenoxy tetranor PGE2 is the free acid form of sulprostone formed by the hydrolysis of the methylsulfonamide bond.1 16-phenoxy tetranor PGE2 is a minor metabolite of sulprostone found in human plasma after parenteral administration of the drug.

HY-108263A

(S)-3-Hydroxy Midostaurin (S)-CGP52421	FLT3 Drug Metabolite	Cancer
(S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC₅₀ values of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML) .

HY-131527

Wy-45494 hydrochloride N-Desmethyl Venlafaxine hydrochloride; Wy 45494	Others	Metabolic Disease
Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC₅₀s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.

HY-116889

15-Keto latanoprost acid	Drug Metabolite	Others
15-keto Latanoprost is a potential metabolite of latanoprost (HY-B0577) when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye.1 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm Hg reduction in pupillary diameter at 5 μg/eye. Again, this is not as potent as many other F-type prostaglandins; for example, prostaglandin F2α will produce this degree of miosis at a dose of less than 1 μg/eye.

HY-113778

15-keto-17-phenyl trinor Prostaglandin F2α 15-keto-17-phenyl trinor PGF2α	Prostaglandin Receptor	Endocrinology
Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.1 Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye.2 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 μg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 μg/eye.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-119663

Averantin	Infection Quinones Microorganisms Classification of Application Fields Anthraquinones Source classification Disease Research Fields	Fungal
Averantin is the minor metabolite of the fungus Cercospora arachidicola . Averantin is an aflatoxin B1 precursor that can be used in the biosynthetic pathway .

HY-113367

Suberylglycine	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Metabolic Disease Endocrine diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid.

HY-113085

3-Hydroxyhippuric acid	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Hydroxyhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids.

HY-N8853

Victoxinine	Structural Classification Natural Products Microorganisms Source classification	Others
Victoxinine is a metabolite of Bipolaris sp. Victoxinine has minor phytotoxic .

HY-N11485

(25R)-12α-Hydroxyspirost-4-en-3-one	Triterpenes Structural Classification Terpenoids Source classification Endogenous metabolite	Drug Metabolite
(25R)-12α-Hydroxyspirost-4-en-3-one is a minor metabolite produced by the action of Nocardia globerula on Hecogenin (HY-N1422) .

Cat. No.	Product Name	Chemical Structure

HY-113367S

Suberylglycine-d4
Suberylglycine-d₄ is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid[1][2].

HY-113367S1

Suberylglycine-d2
Suberylglycine-d₂ is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid[1][2].

HY-133794S

Dasatinib N-oxide-d8
Dasatinib N-oxide-d₈ is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor[1][2].

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minor metabolite

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Isotope-Labeled Compounds

Natural
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