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Results for "

nucleophiles

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (3) Bacterial (3) Biochemical Assay Reagents (19) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (1) FAAH (4) Fluorescent Dye (1) Fungal (1) Glutathione S-transferase (1) Glyoxalase (GLO) (1) HIV (1) Ligands for E3 Ligase (2) Nucleoside Antimetabolite/Analog (1) PROTAC Linkers (1) Proteasome (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	Azide (1)

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Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W009177

S-Methylglutathione	Glyoxalase (GLO)	Others
S-Methylglutathione is an S-substitued glutathione and a stronger *nucleophile* than GSH . S-Methylglutathione has inhibitory effect on glyoxalase 1 .

HY-N0548

α-Angelica lactone 2 Publications Verification	Glutathione S-transferase	Cancer
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

HY-20556

DBU 1,8-Diazabicyclo[5.4.0]undec-7-ene	Biochemical Assay Reagents	Others
DBU acts as a nucleophile and can work as a catalyst .

HY-128429

Trans-2-Hexenal	Endogenous Metabolite	Others
Trans-2-Hexenal can be used for the determination of low-molecular-weight carbonyl compounds which are reactive with biological nucleophiles in biological samples .

HY-18081

PF 750	FAAH Autophagy	Metabolic Disease
PF 750 is a selective and covalent fatty acid amide hydrolase (FAAH) inhibitor, with IC₅₀s varied from 16.2-595 nM in different pre-incubation times. Covalently modifies the enzyme’s active site serine nucleophile .

HY-122426

1-Bromoundecane n-Undecyl bromide	Biochemical Assay Reagents	Others
1-Bromoundecane (n-Undecyl bromide) is a chemical reagent featuring a bromide along a saturated C11 chain. Bromide is easily displaced by nucleophiles such as alcohols or amines. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

HY-131846

6-Cl-5'-PuMP 6-Chloropurine 5'-ribonucleotide	Nucleoside Antimetabolite/Analog	Others
6-Cl-5'-PuMP is a reactive analogue of adenosine 5’-O-monophosphate (5’-AMP), and is suitable for modifying position 6 using various nucleophiles .

HY-W800830

DMG-Nitrophenyl carbonate	Biochemical Assay Reagents	Others
DMG-Nitrophenyl Carbonate is a short reagent featuring a DMG lipid headgroup and a nitrophenyl carbonate, which is readily displaced by amine nucleophiles to form carbamate bonds under mild conditions.

HY-W591314

M-PEG11-Ms	Biochemical Assay Reagents	Others
m-PEG11-Ms is a PEG linker featuring a methoxy cap and a mesylate group. The methoxy cap is inert while the mesylate is a good leaving group which is easily displaced by nucleophiles such as alcohols and amines.

HY-W586329

Thalidomide-4-carbaldehyde	Ligands for E3 Ligase	Others
Thalidomide-4-carbaldehyde is a Thalidomide analogue with an aldehyde. Thalidomide recruiits E3 ligase for the ubiquitinylation and subsequent proteolysis of target proteins. The aldehyde is highly reactive towards amine nucleophiles through reductive amination among other reactions.

HY-W451211

Thalidomide-5-carbaldehyde	Ligands for E3 Ligase	Cancer
Thalidomide-5-carbaldehyde is a Thalidomide analogue with an aldehyde. Thalidomide recruiits E3 ligase for the ubiquitinylation and subsequent proteolysis of target proteins. The aldehyde is highly reactive towards amine nucleophiles through reductive amination among other reactions.

HY-W393115

Diethyl (6-bromohexyl)phosphonate	Biochemical Assay Reagents	Others
Diethyl 6-bromohexylphosphonate is a short linker featuring a bromide and a diethyl phosphonate. The bromide is a good leaving group which can be easily displaced by nucleophiles like alcohols, amines or thiols, while the diethyl phosphonate may be hydrolyzed to allow for esterification.

HY-W190836

N3-PEG2-Tos	Biochemical Assay Reagents	Others
Azide-PEG2-Tos is a small PEG linker featuring an azide and a tosylate. Tosylates are good leaving groups which are easily displaced by nucleophiles while azide is a click chemistry handle which is used to react with terminal alkynes or strained cyclooctynes.

HY-W190738

Azide-PEG8-Tos	Biochemical Assay Reagents	Others
Azide-PEG8-Tos is a small PEG linker featuring an azide and a tosylate. Tosylates are good leaving groups which are easily displaced by nucleophiles while azide is a click chemistry motif which is used to react with terminal alkynes or strained cyclooctynes.

HY-172511

m-PEG9-4-Nitrophenyl carbonate	Biochemical Assay Reagents	Others
m-PEG9-4-nitrophenyl carbonate serves as a PEG linker containing a nitrophenyl carbonate, which is readily displaced by amine nucleophiles to form carbamate bonds under mild conditions. The PEG9 chain bolsters the water solublity of the compound.

HY-W800743

Heptyl 6-bromohexanoate	Biochemical Assay Reagents	Others
Heptyl 6-bromohexanoate is a chemical reagent featuring a bromide linked to a larger ester chain consisting of a C6 ester coupled to a C7 alcohol. Bromide is easily displaced by nucleophiles in substitution reactions. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

HY-150226

Enzyme-IN-1	Proteasome	Inflammation/Immunology
Enzyme-IN-1 (compound 1) is a peptide-based inhibitor of N-terminal nucleophile (Ntn) hydrolases. Specifically, Enzyme-IN-1 inhibits the chymotrypsin-like activity (CT-L) of the 20S proteasome. Enzyme-IN-1 may has potential antiinflammatory properties .

HY-W190936

Thalidomide-O-PEG5-tosyl	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-O-PEG5-Tosyl is a molecule that incorporatess the Thalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. Thalidomide-O-PEG5-tosyl is reactive with nucleophiles such as amine, hydroxy containing molecules.

HY-W440809

Nonyl 8-bromooctanoate	Biochemical Assay Reagents	Others
Nonyl 8-bromooctanoate is a chemical reagent featuring a bromide linked to a larger ester chain consisting of a C8 ester coupled to a C9 chain. Bromide is easily displaced by nucleophiles in substitution reactions.Nonyl 8-bromooctanoate can be used as an intermediate in building lipids for use in lipid nanoparticles.

HY-W800652

(S,R,S)-AHPC-PEG4-tosyl	PROTAC Linkers	Cancer
(S, R, S)-AHPC-PEG4-tosyl is a PROTAC linker that incorporatess an E3 ligase ligand with a PEG4 linker to empower PROTAC drug research & discovery. PEG4 spacer increases the compound's hydrophility. Tosyl group is reactive with amine or other nucleophiles.

HY-W401062

2-Undecyloxirane 1,2-Epoxytridecane	Biochemical Assay Reagents	Others
2-Undecyloxirane (1,2-Epoxytridecane) is a chemical reagent featuring an epoxy group on a C11 chain. The epoxy group undergoes ring opening in the presence of nucleophiles to form a branched structure containing a secondary alcohol. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

HY-W010243

Methylisothiazolinone hydrochloride	Bacterial	Infection
Methylisothiazolinone hydrochloride is the constituent of the biocide Kathon CG. Methylisothiazolinone hydrochloride is an isothiazolone derivative widely used as a preservative. Methylisothiazolinone hydrochloride is also a moderate sensitizer and reacts with GSH .

HY-W800742

Heptadecan-9-yl 6-bromohexanoate	Biochemical Assay Reagents	Others
Heptadecan-9-yl 6-bromohexanoate is a chemical reagent featuring a bromide linked to a larger ester chain consisting of a C6 ester coupled to the central position of a C17 chain. Bromide is easily displaced by nucleophiles in substitution reactions. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

HY-126944

2-Aminobenzanilide 2-Amino-N-phenylbenzamide	Biochemical Assay Reagents	Cancer
2-Aminobenzamide is a neutral and stable compound used as fluorescent tag, numerously in Glycan analysis. 2-aminobenzamide acts as the starting material for several important reactions like Bargellini reaction as an competent ambident nucleophile. Specifically 2-aminobenzamide and its derivatives are used in the blood coagulation cascade .

HY-14380

PF-3845 1 Publications Verification	FAAH Autophagy	Inflammation/Immunology Cancer
PF-3845 is a potent, selective, irreversible and orally active inhibitor of fatty acid amide hydrolase (FAAH), with a K_i of 0.23 µM. PF-3845 is a covalent inhibitor that carbamylates FAAH's serine nucleophile. PF-3845 can reduce pain sensation, inflammation, and anxiety/depression without substantial effects on motility or cognition .

HY-101974

Biotin-PEG3-Bromide	Biochemical Assay Reagents	Others
Biotin-PEG3-Bromide is a short PEG linker featuring a biotin group and a bromide. The bromide is a halogen which is easily displaced by nucleophiles such as alcohols or amines. Alternatively, bromide can be applied in a number of cross-coupling reactions such as in a Suzuki reaction. Biotin is useful for affinity-based applications such as pull-down assays or for ligating with streptavidin proteins.

HY-172294

Mes-PEG2-CH2-t-butyl ester	Biochemical Assay Reagents	Others
Mes-PEG2-CH2-t-butyl ester is a PEG linker consisting of a PEG2 linker for improved water-solubility of the compound and a t-butyl ester group which can be deprotected under acidic conditions. The mesylate serves as an excellent leaving group, offering all the advantages without the limitation of having an acidic proton that could react with nucleophiles.

HY-112526

Thiofluor 623	Fluorescent Dye	Others
Thiofluor 623 (Compound 3) is a fluorescent turn-on probe that can be used for the selective sensing and bioimaging of thiols. Thiofluor 623 displays excellent immunity to interference from nitrogen and oxygen nucleophiles. Thiofluor 623 is essentially nonfluorescent in the absence of thiols, which cleave the probe and release the red-emissive donor-acceptor fluorophore (Ex=563 nm, Em=623 nm) .

HY-W728451

URB694	FAAH	Cardiovascular Disease Neurological Disease
URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare ¹¹C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH .

HY-W800844

NH-bis(PEG8-OH)	Biochemical Assay Reagents	Others
NH-bis(PEG8-OH) is a homobifunctional reagent containing two alcohols joined together by a secondary amine. The alcohols can be used in a variety of ways such as in forming esters with carboxylic acids, while the secondary amine can be used as a nucleophile in linking with ketones, aldehydes, and carboxylic acids. The PEG spacers make this molecule water-soluble, potentially altering its DMPK properties.

HY-28009

2-((7Z,10Z)-Hexadeca-7,10-dien-1-yl)oxirane	Biochemical Assay Reagents	Others
2-(7Z,10Z)-7,10-Hexadecadien-1-yloxirane is an intermediate for the preparation of lipid molecules. 2-((7Z,10Z)-Hexadeca-7,10-dien-1-yl)oxirane features a polyunsaturated chain with an epoxy ring that can be opened by nucleophiles.

HY-106991A

Amustaline dihydrochloride S-303 dihydrochloride	HIV Bacterial	Infection
Amustaline (S-303) dihydrochloride, a nucleic acid-targeted alkylator, is an efficient pathogen inactivation agent for blood components containing red blood cells. Amustaline dihydrochloride has three components: an acridine anchor (an intercalator that targets nucleic acids non-covalently), an effector (a bis-alkylator group that reacts with nucleophiles), and a linker (a small flexible carbon chain containing a labile ester bond that hydrolyzes at neutral pH to yield non-reactive breakdown products) .

HY-W073382

4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid Bis–sulfone Acid	Biochemical Assay Reagents	Others
4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid (Bis-sulfone Acid) is a strong covalent linker featuring a free carboxylic acid and two tosyl groups. Each tosyl group can be displaced by thiol or amine nucleophiles via a Michael addition, and the inclusion of two on this molecule allow this reaction to proceed twice. This may be used to “staple” two reduced cysteine residues on a given protein to reform disulfide bridges. The carboxylic acid is free to react to form amides or esters.

HY-10865

LY2183240 2 Publications Verification	FAAH Autophagy	Neurological Disease
LY2183240 is a highly potent blocker of anandamide uptake (IC₅₀= 270 pM; K_i=540 nM). LY2183240 is a potent, covalent inhibitor of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) with an IC₅₀ of 12.4 nM. LY2183240 inactivates FAAH by carbamylation of the enzyme's serine nucleophile. LY2183240 also inhibits several other brain serine hydrolases with IC₅₀s of 5.3, 0.09, 8.2 nM for MAG lipase, bh6 and KIAA1363, respectively .

HY-126637

Marasmic acid	Bacterial Fungal	Infection
Marasmic acid is a sesquiterpenoid with unsaturated dialdehyde functionality, first isolated from the Basidiomycete Marasmus conigenus. Marasmic acid has antibacterial, antifungal, cytotoxic and mutagenic activities, and its broad-spectrum activity is related to the α,β-unsaturated aldehyde group. However, its detailed biological mechanism of action has not been clarified. Previous studies have suggested that marasmic acid may exert its effects by reacting with endogenous nucleophiles or forming pyrrole derivatives. This study found that marasmic acid interferes with the membrane sensor histidine kinase MoSln1p of M. oryzae, superactivates the HOG pathway and causes cell death, indicating that its mechanism of action is different from other unsaturated dialdehyde sesquiterpenoids.

HY-W250129

2,3,4,5-Tetrafluorobenzoyl chloride	Biochemical Assay Reagents	Others
2,3,4,5-Tetrafluorobenzoyl chloride is a fluorinated organic compound that belongs to the class of benzoyl chlorides. It is a colorless liquid with a pungent smell and is mainly used as an intermediate in the synthesis of various pharmaceutical and pesticide compounds. 2,3,4,5-Tetrafluorobenzoyl chloride is an acylating agent that can react with a variety of nucleophiles, including amines, alcohols, and thiols, to form amides, esters, or thioesters, respectively. Its unique fluorine-containing structure can impart desired properties to target molecules, such as increased lipophilicity or increased stability against metabolic degradation. However, due to its high reactivity and potential health hazards, proper safety measures and handling procedures must be followed when using this compound.

Cat. No.	Product Name

HY-L915

Lysine Focused Covalent Fragment Library	445 compounds
Lysine is the second most common target residue used in the design of TCIs and related covalent ligands. Its appeal lies in its abundance in human proteins, which is approximately three times higher than that of cysteine (5.8% vs. 1.9%). This significantly increases the number of proteins suitable for covalent targeting, especially given that many human proteins lack ligandable cysteine residues. Moreover, it has been suggested that functional lysines have a lower probability of being replaced by mutation, as they often play a crucial role in catalysis by acting as bases or nucleophiles. Additionally, lysines are essential for maintaining the structural integrity of proteins and for regulating post-translational modifications (PTMs). Consequently, targeting lysine has garnered significant interest in recent years. Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 445 fragment molecules which can target lysine residue and can be used for fragment-based covalent drug discovery.

Lysine Focused Covalent Fragment Library

445 compounds

Lysine is the second most common target residue used in the design of TCIs and related covalent ligands. Its appeal lies in its abundance in human proteins, which is approximately three times higher than that of cysteine (5.8% vs. 1.9%). This significantly increases the number of proteins suitable for covalent targeting, especially given that many human proteins lack ligandable cysteine residues. Moreover, it has been suggested that functional lysines have a lower probability of being replaced by mutation, as they often play a crucial role in catalysis by acting as bases or nucleophiles. Additionally, lysines are essential for maintaining the structural integrity of proteins and for regulating post-translational modifications (PTMs). Consequently, targeting lysine has garnered significant interest in recent years.

Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 445 fragment molecules which can target lysine residue and can be used for fragment-based covalent drug discovery.

Cat. No.	Product Name	Type

HY-101974

Biotin-PEG3-Bromide	Fluorescent Dyes/Probes
Biotin-PEG3-Bromide is a short PEG linker featuring a biotin group and a bromide. The bromide is a halogen which is easily displaced by nucleophiles such as alcohols or amines. Alternatively, bromide can be applied in a number of cross-coupling reactions such as in a Suzuki reaction. Biotin is useful for affinity-based applications such as pull-down assays or for ligating with streptavidin proteins.

Biotin-PEG3-Bromide

Fluorescent Dyes/Probes

Biotin-PEG3-Bromide is a short PEG linker featuring a biotin group and a bromide. The bromide is a halogen which is easily displaced by nucleophiles such as alcohols or amines. Alternatively, bromide can be applied in a number of cross-coupling reactions such as in a Suzuki reaction. Biotin is useful for affinity-based applications such as pull-down assays or for ligating with streptavidin proteins.

HY-112526

Thiofluor 623	Fluorescent Dyes/Probes
Thiofluor 623 (Compound 3) is a fluorescent turn-on probe that can be used for the selective sensing and bioimaging of thiols. Thiofluor 623 displays excellent immunity to interference from nitrogen and oxygen nucleophiles. Thiofluor 623 is essentially nonfluorescent in the absence of thiols, which cleave the probe and release the red-emissive donor-acceptor fluorophore (Ex=563 nm, Em=623 nm) .

Cat. No.	Product Name	Type

HY-126944

2-Aminobenzanilide 2-Amino-N-phenylbenzamide	Indicators
2-Aminobenzamide is a neutral and stable compound used as fluorescent tag, numerously in Glycan analysis. 2-aminobenzamide acts as the starting material for several important reactions like Bargellini reaction as an competent ambident nucleophile. Specifically 2-aminobenzamide and its derivatives are used in the blood coagulation cascade .

HY-W250129

2,3,4,5-Tetrafluorobenzoyl chloride	Biochemical Assay Reagents
2,3,4,5-Tetrafluorobenzoyl chloride is a fluorinated organic compound that belongs to the class of benzoyl chlorides. It is a colorless liquid with a pungent smell and is mainly used as an intermediate in the synthesis of various pharmaceutical and pesticide compounds. 2,3,4,5-Tetrafluorobenzoyl chloride is an acylating agent that can react with a variety of nucleophiles, including amines, alcohols, and thiols, to form amides, esters, or thioesters, respectively. Its unique fluorine-containing structure can impart desired properties to target molecules, such as increased lipophilicity or increased stability against metabolic degradation. However, due to its high reactivity and potential health hazards, proper safety measures and handling procedures must be followed when using this compound.

2,3,4,5-Tetrafluorobenzoyl chloride

Biochemical Assay Reagents

2,3,4,5-Tetrafluorobenzoyl chloride is a fluorinated organic compound that belongs to the class of benzoyl chlorides. It is a colorless liquid with a pungent smell and is mainly used as an intermediate in the synthesis of various pharmaceutical and pesticide compounds. 2,3,4,5-Tetrafluorobenzoyl chloride is an acylating agent that can react with a variety of nucleophiles, including amines, alcohols, and thiols, to form amides, esters, or thioesters, respectively. Its unique fluorine-containing structure can impart desired properties to target molecules, such as increased lipophilicity or increased stability against metabolic degradation. However, due to its high reactivity and potential health hazards, proper safety measures and handling procedures must be followed when using this compound.

Cat. No.	Product Name	Target	Research Area

HY-W009177

S-Methylglutathione	Glyoxalase (GLO)	Others
S-Methylglutathione is an S-substitued glutathione and a stronger *nucleophile* than GSH . S-Methylglutathione has inhibitory effect on glyoxalase 1 .

Cat. No.	Product Name		Classification

HY-W190836

N3-PEG2-Tos		Azide
Azide-PEG2-Tos is a small PEG linker featuring an azide and a tosylate. Tosylates are good leaving groups which are easily displaced by nucleophiles while azide is a click chemistry handle which is used to react with terminal alkynes or strained cyclooctynes.

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nucleophiles

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Biochemical Assay Reagents

Peptides

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